scholarly journals Clinical Outcomes and Immunologic Characteristics of Coronavirus Disease 2019 in People With Human Immunodeficiency Virus

2020 ◽  
Author(s):  
Hsi-en Ho ◽  
Michael J Peluso ◽  
Colton Margus ◽  
Joao Pedro Matias Lopes ◽  
Chen He ◽  
...  
Keyword(s):  
At Risk ◽  
Human Immunodeficiency Virus ◽  
Inflammatory Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Cell Counts ◽  
Immunodeficiency Virus ◽  
Factor Α ◽  
Necrosis Factor

Abstract We performed a retrospective study of coronavirus disease 2019 (COVID-19) in people with human immunodeficiency virus (PWH). PWH with COVID-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin 6, interleukin 8, and tumor necrosis factor α were commonly elevated. In all, 19 of 72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of COVID-19 despite antiretroviral therapy and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.

scholarly journals Proinflammatory state, hepcidin, and anemia in older persons

Blood ◽  
2010 ◽  
Vol 115 (18) ◽  
pp. 3810-3816 ◽  
Author(s):  
Luigi Ferrucci ◽  
Richard D. Semba ◽  
Jack M. Guralnik ◽  
William B. Ershler ◽  
Stefania Bandinelli ◽  
...  
Keyword(s):  
Older Persons ◽  
Inflammatory Diseases ◽  
Iron Status ◽  
Population Based ◽  
C Reactive Protein ◽  
Population Based Study ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Factor Α ◽  
Necrosis Factor

Abstract In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (Invecchiare in Chianti, “Aging in the Chianti Area”) study, a population-based study of aging in Tuscany, Italy. Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types. Urinary hepcidin was positively correlated with log(ferritin) and negatively correlated with the soluble transferrin receptor/log(ferritin) ratio but not correlated with markers of inflammation: interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α, and C-reactive protein (CRP). Lower iron was significantly correlated with higher IL-6 and CRP. Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. In conclusion, elevated proinflammatory markers were associated with anemia and low iron status, but not with higher urinary hepcidin. Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation.

Tumour Necrosis Factor Receptor Levels Are Linked to the Acute-Phase Response and Malnutrition in Human-Immunodeficiency-Virus-Infected Patients

1994 ◽  
Vol 86 (4) ◽  
pp. 461-467 ◽  
Author(s):  
U. Süttmann ◽  
O. Selberg ◽  
H. Gallati ◽  
J. Ockenga ◽  
H. Deicher ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Binding Capacity ◽  
Serum Levels ◽  
Tumour Necrosis Factor Receptor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immunodeficiency Virus ◽  
Necrosis Factor

1. Increased release of tumour necrosis factor is thought to contribute to human-immunodeficiency-virus-associated wasting syndrome. Elevated serum concentrations of tumour necrosis factor have, however, mainly been found during acute opportunistic infections and were not correlated with the degree of wasting. This finding may be explained by the paracrine release and the rapid inactivation of tumour necrosis factor. Serum levels of the two recently detected soluble tumour necrosis factor receptor proteins (p55 and p75) are assumed to reflect tumour necrosis factor release. 2. Serum levels of soluble tumour necrosis factor receptors 55 and 75 were measured by an enzyme-linked immunological and biological binding assay in 45 human-immunodeficiency-virus-infected patients and seven healthy control subjects. Patients were followed up for survival. Serum albumin, prealbumin, total iron-binding capacity (transferrin) and C-reactive protein concentrations were measured using standard laboratory methods. Body composition was determined by bioelectrical impedance analysis. 3. Serum concentrations of soluble tumour necrosis factor receptor 55 and 75 were both significantly increased in human-immunodeficiency-virus-infected patients as compared with the healthy control subjects (P < 0.05); soluble tumour necrosis factor receptor concentrations were even more increased in patients with elevated C-reactive protein levels (≥ 5 mg/l) as compared with those with normal C-reactive protein levels (< 5 mg/l; P < 0.0001 and P < 0.01, respectively). An association was observed between serum soluble tumour necrosis factor receptor 55 and 75 concentration and (i) serum albumin concentration (r = −0.46, P < 0.005 and r = −0.63, P < 0.001, respectively), (ii) serum prealbumin concentration (r = −0.42, P < 0.005 and r = −0.57, P < 0.001, respectively), and (iii) serum total iron-binding capacity (transferrin; r = −0.31, P < 0.05 and r = −0.44, P < 0.005, respectively). A correlation was also found between serum soluble tumour necrosis factor receptor 55 level and the extracellular mass-body cell mass quotient (r = 0.63, P < 0.001). 4. The present data provide evidence that the tumour necrosis factor system is involved in the genesis of human-immunodeficiency-virus-associated malnutrition. Serum levels of soluble tumour necrosis factor receptors may be useful for diagnosis and management of the wasting syndrome.

scholarly journals Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration

2011 ◽  
Vol 10 (4) ◽  
pp. 52-58
Author(s):  
V. V. Belov ◽  
S. Yu. Bezdol’nova ◽  
I. I. Dolgushin
Keyword(s):  
Myocardial Infarction ◽  
Systemic Inflammation ◽  
Immunoglobulin A ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Complement Components ◽  
Reactive Protein ◽  
Immune Parameters ◽  
Factor Α ◽  
Necrosis Factor

Aim. To assess the interrelations in the dynamics of immune, clinical, and functional parameters among patients with myocardial infarction (MI) and early fluvastatin administration. Material and methods. The study included 129 men, aged from 42 to 67 years (mean age 57 years): 99 MI patients and 30 healthy controls. In all participants, clinical, biochemical, functional, and immune parameters were assessed, with comparisons between healthy individuals vs. MI patients, as well as between MI patients taking fluvastatin (80 mg/d) vs. MI patients not receiving this medication. Results. In men with MI, chronic systemic inflammation was manifested in elevated levels of C-reactive protein, interleukin (IL) 1β, IL8, tumor necrosis factor α, immunoglobulin A and G, and complement components, as well as in decreased levels of IL1 receptor antagonist, CD 3, CD 4, CD 16, and CD 4/CD 8, compared to healthy controls. Early fluvastatin administration (first post-MI hours) was associated with reduced severity of immune disturbances and systemic inflammation. Conclusion. In MI patients, early fluvastatin administration is associated with a significant reduction in systolic and diastolic blood pressure levels, compared to controls, as well as with a substantial increase in exercise capacity at 2 months.

Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

Nutrition ◽  
2008 ◽  
Vol 24 (4) ◽  
pp. 322-329 ◽  
Author(s):  
Sally D. Poppitt ◽  
Geraldine F. Keogh ◽  
Fiona E. Lithander ◽  
Yu Wang ◽  
Tom B. Mulvey ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein ◽  
Postprandial Response ◽  
Factor Α ◽  
Necrosis Factor
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