scholarly journals Evaluation of Primary Metabolites and Antioxidant Potential Activity of Cayratia trifolia (Leaf and Stems)

2019 ◽  
Vol 9 (4-A) ◽  
pp. 367-372
Author(s):  
, Anita ◽  
Nakuleshwer Dut Jasuja ◽  
Manas Mahur T
Keyword(s):  
Free Radical ◽  
Secondary Metabolites ◽  
Maximum Concentration ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
Minimum Concentration ◽  
Cayratia Trifolia ◽  
Free Radical Scavenging Activities

Cayratia trifolia Linn. Domin Syn. Vitis trifolia (Family: Vitaceae) is commonly known as Fox grape in English; Amlabel, Ramchana in Hindi and Amlavetash in Sanskrit. It is native to Asia and Australia. This plant is used for chronic fever, rheumatic, anti-inflammatory etc. In the present study, quantitative analysis and free radical scavenging activities of stem ethanolic extract of Cayratia trifolia was investigated. The extract was found to possess more secondary metabolites and it exhibit radical scavenging activities, Based on the results it can be concluded that, the stem ethanolic extract of Cayratia trifolia which contains high amount of secondary metabolites and exhibits free radical scavenging activities, phytochemistry from leaves and stems using spectral techniques. This research paper provides information mainly on various biological activities like antimitotic, antidiabetic and anti-implantation and several medicinal uses. Biological activities of few of them have been studied maximum concentration of Proteins (58.4mg/gdw) and minimum concentration in total soluble sugar (0.7mg/gdw) and maximum concentration of Lipid peroxidase (5.01mg/gdw) and minimum concentration in FRAP (0.197mg/gdw). Keywords: Cayratia trifolia; Vitaceae; Phytochemistry; Antioxidant.

scholarly journals STUDIES ON THE PHYTOCHEMICAL SCREENING AND FREE RADICAL SCAVENGING POTENTIALS OF SOLANUM NIGRUM LEAVES EXTRACT

2016 ◽  
Vol 9 (6) ◽  
pp. 316
Author(s):  
Sriram Prasath
Keyword(s):  
Free Radical ◽  
Mineral Content ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
Solanum Nigrum ◽  
Phytochemical Analysis ◽  
Sodium And Potassium

ABSTRACTSolanum nigrum is a paramount in medicinal perspective and belongs to family Solanacea. From different parts of the plant significant pharmacological and biological activities have been reported previously.  In the present study, the ethanolic extract of leaves was investigated for phytochemical analysis, vitamin and mineral content. Phytochemical analysis of the leaves revealed the presence of phenols, alkaloids, flavonoids, glycosides, saponins, tannins, phytosterols and triterpenoides. The leaves extract was found to contain appreciable amounts of flavonoids and phenols. The extract showed the presence of vitamins such as ascorbic acid, folic acid, and niacinamide. It has been found that the leaves of Solanum nigrum is rich in minerals like copper, magnesium, manganese, vanadium, chromium, calcium, zinc, sodium, and potassium. The antioxidant (free radical scavenging) activity of the extract was determined against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) ABTS, Nitric oxide(NO) and Superoxide Scavenging assays. Solanum nigrum leaves extract was found to be antioxidant in nature which is evident from DPPH, ABTS, NO, Superoxide radical scavenging assays. These findings suggest that Solanum nigrum possess biologically important phytoconstituents, significant amounts of vitamins and minerals. IN addition, S. nigrum leaves extract exert free radical scavenging potential in vitro.Key words: Medicinal plants; Solanum nigrum leaves; phytoconstiuents;Antioxidant.  

scholarly journals Chemical Composition of the Essential Oil of Ligularia hodgsonii and Free Radical Scavenging Activity of the Oil and Crude Extracts

2014 ◽  
Vol 9 (10) ◽  
pp. 1934578X1400901
Author(s):  
Zihao Zhou ◽  
Jun Tang ◽  
Xueping Song
Keyword(s):  
Free Radical ◽  
Chemical Composition ◽  
Essential Oil ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
Total Oil ◽  
Lower Capacity ◽  
Free Radical Scavenging Activities

The chemical composition of the essential oil from roots and rhizomes of Ligularia hodgsonii was analyzed by gas chromatography (GC) and GC-mass spectrometry (MS). Forty-seven components were identified, representing 77.0% of the total oil. The main constituents were l-(+)-ascorbic acid 2,6-dihexadecanoate (15.7%), selina-6-en-4-ol (8.4%) and 9,10-dimethyl-1,2,3,4,5,6,7,8-octahydroanthracene (6.6%). The free radical scavenging activities of the essential oil, aqueous extract, ethanolic extract, and crude polysaccharides of L. hodgsonii, as well as some of their major components, were investigated using DPPH and ABTS assays. The essential oil displayed a lower capacity to quench free radicals than the extracts; the ethanolic and aqueous extracts showed considerably higher antioxidant potential that deserves further study.

