Lymphocyte-to-monocyte ratio in predicting the calcific aortic valve stenosis in a Chinese case–control study

Aim: This study examined the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severity of calcific aortic valve stenosis (CAVS) in a Chinese case–control study. Results: The LMR significantly decreased in the patients with CAVS compared with healthy controls. An inverse correlation was observed between the severity of stenosis and LMR in the patients. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe CAVS. Conclusion: This study provides evidence of an inverse correlation between the severity of CAVS and LMR. LMR could potentially be applied as an independent predictor of severe CAVS and could be incorporated into a novel predictive model.

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The Role of Lymphocyte-To-Monocyte Ratio In Predicting The Severe Post-Calcific Stenotic Aortic Dilatation In A Chinese Case-Control Study

10.21203/rs.3.rs-1043408/v1 ◽

2021 ◽

Author(s):

Shanghao Chen ◽

Zezhong Wu ◽

Yan Yun ◽

Hechen Shen ◽

Diming Zhao ◽

...

Keyword(s):

Case Control Study ◽

Independent Predictor ◽

Inverse Correlation ◽

Case Control ◽

Aortic Dilatation ◽

Lymphocyte To Monocyte Ratio ◽

Maximal Diameter ◽

Chinese Case ◽

Control Study

Abstract Background: Calcific aortic valve stenosis (CAVS) represents a serious public health threat to elderly patients. Post-calcific stenotic aortic dilatation, a common feature in CAVS patients, might progress into aneurysm and even dissection, potentially lethal consequences of CAVS, and predicts a dismal prognosis. This study sought to testify the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severe post-calcific stenotic aortic dilatation in a Chinese case-control study.Materials and Methods: 208 consecutive patients with CAVS were recruited retrospectively in a Chinese case- control study, from July 1, 2015 to June 31, 2018. The LMR was statistically analyzed for its prognostic value in the severe post-calcific stenotic aortic dilatation.Results: The LMR was significantly reduced in patients with severe post-calcific stenotic aortic dilatation (2.72 vs. 3.53, p=0.002<0.05) compared to patients without severe post- calcific stenotic aortic dilatation. There was an inverse correlation observed between the maximal diameter of ascending aorta and the LMR in the overall patients (r=-0.217, p=0.002<0.05). For severe post-calcific stenotic aortic dilatation, the incidence of high- LMR group was statistically lower than that of low-LMR group (19.7% vs. 43.9%, p<0.001). And maximal diameter of ascending aorta was significantly reduced in the high-LMR group (4.35vs. 4.76, p=0.003<0.05) compared to low-LMR group. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe post-calcific stenotic aortic dilatation (OR 0.743, 95% CI: [0.573- 0.964], p=0.025).Conclusions: This study provided the evidence of an inverse correlation between the severe post- calcific stenotic aortic dilatation and LMR. And the LMR is potentially applied as an independent predictor of severe post-calcific stenotic aortic dilatation.

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Case Control Study of the Relation between Hyperlipidaemia and Calcific Aortic Valve Stenosis

Clinical Science ◽

10.1042/cs092014pa ◽

1997 ◽

Vol 92 (s36) ◽

pp. 14P-14P

Author(s):

PT Wilmshurst ◽

RN Stevenson ◽

H Griffiths ◽

JR Lord

Keyword(s):

Aortic Valve ◽

Aortic Valve Stenosis ◽

Case Control Study ◽

Case Control ◽

Control Study

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FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study

PLoS ONE ◽

10.1371/journal.pone.0139419 ◽

2015 ◽

Vol 10 (10) ◽

pp. e0139419 ◽

Cited By ~ 2

Author(s):

Cindy Thron ◽

Payam Akhyari ◽

Erhard Godehardt ◽

Artur Lichtenberg ◽

Ulrich Rüther ◽

...

Keyword(s):

Aortic Valve ◽

Aortic Valve Stenosis ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Heterozygote Advantage ◽

Specific Manner ◽

Gender Specific ◽

Control Study

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The relationship between serum pregnancy-associated plasma protein-A level in patients with aortic valve stenosis: a case-control study

Acta Cardiologica ◽

10.1080/00015385.2020.1751956 ◽

2020 ◽

pp. 1-7

Author(s):

E. Merve Girgin ◽

Ayfer Colak ◽

Ersin Cagri Simsek ◽

Burak Toprak ◽

Hülya Yalcin ◽

...

Keyword(s):

Aortic Valve ◽

Aortic Valve Stenosis ◽

Plasma Protein ◽

Case Control Study ◽

Protein A ◽

Case Control ◽

The Relationship ◽

Control Study

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705. Factors Associated with Local Invasion in Infective Endocarditis: a Nested Case-control Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.897 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S403-S403

Author(s):

Abarna Ramanathan ◽

James Witten ◽

Steven M Gordon ◽

Brian Griffin ◽

Gosta Pettersson ◽

...

