scholarly journals Otomycosis at Fann Hospital in Dakar (Senegal): Prevalence and Mycological Study

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Thérèse Dieng
Keyword(s):  
Fungal Species ◽  
University Hospital ◽  
External Ear ◽  
Microscopic Fungi ◽  
Ear Canal ◽  
Important Place ◽  
Mycological Diagnosis ◽  
Direct Microscopic Examination ◽  
National University ◽  
Mycological Examination

Otomycosis are auricular infections caused by microscopic fungi which develop essentially in the external ear canal. Their incidence has increased these past years with the emergence of predisposing factors such as the repetitive use of broad -spectrum antibiotics. The objectives of this study were to determine the prevalence of otomycosis at Fann National University Hospital in Dakar and to identify the fungal species responsible for that. This descriptive retrospective study held from October 2011 to December 2017 at 136 patients with clinically suspected otomycosis. External auditory canal exudates collected with swabs in each patient were observed by direct microscopic examination and cultured in Sabouraud Chloramphenicol medium with and without Actidione at 30-37°C. The strains were identified on the basis of macroscopic, microscopic and physiological characteristics. The mycological examination was positive in 59 patients, that is to say, a prevalence of 43.4%. The positivity rate was significantly higher among women (52.6%) than among men (31%) (p=0.012). This rate was significantly higher among patients suffering from otalgia (75.7%) than among others (p=0.023). On the mycological plan, Aspergillus fumigatus and Candida albicans were the species the most isolated (26.3%) followed by Aspergillus niger (22.8%). These results show that fungal agents have an important place in the etiologies of the external otitis at Fann Hospital CHNU. Hence the interest of the mycological diagnosis for a better treatment of patients.

Squamous Epithelium in the Middle Ear and Sinus

1994 ◽  
Vol 73 (1) ◽  
pp. 47-48
Author(s):  
Alper Tutkun ◽  
Caglar Batman ◽  
Cüneyt Üneri ◽  
Mehmet Ali Sehitoglu
Keyword(s):  
Middle Ear ◽  
Statistical Difference ◽  
Squamous Epithelium ◽  
Normal Skin ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
External Ear ◽  
Ear Canal ◽  
Superior Part

This study has been performed between December 1990—March 1991 in the Microsurgery laboratory of the Marmara University Hospital. Twelve healthy albino guinea pigs were used as a study group while the control group consists of three animals. The potentials for cholesteatoma formation of the squamous epithelium, namely the squamous epithelium of the posterior superior part of the external ear canal skin and normal skin, were investigated. Among 24 subjects who were implanted by canal skin, cholesteatoma was fanned in 21 of them. Likewise, 19 of 24 animals implanted by normal skin came out with cholesteatoma formation. Between these two types of epithelium, there is no statistical difference in cholesteatoma formation (p >0.5).

Idiopathic, inflammatory, medial meatal, fibrotising otitis presenting with lichen planus

2007 ◽  
Vol 121 (8) ◽  
pp. 796-799 ◽  
Author(s):  
E Hopsu ◽  
A Pitkäranta
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
University Hospital ◽  
External Ear ◽  
Disease Entity ◽  
Ear Canal ◽  
Distinct Disease ◽  
Ear Canals ◽  
Oral Lichen ◽  
Distinct Disease Entity

AbstractBackground:Background: Of the acquired ear canal atresias, idiopathic, inflammatory, medial meatal, fibrotising otitis has been suggested as a distinct disease entity, for reasons of aetiology.Objective:To report three more cases of idiopathic, inflammatory, medial meatal, fibrotising otitis and to further consider the possible relationship between this condition and lichen planus.Patients:Three adult patients with idiopathic, inflammatory, medial meatal, fibrotising otitis, two with bilateral aural symptoms, treated and followed up at the department of otorhinolaryngology of Helsinki University Hospital.Results:We found idiopathic, inflammatory, medial meatal, fibrotising otitis, affecting solely the glabrous skin of the osseous part of the external ear canals, in three patients who also suffered from severe oral lichen planus.Conclusions:The aetiopathology or pathophysiology of idiopathic, inflammatory, medial meatal, fibrotising otitis may be linked with lichen planus. Early, active treatment of idiopathic, inflammatory, medial meatal, fibrotising otitis with local corticosteroids may prevent total medial meatal atresia.

