scholarly journals Combination of isotretinoin and Contractubex Anti-Red in acne therapy

2021 ◽  
Vol 24 (3) ◽  
pp. 285-296
Author(s):  
Olga A. Katkhanova ◽  
Svetlana A. Grigoryants ◽  
Irina I. Glazko
Keyword(s):  
Clinical Symptoms ◽  
Acne Vulgaris ◽  
Scientific Data ◽  
Ease Of Use ◽  
Complete Relief ◽  
Severe Acne ◽  
Medical Interventions ◽  
Acne Scars ◽  
Acne Therapy ◽  
Good Cosmetic

BACKGROUND: Acne vulgaris (acne vulgaris) is an urgent interdisciplinary problem. Analyzing modern scientific data on the development of acne vulgaris, it is necessary to focus on the role of inflammation that accompanies dermatosis at all its stages of development, sometimes preceding the formation of clinical symptoms. Prolonged chronic recurrent course, difficulties in choosing the correct therapy tactics, sometimes unreasonable medical interventions, exacerbation, improper skin care lead to the formation of a number of complications. AIMS: To optimize and improve the effectiveness of therapy in patients with moderate and severe degrees acne using isotretinoin and the combined innovative gel Contractubex Anti-Red. MATERIALS AND METHODS: The study included 60 patients aged 18 to 45 years with moderate to severe acne. Isotretinoin was prescribed in standard dosages. To study the effect of Сontraktubex Anti-Red on the dynamics of post-acne, patients with atrophic post-acne scars were divided into 3 subgroups, depending on the regimen of drug use. RESULTS: Almost complete relief of the inflammatory process, regression of elements was noted 12 months after the use of complex therapy, the value of the dermanologic index of acne (DIA) index was more than 70% noted in 62% of patients, significant improvement in 38%. The severity of post-acne scars on the SCAR-S scale changed significantly during treatment and in 53.3% this indicator was 1. The Cadi index decreased by 70% compared to the baseline. CONCLUSION: Good cosmetic effect, safety, absence of side effects, comfort and ease of use make it possible to recommend Contractubex Anti-Red together with basic acne therapy.

Minocycline Topical Foam: A New Drug for the Treatment of Acne

2020 ◽  
Vol 55 (1) ◽  
pp. 105-110
Author(s):  
Erin St. Onge ◽  
W. Cary Mobley
Keyword(s):  
Bacterial Resistance ◽  
Data Extraction ◽  
Acne Vulgaris ◽  
Phase 1 ◽  
Systemic Exposure ◽  
Preclinical Study ◽  
Severe Acne ◽  
Assessment Scores ◽  
Acne Lesion ◽  
Acne Therapy

Objective: To review the safety and efficacy of minocycline 4% topical foam for the treatment of moderate to severe acne vulgaris in adults and pediatric patients aged 9 years and older. Data Sources: A literature search through PubMed and EMBASE was conducted using the following keywords: FMX101, minocycline, foam, and acne. Study Selection and Data Extraction: Articles selected included those describing preclinical and clinical studies of pharmacokinetics, efficacy, or safety of topical minocycline foam. Data Synthesis: Minocycline 4% topical foam was shown in a preclinical study to effectively deliver minocycline to the pilosebaceous unit, with little penetration beyond the stratum corneum. This was consistent with a phase 1 pharmacokinetic study of the foam, which yielded a significantly reduced systemic exposure of minocycline compared with oral minocycline. In phase 2 and phase 3 clinical trials, the foam significantly reduced acne lesion counts and Investigator’s Global Assessment scores of acne severity compared with placebo. The foam has a good safety profile, with headache, mild erythema, hyperpigmentation, and mild dryness among the most common adverse effects. Relevance to Patient Care and Clinical Practice: Topical antibiotics have been a mainstay of acne therapy with the benefit of less systemic exposure compared with oral antibiotics. However, the development of bacterial resistance has reduced their use, thereby reducing options for many patients with acne. Minocycline 4% topical foam is a safe and effective alternative, which may help restore this important therapeutic approach for treating acne vulgaris.

