CLINICO PATHOLOGICAL CORRELATION OF EYELID TUMORS AND THEIR SURGICAL OUTCOME

Detailed Examination ◽

Lymph Node Excision ◽

Excision Biopsy ◽

Presenting Symptoms ◽

Eyelid Tumors ◽

Lid Reconstruction

Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors. The most common presenting symptoms for skin cancer on the eyelids include a mass or tumor, ulceration, or soreness. It is an institution-based study and the patients were recruited from the OPD and Indoor-wards of Aravind Eye Hospital. Each patient was examined by the slit lamp bio-microscope. The size of the tumor is measured with a detailed examination of the tumor-like margin, the involvement of the other adnexal structure, and the lymph node. Excision biopsies were done and send for histopathological examination. Wound closure with lid reconstruction done according to the size and site of the tumor. Out of 66 patients, the clinical diagnosis of 56(85%) patients was correlated with the histopathological diagnosis but in the remaining 10(15%) patients no correlation was found between histopathological and clinical diagnosis. Proper knowledge of the tumor, anatomy of the lid, and history will help in the appropriate diagnosis of eyelid tumor which can be confirmed by histopathological examination. In the present study, tumors were managed with excision biopsy and lid reconstruction was done depending upon the location and extent of the tumor.

Study of glottic lesions in patients undergoing microlaryngeal surgery

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20200072 ◽

2020 ◽

Vol 6 (2) ◽

pp. 277

Author(s):

Vikrant Mittal ◽

Manish Munjal ◽

Rohit Verma ◽

Parth Chopra ◽

Hemant Chopra

Keyword(s):

Clinical Diagnosis ◽

Detailed Examination ◽

Female Ratio ◽

Histopathological Correlation ◽

Male Female Ratio ◽

Male Preponderance ◽

Vocal Nodules ◽

Microlaryngeal Surgery

Background: Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.Methods: 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed. Results: There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.Conclusions: In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.

A retrospective clinico-pathological study of hysterectomy cases in a tertiary care hospital in India – a review of 950 cases.

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v17i1.35287 ◽

2018 ◽

Vol 17 (1) ◽

pp. 88-92

Author(s):

Pal Subrata ◽

Chakrabarti Srabani ◽

Sinha Anuradha ◽

Phukan Jyoti Prakash ◽

Bose Kingshuk ◽

...

Keyword(s):

Clinical Diagnosis ◽

Tertiary Care ◽

Medical Science ◽

Abdominal Hysterectomy ◽

Uterine Bleeding ◽

Care Hospital ◽

Dysfunctional Uterine Bleeding ◽

Common Indication

Introduction: Hysterectomy is the most commonly performed gynaecological surgery in India as well as in abroad. It is frequently done in myometrial and endometrial pathologies and rarely for other causes. Hysterectomy is definitive management for diseases like fibroid, adenomyosis, dysfunctional bleeding, prolapsed uterus and malignant lesions of uterus and adenexa. We aimed our study to observe incidence of different pathologies of uterus and other reproductive organs in hysterectomy specimens and retrospective correlation between clinical diagnosis and histopathological finding of hysterectomy cases.Materials and Methods: Retrospective data were collected from our routine histopathological laboratory. Detailed history, clinical examination and operative findings and provisional diagnosis of all 950 hysterectomy cases were recorded during study period of 2 years. Histopathological diagnosis was correlated with clinical and preoperative diagnosis.Observations: Abdominal hysterectomy (734 cases, 77.26%) was the most common route of approach during surgery. Common pre-operative diagnoses were fibroid uterus (32%), dysfunctional uterine bleeding (28.95%), uterine prolapsed (22.74%). Other causes included uterine polyps (1.6%), complications of pregnancy (2.74%), ovarian tumours (8.42%), cervical carcinomas (2.97%) etc. Common pathologies on histology were leiomyoma (32%), adenomyosis (20.32%), atrophic endometrium (17.26%) and endometrial pathology (8.95%).Discussion: Our study has been correlated with other studies of India and other south Asian countries. Most common indication of hysterectomy in our study is dysfunctional uterine bleeding (32%) but Gupta et al and Jha R et al found utero-vaginal prolapse as most common indication. Leiomyoma was the most common histology diagnosed in the present series. Clinical diagnosis was possible in 67.57% cases in our study similar to Khan et al (70.51%).Conclusions: Histopathological examination of hysterectomy specimens helps to detect the exact causes and underlined pathology.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.88-92

Routine histopathological examination of the foreskin after circumcision for clinically suspected lichen sclerosus in children: Is it a waste of resources?

