Gender-dependent association of TYMS-TSER polymorphism with 5-fluorouracil or capecitabine based chemotherapy toxicity

2021 ◽  
Author(s):  
Charalampia Ioannou ◽  
Georgia Ragia ◽  
Ioanna Balgkouranidou ◽  
Nikolaos Xenidis ◽  
Kyriakos Amarantidis ◽  
...  
Keyword(s):  
Adverse Event ◽  
Cancer Patients ◽  
Drug Administration ◽  
Odds Ratio ◽  
Therapy Discontinuation ◽  
Chemotherapy Toxicity ◽  
Female Patients ◽  
Increased Risk ◽  
Pcr Rflp ◽  
Female Cancer Patients

Aim: TYMS gene encodes for TS enzyme involved in 5-fluorouracil (5-FU) and capecitabine (CAP) metabolism. This study assessed the association of TYMS-TSER and 3RG>C polymorphisms with 5-FU/CAP adverse event (AE) incidence. Materials & methods: TYMS-TSER and 3RG>C polymorphisms were analyzed by use of PCR/PCR-RFLP in 313 5-FU/CAP-treated cancer patients. Results: Female TYMS-TSER 2R carriers were at increased risk for 5-FU/CAP AEs (odds ratio: 2.195; p = 0.032). 2R/2R genotype was the only factor that increased risk for delayed drug administration or therapy discontinuation (odds ratio: 5.049; p = 0.016). No other associations were found. Conclusion: TYMS-TSER 3R/2R polymorphism was associated with incidence of AEs in female cancer patients. This gender-driven association potentially implicates the ER that, in female patients, potentially regulates TS expression.

scholarly journals Thrombocytopenia with Tedizolid and Linezolid

2017 ◽  
Vol 62 (1) ◽  
Author(s):  
Erica Yookyung Lee ◽  
Aisling R. Caffrey
Keyword(s):  
Adverse Event ◽  
Confidence Interval ◽  
Drug Administration ◽  
Odds Ratio ◽  
Reporting System ◽  
Adverse Event Reporting System ◽  
Adverse Event Reporting ◽  
Reporting Odds Ratio ◽  
Event Reporting ◽  
Using Data

ABSTRACT Several studies have suggested the risk of thrombocytopenia with tedizolid, a second-in-class oxazolidinone antibiotic (approved June 2014), is less than that observed with linezolid (first-in-class oxazolidinone). Using data from the Food and Drug Administration adverse event reporting system (July 2014 through December 2016), we observed significantly increased risks of thrombocytopenia of similar magnitudes with both antibiotics: linezolid reporting odds ratio [ROR], 37.9 (95% confidence interval [CI], 20.78 to 69.17); tedizolid ROR, 34.0 (95% CI, 4.67 to 247.30).

scholarly journals The Impact of Marital Status on Stage at Diagnosis and Survival of Female Patients with Breast and Gynecologic Cancers: A Meta-Analysis

2020 ◽  
Author(s):  
Ruixia Yuan ◽  
Chao Zhang ◽  
Qi Li ◽  
Mei Ji ◽  
Nannan He
Keyword(s):  
Marital Status ◽  
Cancer Patients ◽  
Data Extraction ◽  
Meta Analysis ◽  
Survival Outcomes ◽  
Stage At Diagnosis ◽  
Gynecologic Cancers ◽  
Female Patients ◽  
Female Cancer Patients ◽  
The Impact

Abstract Background: The aim of this meta-analysis is to evaluate the effect of marital status on the stage at diagnosis and survival of female patients with breast and gynecologic cancers.Methods: A systematic literature search was conducted on electronic databases (PubMed, Cochrane and EMBASE) till March 31, 2020. Publications investigating the association of marital status with stage at diagnosis and/or cancer-specific mortality (CSM) and/or overall survival (OS) in female patients with breast or gynecologic cancers were retrieved. After studies were selected according to inclusion criteria, data extraction, quality assessment and data analysis were performed. Results: 55 articles were eligible for inclusion, consisting of 1195773 female cancer patients with breast, vulvar, cervical, endometrial and ovarian cancers. Unmarried female cancer patients had higher odds of being diagnosed at later stage [odds ratio (OR) = 1.28, 95% confidence interval (CI): 1.22-1.36)] and worse survival outcomes in CSM [hazard ratio (HR) = 1.22, 95% CI: 1.16-1.28] and OS (HR = 1.20, 95% CI: 1.14-1.25). This estimate did not vary by level of social support, number of adjustment factors, or between America and Europe. Conclusions: Being married is associated with timely diagnosis and favorable prognosis in most women’s cancers. Unmarried female cancer patients have a higher risk of late-stage diagnosis and worse survival outcomes than the married. Greater concern shall be demonstrated towards unmarried female cancer patients. Furthermore, the impact of lacking economic and emotional support on survival outcomes in unmarried female cancer patients deserves particular attention.

