scholarly journals Formulation and Evaluation of 3D Printed Pregabalin Tablets Targeted For Neuropathic Pain By Qbd Approach For Personalized Medicine

2021 ◽  
Vol 11 (6) ◽  
pp. 1-13
Author(s):  
Bhusnure omprakash Gadgeppa ◽  
Mule Shrikrishna Tukaram ◽  
Gholvesachin Baburo ◽  
Giram padamja Sidram ◽  
Gaurav Agarwal Prof.(Dr) ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
3D Printing ◽  
Drug Release ◽  
Thermo Gravimetric Analysis ◽  
Processing Condition ◽  
Gravimetric Analysis ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
3D Printed

The 3D printing technology has been newly employed in the design and formulation of different dosage forms with the aim formulation and evaluation of 3D printed Pregabalin tablets for the treatment of neuropathic pain by QbD approach. Drug (Pregabalin) together with other excipients, were mixed and extruded into filaments by hot melt extrusion. Then with the help of fused deposition modeling these obtained filaments were printed into tablets. Due to the use of different polymers in the printed formulation different release profiles for the 3D printed tablets were obtained. Drug release characteristics change the infill or the size of the printed tablets, allowing the personalization of the tablets. Filaments and tablets were characterized by means of Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X- RAY powder diffraction (XRPD), and thermo gravimetric analysis (TGA). The results showed that after printing, the processing condition did not have a significant impact on the stability of the drug and the crystalline nature of the drug remained. FDM 3D printing makes it possible not only to formulate 3D printing Pregabalin tablets for the treatment of neuropathic pain but also to modify the potential of additive manufacturing in the development of personalized dose medicines. This study presents novel formulations containing Pregabalin for prevention of neuropathic pain and investigates 3D printing technology for personalized production of oral solid dosage from enabling adjustable dose as well as drug release properties.

Fabrication of modified-release custom-designed ciprofloxacin tablets via fused deposition modeling 3D printing

2020 ◽  
Vol 4 (1) ◽  
pp. 17-27
Author(s):  
Nasir Abbas ◽  
Nadia Qamar ◽  
Amjad Hussain ◽  
Sumera Latif ◽  
Muhammad Sohail Arshad ◽  
...  
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Fused Deposition Modeling ◽  
Structural Characteristics ◽  
Thermo Gravimetric Analysis ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Ciprofloxacin Hydrochloride ◽  
Fused Deposition ◽  
Degradation Temperature

Aim: The aim of the present work was to fabricate customized tablets of ciprofloxacin hydrochloride through 3D printing for optimized dosing. Materials & methods: A hot melt extrusion technique was employed to produce polyvinyl alcohol filaments with differing strengths of ciprofloxacin hydrochloride. Drug-loaded filaments were characterized for mechanical strength, thermal behavior and structural characteristics prior to printing of tablets by varying the infill percentage. Final formulations were evaluated for drug release profiles. Results: The prepared formulations contained 15–20% drug. The drug release patterns of different formulations were found to be reliant on infill percentage. Differential scanning calorimetry and thermo-gravimetric analysis confirmed that degradation temperature of drug is way above the printing temperature. Conclusion: This work is potentially significant for optimized antibiotic dosing, which in turn leads to enhanced clinical outcome.

scholarly journals Design with Use of 3D Printing Technology

2020 ◽  
Vol 28 (4) ◽  
pp. 283-291
Author(s):  
Magdalena Rozmus ◽  
Piotr Dobrzaniecki ◽  
Michał Siegmund ◽  
Juan Alfonso Gómez Herrero
Keyword(s):  
3D Printing ◽  
Lower Cost ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Design Concepts ◽  
Fused Deposition ◽  
New Concepts ◽  
3D Printed ◽  
Manufacturing Methods ◽  
Printing Method

AbstractDynamic development of 3D printing technology contributes to its wide applicability. FDM (Fused Deposition Method) is the most known and popular 3D printing method due to its availability and affordability. It is also usable in design of technical objects – to verify design concepts with use of 3D printed prototypes. The prototypes are produced at lower cost and shorter time comparing to other manufacturing methods and might be used for a number of purposes depending on designed object’s features they reflect. In the article, usability of 3D printing method FDM for designing of technical objects is verified based on sample functional prototypes. Methodology applied to develop these prototypes and their stand tests are covered. General conclusion is that 3D printed prototypes manufactured with FDM method proved to be useful for verifying new concepts within design processes carried out in KOMAG.

scholarly journals Research of TPU Materials for 3D Printing Aiming at Non-Pneumatic Tires by FDM Method

