scholarly journals Effects of periodontal treatment on serum inflammatory markers and CD4T-lymphocyte cell count in patients with human immunodeficiency virus infection

2018 ◽  
Vol 71 (11-12) ◽  
pp. 355-359
Author(s):  
Ivana Gusic ◽  
Milanko Djuric ◽  
Tanja Veljovic ◽  
Jelena Mirnic ◽  
Duska Blagojevic ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Interleukin 1 ◽  
Periodontal Therapy ◽  
C Reactive Protein ◽  
Clinical Attachment Level ◽  
Reactive Protein ◽  
Probing Depth ◽  
Immunodeficiency Virus ◽  
Lymphocyte Cell ◽  
Attachment Level

Introduction. Several studies have reported reduction in the serum concentration of systemic inflammatory markers upon completion of periodontal therapy. However, no studies have been conducted on the effects of periodontal therapy on systemic inflammation in human immunodeficiency virus-positive patients. The aim of this study was to investigate the effects of periodontal therapy on the serum levels of systemic inflammatory biomarkers and CD4T-lymphocyte cell count in human immunodeficiency virus-positive patients. Material and Methods. The study included 34 human immunodeficiency viruspositive patients with chronic periodontitis receiving antiretroviral therapy. Periodontal parameters (plaque index, gingival index, papilla bleeding index, probing depth and clinical attachment level) and serum samples, assessed for the levels of interleukin- 1 ?, tumor necrosis factor-?, and C-reactive protein, were evaluated at baseline, 1- and 3-months upon completion of the non-surgical periodontal therapy. The CD4T-lymphocyte count was measured at baseline and three months after treatment completion. Results. Significant reduction in the values of plaque index, gingival index, papilla bleeding index, and probing depth was noted (p < 0.001), whereas the reduction in the median clinical attachment level value did not reach a statistically significant level (F = 1.321; p = 0.261). Local inflammation reduction was accompanied by a significant decrease in serum C-reactive protein (F = 5.765; p = 0.014) and a CD4Tlymphocyte count increase (t = 2.321; p = 0.027). Serum interleukin-1? and tumor necrosis factor-? did not change significantly as a result of periodontal treatment. Conclusion. Periodontal therapy contributes to the reduction of C-reactive protein and improvement of general health in human immunodeficiency virus-positive patients receiving highly active antiretroviral therapy.

scholarly journals Aspectos clínicos, microbiológicos e tratamento periodontal em pacientes fumantes portadores de doença periodontal crônica: revisão da literatura

2016 ◽  
Vol 73 (4) ◽  
pp. 325
Author(s):  
Gabriela Alessandra Da C. Galhardo Camargo ◽  
Mariana Gouvea Latini Abreu ◽  
Renata Dos Santos ◽  
Marcio Alves Crespo ◽  
Leticia De Faria Wenderoscky
Keyword(s):  
Gingival Recession ◽  
Periodontal Therapy ◽  
Clinical Aspects ◽  
Gingival Index ◽  
Periodontal Pathogens ◽  
Clinical Attachment Level ◽  
Qualitative And Quantitative ◽  
Probing Depth ◽  
Microbiological Parameters ◽  
Attachment Level

Objective: the aim of this study was to evaluate, through literature review, clinical aspects (plaque index, gingival index, probing depth, gingival recession and clinical attachment level) and microbiological (qualitative and quantitative presence of periodontal pathogens) in smokers patients and the response to periodontal therapy. Material and Methods: it was selected scientific articles published between the years 1978 and 2014. We were selected scientific articles from MEDLINE, PUBMED and LILACS databases. Results: there are controversies between tobacco and clinical and microbiological parameters. Conclusion: based on the evaluated studies we can conclude that there are significant clinical and microbiological differences in smoking patients and impaired response to periodontal therapy.

scholarly journals Effect of hyperlipidemia on response to nonsurgical periodontal therapy: Statin users versus nonusers

2016 ◽  
Vol 10 (01) ◽  
pp. 069-076 ◽  
Author(s):  
Aditi Sangwan ◽  
Shikha Tewari ◽  
Harpreet Singh ◽  
Rajinder Kumar Sharma ◽  
Satish Chander Narula
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Periodontal Therapy ◽  
Periodontal Treatment ◽  
Clinical Attachment Level ◽  
Nonpharmacological Therapy ◽  
Probing Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Attachment Level

