scholarly journals The effects of combined physical procedures on the functional status of patients with diabetic polyneuropathy

2021 ◽  
pp. 5-5
Author(s):  
Vesna Grbovic ◽  
Svetlana Djukic ◽  
Srdjan Stefanovic ◽  
Natasa Zdravkovic-Petrovic ◽  
Stefan Simovic ◽  
...  
Keyword(s):  
Functional Status ◽  
Lipoic Acid ◽  
Diabetic Polyneuropathy ◽  
Berg Balance Scale ◽  
Alpha Lipoic Acid ◽  
Test Range ◽  
Patients With Diabetes ◽  
Group A ◽  
Michigan Neuropathy Screening Instrument ◽  
Group B

Introduction: Diabetic polyneuropathy is a common chronic complication in patients with diabetes mellitus. This study aimed to determine the importance of applied physical procedures on the functional status in diabetic polyneuropathy patients in comparison to the group of respondents with the applied alpha-lipoic acid. Materials and Methods: 60 subjects were divided into two groups: group A - diabetic polyneuropathy patient?s treatment with physical procedures; and group B - diabetic polyneuropathy patient?s treatment with alpha-lipoic acid. The study protocol implied that the study has lasted for three diagnostic and therapeutic cycles, each lasting for 16 days with the time between cycles of 6 weeks. Results: Manual muscle test, range of motion, Michigan Neuropathy Screening Instrument and Berg balance scale values showed statistically significant improvement at the end of testing the group A respondents, while in the group B respondents there was not any improvement shown. Conclusions: The application of the combined physical procedures shows clear benefit for improvement of muscle strength and mobility of the ankle joint in respondents with diabetic polyneuropathy.

scholarly journals The effects of the physical procedures in patients with diabetic neuropathy

2019 ◽  
Vol 76 (8) ◽  
pp. 787-794
Author(s):  
Vesna Grbovic ◽  
Srdjan Stefanovic ◽  
Svetlana Djukic ◽  
Jasmin Nurkovic ◽  
Natasa Zdravkovic-Petrovic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Therapy ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Pain Reduction ◽  
Life Questionnaire ◽  
Alpha Lipoic Acid ◽  
Group A ◽  
Group B

Background/Aim. Neuropathy represents the most frequent complication in the patients with diabetes mellitus (DM). Symmetric distal sensorimotor polyneuropathy (DSP), which represents the most frequent type of diabetic neuropathy, is present in 30% of hospitalized diabetic patients. The aim of our study was to compare the effects of physical therapy (PT) and alpha-lipoic acid (ALA) supplementation on pain reduction and quality of life improvement in the DSP patients. Methods. The study was performed on 60 adult patients with DM type 2 and DSP. The patients were randomly divided into 2 groups: group A (n = 30) was treated by PT and group B (n = 30) was treated by ALA. The study lasted 6 months during which 3 diagnostictherapeutic cycles were performed. To asses their pain before and after every of 3 cycles, we used visual analog scale (VAS). We also evaluated quality of life before the 1st and after the 3rd cycle with the European Quality of Life Questionnaire (EQ-5D-3L). To analyze results between groups we used mixed between-within subjects ANOVA and statistical significance was set on p < 0.05. Results. Pain intensity showed statistically significant influence of both PT and ALA (? = 0.028; p < 0.001). A statistically significant difference between the effects of those two therapy modalities was observed (F = 4.78; p < 0.05): PT reduced pain to the greater extent than ALA. A statistically significant improvement was found in the domain of pain/discomfort both in the group A (? = 0.54, p < 0.001) and group B (? = 0.57, p < 0.001), as well as anxiety/depression (group A: ? = 0.32, p = 0.008; group B: ? = 0.22, p < 0.019) and EQ-VAS (both groups, p < 0.05). Conclusion. Our research showed that physical therapy had a greater influence in pain reduction than alpha-lipoic acid in the patients with DSP.