scholarly journals CLINICAL RESULTS OF COMPLEX THERAPY ОF PATIENTS WITH ACNE - RESIDENTS OF IODINE DEFICIENCY REGION

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu.P. Karvatska ◽  
O.I. Denysenko
Keyword(s):  
Iodine Deficiency ◽  
Conventional Treatment ◽  
Acne Vulgaris ◽  
Clinical Results ◽  
Complex Treatment ◽  
Immunological Parameters ◽  
Severe Acne ◽  
Complex Therapy ◽  
Acne Therapy

The аim of research – the clinical results of complex therapy in patients with acne vulgaris- residents of the iodine deficiency region should be determined and analyzed consideringthe state of their pituitary-thyroid system, intestinal microbiota and immunologicalparameters.Material and methods. The study involved 109 patients with moderate to severe acnevulgaris, who are the residents of Chernivtsi region - a region with natural iodinedeficiency. Examination of the patients revealed changes in the pituitary-thyroid system,immunological parameters and intestinal biocenosis, which corresponded to the severityof dermatosis. During treatment, patients were divided into 3 groups: I comparative - 36people who received conventional acne therapies and medicines to normalize thyroidhomeostasis; group II comparative - 36 patients who were additionally prescribedprobiotics, and ІІІ (main) - 37 persons who received complex treatment with the additionaladministration of probiotics and immunotropic drug. The effectiveness of treatment ofpatients was evaluated by their earliest and long-term clinical results using statisticalanalysis methods.Results. It has been established that complex therapy of patients with moderate and severeacne vulgaris - residents of the iodine deficiency region with the administration alongsidewith the conventional acne therapy of medicines that normalize detected changes in thepituitary-thyroid system, immunotropic drug glucosaminylmuramyl dipeptide (licopid))and probiotic (lacium) reliably reduces (p <0.01) in comparison with conventional acnetherapy or conventional acne therapy with additional probiotics administration the termsof regress of acute inflammatory elements of acne with the achievement of the state ofclinical remission of dermatosis, (respectively: by 1,54 and 1,41 times). The frequency ofexacerbations acne process of patients with moderate and severe acne vulgaris duringthe year were also reduced (respectively: 1.59 and 1.26 times) relatively to patients in thecomparison groups.Conclusion. The complex therapy of patients with moderate to severe acne - residentsof the iodine deficiency region with administration of medicines to normalize thyroidhomeostasis, immunotropic drug glucosaminylmuramyl dipeptide (licopid) and probiotic(lacium) reliable improves the earliest and long-term clinical results of their treatment incomparison with conventional treatment or treatment using only the probiotic additionalprescription.

scholarly journals Effect of Subcision and Microneedling in the Treatment of Atrophic Acne Scars in Ten Patients: A Case Series

2021 ◽  
Vol 19 (1) ◽  
pp. 74-80
Author(s):  
Megha Tandon
Keyword(s):  
Acne Vulgaris ◽  
Case Series ◽  
Severe Acne ◽  
Acne Scars ◽  
Grading Systems ◽  
Minimal Improvement ◽  
Acne Scarring ◽  
Good Improvement ◽  
Grade 3 ◽  
Facial Acne

Background: Acne vulgaris is a common condition with a prevalence of over 90% among adolescents and post- acne scarring is a well known sequelae. Different types of scars (ice pick, boxcar, and rolling scars) warrant a customized approach of treatment for each type. We propose a novel treatment of atrophic acne scars using combination of subcision and microneedling. Methods: Ten consecutive patients of skin types III - IV with moderate and severe facial acne scarring received three sequential subcision and microneedling treatments after informed consent over a period of three months with an interval of 4 weeks between each session. Goodman and Baron’s qualitative and quantitative acne scar grading systems along with side by side comparison of pre operative and post operative photographs were used for assessment at the end of three sessions of the combination procedure. Results: Estimation of improvement with Goodman and Baron’s Global qualitative acne scarring system , we found good results in patients with Grades 3 and 4 acne scars. Out of 7 patients with grade 4 scars, 29% showed improvement by 2 grades and 71% showed improvement by 1 grade and all the 3 patients with grade 3 scars showed improvement by 1 grade. Quantitative assessment showed 30% patients had minimal improvement, 50% had moderate improvement and 20% had good improvement in scars.  Adverse effects were transient pain, erythema and oedema. Conclusion: Subcision and microneedling are simple and inexpensive office procedures which in combination are well tolerated and are efficacious in treatment of moderate and severe acne scars.    

