Side effects of theragnostic agents currently employed in clinical practice

2021 ◽  
Author(s):  
Alessio RIZZO ◽  
Salvatore ANNUNZIATA ◽  
Massimo SALVATORI
Keyword(s):  
Clinical Practice ◽  
Side Effects

Recent Advances in the Rational Drug Design Based on Multi-target Ligands

2020 ◽  
Vol 27 (28) ◽  
pp. 4720-4740 ◽  
Author(s):  
Ting Yang ◽  
Xin Sui ◽  
Bing Yu ◽  
Youqing Shen ◽  
Hailin Cong
Keyword(s):  
Drug Resistance ◽  
Clinical Practice ◽  
Side Effects ◽  
Drug Design ◽  
Rational Drug Design ◽  
Health Conditions ◽  
Pharmacokinetic Parameters ◽  
Single Target ◽  
Rational Drug ◽  
Huge Challenge

Multi-target drugs have gained considerable attention in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer side effects. Therefore, more attention is being paid to developing drugs that work on multiple targets at the same time, but developing such drugs is a huge challenge for medicinal chemists. Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters. Multi-target drugs, which have long been known and effectively used in clinical practice, are briefly discussed in the present article. In addition, in this review, we will discuss the possible applications of multi-target ligands to guide the repositioning of prospective drugs.

Development of a brief questionnaire (ICQ-S) to monitor inhaled corticosteroid side-effects in clinical practice

Allergy ◽  
2014 ◽  
Vol 69 (3) ◽  
pp. 372-379 ◽  
Author(s):  
J. M. Foster ◽  
S. Schokker ◽  
R. Sanderman ◽  
D. S. Postma ◽  
T. van der Molen
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Inhaled Corticosteroid

scholarly journals Clinical challenges in the management of endocrine side effects of immuno-oncological therapies

2021 ◽  
Author(s):  
Peter Wolf ◽  
Thomas Scherer
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Immune Checkpoint Inhibitor ◽  
Clinical Presentation ◽  
Checkpoint Inhibitor ◽  
Clinical Care ◽  
Short Review ◽  
Current Clinical Practice ◽  
Routine Clinical Care ◽  
Adequate Management

SummaryGiven the growing use of immune checkpoint inhibitor (ICI) therapy in oncology, the prevalence of endocrine side effects is rapidly increasing. As clinicians are nowadays frequently confronted with these side effects in routine clinical care, awareness, better knowledge of endocrine irAEs and their clinical presentation and diagnosis is crucial for an adequate management. In this short-review we give a compact overview of the recent recommendations for the management of endocrine irAE related to ICIs and highlight difficulties and uncertainties in current clinical practice.

Cardiovascular drugs

2014 ◽  
pp. 361-382
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Mechanism Of Action ◽  
Cardiovascular Drugs ◽  
Local Policy ◽  
Research Papers ◽  
Reading Research

The aim of this chapter is to give the reader a brief overview of the main groups of drugs used in the field of cardiac nursing. For each group of drugs, there is a brief description of why they are used, their mechanism of action, examples commonly used in clinical practice, and nursing considerations. However, it is important that nurses keep themselves updated in the use of drugs by reading research papers and international, national, and local guidelines. For doses of drugs, methods of administration, contraindications, and side effects, use a recognized formulary, in addition to any local policy.

Application of a who Protocol on Medical Therapy for Oncologic Pain in an Internal Medicine Hospital

1989 ◽  
Vol 75 (5) ◽  
pp. 470-472 ◽  
Author(s):  
Antonella Goisis ◽  
Maurizio Gorini ◽  
Riccardo Ratti ◽  
Patrizia Luliri
Keyword(s):  
Internal Medicine ◽  
Clinical Practice ◽  
Side Effects ◽  
Symptomatic Therapy ◽  
Pharmacologic Treatment ◽  
Advanced Stage ◽  
Oncologic Patient ◽  
Therapeutic Concepts ◽  
Antidepressive Drugs ◽  
Emotional Component