scholarly journals EFFECT OF ALPHA LIPOIC ACID IN TREATMENT OF TYPE 2 DIABETES

2017 ◽  
Vol 10 (8) ◽  
pp. 204 ◽  
Author(s):  
Priyambada Panda ◽  
Sitansu Kumar Panda ◽  
Tapaswini Mishra
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Lipoic Acid ◽  
Glycosylated Hemoglobin ◽  
Alpha Lipoic Acid ◽  
Before And After ◽  
Group A ◽  
Group B

  Objective: Antioxidant probably can prevent the progression and complications of Type 2 diabetes mellitus (T2DM). Due to effectiveness of alpha lipoic acid (ALA) as an antioxidant, this study was done in T2DM patients to evaluate the effect of ALA on their diabetic status, lipid profile, and oxidative stress (OS) status.Methods: A total of 35 patients with diabetes were selected randomly who were under insulin treatment mainly and grouped as Group “A.” Another age- and sex-matched healthy controls selected grouped as “B.” Both groups supplemented with ALA (300 mg/day) for 6 months continuously. All parameters were tested before and after the supplementation.Results: There was a significant decrease in fasting blood sugar from 161 to 122 mg/dl in Group “A” and from 98 to 90 mg/dl in Group “B.” Postprandial blood sugar (PPBS) and glycosylated hemoglobin (HbA1c) levels also significantly decreased from 211 to 158 mg/dl and 8.81% to 7.2%, respectively, in Group “A.” PPBS levels significantly decreased from 130 to 124 mg/dl in Group “B,” but HbA1c% decreased insignificantly from 5.26% to 5.24% in Group “B.” Lipid profile parameters decreased in both groups except triglyceride level, which show insignificant relation in Group “B.” OS marker malondialdehyde significantly decreased from 1.967 to 1.592 nm/ml in Group “A” and from 0.613 to 0.472 nm/ml in Group “B.” Plasma antioxidant glutathione shows a significant increase in both groups from 2.117 to 2.405 μmol/L in Group “A” and from 2.631 to 2.811 μmol/L in Group “B.” Plasma nitric oxide also shows significant increase in both groups from 1.712 to 1.990 μmol/L and from 2.139 to 2.318 μmol/L, respectively.Conclusion: Therefore, ALA is a potent antioxidant and can be used against oxidative injury associate with T2DM.

scholarly journals Clinical Usefulness of Oral Supplementation with Alpha-Lipoic Acid, Curcumin Phytosome, and B-Group Vitamins in Patients with Carpal Tunnel Syndrome Undergoing Surgical Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Giorgio Pajardi ◽  
Paola Bortot ◽  
Veronica Ponti ◽  
Chiara Novelli
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Lipoic Acid ◽  
Carpal Tunnel ◽  
Surgical Decompression ◽  
Alpha Lipoic Acid ◽  
Oral Supplementation ◽  
Before And After ◽  
Group A ◽  
Tunnel Syndrome ◽  
Group B

We investigated the clinical usefulness of oral supplementation with a combination product containing alpha-lipoic acid, curcumin phytosome, and B-group vitamins in 180 patients with carpal tunnel syndrome (CTS), scheduled to undergo surgical decompression of the median nerve. Patients in Group A (n=60) served as controls and did not receive any treatment either before or after surgery. Patients in Group B (n=60) received oral supplementation twice a day for 3 months both before and after surgery (totaling 6 months of supplementation). Patients in Group C (n=60) received oral supplementation twice a day for 3 months before surgery only. Patients in Group B showed significantly lower nocturnal symptoms scores compared with Group A subjects at both 40 days and 3 months after surgery (bothPvalues<0.05). Moreover, patients in Group B had a significantly lower number of positive Phalen’s tests at 3 months compared with the other study groups (P<0.05). We conclude that oral supplementation with alpha-lipoic acid, curcumin phytosome, and B-group vitamins twice a day both before and after surgery is safe and effective in CTS patients scheduled to undergo surgical decompression of the median nerve.