Canadian Urological Association Journal ◽

10.5489/cuaj.4331 ◽

2018 ◽

Vol 12 (5) ◽

pp. E231-3 ◽

Cited By ~ 1

Author(s):

Fahad A. Alyami ◽

Zhoobin Heidari Bateni ◽

Raken Odeh ◽

Walid A. Farhat ◽

Martin Koyle

Keyword(s):

Clinical Diagnosis ◽

Lichen Sclerosus ◽

Retrospective Chart Review ◽

Clinical Suspicion ◽

Pathological Diagnosis ◽

Balanitis Xerotica Obliterans ◽

Presenting Symptoms ◽

Review Period ◽

The Mean

Introduction: Circumcision is one of the most widely performed procedures in the world. One of the indications for circumcision is lichen sclerosis (LS). The natural history of LS in children is not as well-documented as in adult patients. Surgeons use the appearance of the foreskin or meatus to predict the diagnosis of LS.1 Indeed, if the diagnosis of LS is made in childhood, does it change management in the long-term? Pathological analysis of the excised foreskin is routinely done if there is suspicion of LS. Our aim is to assess the concordance between the clinical and pathological diagnosis of suspected LS and to assess the need for sending the foreskin for pathological examination.Methods: We conducted a retrospective chart review of 64 of 420 boys who underwent circumcision in a tertiary children’s hospital from June 2005 to June 2014, and who had their foreskin sent for pathology due to the clinical suspicion of LS. Demographics, presenting symptoms, presumed clinical diagnosis, pathological findings, and followup data were collected and analyzed. Results: Over the review period, 64 patients underwent circumcision for presumed LS. The mean age of the children was 9.7 years (range 3‒16.5). All the children who had circumcision for presumed LS diagnosis were symptomatic. LS was confirmed in 47 of 64 foreskins (73.5%). Balanitis xerotica obliterans (BXO) was clinically suspected in 40 (85%) of the 47 patients. The mean followup was 10 months (range 1–15), with seven recurrences (15%) during that period. The recurrences required revision surgery in two patients and five were managed with steroids only. Conclusions: In our series, the clinical diagnosis correlated with the pathological diagnosis in most cases. A clinical suspicion of LS without routine foreskin pathological assessment will reduces the overall cost to the healthcare system. Appropriate counselling of the patient/parents and their primary caregiver is imperative, as recurrence is common.

The accuracy value of the dentist’s clinical diagnosis in oral lesions performed on biopsy

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol25no2.26799 ◽

2013 ◽

Vol 25 (2) ◽

Author(s):

Galih Fata Anadza ◽

Endang Syamsudin ◽

Abel Tasman Yuza

Keyword(s):

General Hospital ◽

Clinical Diagnosis ◽

Clinical Examination ◽

Oral Surgery ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery ◽

Oral Lesions ◽

The Difference

Introduction: The diagnosis of a pathological disorder can be made in various stages, namely history taking, clinical examination and supporting examination. Clinical diagnosis is a diagnosis obtained from anamnesis and the results of clinical examination. Histopathological diagnosis is a diagnosis obtained from a microscopic examination of tissue. Clinical diagnosis and histopathological examination results may differ. The aim of the study was to obtain the accuracy value of the dentist’s clinical diagnosis by calculating the number of differences between the clinical diagnosis and the results of the histopathological examination of patients who were biopsied in the Department of Oral Surgery of General Hospital Dr. Hasan Sadikin Bandung. Methods: A retrospective descriptive study of cases of pathological abnormalities biopsied in the Department of Oral and Maxillofacial Surgery of General Hospital Dr Hasan Sadikin Bandung. The total number of study samples was 109 medical records of patients with biopsy. Results: The accuracy value of the clinical diagnosis of dentists was 76%, where the difference between the clinical diagnosis and the histopathological examination was 24%. The most common type of disorder with the greatest difference in diagnosis is ameloblastoma followed by papilloma and mucocele. Conclusion: The accuracy value of the clinical diagnosis of dentists in oral lesions performed biopsy is 76%.