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2492
Author(s):  
Jun Wang ◽  
Bin Yang ◽  
Xiang Lin ◽  
Lei Gao ◽  
Tao Liu ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Low Cost ◽  
Three Dimensional ◽  
Printing Technology ◽  
Performance Simulation ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
3D Printed ◽  
Pneumatic Tires

3D printing technology has been widely used in various fields, such as biomedicine, clothing design, and aerospace, due to its personalized customization, rapid prototyping of complex structures, and low cost. However, the application of 3D printing technology in the field of non-pneumatic tires has not been systematically studied. In this study, we evaluated the application of potential thermoplastic polyurethanes (TPU) materials based on FDM technology in the field of non-pneumatic tires. First, the printing process of TPU material based on fused deposition modeling (FDM) technology was studied through tensile testing and SEM observation. The results show that the optimal 3D printing temperature of the selected TPU material is 210 °C. FDM technology was successfully applied to 3D printed non-pneumatic tires based on TPU material. The study showed that the three-dimensional stiffness of 3D printed non-pneumatic tires is basically 50% of that obtained by simulation. To guarantee the prediction of the performance of 3D printed non-pneumatic tires, we suggest that the performance of these materials should be moderately reduced during the structural design for performance simulation.

scholarly journals A millifluidic chip for cultivation of fish embryos and toxicity testing fabricated by 3D printing technology

RSC Advances ◽  
2021 ◽  
Vol 11 (33) ◽  
pp. 20507-20518
Author(s):  
Petr Panuška ◽  
Zuzana Nejedlá ◽  
Jiří Smejkal ◽  
Petr Aubrecht ◽  
Michaela Liegertová ◽  
...  
Keyword(s):  
3D Printing ◽  
Toxicity Testing ◽  
Toxicity Screening ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fish Embryos ◽  
3D Printed ◽  
Novel Design

A novel design of 3D printed zebrafish millifluidic system for embryonic long-term cultivation and toxicity screening has been developed. The chip unit provides 24 cultivation chambers and a selective individual embryo removal functionality.

scholarly journals 3D-Printed Nanocellulose-Based Cushioning–Antibacterial Dual-Function Food Packaging Aerogel

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3543
Author(s):  
Wei Zhou ◽  
Jiawei Fang ◽  
Shuwei Tang ◽  
Zhengguo Wu ◽  
Xiaoying Wang
Keyword(s):  
3D Printing ◽  
Food Packaging ◽  
Fruits And Vegetables ◽  
Antibacterial Effect ◽  
Dual Function ◽  
Printing Technology ◽  
E Coli ◽  
3D Printing Technology ◽  
The Core ◽  
3D Printed

Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process. Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology. Thus, the 3D-printed cushioning–antibacterial dual-function packaging aerogel with a shell–core structure (CNGA/C–AgNPs) was obtained. The CNGA/C–AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%. Although AgNPs was slowly released, CNGA/C–AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus. Moreover, the CNGA/C–AgNPs packaging aerogel was biodegradable. Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.

APPLICATION OF 3D PRINTING TECHNOLOGY FOR RAPID TOOLING IN SHEET METAL FORMING

2020 ◽  
Vol 3 ◽  
pp. 20-30
Author(s):  
M.A. SEREZHKIN ◽  
D.O. KLIMYUK ◽  
A.I. PLOKHIKH
Keyword(s):  
3D Printing ◽  
Sheet Metal ◽  
Sheet Metal Forming ◽  
Metal Forming ◽  
Rapid Tooling ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Printed Materials ◽  
Printing Parameters

The article presents the study of the application of 3D printing technology for rapid tooling in sheet metal forming for custom or small–lot manufacturing. The main issue of the usage of 3D printing technology for die tooling was discovered. It is proposed to use the method of mathematical modelling to investigate how the printing parameters affect the compressive strength of FDM 3D–printed parts. Using expert research methods, the printing parameters most strongly affecting the strength of products were identified for further experiments. A method for testing the strength of 3D–printed materials has been developed and tested.

scholarly journals Desain dan Pembuatan Prototype Piston Honda MEGAPRO FI Menggunakan 3D Printing

2020 ◽  
Vol 1 (2) ◽  
pp. 81-91
Author(s):  
Frince Marbun ◽  
Richard A.M. Napitupulu
Keyword(s):  
3D Printing ◽  
Computer Aided Design ◽  
Fused Deposition Modeling ◽  
Layer By Layer ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Manufacturing Technologies ◽  
Aided Design