Validation of Neuropad in the Assessment of Peripheral Diabetic Neuropathy in Patients with Diabetes Mellitus Versus the Michigan Neuropathy Screening Instrument, 10g Monofilament Application and Biothesiometer Measurement

2020 ◽  
Vol 18 (5) ◽  
pp. 517-522 ◽  
Author(s):  
Ioanna Zografou ◽  
Fotios Iliadis ◽  
Christos Sambanis ◽  
Triantafyllos Didangelos
Keyword(s):  
Diabetes Mellitus ◽  
Color Change ◽  
High Sensitivity ◽  
Screening Instrument ◽  
Perception Threshold ◽  
Peripheral Diabetic Neuropathy ◽  
Patients With Diabetes ◽  
Group A ◽  
Michigan Neuropathy Screening Instrument ◽  
Group B

Objective: Sudomotor dysfunction is a feature of Diabetic Peripheral Neuropathy (DPN). The indicator plaster Neuropad can provide an easy and accurate way to diagnose DPN. The aim of the present study was to evaluate Neuropad’s specificity, sensitivity and accuracy in detecting DPN in patients with Diabetes Mellitus (DM). Methods: A total of 174 patients with DM (79 with type 1 DM, 88 women), mean age 49.8 ± 16.1 years and mean DM duration 17.3 ± 7.7 years were included in the present study. The following methods were used to diagnose DPN: the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE, respectively), application of 10 g monofilament (MONO) and measurement of vibration perception threshold with biothesiometer (BIO). Neuropad was applied to both feet in all patients and according to the presence or absence of color change of the sticker, patients were divided in two groups: group A (n = 82, complete change in color from blue to pink, depicting normal perspiration) and group B (n = 92, incomplete or no change, depicting abnormal perspiration). Results: MNSIQ and MNSIE were positive for DPN in 111 and 119 patients, respectively. BIO was abnormal in 109 and MONO in 59 patients. Sensitivity of Neuropad testing was 95% vs. MONO, 73% vs. BIO, 73% vs. MNSIE and 75% vs. ΜNSIQ. Specificity was 69, 81, 90 and 92%, respectively and accuracy of the test was 78, 76, 78 and 83%, respectively. Conclusion: Neuropad has a high sensitivity and specificity in detecting DPN vs. MNSIQ, MNSIE and BIO. Neuropad has a high sensitivity but moderate specificity vs. MONO. The accuracy of the test was high in all measurements.

scholarly journals Diabetic Retinopathy Treated with Laser Photocoagulation and the Indirect Effect on Glycaemic Control

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Anna Praidou ◽  
Sofia Androudi ◽  
Periklis Brazitikos ◽  
George Karakiulakis ◽  
Eleni Papakonstantinou ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Glycaemic Control ◽  
Laser Treatment ◽  
Laser Photocoagulation ◽  
Argon Laser ◽  
Previous Treatment ◽  
Blood Levels ◽  
Patients With Diabetes ◽  
Group A ◽  
Group B

Purpose. To identify any possible relation between glycaemic control and previous laser photocoagulation for diabetic retinopathy.Methods. Seventy-two patients with diabetes were included in the study and were separated into 2 groups according to previous treatment (group A) or not (group B) with argon laser photocoagulation. Glycaemic control was estimated by measuring blood levels of HbA1c in four consecutive measurements.Results. Blood levels of HbA1c in group A were significantly lower 3, 6, and 12 months after laser treatment as compared to blood levels of HbA1c before laser treatment (7.1±0.4% versus7.6±0.9%,7.2±0.2% versus7.6±0.9%, and7.1±0.2% versus7.6±0.9%, resp., allP<0.05). Blood levels of HbA1c in group B did not differ significantly in four consecutive measurements.Conclusion. Our results suggest that we should anticipate a better glycaemic control in cases of patients with diabetes previously treated with laser photocoagulation.

scholarly journals EFFICACY OF ROLLING BOARD PERTURBATION TRAINING ON BALANCE AMONG HEMIPARETIC STROKE PATIENTS - A COMPARATIVE STUDY

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Dr. Senthil kumar ◽  
Dr. Franklin Shaju M.K m k ◽  
Dr. Vijaya Senthil Kumar kumar ◽  
Dr. A. velmurugan
Keyword(s):  
Public Health Problem ◽  
Berg Balance Scale ◽  
Major Public Health Problem ◽  
Stroke Patients ◽  
Perturbation Training ◽  
Before And After ◽  
Group A ◽  
Hemiparetic Stroke ◽  
Conventional Physiotherapy ◽  
Group B

