scholarly journals A Streptococcus Intermedius Brain Abscess Causing Obstructive Hydrocephalus and Meningoventriculitis in an Adult Patient With Chronic Granulomatous Disease

1970 ◽  
Vol 10 (2) ◽  
Author(s):  
Fareed Kamar MD ◽  
Vinay Dhingra MD, FRCPC
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Obstructive Hydrocephalus ◽  
Genetic Defect ◽  
Central Nervous System Infection ◽  
Recurrent Infection ◽  
Granulomatous Disease ◽  
Streptococcus Intermedius

An inherited abnormality of phagocytosis, chronic granulomatous disease (CGD), represents an immunodeficiency characterized by recurrent infection and granuloma formation due to a genetic defect in NADPH oxidase. The 36-year-old male patient with CGD described in this case featured a brain abscess due to Streptococcus intermedius infection, complicated by meningoventriculitis and obstructive hydrocephalus. His condition was managed with broad-spectrum antibiotics, interferon gamma-1b, and bilateral external ventricular drains. This report addresses a particular paucity in the literature involving Streptococcus intermedius central nervous system infection in the adult CGD population.

Streptococcus intermedius -brain abscess in chronic granulomatous disease

1999 ◽  
Vol 158 (10) ◽  
pp. 872-873 ◽  
Author(s):  
T. Nagatomo ◽  
S. Ohga ◽  
M. Saito ◽  
H. Takada ◽  
Y. Sasaki ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Granulomatous Disease ◽  
Streptococcus Intermedius

Infection of a Shunt by Mycobacterium fortuitum: Case Report

Neurosurgery ◽  
1991 ◽  
Vol 29 (3) ◽  
pp. 472-474 ◽  
Author(s):  
Kwan-Hon Chan ◽  
Kirpal S. Mann ◽  
W. H. Seto
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Obstructive Hydrocephalus ◽  
Central Nervous System Infection ◽  
Shunt Infection ◽  
Mycobacterium Fortuitum ◽  
Intraventricular Administration ◽  
Ventriculoatrial Shunt ◽  
Pertinent Literature

Abstract Mycobacterium fortuitum is a rare cause of central nervous system infection: however, shunt infection caused by this organism has not been reported. We report a case of shunt infection subsequent to insertion of a ventriculoatrial shunt for obstructive hydrocephalus caused by a cerebellar hematoma. The shunt infection was controlled by removal of the shunt and a combination of systemic and intraventricular administration of amikacin, and oral administration of ofloxacin. The case is discussed and the pertinent literature reviewed.

scholarly journals Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Sanem Eren Akarcan ◽  
Neslihan Karaca ◽  
Guzide Aksu ◽  
Halil Bozkaya ◽  
Mehmet Fatih Ayik ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Staphylococcus Aureus ◽  
Nervous System ◽  
Chronic Granulomatous Disease ◽  
Central Nervous System Involvement ◽  
Primary Immune Deficiency ◽  
Granulomatous Disease ◽  
Hematopoietic Stem ◽  
System Involvement ◽  
Gene Coding

Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding gp91phox protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus. In addition to medical therapy, surgical treatment was necessary for the management of the disease. A 30-month-old girl with an autosomal recessive form of chronic granulomatous disease (CYBA gene mutation affecting p22phox protein) had invasive aspergillosis causing pericarditis, pulmonary abscess, and central nervous system involvement. The devastating course of disease regardless of the mutation emphasizes the importance of early diagnosis and intervention of hematopoietic stem cell transplantation as soon as possible in children with CGD.

Cladophialophora bantiana brain abscess with lymphadenitis

2021 ◽  
Vol 14 (10) ◽  
pp. e246108
Author(s):  
Vinit Suri ◽  
Shishir Pandey ◽  
Nidhi Goyal ◽  
Hena Rani
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Abscess ◽  
Central Nervous System Infection ◽  
Central Nervous System Lymphoma ◽  
Lymph Node Biopsy ◽  
High Grade ◽  
Dematiaceous Fungi ◽  
Common Cause ◽  
Node Biopsy

Cerebral phaeohyphomycosis refers to central nervous system infection by dematiaceous mould or by dark walled fungi which contain the dark pigment melanin in their cell wall which adds to the virulence of fungus. These dematiaceous fungi can cause a variety of central nervous infections including invasive sinusitis, brain abscess, meningitis, myelitis and arachnoiditis. Cladophialophora bantiana among these dematiaceous fungi is the most common cause of brain abscess in immunocompetent and immunocompromised individuals and is known to occur worldwide though is predominantly reported from subtropical regions especially the Asian subcontinent. It is difficult to differentiate these abscesses radiologically from high-grade gliomas, primary central nervous system lymphoma or other infections including toxoplasmosis, nocardiosis, tuberculosis and listeriosis. We describe a 19-year-old male patient with a cerebral abscess caused by C. bantiana where the diagnosis could be suspected by typical MR spectroscopic findings and by identifying the fungus from a lymph node biopsy.

scholarly journals Cladophialophora bantianaBrain Abscess in an Immunocompetent Patient

2011 ◽  
Vol 22 (4) ◽  
pp. 149-150 ◽  
Author(s):  
Sanjay G. Revankar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amphotericin B ◽  
Brain Abscess ◽  
Liposomal Amphotericin ◽  
Brain Lesion ◽  
Central Nervous System Infection ◽  
Surgical Excision ◽  
Immunocompetent Patient ◽  
Immunocompetent Patients

Cladophialophora bantianais a dematiaceous mold with a predilection for causing central nervous system infection, particularly in normal hosts. A case involving a 79-year-old immunocompetent woman who presented with left-sided weakness and a ring-enhancing brain lesion is reported. She underwent surgical excision, which revealed a brain abscess due toC bantiana. The patient was treated with liposomal amphotericin B for several weeks, then switched to voriconazole and flucytosine, but eventually succumbed to the infection. Therapy is not standardized for this rare mycosis, and mortality remains high, even in immunocompetent patients. Additional studies to understand the pathogenesis of this infection and to improve outcomes are needed.

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