Different Faces of Sinonasal Mass Lesions

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2020.v28i3.288 ◽

2021 ◽

Vol 28 (3) ◽

pp. 193-197

Author(s):

Devika T ◽

Shubha P Bhat ◽

Vadisha Srinivas Bhat ◽

Rajeshwary Aroor ◽

Satheesh Kumar Bhandary B ◽

...

Keyword(s):

Nasal Cavity ◽

Clinical Diagnosis ◽

Clinical Features ◽

Nasal Discharge ◽

Appropriate Treatment ◽

Sinonasal Mass ◽

Wide Range ◽

Neoplastic Lesions

Introduction Mass in the nasal cavity presents with a wide range of symptoms, when a presumptive diagnosis is often made with the help of imaging and endoscopy. This study focussed on correlating clinical diagnosis with the histopathological diagnosis so that appropriate treatment can be offered to improve the quality of life of the patient. Materials and Methods The study included 120 cases who presented with symptoms and signs of mass in the nasal cavity, undergoing surgery or diagnostic biopsy. They were evaluated with a detailed history and clinical examination, diagnostic nasal endoscopy, and relevant radiological investigations. Histopathological examination of the biopsy of the excised specimen was performed by Haematoxylin and Eosin stain. Special stains and Immunohistochemistry (IHC) were performed whenever indicated. The clinical diagnosis was correlated with histopathological diagnosis. Results Nasal obstruction was the most frequent symptom followed by nasal discharge. Non-neoplastic lesions made up 85% of cases, while16% of cases were proved as neoplastic lesions. Among neoplastic lesions, 7% were benign, and 9% were malignant. The inflammatory polyp was the most common non-neoplastic lesion. Fischer's exact test showed a correlation between clinical diagnosis and histopathological diagnosis. Non-neoplastic lesions were common in the 4th decade of life; benign lesions were common in the 3rd decade of life, while malignant lesions were common in the 5th decade of life. Conclusion Sinonasal masses present with overlapping clinical features, and sometimes the definite diagnosis is possible only by histopathological examination of the specimen. However, in the presence of characteristic clinical features, accurate clinical diagnosis is possible in most cases, and appropriate treatment can be performed without delay, pending histopathological examination.

MANAGEMENT CHALLENGE IN CHEST WALL NEOPLASMS

The Professional Medical Journal ◽

10.29309/tpmj/2015.22.09.1131 ◽

2015 ◽

Vol 22 (09) ◽

pp. 1176-1180

Author(s):

Niaz Hussain Soomro ◽

Aneeqa Ahsan Zafar ◽

Saifullah Baig ◽

Guzel Maxood ◽

Nisar Rao

Keyword(s):

Chest Wall ◽

Primary Tumor ◽

Malignant Tumors ◽

Case Series ◽

Chest Wall Tumor ◽

Team Approach ◽

Tumor Type ◽

Case Series Study

Introduction: Chest wall neoplasms are rare and represent only about 5% ofall thoracic neoplasm. We present our 2 years analysis of the clinical features, presentation,diagnosis and treatment of chest wall neoplasms. Study design: Case series study. Place andduration of study: Ojha Institute of Chest Diseases, Dow University of Health Sciences, Karachi,Pakistan from Nov 2012- Oct 2014. Methodology: Between 2012 and 2014, 39 patients with solidchest wall masses were enrolled in the study. Tumors were categorized as benign and malignant,including primary and secondary, after histopathological diagnosis with tissue biopsy. Data onpatients’ characteristics, symptoms, tumor type and management was recorded and analysed.Results: The study included 39 patients (20 males and 19 females) with age range 18-71years(mean 36.3). 21(53.8%) patients had benign chest wall tumors while 18(46.1%) patients hadmalignant tumors. Among malignant tumors, 14(77%) patients had primary malignancy whereas 4(22%) patients had chest wall tumor secondary to primary tumor elsewhere. Among these4, the primary tumor remained unknown in 1 patient. The most common benign solid lesionwas chest wal lesion lipoma in 8/21 patients (38%). Among malignant tumors, chondrosarcoma(4/14, 29%) was the most common. Conclusion: Preoperative needs careful assessment of thepatient, radiological imaging and histopathological examination for diagnosis of the tumor inthe chest wall. Using a multidisciplinary team approach, excellent results can be available withcomplete surgical resection, reconstruction of the chest wall and appropriate or neo adjuvanttreatment where necessary.

Castleman's Disease - Unicentric Plasma Cell Variant - A Case Report with Review of Literature

JMS SKIMS ◽

10.33883/jms.v15i1.116 ◽

2012 ◽

Vol 15 (1) ◽

pp. 57-60

Author(s):

Abdul Rashid Lone ◽

Sheikh Aejaz Aziz ◽

Syed Nisar Ahmad ◽

Mir Mohammad Hussain ◽

Ulfat Ara ◽

...

Keyword(s):

Plasma Cell ◽

Castleman’S Disease ◽

Lymph Node Excision ◽

Excision Biopsy ◽

Castleman's Disease ◽

Rare Location ◽

Cell Variant ◽

General Signs ◽

Localized Form

Castleman's disease (CD) is a rare disease with two identified forms. The localized form, often pauci symptomatic is characterized by enlargement of an isolated single lymphnode or lymphnode chain. Multicenteric form frequently presents with general signs. We report a patient who presented with cough and hemoptysis with imaging revealing right hilar lymphadenopathy. After thoracotomy, lymph node excision biopsy was done, histopathological examination revealed plasma cell - variant (PCV) of CD, a rare location for unicentric PCV of CD. JMS 2012;15(1):57-60.

Lymphoepithelial Cyst, A Diagnostic Dilemma: Case Report

Annals of Pathology and Laboratory Medicine ◽

10.21276/apalm.2824 ◽

2020 ◽

Vol 7 (10) ◽

pp. C137-140

Author(s):

Meenu Gill ◽

Sonia Chhabra ◽

Sunita Singh ◽

Dimple Mehrotra ◽

Priyanka Rawat

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Excision Biopsy ◽

Lymphoepithelial Cyst ◽

Diagnostic Dilemma ◽

Submandibular Region

Lymphoepithelial cysts are benign, slowly growing unilocular or multilocular lesions that appear in the head and neck region. They are also called branchial cysts and occur due to lymphocyte induced cystic ductular dilatation. The confirmatory diagnosis is always made on histopathological examination after resection. A 29 years old female patient presented to ENT department, Pt B. D. Sharma PGIMS, Rohtak with a soft to firm, non-tender, swelling in the submandibular region since 2 -3 days and was referred to Department of Pathology for FNAC on which a differential diagnosis of infected epidermoid cyst or squamous cell carcinoma was made and excision biopsy for confirmation and categorization was advised. The swelling was then excised and sent for histopathological examination and a final diagnosis of Lymphoepithelial cyst was made. The confirmatory diagnosis is always made postoperatively by histopathological examination. The treatment of a lymphoepithelial cyst is the surgical approach, which includes complete enucleation of the cyst. This is a case report of a lymphoepithelial cyst diagnosed on histopathology specimen for which differential of Infected cyst or Squamous cell carcinoma was given. The authors intend to highlight the importance of early histopathological diagnosis of Benign LEC as it has been reported to undergo malignant transformation

Histopathological diagnosis of ovarian mass

Journal of Pathology of Nepal ◽

10.3126/jpn.v8i1.19448 ◽

2018 ◽

Vol 8 (1) ◽

pp. 1261-1264

Author(s):

Shahali Shadab ◽

Tadayon Tadayon

Keyword(s):

Malignant Tumors ◽

Age Groups ◽

Germ Cell Tumors ◽

Cystic Teratoma ◽

Mature Cystic Teratoma ◽

Benign Tumors ◽

Hospital Data ◽

Ovarian Masses

Background: Ovarian cysts are common forms of gynecological problems that can be range from physiological cysts to highly aggressive neoplastic lesions. The purpose of this study was to investigate prevalence and frequency of different histopathological patterns of ovarian lesions and their correlation with various parameters in Ahvaz, Iran.Materials and Methods: This is the retrospective study of patients with the ovarian masses at Ahvaz Imam Khomeini Hospital from 2010 - 2015. The relevant clinical details about the patient were retrieved from hospital data. Clinical characteristics of patients such as patient's age, presenting signs and symptoms, histopathological diagnosis, mass type, mass subtype, size of cysts and ovary which is involved were noted. Results: Two hundred sixty seven specimens of ovarian tumor obtained for histopathological examination. Of these, 163(61.0%) were tumor like, 96(36.0%) were benign tumor and 8(3.0%) were malignant. The most common tumor like conditions was Corpus luteum cyst (43.4% cases), among benign and malignant tumors, mature cystic teratoma (17.2% of total) and Epithelial tumors (n=4) were most common. There is a statistically significant positive relation between age and various ovarian masses. (P= 0.002). Histopathological diagnosis wasn't correlated with ovarian involvement.Conclusion: Benign tumors are more common than malignant tumors in all age groups. Germ cell tumors followed by surface epithelial cell tumors are the commonest tumor. Mature cystic teratoma was the most common tumor. Unilaterality is more frequently seen in ovarian tumors and various tumors are seen in various age groups.

A STUDY OF CLINICAL CORRELATION WITH HISTOPATHOLOGICAL DIAGNOSIS OF ABNORMAL UTERINE BLEEDING AT JLNMCH, BHAGALPUR, BIHAR

10.36106/ijsr/2632845 ◽

2021 ◽

pp. 73-74

Author(s):

Archana Jha ◽

Satyendra Kumar ◽

[Prof.] Usha Kumari ◽

Debarshi Jana

Keyword(s):

Clinical Diagnosis ◽

Abnormal Uterine Bleeding ◽

Uterine Bleeding ◽

Clinical Impression ◽

Endometrial Sampling ◽

Carcinoma Of Cervix ◽

Perimenopausal Women ◽

Pathological Evaluation

Background: Abnormal uterine bleeding in perimenopausal women accounts for about 70% of gynaecologic Outpatient Department visits. Perimenoppause, also called the menopausal transition, is the interval in which a woman's body makes a natural shift from more or less regular cycles of ovulation and menstruation toward permanent infertility, or menopause. Polymenorrhagia, intermenstrrual bleeding and metrorrhagia are other common disorders at perimenopause. Endometrial sampling is a safe and effective diagnostic step in evaluation of abnormal uterine bleeding after ruling out medical causes. The present study was aimed to review the causes of abnormal uterine bleeding in perimenopausal women establishing the correlation with clinical diagnosis and histopathological examinations. A total of 150 perimenopausal Material and Methods: women with abnormal uterine bleeding in the age group of 37-51 years for a period of 6 months were included. These women were evaluated clinically and ultrasonographically for the cause of abnormal uterine bleeding. Clinical impression and USG reports were correlated. These women underwent dilatation and curettage for endometrial sampling and specimen sent for histopathological examination. Histopathological reports were correlated with clinical diagnosis. Most of the patients with AUB were Results: between 37-41 years of age (56%). The incidence was high in parity-3 (26%) annd grand multipara (49.33%). The majority of the women were presented with menorrhagia (54.66%). Clinically, majority of the cases were diagnosed as broids 66 (44%) followed by dysfunctional uterine bleeding (DUB) 56 (37.33%). However, histopathological reports conrmed broid in 52 cases, DUB in 49, adenomyosis in 36 and polyp in 11 cases. Fibroi Discussion: ds are common nding in women with menorrhagia. Clinical, radiological and pathological evaluation correlated very well to diagnose broids and DUB. However clinically as well USG proved of little help to diagnose adenomyosis and carcinoma of cervix and endometrium. Thus, histopathological evaluation of endometrium is recommended in perimenopausal women.