scholarly journals Kidney disease and hemodialysis: identification of blood biomarkers to detect heart failure and kidney failure

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Barbara Mayer ◽  
Pollyana Thays Lameira da Costa ◽  
Maria Elena Echevarría-Guanilo ◽  
Silvana Silveira Kempfer ◽  
Kleber Maciel Da Silva Pieri
Keyword(s):  
Heart Failure ◽  
Kidney Disease ◽  
Kidney Failure ◽  
Clinical Management ◽  
Web Of Science ◽  
Blood Biomarkers ◽  
Qualitative Synthesis ◽  
Risk Of Mortality ◽  
Final Sample

Objectives: to identify valid blood biomarkers to detect heart failure and kidney failure associated with kidney disease and hemodialysis. Methods: systematic literature review conducted in August 2018 in the following: Web Of Science, PubMed, Scopus, Cinahal, Cochrane, Science Direct and Lilacs. The guiding question was: “What are the blood biomarkers used to detect heart failure and kidney failure?” A total of 537 publications were found, 94 of these appeared more than once, 383 were excluded after reading titles and abstracts, 32 were excluded after reading the full texts, and 10 were excluded in the quantitative and qualitative synthesis.   Results: 18 papers compose the final sample and report laboratory and imaging tests, instruments to assess the risk of kidney and heart failure, and also clinical management of the progression of kidney and heart failure. All the studies correlated risk of mortality and mortality. Conclusion: laboratory tests are important to identifying kidney and heart failure and need to be used to improve clinical management of the hemodialysis treatment of people with chronic kidney disease in order to improve quality of life and life expectancy.

scholarly journals Healthcare-related impact of gout in hospitalized patients in Spain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Diego Benavent ◽  
Diana Peiteado ◽  
María Ángeles Martinez-Huedo ◽  
María Hernandez-Hurtado ◽  
Alejandro Balsa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Kidney Disease ◽  
Mortality Rates ◽  
Progressive Increase ◽  
Cerebrovascular Diseases ◽  
Hospitalized Patients ◽  
Data Set ◽  
Private Hospitals ◽  
Risk Of Mortality ◽  
General Mortality

AbstractTo analyze the epidemiology, clinical features and costs of hospitalized patients with gout during the last decade in Spain. Retrospective observational study based on data from the Minimum Basic Data Set (MBDS) from the Spanish National Health Service database. Patients ≥ 18 years with any gout diagnosis at discharge who had been admitted to public or private hospitals between 2005 and 2015 were included. Patients were divided in two periods: p1 (2005–2010) and p2 (2011–2015) to compare the number of hospitalizations, mean costs and mortality rates. Data from 192,037 patients with gout was analyzed. There was an increase in the number of hospitalized patients with gout (p < 0.001). The more frequent comorbidities were diabetes (27.6% of patients), kidney disease (26.6%) and heart failure (19.3%). Liver disease (OR 2.61), dementia (OR 2.13), cerebrovascular diseases (OR 1.57), heart failure (OR 1.41), and kidney disease (OR 1.34) were associated with a higher mortality risk. Women had a lower risk of mortality than men (OR 0.85). General mortality rates in these hospitalized patients progressively increased over the years (p < 0.001). In addition, costs gradually rose, presenting a significant increase in p2 even after adjusting for inflation (p = 0.001). A progressive increase in hospitalizations, mortality rates and cost in hospitalized patients with gout was observed. This harmful trend in a preventable illness highlights the need for change and the search for new healthcare strategies.

Mental Disorder in Chronic Heart Failure

Psychiatry ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 109-124
Author(s):  
A. V. Fomicheva ◽  
D. A. Andreev ◽  
B. A. Volel
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Mental Disorders ◽  
Clinical Manifestations ◽  
Maladaptive Behavior ◽  
Dissociative Disorders ◽  
Scientific Publications ◽  
Risk Of Mortality ◽  
Mental Pathology

The aim: analysis of scientific publications on the problem of clinical structure of mental disorders in patients with a chronic heart failure, taking into account cardiological pathology. Material and method: according to the keywords “chronic heart failure”, “mental disorders”, “depression”, “anxiety”, “hypochondria”, “dissociative disorders”, “denial”, “personality”, “coping strategies”, articles were searched in databases MEDLINE/PubMed, Scopus, Webofscience, eLibrary. Conclusion: mental disorders are widespread among patients with chronic heart failure (CHF). They are heterogeneous psychopathological phenomena, the features of which are determined by the specifics of the clinical manifestations of symptoms and the course of the cardiological pathology. Mental disorders in patients with CHF negatively affect the quality of life, lead to an increase in readmission times and a high risk of mortality through maladaptive behavior in illness. At the same time, despite the relevance of the study of mental pathology in CHF, dissociative disorders, leading to the most severe maladaptive disorders of behavior in illness, asthenic disorders, which are one of the most subjectively painful and prognostically significant symptoms, as well as the contribution of personality characteristics to the formation of mental disorders, remain insufficiently studied.