Pain symptomatology is present in 60 % – 80 % of patients affected by advanced cancer, but in most cases it is not adequately treated. Our series, composed of 45 patients affected by cancer in an advanced stage, demonstrates how the application of common concepts of pharmacotherapy, standardized according to a sequential scheme proposed by the WHO, makes it possible to reach total control (in 24.4 % of our cases) or only slight residual persistence (in 68.8 % of our cases) of pain from cancer, with scarce side effects that are easily controlled with symptomatic therapy. According to the type of pain, its behavior in relation to the therapy effected and any previous pharmacologic treatment, the proposed pharmacologic scheme foresees, as the first step, the use of nonnarcotic drugs, eventually associated or substituted with weak narcotics or finally with strong narcotics. Attention is given to modulation of the administration, to guarantee an analgesic effect throughout the day, thus preventing the pain. Irrespective of the analgesic scheme employed, it is more effective if patients affected by chronic oncologic pain (who present an important emotional component) are treated contemporaneously with ansiolytic and antidepressive drugs and those in which nerve structures are involved are treated with steroids. In conclusion, pain of an oncologic patient in an advanced stage can almost always be alleviated or often eliminated by the rigorous application of therapeutic concepts well known by physicians but for various reasons often neglected in clinical practice.

Delirium on clozapine: A tale of friend turned foe-A case report

2020 ◽  
pp. 009121742097282 ◽  
Author(s):  
Aparna Das ◽  
Rebecca Minner ◽  
Lewis Krain ◽  
John Spollen
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Side Effects ◽  
Adverse Effects ◽  
Older Adult ◽  
Psychiatric Illness ◽  
Management Strategies ◽  
Treatment Resistant ◽  
Drug Of Choice ◽  
Life Threatening

Treatment resistant schizophrenia (TRS) is often encountered in clinical practice. Clozapine remains the drug of choice in the management of TRS. Several studies have shown that clozapine is the most effective antipsychotic medication to date for TRS. But it is also well known that it has multiple side effects. Some side effects are transient and relatively benign, while other adverse effects are menacing, serious and life-threatening. Delirium may occur with clozapine and is a therapeutic challenge as there is always a risk of precipitating delirium on clozapine rechallenge. Limited management strategies are available as alternatives for the management of psychiatric illness stabilized on clozapine. In this case report, we describe an older adult patient who developed delirium on clozapine. The aims of this case report are to discuss the mechanism by which clozapine leads to delirium, revisit various factors which could possibly lead to delirium, and discuss the different management strategies available for management of psychiatric illness for a patient previously stabilized on clozapine.

Side-Effects of Rinsing Fluids on the Rat Femoral Artery

1997 ◽  
Vol 22 (5) ◽  
pp. 568-573 ◽  
Author(s):  
O. DELAERE ◽  
U. MENNEN ◽  
W. VAN HEERDEN ◽  
E. RAUBENHEIMER ◽  
A. M. WIESE ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Femoral Artery ◽  
Normal Saline ◽  
Vessel Wall ◽  
Experimental Conditions ◽  
Femoral Arteries ◽  
Heparinized Saline ◽  
Significant Difference ◽  
Ringer’S Lactate

Rinsing rat femoral arteries with various fluids in experimental conditions similar to those in clinical practice was found to have deleterious effects on the intimal and medial layers of the vessels. No statistically significant difference was found between the effects of Ringer’s lactate and normal saline. Heparinized saline produced significantly less damage to the medial layer and less platelet cell deposition. Lignocaine 2% was found to be extremely damaging to the whole vessel wall, and highly thrombogenic. Nevertheless, all the arteries in each group remained patent 4 days after rinsing.

Defining the role of glucocorticoids in inflammation

2018 ◽  
Vol 132 (14) ◽  
pp. 1529-1543 ◽  
Author(s):  
Simona Ronchetti ◽  
Graziella Migliorati ◽  
Stefano Bruscoli ◽  
Carlo Riccardi
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Adverse Effects ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Great Promise ◽  
Body Of Knowledge ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

An established body of knowledge and clinical practice has argued in favor of the use of glucocorticoids in various chronic inflammatory and autoimmune diseases. However, the very well-known adverse effects associated with their treatment hampers continuation of therapy with glucocorticoids. Analyses of the molecular mechanisms underlying the actions of glucocorticoids have led to the discovery of several mediators that add complexity and diversity to the puzzling world of these hormones and anti-inflammatory drugs. Such mediators hold great promise as alternative pharmacologic tools to be used as anti-inflammatory drugs with the same properties as glucocorticoids, but avoiding their metabolic side effects. This review summarizes findings about the molecular targets and mediators of glucocorticoid function.

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