scholarly journals Coronavirus (CoV) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Stephen P.H. Alexander ◽  
Jonathan K. Ball ◽  
Theocharis Tsoleridis

Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. They can cause diseases ranging from the common cold to severe acute respiratory syndrome (SARS).

Author(s):  
Sk Sarif Hassan ◽  
Atanu Moitra ◽  
Pabitra Pal Choudhury ◽  
Prasanta Pramanik ◽  
Siddhartha Jana

Coronaviruses are a large family of RNA viruses which cause respiratory infections ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. This article highlights some key findings based on a thorough scanning of genes of 470 SARS-CoV2 genomes, including the co-presence of ORF7a and ORF8 over the 251 SARS-CoV2 genomes and the absence of the gene ORF7b over the 219 SARS-CoV2 genomes collected from various countries including India.


Author(s):  
Sk Sarif Hassan ◽  
Atanu Moitra ◽  
Pabitra Pal Choudhury ◽  
Prasanta Pramanik ◽  
Siddhartha Sankar Jana

Coronaviruses are a large family of RNA viruses which cause respiratory infections ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. This article highlights some key findings based on a thorough scanning of genes of 475 SARS-CoV2 genomes, including the co-presence of ORF7a and ORF8 over the 256 SARS-CoV2 genomes and the absence of the gene ORF7b over the 219 SARS-CoV2 genomes collected from various countries including India. The presence of the gene ORF7b is found in the SARS-CoV2 genomes containing the L-type strain which is reported to having much higher virulence as compared to the S-type strain.


2021 ◽  
Vol 2 (1) ◽  

Covid 19 being a pandemic has uniformly and bizarrely affected the globe in a most unpredictable manner. So it becomes very important to unravel the transmission dynamics and the effect of the virus which has made it a deadly virus so far. Covid 19 is a member of coronavirus family, which also includes the SARS virus (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Symptoms) virus. The family of Coronavirus includes virus strains that the common cold and flu are caused [1].


Science ◽  
2021 ◽  
Vol 371 (6530) ◽  
pp. 741-745 ◽  
Author(s):  
Jennie S. Lavine ◽  
Ottar N. Bjornstad ◽  
Rustom Antia

We are currently faced with the question of how the severity of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly but that disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of SARS-CoV-2 infection and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, SARS-CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase.


2020 ◽  
Vol 35 (1-2) ◽  
Author(s):  
Pradeep Pagaria ◽  
L. R. Choudhary ◽  
Haridayal Choudhary ◽  
Ganga Ram ◽  
Turfan Khan

Coronavirus outbreak was first reported in Wuhan, China on 31 December, 2019. Coronavirus (CoV) is a large family of viruses that causes illness. It ranges from the common cold to more severe diseases like Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). The novel coronavirus is a new strain of virus that has not been identified in human so far.


2020 ◽  
Vol 6 (2) ◽  
pp. 43-43
Author(s):  
S. Kalimuthu ◽  

Corona viruses are a large family of viruses that are known to cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). A novel corona virus (Co V) is a new strain of corona virus that has not been previously identified in humans. Corona viruses can be transmitted from person to person, usually after close contact with an infected patient. There is no specific treatment for disease caused by a novel corona virus. In this Hypothesis, the author proposes an alternative herbal inhaler, syrup, drug and a vaccine for curing Covid-19.


2021 ◽  
Vol 12 (1) ◽  
pp. 118-123
Author(s):  
Onkar Doke ◽  
Anagha Kaldhone ◽  
Rupali Karkar ◽  
Raisa Shaikh ◽  
Salani Sahani

A respiratory infection owing to a novel corona virus was first identified in Wuhan, China in December 2019. World health organization declared name for this novel corona virus as “COVID-19” is now a worldwide pandemic and has been recognized in more than 200 countries. Corona viruses are virus that is known to cause infection varying from the common cold to more critical diseases like Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). It is known to transmit by respiratory droplets released when corona virus patient coughs, sneezes or talks and if another person inhales the droplets or touches these surfaces and further touches his face, eyes or mouth can get an infection. Currently there are no specific vaccines or medicines for Corona virus disease and treatment given based on symptoms. But many vaccines are under investigation.


2005 ◽  
Vol 13 (2) ◽  
pp. 117-128 ◽  
Author(s):  
Stephen L. Muzzatti

Whether it's a story about crime, the weather, politics, Hollywood celebrities, or public health, sensationalistic and exploitative coverage is a media staple. The mass media's coverage of the outbreak of Severe Acute Respiratory Syndrome (SARS) in the spring of 2003 was no exception. The media's construction of the source, virulence, and transmissibility of this disease, a previously unknown cousin of the common cold, diverged considerably from its medical realities and contributed to a widespread though short-lived moral panic. Drawing on work in the areas of the sociology of health and critical criminology, this article explores the claims-making activities behind the SARS “epidemic.” Specifically, it addresses how threats to the public well-being are manufactured by the media and how these threats draw upon past and present cultural myths of dangerous “others” and contribute to unwarranted public fear, intolerance, and distrust.


Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new virus from the coronavirus family (1) regarded as enveloped, positive-sense, single-stranded ribonucleic acid (RNA) viruses with helical symmetric nucleocapsid (2). According to the whole genome sequencing and phylogenetic analysis of coronavirus strains, a distinct clade of betacoronavirus is shown to be associated with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (3). This novel clade is called the 2019 novel coronavirus (2019-nCoV) and due to more similarity to the SARS virus is also called severe acute respiratory syndrome coronavirus 2. The disease is known as COVID-19.


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