Remote monitoring of patients with heart failure in real clinical practice

Kardiologiia ◽  
2021 ◽  
Vol 61 (8) ◽  
pp. 76-86
Author(s):  
S. N. Nasonova ◽  
A. E. Lapteva ◽  
I. V. Zhirov ◽  
S. N. Tereshchenko ◽  
S. A. Boytsov
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Remote Monitoring ◽  
Outpatient Care ◽  
Death Rate ◽  
Web Of Science ◽  
Patients With Heart Failure ◽  
Available Information ◽  
Real Clinical Practice

Prevalence of chronic heart failure (CHF) is continuously growing and is associated with increased incidence of hospitalizations, morbidity and mortality. Furthermore, the increase in the number of rehospitalizations results in greater expenses and worsening of quality of life. In order to decrease the number of unscheduled hospitalizations and the death rate, the outpatient care should be improved, which can be achieved by using telemedical technologies. The aim of this review was collection and analysis of currently available information about the use of telemonitoring for patients with CHF. A systematic search and analysis of reports published from 2010 through 2020 in Web of Science, Scopus, and PubMed/MEDLINE databases was performed.

scholarly journals A Multicenter Prospective Double Blinded Randomized Controlled Pilot Trial of Intravenous Iron (Ferric Derisomaltose (FDI)) in Iron Deficient but not Anemic Patients with Chronic Kidney Disease on Functional Status.

2020 ◽  
Author(s):  
Sunil Bhandari ◽  
Victoria Allgar ◽  
Archie Lamplugh ◽  
Iain Macdougall ◽  
Philip Kalra
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Exercise Capacity ◽  
Intravenous Iron ◽  
Iron Deficient ◽  
Iv Iron ◽  
Double Blinded

Abstract Background Iron deficiency (ID) is common in patients with chronic kidney disease (CKD). Intravenous (IV) iron in heart failure leads to improvement in exercise capacity and improvement in quality of life measurements; however, data in patients with CKD are lacking.Methods The Iron and the Heart Study was a prospective double blinded randomized study in non-anemic CKD stages 3b-5 patients with ID which investigated whether 1000 mg of IV iron (ferric derisomaltose (FDI) ) could improve exercise capacity in comparison to placebo measured at 1 and 3 months post infusion. Secondary objectives included effects on hematinic profiles and hemoglobin, safety analysis and quality of life questionnaires (QoL).Results We randomly assigned 54 patients mean (SD) age for FDI (n=26) 61.6 (10.1) years vs placebo (n=28; 57.8 (12.9) years) and mean eGFR (32.1 (9.6) vs. 29.1 (9.6) ml/min/1.73m2) at baseline, respectively. Adjusting for baseline measurements, six-minute walk test (6MWT) showed no statistically significant difference between arms at 1 month (p=0.736), or 3 months (p=0.741). There were non-significant increases in 6MWT from baseline to 1 and 3 months in the FDI arm. Hemoglobin (Hb) at 1 and 3 months remained stable. There were statistically significant increases in ferritin (SF) and transferrin saturation (TSAT) at 1 and 3 months (p<0.001). There was a modest numerical improvement in QoL parameters. There were no adverse events attributable to IV iron. Conclusion This study demonstrated a short-term beneficial effect of FDI on exercise capacity, but it was not significant despite improvements in parameters of iron status, maintenance of Hb concentration, and numerical increases in functional capacity and quality of life scores. A larger study will be required to confirm if intravenous iron is beneficial in iron deficient non-anemic non-dialysis CKD patients without heart failure to improve the 6MWT.Trial Registration: European Clinical Trials Database (EudraCT) No: 2014-004133-16https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-004133-16/GBREC no: 14/YH/1209Date First Registered: 2015-02-17 and date of end of trail 2015-05-23Sponsor ref R1766 and Protocol No: IHI 141

scholarly journals Quality of the hospital infection control programs: an integrative review

2020 ◽  
Vol 41 ◽  
Author(s):  
André Luiz Silva Alvim ◽  
Bráulio Roberto Gonçalves Marinho Couto ◽  
Andrea Gazzinelli
Keyword(s):  
Infection Control ◽  
Web Of Science ◽  
Hospital Infection ◽  
Structural Elements ◽  
Control Programs ◽  
Final Sample ◽  
Hospital Infection Control ◽  
Process And Outcome ◽  
And Control

