A case of drug eruption caused by eperisone hydrochloride and cefteram pivoxil. Statistical evaluation of drug eruptions in National Kumamoto Hospital.

1991 ◽  
Vol 53 (2) ◽  
pp. 227-231
Author(s):  
Kayoko NAKAMURA ◽  
Yoshihiro MAEKAWA ◽  
Reiko NOGAMI
Keyword(s):  
Drug Eruption ◽  
Statistical Evaluation ◽  
Drug Eruptions

scholarly journals Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005–2014)

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Hossein Kavoussi ◽  
Mansour Rezaei ◽  
Katayoun Derakhshandeh ◽  
Alireza Moradi ◽  
Ali Ebrahimi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Drug Eruption ◽  
Cross Sectional Study ◽  
Fixed Drug Eruption ◽  
The West ◽  
Cross Sectional ◽  
Drug Eruptions ◽  
Causative Drug ◽  
Fixed Drug ◽  
Antibiotic Group

Background.Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the west of Iran.Method.This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. Demographic, clinical, and drug intake information were collected.Results.Out of 30 patients (17 females and 13 males) with the mean age of26.67±10.21years, 28 (93.3%) and 2 (6.7%) cases had plaque and bullous clinical presentation, respectively. Upper limbs were the most common (90%) site of involvement. The antibiotic group, especially cotrimoxazole (26.1%), was reported to be the most common offending drug, but the causative drug was not determined in 7 (23.3%) patients.Conclusion.Many cases of generalized fixed drug eruption firstly presented as limited lesions and led to generalized lesion due to repeated intake of the causative drug. No causative drug was found in some patients, which might be associated with concurrent intake of several drugs, multiple FDE, and peculiarity of the patch test.

scholarly journals Fenofibrate-Induced Lichenoid Drug Eruption: A Rare Culprit

2017 ◽  
Vol 9 (3) ◽  
pp. 236-242 ◽  
Author(s):  
Fayeza Mohammed ◽  
Laura L. Wally ◽  
Jeffrey E. Karaban ◽  
Vijaya B. Reddy ◽  
Yongsuk Lertratanakul
Keyword(s):  
Side Effect ◽  
Drug Eruption ◽  
Uv Exposure ◽  
Unique Case ◽  
Drug Eruptions ◽  
Familial Association ◽  
Rare Side Effect ◽  
Genetic Mechanisms ◽  
Appropriate Therapy ◽  
Clinically Significant

A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. In addition, we report a potential familial association which underscores the potential for underlying genetic mechanisms to be contributory to lichenoid drug eruptions. A reminder of the physical characteristics of lichen planus, knowledge of the temporal relation between administration of medications and a lichenoid drug eruption, recognition of the effect of UV exposure on lichenoid drug eruptions, and realization for the potential of symptoms to persist despite discontinuation of an offending agent can aid practitioners in promptly diagnosing lichenoid drug eruptions and initiating appropriate therapy.

scholarly journals Skin Test for Cutaneous Adverse Drug Reactions

2020 ◽  
Vol 32 (1) ◽  
pp. 62 ◽  
Author(s):  
Yusuf Wibisono ◽  
Damayanti Damayanti
Keyword(s):  
Skin Test ◽  
Drug Eruption ◽  
False Negative ◽  
Intradermal Test ◽  
Diagnostic Tools ◽  
Diagnostic Process ◽  
Diagnostic Modality ◽  
Prick Test ◽  
Drug Eruptions ◽  
First Choice