ABSTRACT Objective: To evaluate the response to nonsurgical periodontal therapy among hyperlipidemic subjects and whether statin use by hyperlipidemic subjects influences the response. Materials and Methods: This study was conducted on 107 chronic periodontitis subjects (35 normolipidemic [NL] controls, 36 hyperlipidemics on nonpharmacological therapy and 36 hyperlipidemics on statins). Periodontal (plaque index, gingival index [GI], probing depth [PD], and clinical attachment level [CAL]) and biochemical (plasma triglyceride [TG], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], and high-DL-C [HDL-C] levels) examination was done at baseline and 3 months after nonsurgical periodontal treatment. Results: Both the NL and statin groups exhibited significantly greater improvement in GI as compared to the hyperlipidemic group on nonpharmacological therapy (P = 0.004 and 0.006, respectively). Mean change in PD correlated negatively with baseline TC (r = −0.306) and LDL-C (r = −0.360) while mean change in GI positively correlated with baseline HDL-C (r = 0.219). Regression analyses revealed that mean change in PD was negatively associated with LDL-C (β = −0.358, P < 0.001) while mean change in GI was positively associated with HDL-C (β = 0.219, P = 0.023). Conclusions: While higher baseline lipid levels were somewhat detrimental to the resolution of inflammation postperiodontal treatment, the inclusion of statin therapy among hyperlipidemic subjects seemed to improve clinical response as compared to those devoid of the drug. The findings of the study are suggestive of a possible adjunctive role of statins in periodontal treatment that warrants future studies.

scholarly journals C - reactive protein and interleukin - 6 levels among human immunodeficiency virus -infected patients with dysglycemia in Tanzania

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lilian Nkinda ◽  
Kirtika Patel ◽  
Benson Njuguna ◽  
Jean Pierre Ngangali ◽  
Peter Memiah ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immunodeficiency Virus

scholarly journals Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
Darrell H. S. Tan ◽  
Leah Szadkowski ◽  
Janet Raboud ◽  
Tae Joon Yi ◽  
Brett Shannon ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
High Sensitivity ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Future Studies ◽  
Hiv Rna ◽  
Reactive Protein ◽  
Immunodeficiency Virus ◽  
The Impact

Abstract We used generalized estimating equations to quantify the impact of recent vaccination or intercurrent infections on immune and inflammatory biomarkers among 144 human immunodeficiency virus (HIV)-infected adults with HIV RNA &lt; 50 copies/mL on antiretroviral therapy. These events were associated with a 2.244 µg/mL increase in high sensitivity C-reactive protein and should be routinely assessed in future studies.

scholarly journals Clinical Outcomes and Immunologic Characteristics of Coronavirus Disease 2019 in People With Human Immunodeficiency Virus

2020 ◽  
Author(s):  
Hsi-en Ho ◽  
Michael J Peluso ◽  
Colton Margus ◽  
Joao Pedro Matias Lopes ◽  
Chen He ◽  
...  
Keyword(s):  
At Risk ◽  
Human Immunodeficiency Virus ◽  
Inflammatory Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Cell Counts ◽  
Immunodeficiency Virus ◽  
Factor Α ◽  
Necrosis Factor

Abstract We performed a retrospective study of coronavirus disease 2019 (COVID-19) in people with human immunodeficiency virus (PWH). PWH with COVID-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin 6, interleukin 8, and tumor necrosis factor α were commonly elevated. In all, 19 of 72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of COVID-19 despite antiretroviral therapy and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.

scholarly journals Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy

2019 ◽  
Vol 220 (6) ◽  
pp. 1029-1033 ◽  
Author(s):  
Stefanie Kroeze ◽  
Ferdinand W Wit ◽  
Theresa M Rossouw ◽  
Helen C Steel ◽  
Cissy M Kityo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Immune Activation ◽  
Protein C ◽  
C Reactive Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Reactive Protein ◽  
Art Initiation ◽  
Immunodeficiency Virus ◽  
Lipopolysaccharide Binding

AbstractWe evaluated immune biomarker profiles in human immunodeficiency virus (HIV)–infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reactive protein, soluble CD163, and soluble scavenger receptor CD14 were significantly higher during ART than in an HIV-uninfected reference group (n = 90), indicating persistent monocyte/macrophage activation, inflammation, and microbial translocation. Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated soluble CD14. High pre-ART levels of each biomarker strongly predicted residual immune activation during ART. Chemokine (C-C motif) ligand 2, lipopolysaccharide-binding protein, C-reactive protein, and interleukin 6 were differentially expressed between countries. Further research is needed on the clinical implications of residual immune dysregulation.

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