ABSTRACT Objective: To analyze the quality of health in relation to the components of structure, process, and outcome in actions for the prevention and control of infections. Method: An integrative literature review in the LILACS, Web of Science, Scopus, and SciELO databases. The time delimitation covered articles published between January 2009 and May 2019. Results: The final sample consisted of 10 articles published, mainly in Scopus (60%), and in Web of Science (30%). The structural elements varied among the study countries, suggesting opportunities for improvement of organizational characteristics and human resources. Regarding the process of the implemented routines, inconsistencies were found to comply with the guidelines. The result component was not emphasized among the studies included in the review. Conclusion: The quality of hospital infection control programs has yet to be improved among the health services, highlighting the need for investment in the structure, process, and outcome components.

THE RELATIONSHIP OF FAMILY SUPPORT WITH QUALITY OF LIFE AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE IN RUNNING HEMODIALIZATION THERAPY AT PMI HOSPITAL BOGOR

2018 ◽  
Vol 10 (1) ◽  
pp. 15-19
Author(s):  
Fajar Adhie Sulistyo
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Family Support ◽  
Kidney Failure ◽  
Relationship Of ◽  
The Relationship

Background : Chronic kidney disease is a pathophysiological process with diverse etiology, resulting in a progressive decline in renal function, and the patients generally end up with kidney failure. Family support is a support given by families who have blood relations in favor of the health of patients with kidney failure. Quality of life is an individual perception of patients with kidney failure toward his position in life. The aim of this study was to determine the relationship of family support with the quality of life of patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. The method of this research uses uses descriptively analytic type with cross sectional approach. The sample of this researchconsists of 129 respondents. The sampling was taken by accidental sampling technique. The instrument in this study were questionnaires family support and quality of life. The data were analyzed by using univariate and bivariate (using the chi-square test with α = 0.05). Result : Based on the research results through 88 respondents that (68.2%) whose family support is good, then 86 respondents (93%) have a good quality of life, and 2 respondents (5%) have less quality of life. From 8 respondents (6.2%) whose family support is less, 1 respondent (2%) have a good quality of life, and 7 respondents (19%) have a less quality of life. Based on statistical test p = 0.000, it can be concluded that there is significant correlation between both variables. Clonclusion : It is concluded that there is a relationship between family support and the quality of life among patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. Through this research, it is expected to be used as a source reference of information for nurses in hemodialysis room.

scholarly journals Is Guillain–Barré Syndrome Associated With COVID-19 Infection? A Systemic Review of the Evidence

2021 ◽  
Vol 11 ◽  
Author(s):  
Auwal Abdullahi ◽  
Sevim Acaroz Candan ◽  
Melda Soysal Tomruk ◽  
Nuray Elibol ◽  
Olumide Dada ◽  
...  
Keyword(s):  
Methodological Quality ◽  
Web Of Science ◽  
Selection Process ◽  
Guillain Barre Syndrome ◽  
Systemic Review ◽  
Qualitative Synthesis ◽  
Guillain Barré Syndrome ◽  
Review Form ◽  
Guillain Barré

Background: There is emerging evidence that Guillain–Barré syndrome (GBS) may be associated with coronavirus disease 2019 (COVID-19) infection. The aim of this review was to investigate the strength of the evidence.Method: The review was registered in PROSPERO (CDR42020184822). Three electronic databases, MEDLINE, PubMed, and Web of Science, and three preprint servers, MedRvix, ChemRvix, and BioRvix, were searched from December 2019 to 24th September 2020. Studies were included if they were on COVID-19 and of any design. Articles that are reviews or opinion were excluded. The selection process was carried out using EndNote and Rayyan software. The main outcomes in the study were study design, sample size, sex, age, overall GBS symptoms, other COVID-19 symptoms, comorbidity, timing between infection and the onset of neurological symptoms, CT, MRI, and EMG results. Methodological quality of the studies was assessed using the McMaster Critical Review Form. The collected data was analyzed using qualitative synthesis.Findings: Fifty-one high-quality studies (mostly) consisting of 83 patients were included in the study. All of the patients (except in a very few) in the included studies had confirmed diagnosis of COVID-19. Similarly, the diagnosis of GBS was based on standard clinical, electrophysiological, and cerebrospinal fluid (CSF) criteria.Conclusion: GBS may be associated with COVID-19, and therefore, testing for COVID-19 is recommended in patients presenting with GBS during this pandemic.

