scholarly journals Contribution to investigation of klinical picture and renal function in patients with endemic nephropathy

2003 ◽  
Vol 131 (1-2) ◽  
pp. 10-16 ◽  
Author(s):  
Danica Bukvic ◽  
Ljubica Djukanovic ◽  
Slavenka Jankovic
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Early Phase ◽  
Early Stage ◽  
Number Of Patients ◽  
Endemic Nephropathy ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Up to now, detailed investigation of tubular function in patients with endemic nephropathy have been performed in the relatively small number of patients who have already been in chronic renal failure /3,4,5,9,15/. That is why we started this work with the aim to determine renal function of the patients suffering by endemic nephropathy in different stages of the disease, especially in the early stage of the disease. The study included 119 patients with endemic nephropathy who were grouped according to creatinine clearance values into four groups (Table 1). The first group covered the patients with normal crearinine clearance values, and other three covered the patients who were in the different stages of renal failure. The diagnosis of endemic nephropathy was established according to criteria given by Danilovic /7/ and Velimirovic /8/ after ruling out the known renal diseases. The results of clinical and laboratory examinations were processed by appropriate epidemiological and statistical techniques. The results proved that there was no significant difference between sexes of our patients (p>0,05). Objective examination reveals characteristic tan pale yellow with copperish glow on the cheeks, in 15,48% of our patients in the early stage of the disease, which is in accordance with the results of Velimirovic/8/. Among nephropathy patients 13% of them had kidney smaller than normal measured by sonography, and even 51% measured by static scintigraphy, in the early phase of the disease (Table 4, Table 5). The earlier works /11,12/ mainly supported that kidneys get smaller during renal insufficiency, and in the early phase of the disease kidneys have a normal size, whereas the later works indicated that even the patients with normal glomerular filtration have smaller kidneys/13,14,15,16/. The laboratory findings and urine analysis of this disease suggested absens of biochemical indicators of inflammation in endemic nephropathy patients (Table 2, Table 3), which is in accordance with the previous in investigations. We noticed correlation between ceatinine clearance values and values of serum beta 2 microglobulin (r==,56; p==,0002; Figure 1). It has been documented that with decreased of creatinine clearance values serum values of beta 2 microglobulin increased, in chronic renal failure /22/. Quantitative measuring of proteinuria shows values less than 1,0g/l in all examined patients. Proteinuria of tubular type has been described in endemic nephropathy/5,8,13,16/. Beta 2 microglobulinuria have been registered at 10,97% patients with normal creatinine clearance values (Table 7). Increased urinry contrecation of beta 2 microglobulin is generally accepted as an important feature of endemic nephropathy /19,20,21/. Glicosuria increased with the progression of the disease. Urine osmolallity of endemic nephropathy patients decreased with the progression of chronic renal failure (Table 6). 65,46% of the investigated patients of the first group, who were in the clinically early phase of the disease, had decreased urine osmolallity (measuring by coefficient of osmolallity U osm/Posm). The tubular reabsorbtion of the phosphate decreased with the progression of chronic renal failure and that correlation was statistically significant r<0,69; p<0,05; Figure 2). Fractional tubular excretion of sodium increased with the progression of endemic nephropathy (Table7). The obteined results of the function of proximal tubul are comparabile with the results of the other authors, but in the smaller number of patients /4,13,15,16/. Our results of functional investigations of kidney et patients with endemic nephropathy suggests primary tubular dysfunction, and reduced kidney size and that was registered in the early phase of the disease.

Evidence for Dependance of Beta Thromboglobulin Levels on Renal Function

1979 ◽  
Author(s):  
D. Deppermann ◽  
K. Andrassy ◽  
H. Seelig ◽  
E. Ritz ◽  
D. Post
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Serum Concentration ◽  
Normal Renal Function ◽  
Impaired Renal Function ◽  
Sensitive Indicator ◽  
Tubular Proteinuria ◽  
Normal Range ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Beta-Thromboglobulin (TG) is a thrombocytic protein which is released into the circulation upon lysis of thrombocytes. Its serum concentration is thought to be a sensitive indicator of thrombocyte consumption. Although a relation of TG platelet consumption could be observed by us in patients with normal renal function, no such relation was found in pat. with renal failure (RF). Therefore we examined whether TG, similar to beta-2-microglobulin (BMG), behaves like a tubular protein. - Patients and methods - 90 pat. with RF were examined. None of the pat. had diseases with known platelet consumption or medication which interferes with platelets. TG and BMG were measured by RIA. - Results - There was a highly significant correlation between TG, serum creat. (r=0,78) and Ccr (r=0,73) and BMG. The normal range (x ±SD) of TG was 33,9± 9,7 ng/ml and values consistantly about 50 ng/ml were observed at Ccr < 50 ml/l,73 m2. TG was found in tubular proteinuria. - Conclusion - TG is a tubular protein the concentration of which rises in patients with renal failure. This finding invalidates the use of TG for detection of thrombosis in patients with impaired renal function.