Genetic Predisposition to Cervical Cancer and the Association With XRCC1 and TGFB1 Polymorphisms

2017 ◽  
Vol 27 (9) ◽  
pp. 1949-1956 ◽  
Author(s):  
Najla M. Al-Harbi ◽  
Sara S. Bin Judia ◽  
Krishna N. Mishra ◽  
Mohamed M. Shoukri ◽  
Ghazi A. Alsbeih
Keyword(s):  
Confidence Interval ◽  
Cancer Patients ◽  
Genetic Predisposition ◽  
Odds Ratio ◽  
Direct Sequencing ◽  
Trend Test ◽  
Nucleotide Polymorphisms ◽  
Control Subjects ◽  
Allele Dosage ◽  
Increased Risk

ObjectiveCervical carcinoma (CC), a multifactorial cancer, is assumed to have a host genetic predisposition component that modulates its susceptibility in various populations. We investigated the association between CC risk in Saudi women and 6 single-nucleotide polymorphisms (SNPs) in hypothesis-driven candidate genes.MethodsA total of 545 females were included, comprising 232 CC patients and 313 age-/sex-matched control subjects. Six SNPs (CDKN1A C31A, ATM G1853A, HDM2 T309G, TGFB1 T10C, XRCC1 G399A, and XRCC3 C241T) were genotyped by direct sequencing.ResultsOf the 6 SNPs studied, TGFB1 T10C (odds ratio, 0.74; 95% confidence interval, 0.57–0.94) and XRCC1 G399A (odds ratio, 1.45; 95% confidence interval, 1.11–1.90) displayed different frequencies in cancer patients and control subjects and showed statistically significant association in univariate (P = 0.017, P = 0.005, respectively) analysis. The Cochran-Armitage trend test had confirmed the results (P = 0.027 and P = 0.006, respectively), indicating an ordering in the effect of the risk alleles in CC patients. The 2 SNPs, TGFB1 T10C and XRCC1 G399A, showed also degrees of deviation from Hardy-Weinberg equilibrium in cancer patients (P = 0.001 and P = 0.083, respectively) but not in the control subjects. Furthermore, correction for multiple testing using multivariate logistic regression to assess the joint effect of all SNPs has sustained significant statistical association (P = 0.025 and P = 0.009, respectively).ConclusionsTGFB1 T10C and XRCC1 G399A SNPs were associated with CC risk in univariate and multivariate analysis and displayed allele-dosage effects and coselection in cancer patients. Patients harboring the majority allele TGFB1 T10 (Leu) or the variant allele XRCC1 399A (Gln) have approximately 1.5-fold increased risk to develop CC. Host SNPs genotyping may provide relevant biomarkers for CC risk assessment in personalized preventive medicine.

scholarly journals Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Jôice Dias Corrêa ◽  
Mila Fernandes Moreira Madeira ◽  
Renata Gonçalves Resende ◽  
Jeane de Fátima Correia-Silva ◽  
Ricardo Santiago Gomez ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Odds Ratio ◽  
Microscopic Analysis ◽  
Interleukin 17 ◽  
Periodontal Tissues ◽  
Inflammatory Conditions ◽  
Interleukin 17A ◽  
Chronic Periodontal Disease ◽  
Increased Risk ◽  
Pcr Rflp

Objective. Interleukin-17 (IL-17) is a cytokine that induces neutrophil recruitment and the release of inflammatory mediators in several inflammatory conditions; nevertheless, the involvement of IL-17 gene polymorphisms in chronic periodontitis (CP) has not been addressed yet. Our aim was to evaluate the association between periodontal status and the polymorphisms IL-17A G197A and IL-17F C7488T in subjects with CP along with their impact on levels of inflammatory mediators.Material and Methods. Genomic DNA was obtained from 30 CP patients and 30 healthy controls (HCs). IL-17A G197A and IL-17F C7488T polymorphisms were determined using PCR-RFLP. Serum and periodontal tissues were collected and processed for ELISA, myeloperoxidase (MPO), and/or microscopic analysis.Results. The frequencies of genotypes in the CP group were significantly different from those of HC. Odds ratio indicated that increased risks for CP were associated with the -197A allele, not with the -7488T allele. In addition, the -197A allele was correlated with worse clinical parameters, higher MPO activity, and increased expression of inflammatory mediators (IL-17A and IL-8) than the other genotypes.Conclusions. These results indicate that the IL-17A -197A allele is associated with increased risk for CP, likely because this genotype relates to the enhanced inflammation in periodontal tissues.

