Identification of a Common Amino Acid Polymorphism in the p85  Regulatory Subunit of Phosphatidylinositol 3-Kinase: Effects on Glucose Disappearance Constant, Glucose Effectiveness, and the Insulin Sensitivity Index

Diabetes ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 494-501 ◽  
Author(s):  
T. Hansen ◽  
C. B. Andersen ◽  
S. M. Echwald ◽  
S. A. Urhammer ◽  
J. O. Clausen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Insulin Sensitivity ◽  
Regulatory Subunit ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Phosphatidylinositol 3 Kinase ◽  
Amino Acid Polymorphism ◽  
Common Amino Acid ◽  
Glucose Effectiveness ◽  
Glucose Disappearance

Quantitative estimation of insulin sensitivity.

1979 ◽  
Vol 236 (6) ◽  
pp. E667 ◽  
Author(s):  
R N Bergman ◽  
Y Z Ider ◽  
C R Bowden ◽  
C Cobelli
Keyword(s):  
Insulin Sensitivity ◽  
Time Course ◽  
Quantitative Estimation ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Glucose Disappearance ◽  
Glucose Injection ◽  
Measured Time ◽  
Two Parameters ◽  
Parameter Values

We have evaluated the feasibility of using a mathematical model of glucose disappearance to estimate insulin sensitivity. Glucose was injected into conscious dogs at 100, 200, or 300 mg/kg. The measured time course of insulin was regarded as the "input," and the falling glucose concentration as the "output" of the physiological system storing and using glucose. Seven mathematical models of glucose uptake were compared to identify the representation most capable of simulating glucose disappearance. One specific nonlinear model was superior in that it 1) predicted the time course of glucose after glucose injection, 2) had four parameters that could be precisely estimated, and 3) described individual experiments with similar parameter values. Insulin sensitivity index (SI), defined as the dependence of fractional glucose disappearance on plasma insulin, was the ratio of two parameters of the chosen model and could be estimated with good reproducibility from the 300 mg/kg injection experiments (SI = 7.00 X 10(-4) +/- 24% (coefficient of variation) min-1/(microU/ml) (n = 8)). Thus, from a single glucose injection it is possible to obtain a quantitative index of insulin sensitivity that may have clinical applicability.

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