Peripartal leukogram in cows with and without retained placenta

The aim of this study was to investigate whether prepartal leukogram in cows with retained placenta could indicate the presence of subclinical systemic inflammatory response before the onset of disease. After calving, sixteen highly pregnant Holstein cows, aged 3 to 9 years, without clinical signs of the disease prior to calving were divided into two groups: the first group (n=9) were animals without retained placenta, or any visible inflammation after birth; the second group (n=7) were cows with retained placenta. Blood was sampled three times before parturition, at intervals of one week, and once 24 hours after birth. The number of total leukocytes, segmented and non segmented neutrophilic granulocytes (NG), lymphocytes and monocytes were determined by standard laboratory techniques. The results have shown that in the group of cows with retained placenta the number of mature neutrophils was slightly elevated in the third, second and last week before calving, and equal number of non segmented neutrophils in regard to the group with no retention. The results have also shown that, in both groups of cows, 24 hours after calving, the number of total leukocytes and the number of segmented neutrophils decreased, but the number of the non segmented neutrophils increased. Based on this, we can conclude that cows with retained placenta had no systemic inflammatory response during three weeks prepartal period, but 24 hours after calving, systemic inflammatory response was documented in all the cows. Moreover, the intensity of inflammatory response in cows with retained placenta was not more pronounced in comparison to cows without retained placenta.

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Changes in the systemic inflammatory response in women in the third trimester of pregnancy complicated by exacerbation of cytomegalovirus infection

Bulletin physiology and pathology of respiration ◽

10.36604/1998-5029-2020-77-56-62 ◽

2020 ◽

Vol 1 (77) ◽

pp. 56-62

Author(s):

I. N. Gorikov

Keyword(s):

Inflammatory Response ◽

Cytomegalovirus Infection ◽

Systemic Inflammatory Response ◽

Third Trimester ◽

The Third

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Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model

Innate Immunity ◽

10.1177/1753425918819754 ◽

2019 ◽

Vol 25 (1) ◽

pp. 34-45 ◽

Cited By ~ 3

Author(s):

Dorien Kiers ◽

Guus P. Leijte ◽

Jelle Gerretsen ◽

Jelle Zwaag ◽

Matthijs Kox ◽

...

Keyword(s):

Inflammatory Response ◽

Clinical Signs ◽

Systemic Inflammatory Response ◽

Bolus Administration ◽

Continuous Administration ◽

Human Endotoxemia ◽

Inflammatory Parameters ◽

Endotoxemia Model ◽

Over Time

The experimental human endotoxemia model is used to study the systemic inflammatory response in vivo. The previously used lot of endotoxin, which was used for over a decade, is no longer approved for human use and a new Good Manufacturing Practices-grade batch has become available. We compared the inflammatory response induced by either bolus or continuous administration of either the previously used lot #1188844 or new lots of endotoxin (#94332B1 and #94332B4). Compared with lot #1188844, bolus administration of lot #94332B1 induced a more pronounced systemic inflammatory response including higher plasma levels of pro-inflammatory cytokines and more pronounced clinical signs of inflammation. In contrast, continuous infusion of lot #94332B4 resulted in a slightly less pronounced inflammatory response compared with lot #1188844. Furthermore, we evaluated whether lot #1188844 displayed in vivo potency loss by reviewing inflammatory parameters obtained from 17 endotoxemia studies performed in our centre between 2007 and 2016. Despite inter-study variability in endotoxemia-induced effects on temperature, heart rate, symptoms, and leukocyte counts, the magnitude of these effects did not decrease over time. In conclusion, although all lots of endotoxin induce a pronounced inflammatory response, the magnitude differs between lots. We observed no potency loss of endotoxin over time.

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Systemic inflammatory response syndrome (SIRS) in complications of gallstone disease accompanied by mechanical jaundice (review of literature)

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2020-179-6-94-100 ◽

2021 ◽

Vol 179 (6) ◽

pp. 94-100

Author(s):

V. E. Fedorov ◽

N. B. Zakharova ◽

O. E. Logvina

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Gallstone Disease ◽

Clinical Signs ◽

Pathological Process ◽

Systemic Inflammatory Response ◽

Acute Calculous Cholecystitis ◽

Mechanisms Of Development ◽

Inflammatory Changes ◽

Calculous Cholecystitis

At present, the determination of the severity of patients with complications of acute calculous cholecystitis, manifested in the form of mechanical jaundice (MJ), remains an insufficiently studied issue. This is due to the fact that the main attention in the examination of such patients is paid to the diagnosis and assessment of the severity of liver failure, and the signs of SIRS (Systemic Inflammatory Response Syndrome) are not given due attention. In this regard, this literature review presents data on the systemic inflammatory response syndrome in such patients, describes its etiopathogenetic mechanisms of development, presents clinical signs, stages of this pathological process. The role of biomarkers, which can be used to determine the severity of inflammatory changes in the biliary system in MJ, is estimated on the basis of literature data.