scholarly journals POS0487 ASSOCIATION OF RHEUMATOID ARTHRITIS WITH MORTALITY IN A COHORT OF CHRONIC KIDNEY DISEASE PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 476.1-476
Author(s):  
M. Ezeanuna ◽  
D. Prince ◽  
S. A. Alexander ◽  
J. S. Richards ◽  
G. Kerr ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Proportional Hazards ◽  
Current Smoker ◽  
Proportional Hazards Regression ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Race Ethnicity

Background:Rheumatoid Arthritis (RA) is associated with an increased risk of cardiovascular disease. RA is also associated with increased risk of chronic kidney disease (CKD) (1, 2), which is a known cardiovascular risk factor (3). We hypothesized that RA (compared with no RA) would be associated with increased risk of mortality among a cohort of patients with CKD.Objectives:To determine the risk of mortality in RA patients with CKD.Methods:This study was conducted using participants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) prospective Chronic Renal Insufficiency Cohort (CRIC) study. Approximately 3600 participants were enrolled from seven US clinical centers. Patients aged 21 – 74 years with mild to moderate CKD were eligible for enrollment. The primary outcome of interest was all-cause mortality. Secondary outcomes of interest included: kidney event defined as end stage renal disease (ESRD) or 50% decline in estimated glomerular filtration rate (eGFR), myocardial infarction (MI), cerebrovascular accident (CVA), heart failure and a composite cardiovascular endpoint. The association of RA mortality over time was examined using Cox multivariate proportional hazards regression, adjusting for potential covariates (age, sex, race/ethnicity, BMI, current smoker, education).Results:The study cohort included 492 participants with self-reported RA with a mean follow up of 9.5 years. Compared to the non-RA group, RA patients tended to be older, female, Black. Hypertension, diabetes, use of prednisone was more prevalent among the RA cohort. The unadjusted hazards ratio (HR) for mortality based on RA status was 1.45 (1.26, 1.67) but this association was attenuated after adjusting for the confounding factors [aHR 1.09 (0.94, 1.27)] (Table 1). Participants with RA had a significantly higher risk for heart failure than those without RA [aHR 1.17 (1.02, 1.34)]. We did not observe a statistically significant association between RA status and other secondary outcomes.Conclusion:RA was not associated with higher mortality among participants with CKD. However, RA was associated with higher rates of heart failure. Further studies evaluating the mechanisms behind this association are needed.References:[1]Kochi M, Kohagura K, Shiohira Y, Iseki K, Ohya Y. Chronic kidney disease, inflammation, and cardiovascular disease risk in rheumatoid arthritis. J Cardiol. 2018;71(3):277-83.[2]Sumida K, Molnar MZ, Potukuchi PK, Hassan F, Thomas F, Yamagata K, et al. Treatment of rheumatoid arthritis with biologic agents lowers the risk of incident chronic kidney disease. Kidney Int. 2018;93(5):1207-16.[3]Chiu HY, Huang HL, Li CH, Chen HA, Yeh CL, Chiu SH, et al. Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications - A National Population-Based Cohort Study. PLoS One. 2015;10(9):e0136508.[4]Muthukumar P, Dhanapriya J, Gopalakrishnan N, Dineshkumar T, Sakthirajan R, Balasubramaniyan T. Evaluation of renal lesions and clinicopathologic correlation in rheumatoid arthritis. Saudi J Kidney Dis Transpl. 2017;28(1):44-50.Table 1.Estimated hazard ratios (HR) for various outcomes from Cox proportional hazards regression for RA statusUnadjustedModel 1Model 2HR (95% CI)HR (95% CI)HR (95% CI)Death1.45 (1.26, 1.67)1.09 (0.94, 1.27)1.13 (0.97, 1.32)MI or death1.43 (1.25, 1.63)1.09 (0.95, 1.26)1.15 (0.99, 1.33)CVA or death1.42 (1.24, 1.63)1.07 (0.92, 1.24)1.11 (0.95, 1.29)CHF or death1.54 (1.35, 1.75)1.17 (1.02, 1.34)1.22 (1.06, 1.40)Composite1.49 (1.31, 1.69)1.13 (0.99, 1.30)1.18 (1.03, 1.35)Kidney event1.09 (0.94, 1.27)0.91 (0.78, 1.07)1.01 (0.85, 1.20)Model 1 adjusted for: age, sex, race/ethnicity, BMI, current smoker, educationModel 2 adjusted for: model 1 + cardiovascular risk factors (urine albumin creatinine ratio, systolic blood pressure, estimated glomerular filtration rate)Disclosure of Interests:None declared

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