Ear Malformations: Surgical Considerations

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P64-P64
Author(s):  
Gosta Granstrom ◽  
Joachim Salen ◽  
Katharina Schubertsson
Keyword(s):  
Middle Ear ◽  
Surgical Techniques ◽  
University Hospital ◽  
Ear Reconstruction ◽  
External Ear ◽  
Ear Canal ◽  
Ear Malformations ◽  
Autogenous Reconstruction ◽  
Middle Ear Reconstruction ◽  
High Degree

Objective Therapy of ear malformations has changed considerably the last two decades when new surgical techniques are available. This study aimed to evaluate different approaches to improve hearing and esthetics in ear malformations. Methods All patients who underwent rehabilitation for ear malformations between 1960 and 2007 at a University Hospital were investigated. Patients underwent clinical, audiological and x-ray examinations. Attempts to improve hearing were undertaken by ear canal and middle ear reconstruction, and/or bone anchored hearing aid (BAHA). Attempts to improve esthetics of the external ear were undertaken by autogenous reconstruction (AR) and bone anchored episthesis (BAE). Results There were 211 patients (117 male, 94 female) with ear malformations representing 255 ears. 103 of these were syndromic patients. The degree of ear malformation was generally severe, Meurman stage 3 (external ear) and Altman Creemers stage 2B (middle ear). AR (n=64) was successful to a higher degree in milder malformations (93% for Meurman grade 1, 18% for Meurman grade 3). BAE (n=109) was successful to a high degree independent of Meurman degree (92–100%). A mean of 17 dB closure of air-bone gap was obtained by ear canal and middle ear reconstruction (n=111). A mean of 46 dB closure of air-bone gap for BAHA was obtained (n=106). Conclusions With the high degree of success for BAE, this option is valuable for children where AR has failed. With the high degree of success for BAHA, children can be supplied with BAHA early and middle ear reconstruction postponed until adolescence.

Intestinal parasite survey of Kyungpook National University Hospital patients

1971 ◽  
Vol 9 (2) ◽  
pp. 47 ◽  
Author(s):  
Dong Wik Choi ◽  
Sung Deok Park ◽  
Jae Woun Kim ◽  
Doo Hong Ahn ◽  
Young Myung Kim
Keyword(s):  
Intestinal Parasite ◽  
University Hospital ◽  
Hospital Patients ◽  
National University

Rhabdomyosarcoma of the External Ear Canal Treated with Brachytherapy

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Mahvish Qureshi MD ◽  
◽  
Sana Farooki MD ◽  
Chibuzo O’Suoji MD ◽  
◽  
...  
Keyword(s):  
External Ear ◽  
Ear Canal ◽  
External Ear Canal

scholarly journals Circulating regulatory T cells predict efficacy and atypical responses in lung cancer patients treated with PD-1/PD-L1 inhibitors

2021 ◽  
Author(s):  
Da Hyun Kang ◽  
Chaeuk Chung ◽  
Pureum Sun ◽  
Da Hye Lee ◽  
Song-I Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Advanced Nsclc ◽  
Checkpoint Inhibitors ◽  
Standard Of Care ◽  
Treg Cells ◽  
University Hospital ◽  
X Rays ◽  
Lung Cancer Patients ◽  
National University

Abstract Background Immune checkpoint inhibitors (ICIs) have become the standard of care for a variety of cancers, including non-small cell lung cancer (NSCLC). In this study, we investigated the frequency of pseudoprogression and hyperprogression in lung cancer patients treated with ICIs in the real world and aimed to discover a novel candidate marker to distinguish pseudoprogression from hyperprogression soon after ICI treatment. Methods This study included 74 patients with advanced NSCLC who were treated with PD-1/PD-L1 inhibitors at Chungnam National University Hospital (CNUH) between January 2018 and August 2020. Chest X-rays were examined on day 7 after the first ICI dose to identify changes in the primary mass, and the response was assessed by computed tomography (CT). We evaluated circulating regulatory T (Treg) cells using flow cytometry and correlated the findings with clinical outcomes. Results The incidence of pseudoprogression was 13.5%, and that of hyperprogression was 8.1%. On day 7 after initiation of treatment, the frequency of CD4+CD25+CD127loFoxP3+ Treg cells was significantly decreased compared with baseline (P = 0.038) in patients who experienced pseudoprogression and significantly increased compared with baseline (P = 0.024) in patients who experienced hyperprogression. In the responder group, the frequencies of CD4+CD25+CD127loFoxP3+ Treg cells and PD-1+CD4+CD25+CD127loFoxP3+ Treg cells were significantly decreased 7 days after commencement of treatment compared with baseline (P = 0.034 and P < 0.001, respectively). Conclusion Circulating Treg cells represent a promising potential dynamic biomarker to predict efficacy and differentiate atypical responses, including pseudoprogression and hyperprogression, after immunotherapy in patients with NSCLC.