scholarly journals Study of the psychoemotional status of patients with medium and severe acne severity on the background of isotretinoin monotherapy (Sotret)

2020 ◽  
Vol 96 (6) ◽  
pp. 48-55
Author(s):  
Pavel E. Konnov ◽  
Antonina A. Arsenieva ◽  
Yuri A. Tokarev
Keyword(s):  
Quality Of Life ◽  
Social Impact ◽  
Clinical Effect ◽  
Acne Vulgaris ◽  
Life Assessment ◽  
Moderate Degree ◽  
Important Indicator ◽  
Severe Acne ◽  
Acne Therapy

Rationale. Acne vulgaris is a widespread chronic disease with no age, gender, or race restrictions. It does not pose a direct threat to the patient's life, but is reflected in his psycho-emotional status, which requires appropriate medical intervention. Purpose of the study. To study the psychoemotional status of patients aged 2224 years with moderate and severe acne and its changes during monotherapy with isotretinoin (Sotret). Methods. In an open, non-randomized study lasting 12 months, 310 students of the Samara State Medical University were included (52% healthy, 33% with mild acne, 13% with a moderate degree, 2% with a severe degree). All patients in the study before treatment and after 3, 6, 12 months were assessed the severity of the course using the dermatological index of acne (DIA); quality of life assessment using the Cardiff Acne Disability Index (CADI scale); assessment of the psychological and social impact of acne using the APSEA questionnaire. All patients received monotherapy using the drug Erase. The median and interquartile distance Me (Q3-Q1) were indicated as descriptive statistics. The Wilcoxon signed rank test was used to compare related groups. The comparison was carried out with 95% confidence. Results. An analysis of the assessment of the psychological and social status of patients with moderate and severe acne before treatment, 3, 6, 12 months after the start of treatment with isotretinoin (Erase) is presented. The study included 36 people (20 women and 16 men) aged 22 to 24 years with a disease duration from 1 to 10 years. The results of psychological testing at various intervals gave comparable data: all patients had a pronounced persistent level of social maladjustment. An important indicator of the effectiveness of acne therapy with isotretinoin is the frequency of cases of the formation of a persistent clinical effect from treatment, which is clearly expressed in the restoration of the psycho-emotional background of patients, improving the quality of life of patients. Conclusion. An important indicator of the effectiveness of acne therapy with Erase is the frequency of cases of the formation of a stable clinical effect of treatment, which is clearly expressed in the restoration of the psycho-emotional background of patients, improving the quality of life of patients. The treatment allowed us to change the psychoemotional background of our patients for the better, which increased their motivation to study, communication, and the desire for self-development.

scholarly journals Efficacy and outcome of Microneedling (Dermaroller) in post-acne scars

2021 ◽  
Vol 7 (3) ◽  
pp. 256-259
Author(s):  
Lalitha C ◽  
Leelavathy B ◽  
Shwetha S
Keyword(s):  
Therapeutic Option ◽  
Acne Vulgaris ◽  
Treatment Options ◽  
Cost Effective ◽  
Psychological Trauma ◽  
Acne Scar ◽  
Severe Acne ◽  
Delayed Treatment ◽  
Type Iv ◽  
Acne Scars