Background of the study: Stroke is a major public health problem that ranks in the top four causes of death in most of the countries and is responsible for a large proportion of the burden of neurologic disorders. Patients with stroke have poor balance because they cannot control dynamically the size of the base of support or the location of the line of gravity. Perturbation training undergoes the maximal sway possible without losing his balance. Objective of the study: The objective of the study is to find the effects of rolling board perturbation training on balance among hemiparetic stroke patients. Methodology: Thirty clinically diagnosed hemiparetic stroke patients were selected based on the inclusion and exclusion criteria. They were randomly allocated into two groups (Group A and Group B) consists of 15 subjects each. Group A received conventional physiotherapy alone and group B received rolling board perturbation training along with conventional physiotherapy. Intervention lasted for 4 weeks, three days in a week and one hour per day. Balance was measured before and after 4 weeks of intervention by berg balance scale. Conclusion: Both conventional physiotherapy alone and rolling board perturbation training along with conventional physiotherapy significantly improved balance among hemiparetic stroke patients. When comparing both rolling board perturbation training along with conventional physiotherapy is more effective than conventional physiotherapy alone in improving balance among hemiparetic stroke patients.

scholarly journals Diabetic polyneuropathy: diagnosis, prevention, and treatment

2020 ◽  
Vol 12 (4) ◽  
pp. 113-118
Author(s):  
V. A. Golovacheva ◽  
I. A. Strokov
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Nervous System ◽  
Lipoic Acid ◽  
Diabetic Polyneuropathy ◽  
Patient Treatment ◽  
Alpha Lipoic Acid ◽  
Sensorimotor Polyneuropathy ◽  
Chronic Hyperglycemia ◽  
Prevention And Treatment

The most common form of peripheral nervous system damage in diabetes mellitus is distal symmetric sensorimotor polyneuropathy (DSSMPN). Chronic hyperglycemia, dyslipidemia, and impaired microcirculation are considered to be the key mechanisms for the development of DSSMPN, but its pathogenesis is still unclear and continues to be studied. The paper analyzes the issues of diagnosis of DSSMPN and the effective principles of patient treatment. It also discusses the use of alpha-lipoic acid (ALA) as a drug for the pathogenetic treatment of DSSMPN and describes the results of clinical trials of its treatment with ALA preparations.

scholarly journals Effects of Interactive Video Game-Based Exercise on Balance in Diabetic Patients with Peripheral Neuropathy: An Open-Level, Crossover Pilot Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Erica Shih-Wei Hung ◽  
Shih-Ching Chen ◽  
Fan-Chien Chang ◽  
Yaojung Shiao ◽  
Chih-Wei Peng ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Video Game ◽  
Interactive Video ◽  
Berg Balance Scale ◽  
Diabetic Patients ◽  
Functional Balance ◽  
Positive Effects ◽  
Group A ◽  
Group B ◽  
Interactive Video Game

Purpose. This study evaluated the effects of interactive video game-based (IVGB) exercise on balance in diabetic patients with peripheral neuropathy. Materials and Methods. Twenty-four patients were randomly assigned to two groups (12 participants per group). Group A received IVGB training for the first 6 weeks, with no exercise in the subsequent 6 weeks. Group B had no exercise for the first 6 weeks and then underwent IVGB training in the subsequent 6 weeks. For all participants, the Modified Falls Efficacy Scale (MFES), Time Up and Go (TUG) test, Berg Balance Scale (BBS), and Unipedal Stance Test (UST) were employed at weeks 0, 6, and 12 of the experiment. Results. BBS, right-leg UST, and TUG test scores significantly improved after IVGB intervention, whereas MFES and left-leg UST tended to improve after IVGB intervention. Conclusions. This study revealed that 6-week balance-based exercise training using the IVGB system exerted positive effects on functional balance in patients with diabetic peripheral neuropathy (DPN).

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