scholarly journals Three Years Retrospective Study of Melanocytic Lesion in Tertiary Hospital: Comparing Benign & Malignant Data

2021 ◽  
Vol 9 (1) ◽  
pp. 24
Author(s):  
Fitri Ayu Ramadhini

Abstract Melanocytic lesion is defined as skin symptom due to proliferation of melanocytes. It may be considered benign, commonly diagnosed as melanocytic nevus (MN), or may also be malignant as malignant melanoma (MM). Publication of epidemiologic data about melanocytic lesion in Indonesia is limited. The aim of this study was to evaluate the epidemiologic findings of melanocytic lesion based on histopathology and clinical data. This descriptive study was done by collecting retrospective pigmented lesion from histopathology database at Department of Anatomical Pathology dr. Cipto Mangunkusumo National Hospital from 2014 - 2017. Retrieved data were analyzed descriptively for MN and MM include clinical diagnosis, age, sex, location, size and clinical working diagnosis. There were 121 cases of melanocytic lesions consisting of 87.6% MN. Females were more frequent for benign lesions. MN cases were mostly seen at the age below the fourth decade, while from 12 cases of MM found above fourth decade. MN was located mostly on the head and neck, while MM mostly in the lower extremities and soles. There were 75 lesions size and 4 lesions location were unknown data missing. MM is still considered rare. Completing clinical finding in the histopathology request form by surgeons will aid in defining better characteristic of melanocytic lesion in our population. Keyword: epidemiology, melanocytic lesion, nevus melanocytic, malignant melanoma.   Studi Retrospektif Lesi Melanositik dalam Tiga Tahun di RS Tersier: Perbandingan Data Jinak dan Ganas Abstrak Lesi melanositik didefinisikan sebagai lesi kulit akibat proliferasi melanosit. Lesi melanositik dapat dianggap jinak, umumnya didiagnosis sebagai nevus melanositik (NM), atau merupakan ganas yaitu melanoma maligna (MM). Publikasi data epidemiologi tentang lesi melanositik di Indonesia masih terbatas. Tujuan dari penelitian ini adalah untuk melakukan evaluasi gambaran epidemiologis lesi melanositik berdasarkan data histopatologi dan klinis. Penelitian deskriptif ini dilakukan dengan mengumpulkan data retrospektif lesi berpigmen dari basis data histopatologi di Departemen Patologi Anatomi Rumah Sakit Nasional dr. Cipto Mangunkusumo dari tahun 2014 - 2017. Data dianalisis secara deskriptif untuk NM dan MM termasuk diagnosis kerja, usia, jenis kelamin, lokasi, ukuran, dan diagnosis klinis. Terdapat 121 kasus lesi melanositik yang terdiri atas 87,6% NM. Lesi jinak lebih banyak ditemukan pada wanita. Terdapat 75 dan 4 kasus dengan data ukuran lesi dan lokasi tidak tercantum. MM masih dianggap jarang. Kasus NM sebagian besar terlihat pada usia di bawah dekade keempat, sedangkan dari 12 kasus MM di atas dekade keempat. NM sebagian besar terletak di kepala dan leher, sedangkan MM ditemukan di ekstremitas bawah dan telapak kaki. Melengkapi temuan klinis dalam formulir permintaan histopatologi oleh dokter bedah akan membantu dalam menentukan karakteristik lesi melanositik lebih baik pada populasi ini. Kata kunci: epidemiologi, lesi melanositik, nevus melanositik, melanoma maligna

2018 ◽  
Author(s):  
Filipa Tavares Almeida ◽  
Regina Caldas ◽  
Teresa Pereiro ◽  
Celeste Brito

Meyerson nevus represents an uncommon clinical and histological variation of melanocytic lesions that is characterized by an eczematous halo surrounding a melanocytic nevus.1It was first reported by Meyerson and it typically clears spontaneously or resolves with topical corticotherapy.2We report the case of an atypical Meyerson nevus in which, despite intense pruritus, both an eczematous eruption and dermoscopic patterns imputable to a melanocytic lesion were lacking. 1. Balato A, Lembo S, Cirillo T, Megna M, Napolitano M, Balat N. Meyerson phenomenon around naevi: resolution after sun exposure? Acta Dermato-Venereol. 2011; 91:352-3. doi: 10.2340/00015555-1059.2. Gabbi TV, Omar ED, Criado PR, Valente NY, Martins JE. Clinical, dermoscopic and histopathological evaluation of the Meyerson nevus: case report. An Bras Dermatol. 2010;85:681-3.