Peritoneal Dialysis Retardation of Progression of Advanced Renal Failure

2002 ◽  
Vol 22 (2) ◽  
pp. 239-242 ◽  
Author(s):  
Jose Ramon Berlanga ◽  
Belen Marrón ◽  
Ana Reyero ◽  
Carlos Caramelo ◽  
Alberto Ortiz
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Peritoneal Dialysis ◽  
Creatinine Clearance ◽  
Tertiary Care ◽  
Residual Renal Function ◽  
Natural Course ◽  
Number Of Patients ◽  
Rate Of Decline

♦ Objectives The rate of decline of residual renal function is slower in peritoneal dialysis (PD) than in hemodialysis. However, it is unclear which and whether either of the two techniques modifies the natural course of renal failure. We tested whether PD influences the natural course of the progression of chronic renal failure in humans. ♦ Design Retrospective review of clinical charts. ♦ Setting Tertiary-care center. ♦ Patients Fourteen patients were selected from the 36 patients that were treated with PD in our center from January 1997 to June 2000, applying the following criteria: predialysis follow-up longer than 12 months, renal creatinine clearance 20 mL/minute or more at the start of predialysis follow-up, follow-up while on PD longer than 6 months, and renal creatinine clearance above 0 mL/minute at the start of PD. ♦ Main Outcome Measure Residual renal function calculated as renal creatinine clearance obtained from 24-hour urine samples. ♦ Results A lower mean rate of decline of residual renal function was observed during PD than during the predialysis period (–0.06 ± 0.16 vs –0.94 ± 0.74 mL/min/month, p < 0.0005). The rate of decline in renal creatinine clearance was faster in every patient during the predialysis period than during his or her time on PD. ♦ Conclusions These preliminary data support the hypothesis that PD may contribute to the slowing of the natural progression of renal disease in humans, as it does in rodents. Prospective studies involving a larger number of patients are needed to settle the question.

scholarly journals Comparison of Highly Sensitive CRP and Serum Creatinine as an Early Marker of Renal Impairment

1970 ◽  
Vol 7 (1) ◽  
pp. 10-14
Author(s):  
Roksana Yeasmin ◽  
Md Nizamul Hoque Bhuiyan ◽  
Sultana Parveen ◽  
Shamim Ara Ferdous ◽  
Nazmun Nahar
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Early Phase ◽  
Curvilinear Relationship ◽  
Control Group ◽  
Strong Positive Correlation ◽  
Group I ◽  
Hs Crp

A case control study was done during the period of July 2004 to 2005. The study was carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka. 50 diagnosed chronic renal failure patients of both sexes not yet treated by dialysis and 50 age and sex matched healthy subjects were included in the study as case (Group-II) and control (Group-I) respectively. In this study, mean serum HS CRP concentration of CRF patients (50.938 ±38.88)mg/l found to be significantly elevated in comparison to control (1.12±.29mg/l). In CRF patients, serum HS CRP found to show a strong negative correlation with creatinine clearance and a strong positive correlation with blood urea, serum creatinine. This study shows an inverse linear relationship between HS CRP and CCRin contrast to the inverse curvilinear relationship found to exist between serum creatinine and creatinine clearance. Regression analysis between CCR and HS CRP shows a rise of HS CRP Y one unit (mg/l) is accompanied by creatinine clearance to be decreased by 0 .44ml/min. Mean serum HS CRP concentration in chronic renal failure increases significantly. Early phase of decreased CCR can not be detected by the serum creatinine because serum creatinine does not increase until there is significant fall ( 30 ml/min) of creatinine clearance. In contrast to this serum HS CRP begins to rise from the very beginning of the fall of creatinine clearance. So the early phase of decreased creatinine clearance could be detected by simultaneous rise of serum HS CRP. Key Words: HS CRP, CRF, CCR.     DOI = 10.3329/jom.v7i1.1356 J MEDICINE 2006; 7 : 10-14

