Seroprevalence of hepatitis b, c and HIV among patients attending a multispecialty hospital: An 8 year old retrospective study

Background. Lamivudine is the most affordable drug used for chronic hepatitis B and has a high safety profile. With the daily dose of 100 mg there is progressive appearance of resistance to lamivudine therapy. In our study we used 150 mg of lamivudine daily as a standard dose which warrants further exploration for the efficacy of the drug. Aims of the Study. To assess the efficacy of lamivudine 150 mg daily on resistance in patients with chronic hepatitis B. Methods. This retrospective study consists of 53 patients with chronic hepatitis B treated with 150 mg of lamivudine daily. The biochemical and virological response to the treatment were recorded at a 1-year and 2-, 3-, 4-, and 5-year period and time of emergence of resistance to the treatment was noted. Results. The mean age of the patients was 54 years with 80% being males. The resistance to lamivudine 150 mg daily at 1 year and 2, 3, and 5 years was 12.5%, 22.5%, 37.5%, and 60%, respectively, which is much less compared to the standard dose of 100 mg of lamivudine. Conclusions. Lamivudine is safe and a higher dose of 150 mg daily delays the resistance in patients with chronic hepatitis B.

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Prevalence of hepatitis delta virus infection among hepatitis b virus surface antigen positive patients diagnosed in a Central Hospital in Portugal, a 5 years retrospective study

Journal of Clinical Virology ◽

10.1016/j.jcv.2016.08.149 ◽

2016 ◽

Vol 82 ◽

pp. S75

Author(s):

F. Paramés ◽

S. Paulo ◽

P. Barbeiro ◽

J. Sampaio ◽

H. Proença ◽

...

Keyword(s):

Retrospective Study ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Hepatitis Delta Virus ◽

Central Hospital ◽

Virus Surface ◽

Hepatitis Delta Virus Infection ◽

B Virus ◽

Delta Virus

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The frequency of hepatitis B virus infection in patients chronically infected with hepatitis C virus: a retrospective study

Türkiye Aile Hekimliği Dergisi ◽

10.2399/tahd.12.003 ◽

2012 ◽

Vol 16 (1) ◽

pp. 3-7

Author(s):

Fatih Akca

Keyword(s):

Hepatitis C Virus ◽

Retrospective Study ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Hepatitis B Virus Infection ◽

B Virus

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Factors associated with response to lamivudine: Retrospective study in a tertiary care clinic serving patients with chronic hepatitis B

Journal of Gastroenterology and Hepatology ◽

10.1111/j.1440-1746.2005.03577.x ◽

2005 ◽

Vol 20 (3) ◽

pp. 433-440 ◽

Cited By ~ 4

Author(s):

HIE-WON L HANN ◽

MICHELE L JONSSON FUNK ◽

DANIEL M ROSENBERG ◽

RANDY DAVIS

Keyword(s):

Chronic Hepatitis ◽

Retrospective Study ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Tertiary Care ◽

Care Clinic ◽

Factors Associated

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Effect of Positive Hepatitis B Surface Antigen on The Risk of Synchronous Liver Metastasis: A Retrospective Study of 868 Consecutive Patients of Newly Diagnosed Gastric Cancer

10.21203/rs.3.rs-113459/v1 ◽

2020 ◽

Author(s):

Tingya Wang ◽

Haijun Zhang

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Logistic Regression ◽

Regression Analysis ◽

Retrospective Study ◽

Liver Metastasis ◽

Hepatitis B ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

Newly Diagnosed

Abstract Background. The study aimed to explore the influence of hepatitis B virus (HBV) infection on the risk of synchronous gastric cancer liver metastasis (synGCLM).Methods. This was a retrospective study which enrolled 868 patients with newly diagnosed gastric cancer (GC). The study compared the prevalence of synGCLM between hepatitis B surface antigen (HBsAg)-positive (HBsAg+) and -negative (HBsAg-) patients. Logistic regression analysis was utilized to analyze the risk factors for synGCLM. Among patients with and without synGCLM, aspartate aminotransferase to platelet ratio index (APRI), liver fibrosis-4 index (FIB-4) and hepatitis B e antigen (HBeAg) status were further analyzed. Results. The prevalence of synGCLM in the HBsAg+ patients was higher than that in the HBsAg- patients, which was statistically significant (P = 0.025). Multivariate logistic regression analysis demonstrated that HBsAg, the elevated level of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) were risk factors for synGCLM. Among the HBsAg+ patients, both ARPI and FIB-4 were significantly higher in the patients with synGCLM (synGCLM+) than those without synGCLM (synGCLM-) (ARPI: P = 0.045; FIB-4: P = 0.047); HBeAg positivity was detected in 20.0% of synGCLM+ patients compared to 6.0% of synGCLM- patients, but the difference was of no significance (P = 0.190). Conclusions. HBV infection significantly increases the risk of synGCLM, and elevated ARPI and FIB-4 may be pro-metastatic especially among the HBsAg+ GC patients.

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Seroepidemiology of Hepatitis B and C Virus Infections: A Five-Year Retrospective Study Among Blood Donors in Saboba District in the Northern Region of Ghana

10.21203/rs.3.rs-149110/v1 ◽

2021 ◽

Author(s):

Abel Makija Nlankpe ◽

Patrick Kwesi Owiafi ◽

David Adedia ◽

Jacob Nabei Nignan ◽

Precious Kwablah Kwadzokpui

Keyword(s):

Retrospective Study ◽

Hepatitis B ◽

Blood Donors ◽

Adult Population ◽

Public Health Education ◽

Northern Region ◽

Female Group ◽

Seroprevalence Rate ◽

Virus Infections ◽

Hcv Coinfection

Abstract Background and Objectives: Chronic hepatitis B and C infections are capable of progressing to liver cirrhosis and hepatocellular carcinoma. Globally, it has been estimated that over 2 billion and 170 million people are living with hepatitis B and C infections, respectively. Ghana remains one of the highly endemic countries challenged by continues spread of these viral agents in Africa. This study aimed to determine the seroprevalence and trend of Hepatitis B and C coinfections among blood donors in Saboba District of the Northern Region of Ghana. Methods: A five-year hospital based retrospective study was carried out among 8,605 blood donors comprising 8517 males and 88 females using data on blood donors from Saboba Assemblies of God Hospital located in the Saboba District in the Northern Region of Ghana from 2013 to 2017. Blood bank records on HBV and HCV potential blood donors who visited the hospital to donate blood was retrieved. Donor demographic details, i.e. age and gender were also recovered. Donors who were registered to the hospital but were not residents of the Northern Region were excluded from the study. Donors with incomplete records were also excluded from the study. The data was managed using Microsoft Excel spreadsheet 2016 and analysed using GraphPad Prism statistical software. Results: The overall prevalence of asymptomatic viral hepatitis B and C infection in the general adult population was 9.59% and 12.71%, respectively, with an HBV/HCV coinfection rate of 2.23%. The number of donors generally declined with advancement in years from 2038 (23.68%) since 2013 to as low as 1169 (13.59%) in 2016, except for 2017 where a sharp increase of 1926 (22.38%) was observed. The first and second highest proportions of donors fell within the age categories of 20-29 [51.53% (4434)] and 30-39 [32.90% (2831)]. Seroprevalence rate of HBV, HCV and HBV/HCV coinfection rates were generally higher among the female group than observed among the male category. The year-to-year variation in HBV, HCV and HBV/HCV infection was statistically significant. The highest year-to-year HBV seropositivity rate was 11.48% in the year 2013, while that for HCV and HBV/HCV coinfection was 16.24% and 5.85% respectively both documented in the year 2014. HBV and HBV/HCV coinfection rate was highest among donors aged <20 years old, while HCV seroprevalence was highest among donors aged 50-59 years old. Conclusion: Seroprevalence of HBV and HCV among donors in the Saboba District of the Northern Region of Ghana is endemic. The HBV/HCV coinfections rate also raises serious concern owing to its high prevalence rate among the younger age. Intensive public health education coupled with mobile screening and mass vaccination of seronegative individuals is advised so as to help curb further spread of the infection and in effect help safeguard the health status of potential donors in the district.

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