2021 ◽  
Vol 19 (1) ◽  
pp. 81-83
Author(s):  
Anil Kumar Bhatta ◽  
Uma Keyal ◽  
Yeqiang Liu 

Congenital melanocytic nevus  is benign pigmented lesion of the skin usually present at birth. Here we report a case of 61-year-old male who presented with a pigmented lesion on the trunk, which on biopsy showed features of both  congenital melanocytic nevus and fibroepithelioma of Pinkus. We reviewed literature for this combination and found only one case reported so far. Hence, it seems that it is very unusual to seefibroepithelioma of Pinkus in conjunction with a melanocytic lesion. 


2018 ◽  
Vol 21 (2) ◽  
pp. 252-270 ◽  
Author(s):  
Chen Yang ◽  
Alejandro A Gru ◽  
Louis P Dehner

The acquired melanocytic nevus is the most common lesion encountered by pediatric pathologists and dermatopathologists in their daily practice. In most cases, there are few difficulties in histopathologic diagnosis. However, it is the acquired melanocytic lesion known as the Spitz nevus, with its intrinsic atypical features which becomes the challenge since it exists along a histopathologic and biologic continuum from the atypical Spitz tumor to spitzoid melanoma. The frustration with some of these spitzoid lesions is that even the “experts” cannot agree as to the differentiation of one from the other even at the level of molecular genetics. Other melanocytic lesions are discussed including the congenital melanocytic nevus with its proliferative nodule(s) and melanoma as the ultimate complication. Although uncommon, cutaneous melanoma in the first 2 decades is emerging as a clinical problem especially in young women in the second decade of life. These are ultraviolet-associated neoplasms whose histopathologic and prognostic features are identical to the adult experience. Considerable progress has been made over the past 15 to 20 years in our understanding of cutaneous melanocytic lesions, but gaps still exist in the important group of spitzoid lesions. It can also be anticipated that more cutaneous melanomas in children will be seen in the future based upon epidemiologic studies.


2011 ◽  
Vol 1 (2) ◽  
pp. 31 ◽  
Author(s):  
Oderay Mabel Cedeño Díaz ◽  
Roberto Garcia Leal ◽  
Cesar La Cruz Pelea

Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.


2005 ◽  
Vol 11 (20) ◽  
pp. 7234-7242 ◽  
Author(s):  
Dmitri Talantov ◽  
Abhijit Mazumder ◽  
Jack X. Yu ◽  
Thomas Briggs ◽  
Yuqiu Jiang ◽  
...  

2015 ◽  
Vol 6 (03) ◽  
pp. 417-419 ◽  
Author(s):  
Gian Chand Rajput ◽  
Deepti Mahajan ◽  
Kulbhushan Prakash Chaudhary ◽  
V. Deewana

ABSTRACTA kissing nevus is a type of congenital compound nevus that affects equal portions of the upper and lower eyelid, and it extends to the lid margins. Congenital divided nevi of the eyelids are a rare melanocytic lesion. Only 30 patients are reported in the literature. We report a 40-year-old female of rural background who presented with a large painless enlarging pigmented mass, involving both upper and lower left eyelid since the past 20 years. Complete excision of the lesion was done, and the mass sent for histopathology, which revealed a compound nevus involving both lids. Surgery removed the obstruction, which had caused decreased visual acuity and had altered the cosmetic appearance of the patient. Lesions on the upper lid cause a mechanical ptosis, covers the visual axis, which causes obstruction in vision and is cosmetically unacceptable. There is a definite risk of malignant change in the nevus giving rise to malignant melanoma, and hence they should be removed as early as possible to give better functional and cosmetic results.