Plasma Level and Renal Clearance of Oxalate in Normal Subjects and in Patients with Primary Hyperoxaluria or Chronic Renal Failure or Both

1979 ◽  
Vol 56 (4) ◽  
pp. 299-304 ◽  
Author(s):  
A. R. Constable ◽  
A. M. Joekes ◽  
G. P. Kasidas ◽  
P. O'regan ◽  
G. A. Rose
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Plasma Level ◽  
Creatinine Clearance ◽  
Primary Hyperoxaluria ◽  
Normal Subjects ◽  
Enzymatic Method ◽  
Common Cause ◽  
Radioisotopic Method

1. Plasma oxalate has been measured by a radioisotopic method applicable to all concentrations of plasma oxalate and renal function, and also by an enzymatic method which was only applicable to raised concentrations of plasma oxalate. 2. Where the two methods could be applied simultaneously, the agreement between them was good. 3. Plasma oxalate was 86% ultrafiltrable at concentrations of up to 44 μmol/l. 4. Oxalate clearance and the exchangeable oxalate pool were also measured. The ratio of oxalate clearance to creatinine clearance was greater than unity in most normal subjects and patients. 5. These methods were used in normal subjects and in patients with primary hyperoxaluria and/or chronic renal failure. A raised plasma oxalate concentration was found in both conditions. Chronic renal failure is probably the most common cause of a raised plasma oxalate.

SERUM GASTRIN AND SERUM CALCITONIN IN PATIENTS WITH CHRONIC RENAL FAILURE

1979 ◽  
Vol 91 (3) ◽  
pp. 564-570 ◽  
Author(s):  
C. K. Christensen ◽  
H. E. Nielsen ◽  
O. Kamstrup ◽  
K. J. Olsen ◽  
M. Brandsborg ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Significant Positive Correlation ◽  
Serum Gastrin ◽  
Serum Concentrations ◽  
Serum Calcitonin ◽  
Normal Controls ◽  
Reduced Renal Function

ABSTRACT The interrelationship between serum gastrin and serum calcitonin concentrations was studied in 73 patients with chronic renal failure. In both haemodialyzed and non-dialyzed patients increased serum concentrations of these hormones were found compared with normal controls. In non-dialyzed patients with creatinine clearance above 10 ml/min a highly significant correlation between serum gastrin and creatinine clearance was found, whereas no correlation was found in patients with creatinine clearance below 10 ml/min. Between serum gastrin and serum calcitonin, a significant positive correlation was found in non-dialyzed patients. whereas no correlation could be demonstrated in haemodialyzed patients. These findings may be explained by a relationship between the two hormones or be secondary to a decreased elimination due to the reduced renal function.

scholarly journals Renal and systemic oxygen consumption in patients with normal and abnormal renal function.

1992 ◽  
Vol 2 (11) ◽  
pp. 1617-1626
Author(s):  
B R Kurnik ◽  
L S Weisberg ◽  
P B Kurnik
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Renal Function ◽  
Oxygen Consumption ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Oxygen Extraction ◽  
Renal Oxygen Consumption ◽  
Systemic Oxygen ◽  
Renal Oxygen

