scholarly journals Eco-friendly and miniaturized analytical method for quantification of Rifaximin in tablets

2019 ◽  
Vol 3 (2) ◽  
pp. 23-29
Author(s):  
Clara Motta ◽  
Ana Kogawa ◽  
Marlus Chorilli ◽  
Hérida Salgado
Keyword(s):  
Analytical Chemistry ◽  
Quality Control ◽  
Analytical Method ◽  
Low Cost ◽  
Ultraviolet Region ◽  
Waste Generation ◽  
Green Analytical Chemistry ◽  
Average Recovery ◽  
Relative Standard ◽  
A Current

Rifaximin is an oral antimicrobial, semisynthetic and nonabsorbable with minimal adverse effects that act locally in the gastrointestinal tract. Rifaximin does not have standardized methods of analysis for the tablets evaluation in official compendiums. The objective of this study is to develop and validate an analytical method for the quantification of rifaximin in tablets by spectrophotometry in the ultraviolet region, aiming at a miniaturized and eco-friendly method. The method was performed using 700 μL cuvette and purified water: ethanol (4:1, v/v) as diluent. The wavelength used was 233 nm and the range of concentrations was 4-14 µg mL-1. It was linear with correlation coefficient greater than 0.9999, precise with relative standard deviation equal 0.80%, 1.19% and 1.19% for intraday, interday and interanalyst precision, respectively, exact with average recovery of 100.56%, selective against the presence of interferents such as impuruties, matrix compouds and solvents used and robust with the change of ethyl alcohol brand and proportion used as diluent. The method developed presents advantages as, minimum waste generation, reduction in amount of sample, standard and solvents used and reduction in time of analysis. Then this method can be used in rotine analysis of rifaximin tablets as a alternative method, reliable, effective, really fast, low cost, eco-friendly and miniaturized. This study contemplates a current and innovative topic which is extremely important for the area of Quality Control of drugs and medicines and for the sustainable Green Analytical Chemistry.

scholarly journals NEW, GREEN AND MINIATURIZED ANALYTICAL METHOD FOR DETERMINATION OF CEFADROXIL MONOHYDRATE IN CAPSULES

2019 ◽  
Vol 3 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Bianca Marco ◽  
Ana Kogawa ◽  
Hérida Salgado
Keyword(s):  
Analytical Chemistry ◽  
Standard Sample ◽  
Low Cost ◽  
Visible Region ◽  
Hplc Method ◽  
Minimal Amount ◽  
Green Analytical Chemistry ◽  
Color Reagent ◽  
Routine Quality Control

Cefadroxil, an oral antimicrobial, presents few techniques optimized for the reduction of solvents and toxic residues and/or non-use of them. So, a quantitative, new and miniaturized method for determination of cefadroxil monohydrate in capsules has been developed and validated by spectrophotometric method in the visible region according to the international guidelines. The analyzes were performed using microplates containing 96 wells, 1 % of phenolphthalein and sodium hydroxide 0.1 M as reagent at 552 nm. The method was (i) linear in the range of 15-115 µg mL-1, (ii) selective when comparing standard, sample, adjuvants and color reagent, (iii) precise with deviations below 4 %, (iv) accurate when comparing the proposed method with the HPLC method, (v) robusts by making small and deliberate modifications to the method, (vi) besides being fast, low cost, eco-friendly and generates minimal amount of waste. The method can be applied to the routine quality control of cefadroxil monohydrate in capsules and an effective and accessible alternative that contemplates the concepts of current and sustainable green analytical chemistry.

scholarly journals Implementing Green Analytical Methodologies Using Solid-Phase Microextraction: A Review

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5297
Author(s):  
Kayla M. Billiard ◽  
Amanda R. Dershem ◽  
Emanuela Gionfriddo
Keyword(s):  
Analytical Chemistry ◽  
Sample Preparation ◽  
Analytical Method ◽  
Analytical Methods ◽  
Solid Phase Microextraction ◽  
Method Development ◽  
Assessment Tool ◽  
Solid Phase ◽  
Assessment Tools ◽  
Green Analytical Chemistry