Acne vulgaris is a common dermatological disorder affecting teenagers and young adults with the consequence of scarring. As acne is considered as a normal occurrence and neglected or delayed treatment of severe acne lead to cosmetically disfiguring scarring leading to much psychological trauma to youngsters. Acne scarring can be atrophic or hypertrophic. There are multitude of treatment options for atrophic acne scars like dermabrasion, chemical peels and lasers. But these cosmetic procedures are have drawbacks like requiring fine skills and long downtime (dermabrasion), or expensive for most of the population(laser). Microneedling using dermaroller is an inexpensive safe therapeutic option for the Indian skin type with less complication. The aim of this study was to evaluate the efficacy of microneedling (dermaroller) in different types of atrophic acne scar and it’s complications.A descriptive study was performed using 30 patients with atrophic acne scar treated with microneedling for a period of two years. Details of duration, site, type and depth of acne scar along with skin types was recored. Patients were given dermaroller treatment for 4 session, each spaced at one month interval and results assessed at the end of each session and at end of six months. In this study, 30 patients with atrophic acne scars of grade 2 and 3 were treated with microneedling therapy and efficacy and complication of this therapy were evaluated. These patients had all three types of atrophic scars- rolling, ice- pick and boxcar, these 27 patients showed 50 % improvement in their scar score at the end of the study (6 months). Among above mentioned scar types, rolling and boxcar scar showed improvement by 47.42% and 65.40% respectively at the end of the study, whereas ice-pick scars showed no significant improvement. According to the modified acne scar scoring system, 55.6% of the patients had improvement in their scar scoring between 41 and 50% (good response) and 44.4 % had improvement of more than 50 % (very good response). All patients were satisfied with the outcome of the procedure.Microneedling is a safe, cost effective, innovative procedure in the treatment armamentarium of acne scars without major complications. This is found to be safe to use in Fitzpatrick type IV and V scars. However, further studies are necessary to validate these findings.

Maintenance acne therapy: prophylactic efficacy of fixed combination of adapalene and benzoyl peroxide

2020 ◽  
pp. 57-62
Author(s):  
L. S. Kruglova ◽  
N. V. Gryazeva
Keyword(s):  
Maintenance Therapy ◽  
Fixed Combination ◽  
Psychological Impact ◽  
Supportive Therapy ◽  
Prophylactic Efficacy ◽  
Severe Acne ◽  
Topical Retinoids ◽  
Acne Therapy ◽  
Group 2 ◽  
Treatment Observation

Acne is a chronic disease and even reliable therapies do not completely ensure absence of relapses. Acne relapses have a negative psychological impact on patients, as they feel unable to control the disease and achieve complete and long-lasting recovery. Supportive therapy is necessary to prolong the remission of acne achieved with initial successful treatment and to minimize the risk of relapse. According to the literature sources, the most justified as a maintenance therapy is the use of topical retinoids, which have been shown to be effective in the prevention of exacerbations of acne. In the present study 54 patients were involved who after the active therapy used a fixed combination of adapalene 0.1% / BPO 2.5% as maintenance treatment. Only 1 patient (2.9%) with moderate acne and 2 patients (5.8%) with severe acne had a relapse within 6 months of maintenance therapy. The absence of adverse events during the course of treatment was recorded, as well as high adherence of patients to the treatment. During the period of post-treatment observation (6 months after maintenance therapy), among the patients without exacerbations during maintenance therapy, a relapse occurred in 2 (7.1%) patients of group 1 (n = 28) and 2 (8.7%) patients of group 2 (n = 23). The obtained data indicates that maintenance therapy with Effezel® gel can extend the achieved effectiveness of the treatment and prevent the development of relapses.

Efficacy and safety of oral dapsone in acne vulgaris – experience of a tertiary care teaching hospital in central Lahore

2020 ◽  
Vol 14 (2) ◽  
pp. 87-90
Author(s):  
Sadaf Amin Chaudhry ◽  
Nadia Ali Zafar ◽  
Rabia Hayat ◽  
Ayesha Noreen ◽  
Gulnaz Ali ◽  
...  
Keyword(s):  
Side Effects ◽  
Therapeutic Option ◽  
Acne Vulgaris ◽  
Treatment Options ◽  
Tertiary Care ◽  
Poor Response ◽  
Global Assessment Scale ◽  
Severe Acne ◽  
Hematologic Profile