Keyword(s):

Infective Endocarditis ◽

Aortic Valve ◽

Case Control Study ◽

Cleveland Clinic ◽

Case Control ◽

Paravalvular Leak ◽

Multivariable Logistic Regression Model ◽

Local Invasion ◽

Nested Case Control ◽

Control Study

Abstract Background A substantial proportion of infective endocarditis (IE) cases are complicated by local invasion. The purpose of this study was to identify patient and disease characteristics that increase the odds of local invasion in surgically treated IE patients. Methods This was a nested case-control study. All episodes of IE for patients admitted to Cleveland Clinic from January 1st, 2013 – June 30th, 2016 were identified from the Cleveland Clinic IE Registry. Patients >18 years of age who underwent surgery for IE were included. Data was compiled by manual review of the Electronic Medical Record. Local invasion, defined as peri-annular extension, peri-valvular abscess, intra-cardiac fistula or pseudoaneurysm, was ascertained from the surgical operative note. Associations of selected factors with local invasion were examined in a multivariable logistic regression model. Results Among 510 patients who met inclusion criteria, 206 had local invasion. Mean age was 56 years and 369 (72 %) were male. Overall 344 (67 %) had aortic valve, 228 (45%) mitral valve, and 66 (13%) tricuspid or pulmonic valve involvement. Aortic valve involvement (OR 5.76, 95% CI 3.44 – 9.98), mechanical valve (OR 7.63, 95% CI 3.63 – 17.07), bioprosthetic valve (OR 3.20, 95% CI 1.99 – 5.19), significant paravalvular leak (OR 2.27, 95% CI 1.09 – 4.97), new atrioventricular nodal block (OR 3.05, 95% CI 1.57 – 6.09), Staphylococcus aureus infection (OR 2.11, 95% CI 1.20 – 3.76), coagulase negative staphylococcal infection (OR 2.38, 95% CI1.27 – 4.54), and non- viridans group streptococcal infection (OR 4.21, 95% CI 1.81 – 10.06) were significantly associated with local invasion. Conclusion Intra-cardiac and microorganism factors, but not comorbid conditions, are associated with local invasion in IE. Disclosures All Authors: No reported disclosures

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Influenza A (H1N1) virus infection and TNF-308, IL6, and IL8 polymorphisms in Egyptian population: a case–control study

The Journal of Basic and Applied Zoology ◽

10.1186/s41936-019-0131-1 ◽

2019 ◽

Vol 80 (1) ◽

Cited By ~ 1

Author(s):

Shaimaa Moustafa Elsayed ◽

Omayma Mohamed Hassanein ◽

Nagwa Hassan Ali Hassan

Keyword(s):

Influenza A ◽

Case Control Study ◽

H1n1 Virus ◽

Case Control ◽

Severe Illness ◽

Study Results ◽

Influenza A H1n1 ◽

Pandemic Strains ◽

Study Participants ◽

Control Study

Abstract Background The importance of influenza is increasing mainly because of the appearance of novel pandemic strains such as swine and avian. Each year, influenza has spread around the world causing about 250,000–500,000 deaths and more than 5 million cases of severe illness. The objective is as follows: evaluating the outcomes of patients with influenza A (H1N1) virus in relation to certain TNF-308, IL6, and IL8 polymorphisms and identifying the associated factors with the severe outcome. Subject and methods This is a case–control study. The cases were patients confirmed by real-time polymerase chain reaction (RT-PCR) to be influenza A (H1N1) virus infected. The controls were healthy individuals. Medical history and outcome of the disease was registered. In all study participants, polymorphisms of TNF rs1800629, IL6 rs18138879, and IL8 rs4073; odds ratio (OR); and the 95% confidence interval (95% CI) were calculated. Results Infection with influenza A (H1N1) virus was associated more with the following genotypes: TNF-308 AA (OR = 4.041; 95% CI = 1.215–13.4) and IL8 AA (OR = 3.273; 95% CI = 1.372–7.805). According to our study results, HCV (OR = 3.2, 95% CI 1.2–8.5), renal disease (OR = 3.4, 95% CI 0.9–13.6), cancer (OR = 3.1, 95% CI 0.3–31.1), TB (OR = 8.4, 95% CI 1.8–39.7), ICU (OR = 2.9, 95%1.2–7.1), and mortality (OR = 7.9, 95% CI 0.9–67.4) are considered as risk factors for influenza A (H1N1)-infected patients. Conclusions Our findings concluded that TNF-308 (AA) and IL8 (AA) polymorphisms may increase the susceptibility to be infected with H1N1influenza virus.

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