Background: The incidence of drug eruptions is increasing during the last few years due to a large number of new medications. Early detection of the causative agent and the prevention from exposure are crucial managements in terms of drug eruption, mainly to prevent its recurrence. Objective: To understand skin test as a diagnostic modality in drug eruption, which includes skin patch test, skin prick test, and intradermal test. Literature review: Drug eruption is a form of skin eruption triggered by the use of medications, topical or systemic, in the right dose and indication. The manifestation can vary from maculopapular, urticaria, pustular, and bullous eruption; from the most nonsignificant to a life-threatening reaction. A diagnostic procedure is critical to discover the type of drugs that cause the eruption, i.e., skin test, specific IgE measurement, histamine-release test, and provocation test. Skin test is the first choice in the diagnostic process as it is simple, easy, practical and has high sensitivity and specificity. Conclusion: Skin test is one of the many available diagnostic tools.  However, both false positive and false negative results might still arise. The experts are currently attempting to come up with more accurate and practical tests to aid the diagnostic of drug eruption, thus preventing its occurrence.

scholarly journals Ofloxacin/ tinidazole induced fixed drug eruption- a case report

2021 ◽  
Vol 2 (1) ◽  
pp. 36-38
Author(s):  
Monika Kapoor
Keyword(s):  
Adverse Drug Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Causative Agents ◽  
Inflammatory Drugs ◽  
Cutaneous Adverse Drug Reaction

Introduction: An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp borders, erythematous lesions with or without blisters developing within an hour or in a few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection. Case report: This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

scholarly journals Fixed drug eruption caused by tadalafil - case report

2013 ◽  
Vol 88 (4) ◽  
pp. 617-619 ◽  
Author(s):  
Milan Bjekic ◽  
Milica Markovic ◽  
Sandra Sipetic
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Drug Eruption ◽  
Personal History ◽  
Oral Lesions ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Short Course ◽  
Fixed Drug ◽  
Recreational Use

Fixed drug eruptions (FDE) are commonly reported type of mucocutaneous drug eruption. The aim of this paper is to present a patient with multiple mucocutaneous erythema fixum type lesions caused by oral tadalafil use. A short course of topical corticosteroid therapy resulted in complete resolution of all lesions leaving residual hyperpigmentation of the involved skin sites. Mucosal oral lesions were effectively treated with gingival hyaluronic acid 0.2% gel. Conclusion: when assessing a patient of any age with drug eruptions, a thorough personal history should be obtained, in particular data on regular or recreational use of phospodiesterase type 5 inhibitors.

scholarly journals Diagnostic Tools and Biomarkers for Severe Drug Eruptions

2021 ◽  
Vol 22 (14) ◽  
pp. 7527
Author(s):  
Manabu Yoshioka ◽  
Yu Sawada ◽  
Motonobu Nakamura
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Drug Eruption ◽  
Adverse Reactions ◽  
Stevens Johnson Syndrome ◽  
Diagnostic Tools ◽  
Clinical Aspects ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Severe Cutaneous Adverse Reactions ◽  
Cutaneous Adverse Reactions

In accordance with the development of human technology, various medications have been speedily developed in the current decade. While they have beneficial impact on various diseases, these medications accidentally cause adverse reactions, especially drug eruption. This delayed hypersensitivity reaction in the skin sometimes causes a life-threatening adverse reaction, namely Stevens-Johnson syndrome and toxic epidermal necrolysis. Therefore, how to identify these clinical courses in early time points is a critical issue. To improve this problem, various biomarkers have been found for these severe cutaneous adverse reactions through recent research. Granulysin, Fas ligands, perforin, and granzyme B are recognized as useful biomarkers to evaluate the early onset of Stevens-Johnson syndrome and toxic epidermal necrolysis, and other biomarkers, such as miRNAs, high mobility group box 1 protein (HMGB1), and S100A2, which are also helpful to identify the severe cutaneous adverse reactions. Because these tools have been currently well developed, updates of the knowledge in this field are necessary for clinicians. In this review, we focused on the detailed biomarkers and diagnostic tools for drug eruption and we also discussed the actual usefulness of these biomarkers in the clinical aspects based on the pathogenesis of drug eruption.

scholarly journals Severe Generalized Bullous Fixed Drug Eruption Treated with Cyclosporine: A Case Report and Literature Review

