Features of adjusting the aggregate state of women’s blood with dysfunctional bleeding in reproductive age

The general coagulation blood potential, fibrinolytic activity of plasma, antiplasmin and plasmin potential activity, fibrinogen level in blood serum, antithrombin III activity, concentration of soluble fibrin-monomer complexes in the blood serum were estimated in women with anaemia of I degree on a background of the dysfunctional uterine bleeding. The changes of blood fibrinolytic potential have secondary nature, that is conditioned by activating the trombinogenesis and fibrinogenesis externally. The hypercoagulation develops by activating the hemopexis through the external mechanism of protrombinasa formation, which is accompanied by a decrease of anticoagulation potential and an increase of aggregation features of thrombocytes.

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Prevention of massive intraoperative bleedings associated with heparin with the systemic use of fibrin monomer in the experiment

ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» ◽

10.25557/0031-2991.2019.04.48-55 ◽

2019 ◽

pp. 48-55

Author(s):

А.П. Момот ◽

В.М. Вдовин ◽

Д.А. Орехов ◽

Н.А. Лычёва ◽

И.Г. Толстокоров ◽

...

Keyword(s):

Liver Injury ◽

Blood Loss ◽

Unfractionated Heparin ◽

Loss Rate ◽

Antithrombin Iii ◽

Fibrinogen Level ◽

Circulating Blood Volume ◽

Intraoperative Bleeding ◽

Fibrin Monomer ◽

Antithrombin Iii Activity

Цель исследования - изучение способности фибрин-мономера предупреждать тяжелую интраоперационную кровопотерю, ассоциированную с введением нефракционированного гепарина, при дозированной травме печени. Методика. На кроликах «Шиншилла» индуцировали гипокоагуляцию нефракционированным гепарином (150 ед/кг). Профилактику интраоперационных кровотечений осуществляли внутривенным введением фибрин-мономера (0,25 мг/кг) за 1 ч до травмы или протамина сульфата (1,5 мг/кг) за 10 мин до травмы. После нанесения стандартной травмы печени оценивали объем (в % ОЦК) и темп (мг/с) кровопотери. Анализировали число тромбоцитов, активированное парциальное тромбопластиновое время, протромбиновое и тромбиновое время свертывания, уровень фибриногена и активность антитромбина III, параметры ротационной тромбоэластометрии крови. Результаты. Объем кровопотери в группах животных после в/в введения фибрин-мономера и протамина сульфата на фоне гепаринизации был, соответственно, в 5,1 и 4,0 раза меньше по сравнению с группой плацебо, получавшей тот же антикоагулянт. Вместе с тем, фибрин-мономер не влиял на параметры коагулограммы (отсутствие видимого гемостазиологического эффекта) и тромбоэластограммы, тогда как применение протамина сульфата в качестве антидота гепарина сопровождалось нормализацией данных тромбоэластометрии и коррекцией гипокоагуляционного сдвига по активированному парциальному тромбопластиновому времени, протромбиновому и тромбиновому времени. Заключение. Установлено, что фибрин-мономер (0,25 мг/кг) снижает посттравматическое кровотечение в условиях блокады свертывания крови гепарином без видимых признаков восстановления гемостатического равновесия. The research objective was to study the ability of fibrin monomer to prevent severe intraoperative blood loss associated with administration of unfractionated heparin in controlled liver injury. Methods. Hypocoagulation was induced in chinchilla rabbits with unfractionated heparin (150 U/kg). Intraoperative bleeding was prevented by administration of fibrin monomer (FM, 0.25 mg/kg, i.v.) one hour prior to the injury and of protamine sulfate (PS, 1.5 mg/kg, i.v.) 10 min prior to the injury. Following the liver injury, blood loss was assessed as percentage of circulating blood volume and the blood loss rate (mg/s). Platelet counts, aPTT, PT, TT, fibrinogen level, antithrombin III activity, and parameters of blood rotation thromboelastometry were analyzed. Results. The volume of blood loss was 5.1 times and 4.0 times less, respectively, after the FM and PS administration during heparinization compared to the placebo group treated with the same anticoagulant. However, FM affected neither coagulogram indexes (no visible hemostasiological effect) nor thromboelastogram while the use of PS as an antidote for heparin was associated with normalization of thromboelastometric data and correction of hypercoagulative changes in aPTT, PT, TT. Conclusion. FM at a dose of 0.25 mg/kg reduced severity of posttraumatic bleeding induced by heparin inhibition of coagulation with no visible signs of hemostatic balance recovery.

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Hemostatic system parameters and level of magnesium in patients with beta-thalassemiа

Kazan medical journal ◽

10.17816/kmj2020-188 ◽

2020 ◽

Vol 101 (2) ◽

pp. 188-192

Author(s):

N R Aliyeva

Keyword(s):

Antithrombin Iii ◽

Fibrinogen Level ◽

Serum Magnesium ◽

Beta Thalassemia ◽

Control Group ◽

System Parameters ◽

Hemostatic System ◽

Thalassemia Minor ◽

Antithrombin Iii Activity ◽

D Dimer

Aim. To study the hemostatic system parameters and magnesium levels in patients with beta-thalassemia. Methods. The object of the study was the blood serum of 96 women with beta-thalassemia: 46 patients with intermediate beta-thalassemia and 50 patients with beta-thalassemia minor, without clinical manifestations of hypercoagulation. The blood serum of 30 healthy donors was used as the control group. It was studied hemostasis system parameters: platelet count activated partial thromboplastin time (aPTT), prothrombin time, plasma fibrinogen level, D-dimer level, euglobulin clot lysis time, antithrombin III activity. The serum magnesium level and risk of deficiency were determined using the MDQ questionnaire. Results. In patients with intermediate beta-thalassemia, an increase in the level of thrombinemia marker D-dimer (500 ng/ml) was revealed. Patients with intermediate beta-thalassemia were divided into two groups according to the revealed level of D-dimer: 14 (30.46.8%) patients with latent hypercoagulation in group 1 and 32 (69.66.8%) patients without latent hypercoagulation in group 2. It was found that in the group with a high levels D-dimer, fibrinogen level was increased (p 0.05), fibrinolysis time was prolonged (p 0.05), activated partial thromboplastin time was shortened (p 0.05), and antithrombin III activity was slightly reduced (p 0.05). The serum magnesium level in patients of the first group was lower (t=7.3; p 0.001), and the risk of deficiency in the questionnaire was higher than in patients of the second group (r=0.785, p 0.05). Hemostasis and magnesium levels in patients with beta-thalassemia minor did not differ from the control group (p 0.05). Conclusion. One-third of patients with intermediate beta-thalassemia have a pre-thrombotic state for hemostasis latent hypercoagulation and magnesium deficiency which can be predictors of clinical signs of thrombosis.

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DNA Length Polymorphism Present in the Antithrombin III Promoter Region Does not Influence Plasma Antithrombin III Activity Levels

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650280 ◽

1996 ◽

Vol 75 (02) ