scholarly journals The impact of labor induction at 39 weeks gestation compared with expectant management on maternal and neonatal morbidity in low-risk women: A United States of America Cohort Study

2020 ◽  
Author(s):  
Sabrina Burn ◽  
Ruofan Yao ◽  
Maria Diaz ◽  
Jordan Rossi ◽  
Stephen Contag
Keyword(s):  
Cohort Study ◽  
Expectant Management ◽  
Neonatal Morbidity ◽  
Induction Of Labor ◽  
P Value ◽  
Cesarean Hysterectomy ◽  
Management Group ◽  
Induction Group ◽  
Prolonged Ventilation ◽  
Nicu Admission

Objective: To determine maternal and neonatal morbidity associated with induction of labor at 39 weeks compared with expectant management through 42 weeks. Design: Cohort study Setting & Population: Low risk American women who delivered between 39 and 42 weeks in 2015 to 2017. Methods: Data was abstracted from the national vital statistics database. Multivariable log-binomial regression analysis was conducted to estimate the relative risk of morbidity. Main Outcome Measures: Maternal morbidity included Triple I, blood transfusion, ICU admission, uterine rupture, cesarean hysterectomy, and cesarean delivery. Neonatal morbidity included 5 minute Apgar ≤3, prolonged ventilation, seizures, NICU admission, and neonatal death. Results: A total of 1,885,694 women were included for analysis. Women undergoing induction of labor at 39 weeks were less likely to develop Triple I (p-value < 0.001; aRR 0.66; 95% CI [0.64-0.68]) and require a cesarean section (p-value <0.01; aRR 0.69l 95% CI [0.68-0.69]) than the expectant management group. There was a small, but significant increase in cesarean hysterectomy in the induction group (p-value <0.01; aRR 1.32; 95% CI [1.05-1.65]). Neonates of the induction group were less likely to have 5 minute Apgar ≤3 (p-value < 0.01; aRR 0.69; 95% CI [0.64-0.74]), prolonged ventilation (p-value < 0.01; aRR 0.77; 95% CI [0.72-0.82]), NICU admission (p-value < 0.01; aRR 0.80; 95% CI [0.79-0.82]), and/or neonatal seizures (p-value <0.01; aRR 0.80; 95% CI [0.66-0.98]) compared to the expectant management group. Conclusions: Induction of labor at 39 weeks gestation compared with expectant management is not harmful and has maternal and neonatal benefits.

scholarly journals Impact of Labor Induction at 39 Weeks Gestation Compared with Expectant Management on Maternal and Perinatal Morbidity among a Cohort of Low-risk Women

2021 ◽  
Author(s):  
Sabrina C. Burn ◽  
Ruofan Yao ◽  
Maria Diaz ◽  
Jordan Rossi ◽  
Stephen Contag
Keyword(s):  
Cesarean Delivery ◽  
Lower Risk ◽  
Fetal Death ◽  
Expectant Management ◽  
Low Risk ◽  
P Value ◽  
Cesarean Hysterectomy ◽  
Increased Risk ◽  
Nicu Admission ◽  
Low Risk Women

Abstract Objective: To determine rates of maternal and perinatal outcomes after induction of labor (IOL) at 39 weeks compared with expectant management.Methods: Cohort study of low risk women delivered between 39-42 weeks from 2015 to 2018. We excluded births with fetal abnormalities, previous cesarean, multiple pregnancies or those with spontaneous onset of labor (SOL) or indicated delivery at 39 weeks. Data was abstracted from National Center for Health Statistics birth files. Relative risks (aRR) were estimated with multivariable log-binomial regression. Main Outcome Measures: Maternal outcomes: chorioamnionitis (Triple I), blood transfusion, neonatal intensive care unit (NICU) admission, uterine rupture, cesarean delivery and cesarean hysterectomy. Fetal and infant outcomes: fetal death, 5-minute Apgar ≤3, prolonged ventilation, seizures, ICU admission, and death within 28 days. Results: There were 15,900,956 births, with 8,540,063 after exclusions. The IOL group included 1,177,790 births excluding women with diabetes or hypertensive disease. There were 3,835,185 births after 39 weeks excluding women with diabetes or chronic hypertension. With IOL at 39 weeks the risk for blood transfusion (p-value < 0.01; aRR 0.78; 95% CI [0.75-0.82]), Triple I (p-value < 0.01; aRR 0.71; 95% CI [0.70-0.73]) and cesarean delivery (p-value <0.01; aRR 0.87; 95% CI [0.87-0.88]) were lower, albeit increased risk of cesarean hysterectomy (p-value <0.01; aRR 1.23; 95% CI [1.07-1.41]). Neonates had a lower risk for 5-minute Apgar ≤3 (p-value < 0.01; aRR 0.68; 95% CI [0.66-0.71]), prolonged ventilation (p-value < 0.01; aRR 0.84; 95% CI [0.81-0.87]), NICU admission (p-value < 0.01; aRR 0.86; 95% CI [0.85-0.87]), and neonatal seizures (p-value <0.01; aRR 0.85; 95% CI [0.76-0.96]). There was no difference in risk for neonatal death 0.99% (p-value 0.99; aRR 1.00; 95%CI [0.99-1.00]), or fetal death (p-value 0.78; aRR 1.0002; 95%CI [0.99-1.002]. This benefit was greater compared with each subsequent week.Conclusions: Induction of labor at 39 weeks of gestation in a low risk cohort is associated a lower risk of cesarean delivery, transfusions and infection, as well as lower neonatal morbidity, without difference in fetal or neonatal death. This appears to be associated with increased risk for cesarean hysterectomy.

Management of labor after external cephalic version

2021 ◽  
Vol 49 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Gabriel Levin ◽  
Amihai Rottenstreich ◽  
Raanan Meyer ◽  
Yishay Weill ◽  
Raphael N. Pollack
Keyword(s):  
Cesarean Delivery ◽  
Multivariate Logistic Regression Analysis ◽  
Expectant Management ◽  
Induction Of Labor ◽  
External Cephalic Version ◽  
Multivariate Logistic Regression ◽  
Management Group ◽  
Induction Group ◽  
Gestation Age

AbstractObjectivesCurrent literature evaluating the role of induction of labor (IOL) following successful external cephalic version (ECV) attempt as compared to expectant management is limited. We aim to assess the risk of cesarean delivery in those undergoing immediate IOL following successful ECV as compared to those who were expectantly managed.MethodsA retrospective cohort study of successful external cephalic versions. The study group included 57 women that were induced after procedure in the lack of maternal or fetal indications for induction of labor. These women were compared to 341 expectantly managed women. Maternal and fetal characteristics and outcomes were compared.ResultsGestation age at delivery was higher among the expectant management group (401/7 vs. 384/7, median, p=0.002) as compared to the induction group. Cesarean delivery rates were similar between both groups (28 [8.2%] vs. 3 [5.3%], p=0.44). In a multivariate logistic regression analysis, only nulliparity was significantly associated with cesarean delivery (adjusted odds ratio 3.42, confidence interval 1.61–7.24, p=0.001). No correlation was found between the version-to-delivery interval and the risk for cesarean delivery.ConclusionsInduction of labor after successful ECV was not shown to influence cesarean delivery rates. As immediate IOL may result in higher rate of early-term deliveries, and in light of the lack of clinical benefit, we advocate against elective IOL following successful ECV.

scholarly journals Bayesian Scepsis About SWEPIS: Quantifying the Evidence That Early Induction of Labour Prevents Perinatal Deaths

2020 ◽  
Author(s):  
Eric-Jan Wagenmakers ◽  
Alexander Ly
Keyword(s):  
Clinical Trial ◽  
Bayesian Analysis ◽  
Randomized Clinical Trial ◽  
Clinical Studies ◽  
Expectant Management ◽  
Induction Of Labour ◽  
Perinatal Deaths ◽  
Management Group ◽  
Induction Group

In a recent randomized clinical trial, Wennerholm and colleagues compared induction of labour at 41 weeks with expectant management and induction at 42 weeks. The trial was stopped early, because six perinatal deaths occurred in the expectant management group, whereas none occurred in the induction group. Our Bayesian reanalysis finds that the SWEPIS data indeed support the hypothesis that induction of labour at 41 weeks of pregnancy is associated with a lower rate of stillbirths. However, the degree of this support is moderate at best, and arguably provides insufficient ground for terminating the study. In general, it seems hazardous to terminate clinical studies on the basis of a single P&lt;0.05 result, without converging support of a Bayesian analysis.

Nonmedically Indicated Induction of Labor Compared with Expectant Management in Nulliparous Women Aged 35 Years or Older

2018 ◽  
Vol 36 (01) ◽  
pp. 045-052 ◽  
Author(s):  
Katherine Bowers ◽  
Jane Khoury ◽  
Tetsuya Kawakita
Keyword(s):  
Intensive Care Unit ◽  
Cesarean Delivery ◽  
Retrospective Cohort ◽  
Neonatal Intensive Care ◽  
Expectant Management ◽  
Induction Of Labor ◽  
Neonatal Outcomes ◽  
Nulliparous Women ◽  
Maternal And Neonatal Outcomes ◽  
Nicu Admission

Objective This article compares maternal and neonatal outcomes in women aged ≥ 35 years who experienced nonmedically indicated induction of labor (NMII) versus expectant management. Study Design This was a retrospective cohort study of nulliparas aged ≥ 35 years with a singleton and cephalic presentation who delivered at term. Outcomes were compared between women who underwent NMII at 37, 38, 39, and 40 weeks' gestation and those with expectant management that week. Adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs) were calculated, controlling for predefined covariates. Results Of 3,819 nulliparas aged ≥ 35 years, 1,409 (36.9%) women underwent NMII. Overall at 39 weeks' gestation or later, maternal and neonatal outcomes were similar or improved with NMII. At 37, 38, and 39 weeks' gestation, NMII compared with expectant management was associated with decreased odds of cesarean delivery at 37, 38, and 39 weeks' gestation. At 40 weeks' gestation, NMII compared with expectant management was associated with an increased odds of operative vaginal delivery and a decreased odds of neonatal intensive care unit (NICU) admission. Conclusion In nulliparous women aged ≥ 35 years, NMII was associated with decreased odds of cesarean delivery at 37 to 39 weeks' gestation and decreased odds of NICU admission at 40 weeks' gestation compared with expectant management.

scholarly journals Hazards and benefits of elective induction of labor at term

2020 ◽  
Vol 9 (9) ◽  
pp. 3626
Author(s):  
Perveena Fareed ◽  
Suzaira Bashir ◽  
Sameer Ahmed Lone
Keyword(s):  
Caesarean Section ◽  
Mode Of Delivery ◽  
Induction Of Labor ◽  
Control Group ◽  
Group 4 ◽  
Induction Group ◽  
Group Rate ◽  
Elective Induction ◽  
Nicu Admission ◽  
Spontaneous Onset

Background: The objective of this study was to compare the rates of caesarean section and neonatal outcome in patients with elective induction of labor compared to patients with spontaneous onset of labor.Methods: Authors studied 200 patients with 100 in elective induction group and 100 in spontaneous onset laboring group. Two groups were compared with respect to demographic profile, basic examination, ultrasound findings, P/A, P/V findings, duration of labor, mode of delivery and neonatal outcome.Results: Various parameters like age residence, per abdominal findings were comparable in two groups. Labor was not prolonged in study group compared to control group. Rate of caesarean section remained high in induction group (21%) in comparison to spontaneous laboring group (4%). Rate of instrumental deliveries did not differ significantly between the groups. 5 min Apgar score did not vary significantly; however, the NICU admission was higher in induction group compared to spontaneous laboring group. Duration of hospital stay was longer in study group.Conclusions: Elective induction of labor has higher rates of caesarean deliveries. NICU admission was also longer in induction group.

scholarly journals The study of association of fetal and maternal factors in the occurrence of hyperbilirubinemia in early neonatal period

2020 ◽  
Vol 8 (3) ◽  
pp. 967
Author(s):  
Megha Goyal ◽  
Anshuman Srivastava
Keyword(s):  
Serum Bilirubin ◽  
Neonatal Morbidity ◽  
Total Serum ◽  
P Value ◽  
Maternal Factors ◽  
Chi Square ◽  
Oral Contraceptive Pills ◽  
Factors Affecting ◽  
Nicu Admission ◽  
Group B

Background: Hyperbilirubinemia in neonates is considered to be one of the common phenomena which generally occurs during the first week of life and usually leads to NICU admission in both term and preterm new-born babies. It is also regarded as one of the most common causes which leads to neonatal morbidity and mortality.Methods: A total of 100 neonates along with their mothers were enrolled in the study from time period between 2018 to March 2019. Newborns were assessed daily for the jaundice and serum bilirubin levels were done. Various fetal-maternal factors included in proforma were. analysed to find out the association of feto-maternal factors in the occurrence of significant neonatal hyperbilirubinemia. Two groups, group A <15.7 mg/dl and group B>=15.7 mg/dl were taken. For data analysis chi square test is applied and p-value is calculated.Results: Statistically significant association between total serum bilirubin with neonatal factors like birth weight (p<0.014), maturity (p<0.011), period of gestation (p<0.003), and heart rate abnormality (p<0.005) and maternal factors like age in years (p<0.05), oral contraceptive pills use (p<0.005),  and anti-epileptics use (p<0.034) were found to be linked to neonatal hyperbilirubinemia.Conclusions: Neonatal jaundice should be considered as the main policy in all health care settings of the country. Therefore, identification of factors affecting the incidence of jaundice can be effective in preventing susceptible predisposing factors in new-borns and high-risk mothers.

scholarly journals A comparative study of feto-maternal outcome in expectant management versus active management in pre-labor rupture of membranes at term

2017 ◽  
Vol 7 (1) ◽  
pp. 146
Author(s):  
Savitha T. S. ◽  
Pruthvi S. ◽  
Sudha C. P. ◽  
Vikram S. Nadig
Keyword(s):  
Caesarean Section ◽  
Maternal Morbidity ◽  
Caesarean Section Rate ◽  
Mode Of Delivery ◽  
Expectant Management ◽  
Neonatal Morbidity ◽  
Neonatal Infection ◽  
Induction Of Labour ◽  
Active Management ◽  
Induction Group

Background: Premature rupture of the membranes at term is spontaneous rupture of the membranes after 37 weeks of gestation and before the onset of the regular painful uterine contractions, complicates 5-10% of pregnancies, 80% of cases of PROM occur at term. It complicates the pregnancy leading to maternal and fetal complications, immediate risks such as cord prolapse, cord compression and placental abruptions, and later risks such as maternal or neonatal infection and the interventions such as caesarean section and instrumental vaginal delivery. These cases are either managed conservatively or by immediate induction of labour. Objective of present study is to compare the efficacy and safety of induction of labor versus expectant management at term PROM, in terms of maternal and fetal outcome.Methods: A randomized control trial of 100 women coming to KIMSH from 01 /04 /2015 to 01 /05 /2016 with PROM at term with duration of leak ≤6 hours and a Bishop score ≤5 were assigned to group A immediate induction group and group B expectant management group with 50 cases in each group.Results: The mean interval from PROM to delivery was significantly shorter in the induction Group 15.62±4.97 as compared with expectant group 17.58±4.78. Incidence of maternal morbidity and neonatal morbidity was comparable in both the groups. Intrapartum complications and mode of delivery were similar in both groups.Conclusions: Immediate induction of labour in cases of PROM at term using oral misoprostol resulted in shorter induction delivery interval and hospital stay. Maternal morbidity and neonatal morbidity was comparable in both groups. It is concluded that immediate induction is better than expectant management. With active management many patients delivered vaginally within 24 hours without increase in the Caesarean section rate and decreased the need for oxytocin augmentation.

scholarly journals Induction of labour at 41 weeks versus expectant management until 42 weeks (INDEX): multicentre, randomised non-inferiority trial

BMJ ◽  
2019 ◽  
pp. l344 ◽  
Author(s):  
Judit KJ Keulen ◽  
Aafke Bruinsma ◽  
Joep C Kortekaas ◽  
Jeroen van Dillen ◽  
Patrick MM Bossuyt ◽  
...  
Keyword(s):  
Apgar Score ◽  
Perinatal Outcome ◽  
Primary Outcome ◽  
Expectant Management ◽  
Induction Of Labour ◽  
Maternal Outcomes ◽  
Management Group ◽  
Induction Group ◽  
Significant Difference ◽  
Low Risk Women

Abstract Objective To compare induction of labour at 41 weeks with expectant management until 42 weeks in low risk women. Design Open label, randomised controlled non-inferiority trial. Setting 123 primary care midwifery practices and 45 hospitals (secondary care) in the Netherlands, 2012-16. Participants 1801 low risk women with an uncomplicated singleton pregnancy: randomised to induction (n=900) or to expectant management until 42 weeks (n=901). Interventions Induction at 41 weeks or expectant management until 42 weeks with induction if necessary. Primary outcome measures Primary outcome was a composite of perinatal mortality and neonatal morbidity (Apgar score <7 at five minutes, arterial pH <7.05, meconium aspiration syndrome, plexus brachialis injury, intracranial haemorrhage, and admission to a neonatal intensive care unit (NICU). Secondary outcomes included maternal outcomes and mode of delivery. The null hypothesis that expectant management is inferior to induction was tested with a non-inferiority margin of 2%. Results Median gestational age at delivery was 41 weeks+0 days (interquartile range 41 weeks+0 days-41 weeks+1 day) for the induction group and 41 weeks+2 days (41 weeks+0 days-41 weeks+5 days) for the expectant management group. The primary outcome was analysed for both the intention-to-treat population and the per protocol population. In the induction group, 15/900 (1.7%) women had an adverse perinatal outcome versus 28/901 (3.1%) in the expectant management group (absolute risk difference −1.4%, 95% confidence interval −2.9% to 0.0%, P=0.22 for non-inferiority). 11 (1.2%) infants in the induction group and 23 (2.6%) in the expectant management group had an Apgar score <7 at five minutes (relative risk (RR) 0.48, 95% CI 0.23 to 0.98). No infants in the induction group and three (0.3%) in the expectant management group had an Apgar score <4 at five minutes. One fetal death (0.1%) occurred in the induction group and two (0.2%) in the expectant management group. No neonatal deaths occurred. 3 (0.3%) neonates in the induction group versus 8 (0.9%) in the expectant management group were admitted to an NICU (RR 0.38, 95% CI 0.10 to 1.41). No significant difference was found in composite adverse maternal outcomes (induction n=122 (13.6%) v expectant management n=102 (11.3%)) or in caesarean section rate (both groups n=97 (10.8%)). Conclusions This study could not show non-inferiority of expectant management compared with induction of labour in women with uncomplicated pregnancies at 41 weeks; instead a significant difference of 1.4% was found for risk of adverse perinatal outcomes in favour of induction, although the chances of a good perinatal outcome were high with both strategies and the incidence of perinatal mortality, Apgar score <4 at five minutes, and NICU admission low. Trial registration Netherlands Trial Register NTR3431.

Preterm Prelabor Rupture of Membranes: Outcomes with Expectant Management until 34 versus 35 Weeks

2018 ◽  
Vol 36 (07) ◽  
pp. 659-668
Author(s):  
Tara A. Lynch ◽  
Courtney Olson-Chen ◽  
Sarah Colihan ◽  
Jeffrey Meyers ◽  
Conisha Holloman ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Expectant Management ◽  
Neonatal Morbidity ◽  
Estimating Equation ◽  
Antibiotic Administration ◽  
Fetal Demise ◽  
Maternal Sepsis ◽  
Nicu Admission ◽  
Prelabor Rupture Of Membranes

Objective To evaluate outcomes with expectant management of preterm prelabor rupture of membranes (PROM) until 35 weeks versus immediate delivery at ≥34 weeks. Study Design This was a multicenter retrospective cohort study of singletons with preterm PROM at >20 weeks from 2011 through 2017. Groups were defined as expectant management until 35 weeks versus immediate delivery at ≥34 weeks. Primary outcome was composite neonatal morbidity: need for respiratory support, culture positive neonatal sepsis, or antibiotic administration for >72 hours. Univariate and general estimating equation models were used with p < 0.05 considered significant. Results A total of 280 mother–infant dyads were included. There was no difference in composite neonatal outcome in pregnancies managed with expectant management compared with immediate delivery (43.4 vs. 37.5%; p = 0.32). Those with expectant management had shorter length of neonatal intensive care unit (NICU) admission but higher rates of neonatal antibiotics for > 72 hours, endometritis, and histological chorioamnionitis. There were no cases of fetal demise, neonatal death, or maternal sepsis, and only three cases of neonatal sepsis. Conclusion There is no difference in composite neonatal morbidity in pregnancies with preterm PROM managed with expectant management until 35 weeks as compared with immediate delivery at 34 weeks. Expectant management is associated with a decreased length of NICU admission but increased short-term infectious morbidity.

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