2021 ◽  
pp. 154-163
Author(s):  
Hailey C. Barootes ◽  
Erin R. Peebles ◽  
Doreen Matsui ◽  
Michael Rieder ◽  
Awatif Abuzgaia ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cyclosporine A ◽  
Drug Eruption ◽  
Paediatric Population ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Paediatric Case ◽  
Oral Ibuprofen

Generalized bullous fixed drug eruptions (GBFDEs) are rare in the paediatric population. We present the case of a 7-year-old girl with GBFDE believed to be secondary to oral ibuprofen, who experienced rapid resolution of lesions and cessation of blistering with a 3-week course of oral cyclosporine. To the best of our knowledge, this is the first report of a paediatric case of GBFDE treated with cyclosporine. In our report, we review published cases of GBFDE in children, and all adult cases managed with cyclosporine.

scholarly journals Clinical Profile of Severe Cutaneous Drug Eruptions in a Tertiary Care Hospital

2019 ◽  
Vol 15 (3) ◽  
pp. 156-159
Author(s):  
Rupak Bishwokarma Ghimire ◽  
Sabina Bhattarai ◽  
Govinda Pokharel ◽  
Eliz Aryal ◽  
Prashanna Raj Shrestha
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Drug Eruption ◽  
Tertiary Care ◽  
College Teaching ◽  
Intracerebral Hematoma ◽  
Care Hospital ◽  
Medication History ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Drug Eruptions

Background: An adverse cutaneous reaction caused by a drug is any undesirable change in the structure or function of the skin, its appendages or mucous membranes and it encompass all adverse events related to drug eruption, regardless of the etiology.  Methods: This is a retrospective descriptive cross-sectional study done fom April 2017 to March 2019 at dermatology department of Kathmandu Medical College Teaching Hospital. Sample size was calculated as 42 with prevalance of severe cutaneous drug eruption as 3%. After the medication history was taken, all suspected causative drugs were discontinued. For the initial 5 to 7 days, all patients were treated with intravenous corticosteroids and oral antihistamines. Follow up after one week, 2 weeks and one month were suggested for assessment of outcomes. Results: Out of 42 patients, 22 (52.38%) were females and 20 (47.62%) males. Most were in age groups 16-39 & 46-60 counting to 14 (33.33%) in each group. Acute morbilliform eruption was the most common presentation 20 (47.6%) followed by Steven Johnson Syndrome-Toxic Epidermal Necrolysis in 16 (38.1%). The most common offending drug group in this study was antileptics 9 (21.43%), followed by NSAIDs 8 (19.05%), antibiotics 7 (16.67%), allopurinol 4(9.52%%). Patients were discharged after 7 days with tapering dose of oral prednisolone upto 6 weeks for all patients. However, three patients died due to Toxic Epidermal Necrolysis along with comorbid conditions like intracerebral hematoma, COPD with pneumonia. Conclusion: Adverse cutaneous drug reactions should be recognized early for timely intervention. Previously sensitized patients should be made aware about fatal outcomes, symptoms, cross reactivites as well as over the counter preparations.

scholarly journals A case of self-treatment induced oral mucosal fixed drug eruptions associated with use of tinidazole - a case report

2021 ◽  
Vol 9 (6) ◽  
pp. 1794
Author(s):  
Swathi C. Prabhu ◽  
Harshavardhan K. Shetty
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Oral Mucosa ◽  
Medical Practice ◽  
Drug Eruption ◽  
Case Reports ◽  
Common Site ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Fixed Drug

Fixed drug eruptions (FDE) is a type of adverse reaction to drugs encountered in medical practice. Skin, glans penis is most common site of involvement. We hereby report a case of fixed drug eruption on oral mucosa due to tinidazole, a nitroimidazole-derivative which the patient had taken as he was suffering from gastro-intestinal distress. Very limited case reports have been found in literature with respect to tinidazole causing FDE.

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