Prevalence of external ear disorders in Belgian stray cats

2017 ◽  
Vol 20 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Anouck Bollez ◽  
Hilde de Rooster ◽  
Alessandra Furcas ◽  
Sophie Vandenabeele
Keyword(s):  
Body Condition ◽  
Otitis Externa ◽  
Body Condition Score ◽  
External Ear ◽  
Ear Canal ◽  
Malassezia Species ◽  
External Ear Canal ◽  
Stray Cats ◽  
Condition Score ◽  
Ocular Discharge

Objectives Feline otitis externa is a multifactorial dermatological disorder about which very little is known. The objective of this study was to map the prevalence of external ear canal disorders and the pathogens causing otitis externa in stray cats roaming around the region of Ghent, Belgium. Methods One hundred and thirty stray cats were randomly selected during a local trap–neuter–return programme. All cats were European Shorthairs. This study included clinical, otoscopic and cytological evaluation of both external ears of each cat. Prospective data used as parameters in this study included the sex, age and body condition score of each cat, as well as the presence of nasal and/or ocular discharge, and the results of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) Snap tests. Results Remarkably, very few (sub)clinical problems of the external ear canal were found in the stray cat population. Malassezia species was by far the most common organism found in the external ear canals of the 130 stray cats. A total of 96/130 (74%) cats were found to have Malassezia species organisms present in one or both ears based on the cytological examination. No correlation was found between the parameters of sex, age, body condition score, the presence of nasal and/or ocular discharge and FIV and FeLV status, and the presence of parasites, bacteria or yeasts. Conclusions and relevance This study provides more information about the normal state of the external ear canal of stray cats. The ears of most stray cats are relatively healthy. The presence of Malassezia species organisms in the external ear canal is not rare among stray cats.

scholarly journals Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke

2021 ◽  
Vol 50 (3) ◽  
pp. 270-278
Author(s):  
Chan-Hyuk Lee ◽  
Sang Hyuk Lee ◽  
Young I. Cho ◽  
Seul-Ki Jeong
Keyword(s):  
Ischemic Stroke ◽  
Carotid Artery ◽  
Signal Intensity ◽  
Internal Carotid ◽  
University Hospital ◽  
Large Artery ◽  
Intensity Gradient ◽  
National University ◽  
Endothelial Shear Stress ◽  
Stroke Center

<b><i>Background:</i></b> Common carotid artery (CCA) and internal carotid artery (ICA) are aligned linearly, but their hemodynamic role in ischemic stroke has not been studied in depth. <b><i>Objectives:</i></b> We aimed to investigate whether CCA and ICA endothelial shear stress (ESS) could be associated with the ischemic stroke of large artery atherosclerosis (LAA). <b><i>Methods:</i></b> We enrolled consecutive patients with unilateral ischemic stroke of LAA and healthy controls aged &#x3e;60 years in the stroke center of Jeonbuk National University Hospital. All patients and controls were examined with carotid artery time-of-flight magnetic resonance angiography, and their endothelial signal intensity gradients (SIGs) were determined, as a measure of ESS. The effect of right or left unilateral stroke on the association between carotid artery endothelial SIG and ischemic stroke of LAA was assessed. <b><i>Results:</i></b> In total, the results from 132 patients with ischemic stroke of LAA and 121 controls were analyzed. ICA endothelial SIG showed significant and independent associations with the same-sided unilateral ischemic stroke of LAA, even after adjusting for the potential confounders including carotid stenosis, whereas CCA endothelial SIG showed a significant association with the presence of the ischemic stroke of LAA. <b><i>Conclusion:</i></b> Although CCA and ICA are located with continuity, the hemodynamics and their roles in large artery ischemic stroke should be considered separately. Further studies are needed to delineate the pathophysiologic roles of ESS in CCA and ICA for large artery ischemic stroke.

Prevalence of external auditory canal exostoses in Australian surfboard riders

2004 ◽  
Vol 118 (5) ◽  
pp. 348-351 ◽  
Author(s):  
William Hurst ◽  
Michael Bailey ◽  
Benjamin Hurst
Keyword(s):  
External Auditory Canal ◽  
Cold Water ◽  
Control Group ◽  
External Ear ◽  
Ear Canal ◽  
External Ear Canal ◽  
Rate Of Growth

This paper assessed 300 surfboard riders, comprising 229 males and 71 females to determine the prevalence and rate of growth of exostoses in this population. A group of cold water swimmers and a control group were also examined. Significant obstruction, defined as two thirds or more occlusion of the ear canal was noted in 90 of the male surfers and 10 female surfers. This degree of occlusion was found in seven of the 32 cold water swimmers. A male surfer who has surfed regularly for 20 years or more has a one in two chance of developing significant obstruction of the external ear canal resulting from exostoses and this is a three in seven chance for females.

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