scholarly journals Elucidative epidemiological study in female cancer patients

2021 ◽  
Vol 7 (2) ◽  
pp. 122
Author(s):  
Manaswini Pittala ◽  
Juveria Tarannum ◽  
Deekshitha Ch ◽  
Pratap Reddy B. ◽  
Shyam Sunder A.
Keyword(s):  
Cancer Patients ◽  
Sexual Intercourse ◽  
Reproductive Factors ◽  
First Sexual Intercourse ◽  
Factors Associated ◽  
Early Menarche ◽  
First Child ◽  
Increased Risk ◽  
Female Cancer Patients ◽  
Risk Of Cancer

<p class="abstract"><strong>Background:</strong> As cases of cancer in women are increasing day to day, it is mandatory to assess risk factors associated with female cancer patients. Our study is designed to elucidate different reproductive factors associated with female cancer patients attending hospital.</p><p class="abstract"><strong>Methods:</strong> 200 female patients who attended the hospital with cancer are studied by asking questions directly to patients following a standard questionnaire regarding reproductive factors like age at menarche, age at first child birth, age at first sexual intercourse, breastfeeding, age at menopause. It was a Retrospective study analyzed via MS Excel calculations.  </p><p class="abstract"><strong>Results:</strong> In this study it explains that in female cancer cases, mostly patients were seen having early menarche, also women were in menopause stage mostly, and mostly lactating mothers with breast feeding frequency up to 1-2 years are seen. It also explains that in female cancer cases, women mostly had young maternal age at first child, with carcinoma of cervix and carcinoma of breast reported mostly.</p><p class="abstract"><strong>Conclusions:</strong> In this study we conclude that in females who have early menarche, women with early age at first sexual intercourse, age at first pregnancy, are strongly interrelated and have increased risk of carcinoma. The changes which result in relative risk of cancer associated with menopause are believed to be due to increase in body mass index (BMI), which makes adipose tissue the main site of estrogen production after menopause. Hence, identifying these factors which may be associated with the process of carcinogenesis development in females.</p>

scholarly journals A Study of Mental Health among Patients of Cancer

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Dr. Arvind Dungrani
Keyword(s):  
Mental Health ◽  
Cancer Patients ◽  
General Hospital ◽  
Health Measurement ◽  
Male And Female ◽  
Female Patients ◽  
Self Evaluation ◽  
Environmental Mastery ◽  
Female Cancer Patients ◽  
The Difference

This study was conducted to investigate the difference in Mental Health among Patients of cancer. Total 60 samples of Male and Female cancer patients were taken from Sir. T. General Hospital from Bhavnagar City (Gujarat). Their Samples were also taken the data was collected with the help of ‘Mental Health Inventory’ Developed by Dr. A. K. Shreevastav and Dr. Jagdish (1982).The Original Hindi Inventory was translated in Gujarati and Standardized by Bhava Thummar (2009). The Data was used to obtain the Mental Health measurement of the subjects. The collected data was statistically analyzed with the help of ‘t’ test. The Results show that Mental Health for positive self Evaluation of the Male and Female Patients were not significant (t = 0.17). The Mental Health for perception of Reality of the Male and Female Patients were not significant (t = 1.34). The Mental Health for Integration of Personality of the Male and Female Patients were not significant (t = 1.74).The Mental Health for Autonomy of the Male and Female Patients were not significant (t = 0.66). The Metal Health for Group – oriented Attitude of the Male and Female Patients were not significant (t = 0.76). The Mental Health for Environmental Mastery of the Male and Female Patients were not significant (t = 0.20). The overall Mental Health of the Male and Female Patients were not significant (t = 1.25).

scholarly journals Real-world Study of Antiresorptive-Related Osteonecrosis of Jaw Based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) database

2021 ◽  
Author(s):  
JING PENG ◽  
LEI REN ◽  
mingli WU ◽  
xia wang ◽  
Tian wei ◽  
...  
Keyword(s):  
Adverse Event ◽  
Drug Administration ◽  
Odds Ratio ◽  
Reporting System ◽  
Adverse Event Reporting System ◽  
Osteonecrosis Of The Jaw ◽  
Adverse Event Reporting ◽  
Event Reporting ◽  
Antiresorptive Drugs ◽  
Osteonecrosis Of Jaw

Objective To explore the risk signals of osteonecrosis of jaw induced by antiresorptive drugs and provide references for the clinical safety application. Method Based on the Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 to June 2021, We chosen ‘Osteonecrosis of jaw’ as Preferred Terms (PT) and antiresorptive drugs. We used proportional reporting ratio (PRR), odds ratio (reporting odds ratio, ROR), Bayesian confidence propagation neural network (BCPNN) and multi-item Gamma-Poisson contraction (MGPS) algorithm to evaluate the association between drugs and adverse events. Results 27,065 reports related to osteonecrosis of the jaw in the FAERS dated from January 2004 to June 2021 . A total of 9 antiresorptive agents were included in the analysis. Affected patients tended to be older than 65 years. Most cases were reported from North America (39.82%) and Europe (36.15%) and were submitted by health-care professionals (81.44%). Pamidronate and clodronic acid showed a higher score than the other agents in every method. Zoledronic acid and denosumab were reported more than other agents.. Rate of hospitalization due to antiresorptive-related osteonecrosis of the jaw was from 7.66% to 28.78%; rate of fatality was from 0 to 12.78%. Conclusion All antiresorptive drugs may cause ONJ, and ONJ can be effectively prevented. Practitioners should consider the factors that may increase the likelihood of ONJ. The findings support a continued surveillance and risk factor identification studies.

