<b>OBJECTIVE</b>
<p>We investigated the relationship between fasting serum fructose levels and the risk of incident type 2
diabetes in a prospective Chinese cohort. </p>
<p><b>RESEARCH
DESIGN AND METHODS</b></p>
<p>Among 949
community-based participants aged ≥ 40 years old
without diabetes at baseline, fasting serum fructose levels were measured using
liquid chromatography-tandem mass spectrometry. The participants were followed
up for the occurrence of diabetes. Cox regression models were performed to analyze the effect of
fasting serum fructose levels on risk of incident diabetes. </p>
<p><b>RESULTS</b></p>
<p>During a median
of 3.5 years follow-up, 179 of 949 (18.9%) subjects developed type 2 diabetes.
Elevated fasting serum fructose levels were
associated with an increased risk of incident diabetes in a
dose-response manner. After adjusting
for age, sex, body mass index(BMI), lipid profiles, blood pressure, liver
function, smoking and drinking status, baseline glucose level and sugar
sweetened beverage(SSB) consumption, 1-SD increased fasting fructose level was
associated with 35% (95% confidence interval:1.08-1.67) increased risk of
developing diabetes. After further adjustment for serum uric acid and eGFR, the
association was partially attenuated (hazard ratio,1.33; 95% confidence
interval, 1.07-1.65). The association was similar by age, prediabetes
status, BMI, and family history of diabetes, but attenuated in women(P for heterogeneity=0.037). </p>
<p><b>CONCLUSIONS </b></p>
<p>Elevated fasting serum fructose levels were
independently associated with increased risk of incident type 2 diabetes in middle-aged and older Chinese population.<b> </b>Our data suggest higher fasting serum
fructose levels might serve as a biomarker and/or a contributor to incident
diabetes.</p>
Fasting Serum Fructose Levels Are Associated With Risk of Incident Type 2 Diabetes in Middle-Aged and Older Chinese Population