3D printing technology has great potential in today's manufacturing world, one of its uses is in making miniatures or prototypes of a product such as a piston. One of the most famous and inexpensive 3D printing (additive manufacturing) technologies is Fused Deposition Modeling (FDM), the principle FDM works by thermoplastic extrusion through a hot nozzle at melting temperature then the product is made layer by layer. The two most commonly used materials are ABS and PLA so it is very important to know the accuracy of product dimensions. FDM 3D Printing Technology is able to make duplicate products accurately using PLA material. FDM machines work by printing parts that have been designed by computer-aided design (CAD) and then exported in the form of STL or .stl files and uploaded to the slicer program to govern the printing press according to the design. Using Anet A8 brand 3D printing tools that are available to the public, Slicing of general CAD geometry files such as autocad and solidwork is the basis for making this object. This software is very important to facilitate the design process to be printed. Some examples of software that can be downloaded and used free of charge such as Repetier-Host and Cura. by changing the parameters in the slicer software is very influential in the 3D printing manufacturing process.

scholarly journals Implementation of 3D Printing Technology in the Food Industry

2021 ◽  
pp. 50-54
Author(s):  
Nor Aiman Sukindar ◽  
Noorazizi Mohd Samsuddin ◽  
Sharifah Imihezri Bt. Syed Shaharuddin ◽  
Shafie Kamaruddin ◽  
Ahmad Zahirani Ahmad Azhar ◽  
...  
Keyword(s):  
3D Printing ◽  
New Product Development ◽  
Food Industry ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fabrication Cost ◽  
Food Packages ◽  
3D Printed ◽  
The Cost ◽  
Fabrication Time

This project involves the implementation of 3D printing technology on designing and fabricating food holders in the food industry. Food holders are designed to hold the food packages in the filling line for food manufacturing industries that apply retort technology. Therefore, this study aims to implement the 3D printing technology in particular FDM to fabricate food holders for the food processing industry. The approach of using this technology is focused on giving more view on the capability of 3D printing technology, aiming at reducing the overall process fabrication cost and fabrication time. Hence, the fabrication cost and time between FDM and conventional machining methods were compared. This study revealed that Organic Gain food industry was able to reduce the cost and fabrication time for the food holder up to approximately 96.3% and 72% respectively. This project gives an insight into the ability of 3D printing technology in delivering the demands of the industry in producing parts as well as the adaptability of the technology to the industry in new product development. The project was carried out successfully and the 3D printed food holder has been tested and functions smoothly.

scholarly journals Promising Applications of Additive-Manufactured (3D-printed) Electrochemical Sensors for Forensic Chemistry

2021 ◽  
Author(s):  
Sílvia Castro ◽  
Raquel Rocha ◽  
Afonso João ◽  
Eduardo Richter ◽  
Rodrigo Munoz
Keyword(s):  
3D Printing ◽  
Illicit Drugs ◽  
Industrial Revolution ◽  
Electrochemical Sensors ◽  
Forensic Chemistry ◽  
Recent Contribution ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Wide Range ◽  
3D Printed

Additive-manufacturing is one of the major pillars of the new industrial revolution and the three-dimensional (3D) printing technology has been highlighted in this scenario. Among the many areas benefited by 3D-printing, the development of electrochemical sensors has appeared in evidence in the last years. One potential application of 3D-printed electrochemical sensors is devoted to forensic chemistry, which demands for portable analytical methods that can provide on-site measurements and thus bring a relevant information in loco. In this context, this review highlights the recent contribution of 3D-printing technology on the development of electrochemical sensors with great promises for on-site analysis in “real-world” forensic scenarios. From the detection of trace explosives, gunshot residues, illicit drugs and chemical threats, to the measurement of adulterants in food and fuels, we show the wide range of applications that 3D-printed electrochemical sensors have been proposed and future demands that can be addressed by such a powerful, affordable, and accessible tool.

Design and Verification of a Metal 3D Printing Device Based on Contact Resistance Heating

2019 ◽  
Vol 298 ◽  
pp. 64-68
Author(s):  
Yu Hua Dai ◽  
Xi Wang
Keyword(s):  
3D Printing ◽  
Contact Resistance ◽  
Fused Deposition Modeling ◽  
Numerical Control ◽  
Control Technique ◽  
Resistance Heating ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
Metal 3D Printing

As a branch of 3D printing technology, metal 3D printing is an important advanced manufacturing processing method. Metal 3D printing technology has been widely applied in a variety of areas, including the aerospace field, biomedical research and mold manufacturing. This paper proposed a new method for melting metal wires via contact resistance heating. Through the combination of a numerical control technique, a mechanical structure and computer software, a metal 3D printing device was designed based on the principle of fused deposition modeling. The printing nozzle of the device can be heated to over 1400°C in a few minutes. Additionally, we performed experiments with aluminum wire to demonstrate the feasibility of the printing method. The designed consumer-level desktop metal 3D printer cost less than 1500 dollars to fabricate.

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