scholarly journals Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

Diabetes ◽  
2016 ◽  
Vol 65 (8) ◽  
pp. 2448-2460 ◽  
Author(s):  
Hanieh Yaghootkar ◽  
Luca A. Lotta ◽  
Jessica Tyrrell ◽  
Roelof A.J. Smit ◽  
Sam E. Jones ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Disease ◽  
Lower Risk ◽  
Genetic Evidence

scholarly journals Behavioral Strategies to Lower Postprandial Glucose in Those with Type 2 Diabetes May Also Lower Risk of Coronary Heart Disease

2018 ◽  
Vol 10 (1) ◽  
pp. 277-281 ◽  
Author(s):  
Daniel J. Cox ◽  
Kun Fang ◽  
Anthony L. McCall ◽  
Mark R. Conaway ◽  
Tom A. Banton ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lower Risk ◽  
Postprandial Glucose ◽  
Behavioral Strategies

scholarly journals Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis

2020 ◽  
Author(s):  
Qin Wang ◽  
Clare Oliver-Williams ◽  
Olli T Raitakari ◽  
Jorma Viikari ◽  
Terho Lehtimäki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Kidney Function ◽  
Lower Risk ◽  
Density Lipoprotein ◽  
Metabolic Effects ◽  
Anthropometric Measures ◽  
Insulin Metabolism

Abstract Aims  Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular effects of genetic mimicry of ANGPTL3 and ANGPTL4 inhibition and compare them to the effects of genetic mimicry of LPL enhancement. Methods and results  Associations of genetic variants in ANGPTL3 (rs11207977-T), ANGPTL4 (rs116843064-A), and LPL (rs115849089-A) with an extensive serum lipid and metabolite profile (208 measures) were characterized in six cohorts of up to 61 240 participants. Genetic associations with anthropometric measures, glucose-insulin metabolism, blood pressure, markers of kidney function, and cardiometabolic endpoints via genome-wide summary data were also explored. ANGPTL4 rs116843064-A and LPL rs115849089-A displayed a strikingly similar pattern of associations across the lipoprotein and lipid measures. However, the corresponding associations with ANGPTL3 rs11207977-T differed, including those for low-density lipoprotein and high-density lipoprotein particle concentrations and compositions. All three genotypes associated with lower concentrations of an inflammatory biomarker glycoprotein acetyls and genetic mimicry of ANGPTL3 inhibition and LPL enhancement were also associated with lower C-reactive protein. Genetic mimicry of ANGPTL4 inhibition and LPL enhancement were associated with a lower waist-to-hip ratio, improved insulin-glucose metabolism, and lower risk of coronary heart disease and type 2 diabetes, whilst genetic mimicry of ANGPTL3 was associated with improved kidney function. Conclusions  Genetic mimicry of ANGPTL4 inhibition and LPL enhancement have very similar systemic metabolic effects, whereas genetic mimicry of ANGPTL3 inhibition showed differing metabolic effects, suggesting potential involvement of pathways independent of LPL. Genetic mimicry of ANGPTL4 inhibition and LPL enhancement were associated with a lower risk of coronary heart disease and type 2 diabetes. These findings reinforce evidence that enhancing LPL activity (either directly or via upstream effects) through pharmacological approaches is likely to yield benefits to human health.

scholarly journals Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Diabetes ◽  
2018 ◽  
Vol 68 (1) ◽  
pp. 207-219 ◽  
Author(s):  
Yingjie Ji ◽  
Andrianos M. Yiorkas ◽  
Francesca Frau ◽  
Dennis Mook-Kanamori ◽  
Harald Staiger ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Disease ◽  
Lower Risk ◽  
Liver Fat ◽  
Genome Wide ◽  
Abdominal Mri ◽  
Ectopic Liver ◽  
Genetically Determined

2436-PUB: Predicting Risk for New-Onset Type 2 Diabetes in Chinese People with Coronary Heart Disease and Impaired Glucose Tolerance

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2436-PUB
Author(s):  
SHISHI XU ◽  
CHARLES A. SCOTT ◽  
RUTH L. COLEMAN ◽  
JAAKKO TUOMILEHTO ◽  
RURY R. HOLMAN
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Chinese People ◽  
Onset Type ◽  
New Onset
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