2017 ◽  
Vol 5 (4) ◽  
pp. 549-550 ◽  
Author(s):  
Georgi Tchernev ◽  
Ilia Lozev ◽  
Ivan Pidakev ◽  
Torello Lotti ◽  
Uwe Wollina ◽  
...  

We present a 6-month-old male patient, who was consulted with dermatologist by his parents, because of a pigmented lesion, present since birth, covering almost the all skin of the back and buttocks.  A sharply bordered, unequally coloured congenital pigmented nevus, measuring approximately 21 cm in diameter was observed in the whole body skin examination. The lesion was affecting the lower 2/3 of the skin of the back and the top half of the gluteus area, extending to the lateral part of the tors, forward the abdomen and the upper lateral part of the hips, composed by multiple darker-pigmented nests and several lighter areas, with single depigmented zones, hairy surface, irregularly infiltrated on palpation. Congenital melanocytic nevi are presented in approximately 1% of newborns, while giant congenital melanocytic nevi (GCMN) are the most uncommon subtype of them; with occurrence rate 1 in 50,000 births. They affect 2% of a total body surface or presenting in a diameter larger than 20 cm in older children. Although not common, the possible malignant transformation remains one of the most important considerations related to them, as the related lifetime risk of melanoma is 4% to 10%. Treatment recommendations include non-surgical methods as dermabrasion only within the first two weeks of life, for prevention the possible melanocytic deeper migration, while serial surgical excisions or tissue expanders could be useful treatment tool even in later stages. Nevertheless, cosmetic result is not always satisfactory, and the risk of malignant changes remains, in cases of previous melanocytic migration in deeper layer. Recent article suggests the potential role in the treatment of GCMN with NRAS inhibitor trametinib, approved for treatment of advanced melanoma, associated with underlying NRAS mutations. Although promising, the drug could be useful in paediatric patients, only with associated NRAS gene mutation. It is still unclear whether it could be helpful, independent of the NRAS status.


2018 ◽  
Vol 5 (3) ◽  
pp. 171-175
Author(s):  
Lindsay A. McGrath ◽  
James F. Bacon ◽  
Paul Rundle ◽  
Ian G. Rennie ◽  
Hardeep Singh Mudhar

Malignant melanoma is the most common primary malignant tumour of the iris, but represents a small proportion of all uveal melanomas. The authors describe a 34-year-old male with a pigmented lesion of the iris. The lesion remained stable for 7 years, but the patient re-presented after this time with sudden enlargement of the mass and hyphaema. Excisional biopsy confirmed cavitary melanoma of the iris. This is the first reported case of cavitation in a primary iris melanoma. The patient has not had any further adjuvant treatment and remains metastasis free at 5 years of follow-up.


2019 ◽  
Vol 11 (1) ◽  
pp. 77-81
Author(s):  
Yogita Rajbhandari ◽  
Sharad Gupta ◽  
Reena Yadav ◽  
Ashma Manandhar ◽  
Aye Myat Mon ◽  
...  

Background: Conjunctival malignant melanoma is a rare ocular malignancy most commonly affecting mostly the elderly population. It is a pigmented lesion which canarise from primary acquired melanosis, de novo or from preexisting nevus. Case: A 63 year old male presented with a chief complaints rapidly increasing mass in the left eye for two months following trauma with a wooden stick. He had preexisting nevus in the same eye. His best corrected visual acuity was 6/12 in right eye and 1/60 left eye respectively. Slit lamp biomicroscopy examination showed 4 cm x 4 cm pigmented mass in the nasal bulbar and inferior palpebral conjunctiva causing mechanical ectropion of the lower lid with keratinization of palpebral conjunctiva. Incisionalbiopsy of conjunctiva showed malignant melanoma. On computed tomography, there was expansion of bony orbit. Considering all the findings, exenteration of the left orbitwas done. Histopathological report of exenterated mass was suggestive of malignantmelanoma of conjunctiva. Conclusion: Conjunctival melanoma is a rare malignant tumor of eye which has high metastasis rate and the treatment option is surgery with adjuvant therapy.


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