Implementing green analytical methodologies has been one of the main objectives of the analytical chemistry community for the past two decades. Sample preparation and extraction procedures are two parts of analytical method development that can be best adapted to meet the principles of green analytical chemistry. The goal of transitioning to green analytical chemistry is to establish new methods that perform comparably—or superiorly—to traditional methods. The use of assessment tools to provide an objective and concise evaluation of the analytical methods’ adherence to the principles of green analytical chemistry is critical to achieving this goal. In this review, we describe various sample preparation and extraction methods that can be used to increase the greenness of a given analytical method. We gave special emphasis to modern microextraction technologies and their important contributions to the development of new green analytical methods. Several manuscripts in which the greenness of a solid-phase microextraction (SPME) technique was compared to other sample preparation strategies using the Green Analytical Procedure Index (GAPI), a green assessment tool, were reviewed.

Green analytical chemistry: Opportunities for pharmaceutical quality control

2016 ◽  
Vol 71 (9) ◽  
pp. 861-871 ◽  
Author(s):  
A. B. Eldin ◽  
O. A. Ismaiel ◽  
W. E. Hassan ◽  
A. A. Shalaby
Keyword(s):  
Analytical Chemistry ◽  
Quality Control ◽  
Green Analytical Chemistry ◽  
Pharmaceutical Quality

scholarly journals Rapid Analysis of Milk Using Low-Cost Pocket-Size NIR Spectrometers and Multivariate Analysis

Foods ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1090 ◽  
Author(s):  
Jordi Riu ◽  
Giulia Gorla ◽  
Dib Chakif ◽  
Ricard Boqué ◽  
Barbara Giussani
Keyword(s):  
Analytical Chemistry ◽  
Near Infrared ◽  
Multivariate Calibration ◽  
Low Cost ◽  
Analytical Data ◽  
Acquisition Time ◽  
Green Analytical Chemistry ◽  
Data Acquisition Time ◽  
Commercial Milk ◽  
New Generation

The miniaturisation of analytical devices, reduction of analytical data acquisition time, or the reduction of waste generation throughout the analytical process are important requirements of modern analytical chemistry, and in particular of green analytical chemistry. Green analytical chemistry has fostered the development of a new generation of miniaturized near-infrared spectroscopy (NIR) spectrometric systems. However, one of the drawbacks of these systems is the need for a compromise between the performance parameters (accuracy and sensitivity) and the aforementioned requirements of green analytical chemistry. In this paper, we evaluated the capabilities of two recently developed portable NIR instruments (SCiO and NeoSpectra) to achieve a rapid, simple and low-cost quantitative determination of commercial milk macronutrients. Commercial milk samples from Italy, Switzerland and Spain were chosen, covering the maximum range of variability in protein, carbohydrate and fat content, and multivariate calibration was used to correlate the recorded spectra with the macronutrient content of milk. Both SCiO and NeoSpectra can provide a fast and reliable analysis of fats in commercial milk, and they are able to correctly classify milk according to fat level. SCiO can also provide predictions of protein content and classification according to presence or absence of lactose.

scholarly journals GREEN ANALYTICAL METHOD FOR QUANTIFICATION OF SECNIDAZOLE IN TABLETS BY HPLC-UV

2018 ◽  
Vol 2 (2) ◽  
pp. 20-26
Author(s):  
Jéssica Lima ◽  
Ana Kogawa ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Analytical Chemistry ◽  
Particle Size ◽  
Analytical Method ◽  
Mobile Phase ◽  
Toxic Waste ◽  
Green Analytical Chemistry ◽  
Injection Volume ◽  
As Stress ◽  
Routine Quality Control

A simple, rapid, economic and green analytical method was validated for the determination of secnidazole in tablets. The aim was to contribute to the green analytical chemistry since it has low use of organic solvent and low production of toxic waste. For the HPLC-UV method, the mobile phase was a mixture of purified water + 0.7 % acetic acid and ethanol (78:22, v/v), flow rate was 1.3 mL min-1 on column CN Phenomenex Luna (250 x 4.60 mm, 5 μm particle size), injection volume was 20 μL with UV detection at 318 nm and retention time of 4.26 minutes. The method was linear over the concentration range of 5-100 μg mL-1 (r = 0.9998) with limits of detection and quantitation of 0.533 e 1.615 μg mL-1, respectively. The precision of the method showed RSD less than 2 %. The accuracy determined by the average recoveries was 99.58 %. The secnidazole tablets were subjected to oxidation, acid, alkaline, neutral and photolysis degradation as stress conditions and the method was considered as indicative of stability. The method is adequate and safe to be a great alternative method in routine quality control analyzes for determination and quantification of secnidazole tablets.