Systemic and renal oxygen consumption and hemodynamics were studied in patients with normal renal function (NI; serum creatinine concentration (Screat), 1.0 +/- 0.04 mg/dL) and those with moderate chronic renal failure with diabetes mellitus Screat, 2.7 +/- 0.2 mg/dL) or without diabetes mellitus (Screat, 2.4 +/- 0.1 mg/dL). Patients with chronic renal failure were anemic and had normal systemic oxygen consumption (NI, 10,564 +/- 277; chronic renal failure, 9,669 +/- 362 mumol of O2/min) and elevated systemic oxygen extraction (NI, 22.9 +/- 1; chronic renal failure, 30.9 +/- 1.2%) (P less than 0.02). Cardiac output and index and arterial oxygen saturation were equivalent in normal patients and in patients with chronic renal failure. Patients with chronic renal failure had higher renal oxygen extraction (NI, 7.3 +/- 0.8; chronic renal failure, 13.9 +/- 1%), lower RBF (NI, 572 +/- 146; chronic renal failure, 197 +/- 20 mL/min/kidney), and lower renal oxygen consumption per kidney (NI, 391 +/- 101; chronic renal failure, 177 +/- 20 mumol of O2/min/kidney) than did normal patients (P less than 0.02). There was a linear relationship between hemoglobin and RBF (r = 0.47, P less than 0.02). Patients with chronic renal failure and diabetes had lower RBF (diabetes mellitus, 146 +/- 23; without diabetes, 242 +/- 28 mL/min/kidney) and renal oxygen consumption per kidney (diabetes mellitus, 131 +/- 21; without diabetes, 218 +/- 29 mumol of O2/min/kidney (P less than 0.03) but equivalent renal oxygen extraction when compared with patients without diabetes. Patients with chronic renal failure without diabetes mellitus had higher renal oxygen consumption when expressed per 100 mL of creatinine clearance (diabetes mellitus, 1,016 +/- 150; without diabetes mellitus, 1,453 +/- 175 mumol of O2/min/100 mL of creatinine clearance; P less than 0.03). There was a significant linear relationship (P less than 0.005, r = 0.38) between calculated creatinine clearance and renal oxygen consumption with a y intercept representing basal renal oxygen consumption (115 mumol of O2/min/kidney) and a slope of 2.3 mumol of O2/mL. Patients with moderate chronic renal failure have normal systemic oxygen consumption but reduced RBF and renal oxygen consumption. The latter parameters are even lower in patients with chronic renal failure and diabetes. Renal hypermetabolism is more likely to exist in nondiabetic than diabetic renal disease. Basic human renal physiology and pathophysiology are described by the relationships between renal oxygen consumption, blood flow, oxygen extraction, and creatinine clearance in patients with normal and abnormal renal function of varied cause.

Bone marrow-derived endothelial progenitor cells confer renal protection in a murine chronic renal failure model

2010 ◽  
Vol 299 (2) ◽  
pp. F325-F335 ◽  
Author(s):  
Odongua Sangidorj ◽  
Seung Hee Yang ◽  
Hye Ryoun Jang ◽  
Jung Pyo Lee ◽  
Ran-hui Cha ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Early Stage ◽  
Cell Damage ◽  
Potential Candidate ◽  
Renal Protection ◽  
Endothelial Progenitor ◽  
Surface Marker Analysis

Endothelial cell damage and impaired angiogenesis substantially contribute to the progression of chronic renal failure (CRF). The effect of endothelial progenitor cell (EPC) treatment on the progression of CRF is yet to be determined. We performed 5/6 nephrectomy to induce CRF in C57BL/6 mice. EPCs were isolated from bone marrow, grown in conditioned medium, and characterized with surface marker analysis. The serial changes in kidney function and histological features were scrutinized in CRF mice and EPC-treated CRF (EPC-CRF) mice. Adoptively transferred EPCs were present at the glomeruli and the tubulointerstitial area until week 8 after transfer. In CRF mice, renal function deteriorated steadily over time, whereas the EPC-CRF group showed less deterioration of renal function as well as reduced proteinuria along with a relatively preserved kidney structure. Renal expression of proinflammatory cytokines and adhesion molecules was already decreased in the EPC-CRF group at the early stage of disease, at which point the renal function and histology of CRF and EPC-CRF mice were not different. Angiogenic molecules including VEGF, KDR, and thrombospondin-1, which were decreased in the CRF group, were restored by EPC treatment. In conclusion, EPCs trafficked into the injured kidney protected the kidney from the inflammatory condition and consequently resulted in functional and structural renal preservation. Our study suggests EPCs as a potential candidate for a novel therapeutic approach in CRF.

Oral and Maxillofacial Manifestations of Mineral and Bone Disorders Associated with Chronic Renal Failure

2017 ◽  
Vol 68 (6) ◽  
pp. 1325-1328
Author(s):  
Andrada Raluca Doscas ◽  
Mihail Balan ◽  
Mihai Liviu Ciofu ◽  
Doriana Agop Forna ◽  
Marius Cristian Martu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Health Concern ◽  
Oral Manifestations ◽  
End Stage Renal Failure ◽  
Brown Tumors ◽  
The Mean ◽  
End Stage

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.

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