scholarly journals A systematic review and meta-analysis of cancer patients affected by a novel coronavirus

2020 ◽  
Author(s):  
Bhanu Prasad Venkatesulu ◽  
Viveksandeep Thoguluva Chandrasekar ◽  
Prashanth Giridhar ◽  
Pragati Advani ◽  
Amrish Sharma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Odds Ratio ◽  
Normal Population ◽  
Meta Analysis ◽  
Case Fatality ◽  
Categorical Variables ◽  
Mortality And Morbidity ◽  
Cancer Subtypes ◽  
Increased Risk

Background Cancer patients with COVID-19 disease have been reported to have double the case fatality rate of the general population. Materials and methods A systematic search of PubMed/MEDLINE, Embase, Cochrane Central, Google Scholar, and MedRxiv was done for studies on cancer patients with COVID-19. Pooled proportions were calculated for categorical variables. Odds ratio and forest plots were constructed for both primary and secondary outcomes. The random-effects model was used to account for heterogeneity between studies. Results This systematic review of 31 studies and meta-analysis of 181,323 patients from 26 studies involving 23,736 cancer patients is the largest meta-analysis to the best of our knowledge assessing outcomes in cancer patients affected by COVID-19. Our meta-analysis shows that cancer patients with COVID-19 have a higher likelihood of death (odds ratio, OR 2.54), which was largely driven by mortality among patients in China. Cancer patients were more likely to be intubated, although ICU admission rates were not statistically significant. Among cancer subtypes, the mortality was highest in hematological malignancies (OR 2.43) followed by lung cancer (OR 1.8). There was no association between receipt of a particular type of oncologic therapy and mortality. Our study showed that cancer patients affected by COVID-19 are a decade older than the normal population and have a higher proportion of co-morbidities. There was insufficient data to assess the association of COVID-directed therapy and survival outcomes in cancer patients. Despite the heterogeneity of studies and inconsistencies in reported variables and outcomes, these data could guide clinical practice and oncologic care during this unprecedented global health pandemic. Conclusion Cancer patients with COVID-19 disease are at increased risk of mortality and morbidity. A more nuanced understanding of the interaction between cancer-directed therapies and COVID-19-directed therapies is needed. This will require uniform prospective recording of data, possibly in multi-institutional registry databases.

scholarly journals Retrospective Toxicological Profiling of Radium-223 Dichloride for the Treatment of Bone Metastases in Prostate Cancer Using Adverse Event Data

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 149 ◽  
Author(s):  
Theodoros G. Soldatos ◽  
Ioannis Iakovou ◽  
Christos Sachpekidis
Keyword(s):  
Prostate Cancer ◽  
Adverse Event ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Safety Profile ◽  
Adverse Event Reporting System ◽  
Castration Resistant Prostate Cancer ◽  
Risk Of Death ◽  
Radium 223 ◽  
Increased Risk

Background and Objective: Radium-223 dichloride (Xofigo®) is a calcium mimetic agent approved for the treatment of castration-resistant prostate cancer patients with symptomatic bone metastases and no known visceral metastatic disease. This targeted, α-particle-emitting therapy has demonstrated significant survival benefit accompanied by a favorable safety profile. Nevertheless, recent evidence suggests that its combined use with abiraterone and prednisone/prednisolone may be associated with increased risk of death and fractures. While the precise pathophysiologic mechanisms of these events are not yet clear, collecting evidence from more clinical trials and translational studies is necessary. The aim of our present study is to assess whether accessible sources of patient outcome data can help gain additional clinical insights to radium-223 dichloride’s safety profile. Materials and Methods: We performed a retrospective analysis of cases extracted from the FDA Adverse Event Reporting System and characterized side effect occurrence by using reporting ratios. Results: A total of ~1500 prostate cancer patients treated with radium-223 dichloride was identified, and side effects reported with the use of radium-223 dichloride alone or in combination with other therapeutic agents were extracted. Our analysis demonstrates that radium-223 dichloride may often come with hematological-related reactions, and that, when administered together with other drugs, its safety profile may differ. Conclusions: While more prospective studies are needed to fully characterize the toxicological profile of radium-223 dichloride, the present work constitutes perhaps the first effort to examine its safety when administered alone and in combination with other agents based on computational evidence from public real-world post marketing data.

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