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Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses

Animals ◽

10.3390/ani11072015 ◽

2021 ◽

Vol 11 (7) ◽

pp. 2015

Author(s):

Irene Nocera ◽

Francesca Bonelli ◽

Valentina Vitale ◽

Valentina Meucci ◽

Giuseppe Conte ◽

...

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Lactate Concentration ◽

Clinical Signs ◽

Blood Lactate Concentration ◽

Systemic Inflammatory Response ◽

Negative Score ◽

Positive Score ◽

Circulating Levels ◽

Sampling Times

Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0–6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic.

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PROCALCITONIN DAN INTERLEUKIN-6 PADA SEPSIS DENGAN GEJALA SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v19i2.1064 ◽

2018 ◽

Vol 19 (2) ◽

pp. 98

Author(s):

Indranila KS ◽

Tjahjati DM ◽

Emma Emma

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Positive Predictive Value ◽

Diagnostic Test ◽

Interleukin 6 ◽

Predictive Value ◽

Clinical Signs ◽

Area Under The Curve ◽

Diagnostic Value ◽

Systemic Inflammatory Response

Sepsis is the cause of patient’s death in the intensive care unit. Sepsis is an inflammatory response to infections. Infection whencontinued can cause systemic inflammatory response syndrome (SIRS). Clinical signs and pathology of SIRS are similar to sepsis, thusclinical as well as laboratory examination is needed to distinguish these. Culture result usually can be seen at least 24 hours aftersampling. In this case a test is needed to diagnose sepsis quickly so that the patient does not experience more severe conditions. Theindicator used in the diagnostic procedure is to know the diagnostic value of procalcitonin (PCT) levels as well as of interleukin-6 (IL-6)for the diagnosis of sepsis. Thirty-two blood samples of patients treated in the Department of SIRS. Dr. Kariadi Semarang were takenconsecutively from November 2011 up to January 2012. PCT levels are determined by ELFA, levels of IL-6 were determined by ELISAmethod. To determine the sensitivity, specificity, positive predictive value and negative predictive value, 2 × 2 table was used. The ROCcurve (receiver operating characteristic) showed an area under the curve of PCT of 0.83 (95% CI = 0.66 to 0.99), cut-off 5.1 ng/mL wasused as an indicator of sepsis. PCT diagnostic test results showed 88.9% sensitivity, 73.9% specificity, 57.1% positive predictive value andnegative predictive value of 94.4%. The area under the curve for IL-6 was 0.67 (95% CI = 0.47 to 0.86), cut off 47.2 pg/mL as an indicatorof sepsis. Diagnostic tests results showed 77.8% sensitivity, 60.9% specificity, 43.7% positive predictive value and negative predictive valueof 87.5%. It can be concluded that the examination of serum PCT levels can be used as a diagnostic test (screening test) for sepsis.

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Lymph-stimulating therapy in the systemic inflammatory response syndrome correction

Kazan medical journal ◽

10.17750/kmj2016-239 ◽

2016 ◽

Vol 97 (2) ◽

pp. 239-244

Author(s):

A I Musaev ◽

U E Usubakunov

Keyword(s):

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Abdominal Cavity ◽

Main Group ◽

Systemic Inflammatory Response ◽

Venous Stasis ◽

Control Group ◽

C Reactive Protein ◽

Reactive Protein ◽

The Third

Aim. To determine the effectiveness of indirect antibiotics and lymphotropic therapy for the systemic inflammatory response syndrome correction in patients who underwent abdominal surgery.Methods. There were two groups with systemic inflammatory response syndrome in the postoperative period: 212 patients with various diseases of the abdominal cavity, who received conventional systemic complex therapy, and 146 patients whose complex treatment included antibiotics and lymphotropic therapy (administration of the cephalosporin antibiotics with lymphotropic mixture into the tibia subcutaneous tissue with the prior venous stasis creation). In both groups, patients with destructive forms of cholecystitis and appendicitis complicated by local or general peritonitis dominated. The dynamics of systemic inflammatory response syndrome clinical indicators, as well as laboratory parameters were assessed: the white blood cells count, leukocyte intoxication index, C-reactive protein and blood albumin. The data obtained on the 1st, 3rd and 5-6 days after surgery were analyzed.Results. In both groups clinical and laboratory symptoms positive dynamics was noted, which was more pronounced in the main group. In the control group leukocyte intoxication index increased on the third day and then decreased, but did not reach normal values on 10th day, while in the main group leukocyte intoxication index decreased already on the third day with its full normalization to 10th day. A faster normalization of white blood cell count, albumin level and C-reactive protein concentration decrease are also observed in the main group. Using indirect lymphotropic therapy was associated with reduction of postoperative complications and lethality rates.Conclusion. Lymphotropic therapy is an effective method of the systemic inflammatory response syndrome correction and can be recommended for the postoperative management of patients with abdominal surgery.

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