Background: Acne is the eighth most prevalent disease affecting 9.4% of the population worldwide and its prevalence in our country is estimated to be around 5%. Severe inflammatory acne is most likely to leave scars and in order to prevent facial disfigurement due to acne scarring, early treatment is desirable. Various treatment options have been formulated for acne, and are tailored according to the severity of the disease. Numerous clinical trials have been conducted till now, to determine the usefulness and side effect profile of such therapies, making acne treatment a highly studied area in dermatology. Objective of this study is to highlight the fact that oral Dapsone could be used as a cheaper alternate to isotretinoin in recalcitrant severe acne, especially in females where retinoids are sometimes contraindicated. Patients and methods: 51 patients, suffering from severe nodulocystic acne, fulfilling the criteria, were enrolled from the Department of Dermatology, Sir Ganga Ram Hospital, Lahore. All the study patients were given oral Dapsone 50mg for initial two weeks and then 100mg daily for the next 10 weeks along with oral cimetidine and topical clindamycin application twice daily. Investigator Global Assessment Scale (IGAS) was employed to measure effectiveness. The treatment was considered ʽeffectiveʹ if the patient achieves 2 or more than 2-grade improvement or almost clear or clear skin at the end of 12 weeks according to IGAS scale. The lesion counts were also done before the start of therapy (day 1) and at every two weeks follow up for 12 weeks. The change in lesion count observed between the baseline number and that seen at follow up visits was also used to evaluate the effectiveness of oral Dapsone. Safety was analyzed by fortnightly visits of the patients to look for any undesirable side effects and monitoring of the hematologic profile of the patients. Final follow up was done at the end of 16 weeks. Results: The study was conducted on 51 patients, with a ratio of 1:3 for males and females and a mean age of 25.2 years (SD ±5.81). At 12th week, patients had significant reduction in their acne lesions; with 7 patients (13.7%) showing completely clear skin, 17 patients (33.3%) had almost clear skin, 5 patients (9.8%) had 3-grade improvement. Twelve patients (23.5%) had 2-grade improvement from baseline score and only 2 patients (3.9%) had 1-grade improvement from baseline. Based on percentage reduction of lesions, excellent response was seen in 32 patients (62.7%), good response in 9 patients (17.6%), moderate response in 2 patients (3.9%), while no patient showed poor response. Dapsone was discontinued in 8 patients due to derangement of hematologic profile. Conclusion: Oral Dapsone, when given carefully, is a very effective therapeutic option in severe recalcitrant acne, with limited side effects.

The Keloid Intervention Benefit Inventory 21: A New Assessment Tool for the Quality of Life of Patients with Auricular Keloids

2021 ◽  
Author(s):  
Daniel Häussler ◽  
Stefanie Hüttemann ◽  
Christel Weiß ◽  
Nicole Karoline Rotter ◽  
Haneen Sadick
Keyword(s):  
Quality Of Life ◽  
Internal Consistency ◽  
Social Impact ◽  
Assessment Tool ◽  
Clinical Symptoms ◽  
Physical Symptoms ◽  
Medical Intervention ◽  
Medical Interventions ◽  
Before And After

Abstract Purpose The assessment of the quality of life (QoL) of patients with chronic diseases before and after medical interventions has gained increasing importance in recent decades. Particularly for patients with visible keloid scars in the head and neck region, standardized measurement tools are either absent or have been shown to be insufficient. The aim of the present study was to create a new standardized questionnaire that is specific to auricular keloid patients and reflects their clinical symptoms and QoL. Methods The Keloid Intervention Benefit Inventory 21 (KIBI-21) questionnaire was developed in two stages. First, a group of experts identified a pool of 26 questions and modified and supplemented the items through a comparison with existing QoL assessments so that they related to keloid-specific clinical symptoms and the QoL of patients with auricular keloids before and after a medical intervention. This questionnaire was distributed to 27 outpatients who had undergone medical interventions for visible auricular keloids. Second, a sequential statistical analysis was conducted. This included a single-item assessment and reduction, analysis for internal consistency, construct validity, and divergence validity as well as a factor analysis. The analyses were performed for the entire questionnaire and for the items in the subcategories General Health, Physical Symptoms, Self-Esteem, and Social Impact. Results The final version of this newly validated and standardized KIBI questionnaire consisted of 21 items, of which each item was assigned to only one subscale. The questionnaire showed a Cronbach's α of 0.84 with a good internal consistency. In the item correlation validity, strong associations were found in all subscales, except for the Social Impact Subscale. Conclusion The keloid-specific QoL questionnaire KIBI-21 proved to be a reliable and reproducible instrument to assess the QoL and clinical symptoms in patients suffering from auricular keloids before and after a medical treatment.

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