scholarly journals Serum Uric Acid in Pre-eclampsia

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Dr. Yanglem Ajitkumar ◽  
Dr. Sangeeta Naorem ◽  
Dr. Victoria Kshetrimayum ◽  
Dr. Yengkhom Upen Singh ◽  
Dr. Sneha Saha ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Clinical Manifestations ◽  
Common Finding ◽  
Perinatal Morbidity ◽  
Medical Sciences ◽  
Normal Controls ◽  
Control Study

Background: Hypertension in pregnancy is a major cause of maternal death and also a major source of maternal and perinatal morbidity and perinatal morbidity. Hyperuricemia is a common finding in preeclamptic pregnancies. The elevation of uric acid in preeclamtic women often precedes hypertension and proteinuria, the clinical manifestations used to diagnose the disorder. The aim of this study is estimation of serum uric acid in preeclamptic patients. A case-control study was done in the Department of Biochemistry in collaboration with Deptt of Obstetrics & Gynaecology, Regional Institute Of Medical Sciences (RIMS), Impha(Manipur), India. Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in antenatal ward, Deptt of Obstretics and Gynaecology, RIMS hospital. The blood samples were collected from these patients and analysed for serum uric acid level. Results: The serum uric levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean±SD of uric acid was 8.82±1.68 mg% in cases compared to 4.06±0.96 mg% in the controls. Conclusion: Hyperuricemia can be used as biomarker for identifying women at risk of preeclampsia and its complications with adverse effects

scholarly journals Prevalence of hyperuricemia in Chitwan District of Nepal

1970 ◽  
Vol 6 (2) ◽  
pp. 18-23 ◽  
Author(s):  
S Kumar ◽  
AR Singh ◽  
R Takhelmayum ◽  
P Shrestha ◽  
JN Sinha
Keyword(s):  
Developing Countries ◽  
Uric Acid ◽  
Key Words ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Medical Sciences ◽  
Menopausal Women ◽  
Males And Females

The prevalence of hyperuricemia has been increasing in both developed and developing countries. The purpose of present study was to know the prevalence of hyperuricemia in the population of Chitwan district as well as to compare the prevalence of hyperuricemia between Mongolian and non-Mongolian races of Chitwan district, who had attended the College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal during the period of January 1999 to December 2003. In this study 3794 subjects were investigated for serum uric acid level (SUA). Hyperuricemia is defined as SUA more than 7mg/dl for males and menopausal women and 6mg/dl for pre-menopausal females. SUA was estimated by Caraway method in digital colorimeter. Overall prevalence was 21.42%; the condition was more common in men than women (26.78% vs. 16.82%; p<0.001). The prevalence was higher in Mongolian than non Mongolian both in males and females (24.50 % Vs 21.06%; p>0.05). Key words: Hyperuricemia; SUA; digital colorimeter DOI: 10.3126/jcmsn.v6i2.3612   Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 18-23

scholarly journals Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

2021 ◽  
Vol 19 (1) ◽  
pp. 50-54
Author(s):  
Aruna Sayami ◽  
Aatmaram Gupta ◽  
Narayan Gautam
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Acid Value ◽  
High Serum ◽  
Control Group ◽  
Control Study

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

scholarly journals Potential role of serum homocysteine and uric acid level as a predictive marker for pre-eclampsia

2019 ◽  
Vol 5 (5) ◽  
pp. 119
Author(s):  
Saroj Kunwar ◽  
Rajesh Kumar Thakur ◽  
Rupa Nepal ◽  
Lakshan Paudel ◽  
Bimal Chaulaigai ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Sensitivity And Specificity ◽  
Uric Acid Level ◽  
Acid Level ◽  
Homocysteine Level ◽  
Serum Uric Acid Level ◽  
Predictive Marker ◽  
Serum Homocysteine

<p class="abstract"><strong>Background:</strong> Hypertension is one of the common disorders during pregnancy and can cause severe health complications for both mother and developing fetus. Pre-eclampsia (PE) is a form of hypertensive disorder complicating pregnancy. This study was aimed to estimate serum uric acid and homocysteine level as a potential biomarker for prediction of preeclampsia.</p><p class="abstract"><strong>Methods:</strong> 85 pre-eclamptic pregnant women and 50 normotensive pregnant women were recruited from department of Obstetrics and Gynecology, Star Hospital after obtaining the informed written consent. Blood samples were collected and analyzed for serum homocysteine and serum uric acid level.  </p><p class="abstract"><strong>Results:</strong> Serum uric acid and homocysteine levels were found to be significantly higher in pre-eclamptic cases than in controls (6.5±0.7 mg/dl and 13.5±5.4 µmol/l in cases versus 4.3±0.8 mg/dl and 10.1±4.6 µmol/l in healthy controls). Maximum sensitivity and specificity of serum uric acid was obtained at a cut-off of 5.5 mg/dl (sensitivity- 91% and Specificity- 88%) and serum homocysteine at 10.7 µmol/l (sensitivity-67% and specificity-64%) respectively.</p><p class="abstract"><strong>Conclusions:</strong> At optimum cut off value serum uric acid showed highest sensitivity and specificity for diagnosis of pre-eclampsia. Thus, serum uric acid level is better predictive marker compared to serum homocysteine level for pre-eclampsia.</p>

scholarly journals Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women

2020 ◽  
Vol 4 (1) ◽  
pp. 20-22
Author(s):  
Hudda Abbas ◽  
Samina Badar ◽  
Zunera Javed ◽  
Mohammad Ahmed Abdelmoneam Ramdan
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Outpatient Department ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Third Trimester

Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p’ value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.

scholarly journals Association between Serum Uric Acid Levels and Perinatal Outcome in Women with Preeclampsia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Robinson Uchenna Ugwuanyi ◽  
Irozuruike Munachiso Chiege ◽  
Felix Eke Agwu ◽  
George Uchenna Eleje ◽  
Nonso Martin Ifediorah
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Perinatal Outcome ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Elevated Serum ◽  
Categorical Variables ◽  
Multiple Gestation

Objectives. To compare serum uric acid levels with disease severity and perinatal outcome among preeclamptic and normal pregnant women. Materials and Methods. This was a case-control study carried out in Federal Medical Centre, Umuahia, Nigeria. Consenting pregnant women were consecutively recruited into two groups comprising pregnant women diagnosed with preeclampsia and normotensive nonproteinuric pregnant women. Exclusion criteria included pregnant women who were current smokers, took alcohol, and diagnosed with multiple gestation, diabetes mellitus, or renal failure. Associations between categorical variables such as preeclampsia severity and perinatal outcomes were done using logistic regression while means of continuous variables such as serum uric acid were compared using Student’s t-test. Data were presented using odds ratios (ORs) with 95% confidence intervals (95% CI) and a statistical significance level set at P value ˂ 0.05. Data analysis was done using Statistical Package for Social Sciences version 22. Results. One hundred and two participants were finally analysed. Fifty-one participants were recruited in each arm. Women with preeclampsia had significantly high serum uric acid level versus controls (6.08 ± 0.49 mg/dL vs. 5.20 ± 0.19; P < 0.001 ). Women with elevated serum uric acid levels (˃6 mg/dL) were found to be 4 times more likely to have severe preeclampsia ( P = 0.022 , OR = 4.00, 95% CI = 1.225–13.056), 66 times more likely to have APGAR score ˂7 in the first minute ( P < 0.001 , OR = 66.00, 95% CI = 6.991–623.128), and 3 times more likely to have lower birth weight ( P = 0.038 , OR = 3.400, 95% CI = 1.073–10.775) than those with normal serum uric acid levels. Conclusions. The mean serum uric acid level in a preeclamptic is higher than that of normal pregnant control, and higher levels are associated with severity of the disease and significantly associated with poorer perinatal outcome.

scholarly journals Role of Serum Uric Acid as a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Soheila Manifar ◽  
Arezoo Rahimzamani ◽  
Mohammad Shirkhoda ◽  
Mohammad Nikkhah Ghamsari ◽  
Mahin Bakhshi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Case Control ◽  
Healthy Controls ◽  
Control Study

The antioxidant properties of uric acid may have a protective effect against the formation of oxygen radicals and subsequently against carcinogenicity. The present study aimed at evaluating the serum level of uric acid in patients with oral squamous cell carcinoma (OSCC) with different histopathological grades. In this descriptive-analytical, case-control study, patients with OSCC and healthy controls were selected and matched regarding age and gender. The serum samples were collected from patients (before radiotherapy and chemotherapy) and controls, and their serum uric acid levels were measured enzymatically. Data were analyzed using independent t-test and ANOVA at 0.05 level of significance. The mean serum uric acid level in OSCC patients (4.2±1.5 mg/dL) and healthy controls (4.38±1.22 mg/dL) was not significantly different (P=0.377). No significant association was noted between the histopathological grade of OSCC and mean serum uric acid (P=0.781). The serum uric acid level had a direct significant correlation with age in OSCC patients (P<0.001). The results of this study did not support the role of uric acid as a protective biomarker in OSCC. Further prospective studies are recommended to better elucidate the role of uric acid in the etiology of OSCC.

scholarly journals Alterations in serum uric acid values in a sample of Nigerian pregnant women.

2019 ◽  
Vol 6 (4) ◽  
pp. 111-114
Author(s):  
Chisom Clara Wagbara ◽  
Chizindu Akudubike Alikor
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Elevated Serum ◽  
First Trimester ◽  
Progressive Increase ◽  
Third Trimester ◽  
Mean Values ◽  
Renal Tubular

Introduction: Serum uric acid level is an important prognostic variable in pregnancy as subjects with preeclampsia have elevated serum uric acid levels. Methods: The concentrations of serum uric acid were investigated in 100 women of which 75 were pregnant women and categorized into 3 groups of 25 each, based on their trimesters of pregnancy and 25 non-pregnant women, which served as control. Results: In the first trimester, the mean values of uric acid were 122 μmol/L with a decrease in the levels of uric acid when compared with the control levels of 308 μmol/L (p<0.05). In the second trimester, the values of uric acid were 199umol/l with a significant (p<0.05) decrease in the levels of uric acid when compared with the controls. In the third trimester of pregnancy, the values of uric acid were 360 μmol/L. There was a significant (p<0.05) increase in the level of uric acid when compared with the controls. Conclusion: The progressive increase in the levels of uric acid through the trimesters of pregnancy suggests an impairment in uric acid excretion, may be with concomitant increase in renal tubular re-absorption of uric acid, thereby leading to hyperuricaemia.

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