scholarly journals Chemometric Calculation for Determination of Betamethasone and Neomycin Mixture in Cream Supply by Ultraviolet Spectrophotometry

2019 ◽  
Vol 7 (22) ◽  
pp. 3911-3916
Author(s):  
Muchlisyam Bachri ◽  
Julia Reveny ◽  
Yade Metri Permata ◽  
D. N. Panjaitan
Keyword(s):  
Analytical Chemistry ◽  
Quality Control ◽  
Multivariate Calibration ◽  
Predictive Ability ◽  
Ultraviolet Spectrophotometry ◽  
Spectrophotometric Methods ◽  
Chemometric Technique ◽  
Relative Standard ◽  
Recovery Percentage

BACKGROUND: Chemometric can be defined as a branch of analytical chemistry using statistical principles to design and select optimal analytical procedures and experiments. The chemometric technique that applies in the design of quantitative calibration curves in the spectral analysis is very important in quality control of the component contained in the drug mixture of 2 or 3 drug components or more, especially the component that has the adjacent wavelength when the spectrum overlap.  AIM: The purpose of this study was to conduct research that examines betamethasone and neomycin mixture in cream with the UV spectrophotometric methods using a chemometric calculation. METHODS: Chemometric calculation for determination of betamethasone and neomycin mixture in cream supply by ultraviolet spectrophotometric. RESULTS: The result of betamethasone and neomycin levels were 91.35% and 97.56%, relative standard deviation (RSD) for betamethasone and neomycin 0.93%; 1.73% and recovery percentage 99.09%; 99.94%. On the multivariate calibration of PLS ​​betamethasone and neomycin with each RMSEC value of 0.0230 and 0.3553 with the value of RMSECV 0.7187 and 0.3586 with RMSEP value 0.1558 and 0.0820. Thus, the predictive ability of the research is still acceptable and is well used for grade determination of betamethasone and neomycin content ​​fulfil the requirement for cream preparation according to USP edition XXX. CONCLUSION: Methods of UV spectrophotometric with chemometric can be used in the determination of BET and NEO levels in cream preparations and BET level is 91.35% with a range of 90-110%, and NEO level is 97.56% with a range of 94.45-98.71%. These levels have met the requirements of the levels listed in Indonesian Pharmacopoeia, 2014.

scholarly journals Development and Validation of Analytical Method for Determination of an Important Flavonoid in Malva neglecta

2019 ◽  
pp. 1-8
Author(s):  
Naira Nayeem Akmal ◽  
Mohd. Imran ◽  
Mohammad Ali Mujtaba
Keyword(s):  
Quality Control ◽  
Calibration Curve ◽  
Analytical Method ◽  
Methanolic Extract ◽  
Hplc Method ◽  
Average Recovery ◽  
Acceptance Criterion ◽  
Development And Validation ◽  
Validation Of Analytical Method

Development of genuine and dependable analytical methods which profile marker phytoconstituents in   an extract containing a mixture of several components is a challenging task. A simple, rapid, precise, and reliable HPLC method was developed for quantification of quercetin from the methanolic extract of Malva neglecta. The estimation was carried out using Phenomenex Gemini-NX-5 µm C18 .The parameters  considered for validation were accuracy, precision, linearity and robustness. The calibration curve was found to be linear in a concentration range of 20–100 μg/mL.The correlation coefficient was r2=0.9996. The % average recovery of quercetin was found to be in the range of 99.82 to 100.52% which was within the acceptance criterion indicating the accuracy of the method. The results of the robustness study indicated that there is no influence of minor changes. The developed and validated method can be successfully used for the determination of quercetin in Malva neglecta; thereby helping in authentication and quality control of this plant.

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