scholarly journals Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer’s Disease Therapy

2017 ◽  
Vol 11 (1) ◽  
pp. 24-37 ◽  
Author(s):  
Gerard A. K. Teponnou ◽  
Jacques Joubert ◽  
Sarel F. Malan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Free Radical ◽  
Inhibitory Activity ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Linker Chain ◽  
Chain Lengths ◽  
Free Radical Scavenging Activities

The versatile biological activities of tacrine, trolox and β-carboline derivatives make them promising lead structures for the development of multifunctional Alzheimer’s disease (AD) agents. Based on the topology of the active site of cholinesterases and other target proteins involved in the pathogenesis of AD, we have designed and synthesized tacrine-trolox and tacrine-tryptoline hybrids with various linker chain lengths. The hybrids containing the trolox moiety (8a-8d) showed moderate to high TcAChE inhibition (IC50: 17.37 - 2200 nM), eqBuChE inhibition (IC50: 3.16 – 128.82 nM) and free radical scavenging activities (IC50: 11.48 – 49.23 µM). The hybrids with longer linker chain lengths in general showed better ChE inhibitory activity. As expected, free radical scavenging activities were not significantly affected by varying linker chain lengths. The hybrid compound containing the tryptoline moiety linked with a 7 carbon spacer to tacrine (14) displayed the best AChE and BuChE inhibitory activity (IC50 = 17.37 and 3.16 nM). Docking experiments exhibited that compounds 8d and 14 were able to bind to both the CAS and PAS of TcAChE and eqBuChE, suggesting that they will be able to inhibit ChE induced Aβ aggregation. Novel multi-target agents that exhibit good ChE inhibition (8d and 14) and anti-oxidant (8d) activity were identified as suitable candidates for further investigation.

scholarly journals IN VITRO ANTIOXIDANT CAPACITY AND FREE RADICAL SCAVENGING ACTIVITIES OF CARDIOSPERMUM HALICACABUM LINN.

2018 ◽  
Vol 11 (7) ◽  
pp. 421
Author(s):  
Savitha G ◽  
Vishnupriya V ◽  
Surapaneni Krishnamohan
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
The Body ◽  
Ferrous Ion ◽  
Harmful Effects ◽  
Radical Scavenging Assay ◽  
Free Radical Scavenging Activities

Objective: Free radicals and oxidants are produced in the body during normal cellular metabolism and exposure to pollutions and ionizing radiations. They exert beneficial and harmful effects to the human body. Harmful effects of these radicals are destroyed by either antioxidants of our body in situ or antioxidants which are supplied through foods. Hence, the aim of this present study is to assess the antioxidant and free radical scavenging capacity of the easily available edible plant Cardiospermum halicacabum Linn. (Mudakathan keerai).Methods: Antioxidant and free radical scavenging activities of the aerial parts extract of C. halicacabum was determined by 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging assay, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assay, ferrous ion chelating assay, nitric oxide (NO) radical scavenging assay, superoxide radical scavenging assay, hydroxyl radical scavenging assay, and lipid peroxidation assay.Results: Remarkable free radical scavenging potential was observed in the ethanolic extract of C. halicacabum with IC50 values on all tested radicals, namely DPPH (IC50=34.06 μg/ml), ABTS (IC50=21.45 μg/ml), ferrous ion chelating (IC50=19.56 μg/ml), NO (IC50=25.16 μg/ml), superoxide (IC50=35.16 μg/ml), hydroxyl (IC50=28.56 μg/ml), and lipid peroxidation (IC50=33.12 μg/ml). The results revealed that ethanolic extract of C. halicacabum Linn. has significant antioxidant activity.Conclusion: The present study suggested that the aerial part extract of C. halicacabum serves as a good source of natural antioxidants.

Antioxidant and Free Radical Scavenging Activities of Chitosan Materials

2014 ◽  
Vol 1002 ◽  
pp. 81-90 ◽  
Author(s):  
Qing Xu ◽  
Tian Zhong ◽  
Hui Li Li
Keyword(s):  
Free Radical ◽  
Functional Properties ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Natural Antioxidant ◽  
Biomedical Science ◽  
Antioxidant Ability ◽  
Potential Applications ◽  
Free Radical Scavenging Activities

Chitosan and its derivatives, which are known to possess multiple functional properties, have captured considerable interest due to their biological activities and potential applications in food, pharmaceutical, agricultural and environmental industries. This paper focuses on the antioxidant and free radical scavenging activities of various chitosan materials based on our and others’ latest research results, including scaffold, film, tablet, nanoparticle, and so on. The free radical scavenging mechanisms are summarized. This work may provide more insights into the antioxidant ability of chitosan and its derivatives and potentially enable them to use as natural antioxidant materials for application in food, agriculture, cosmetic and biomedical science.

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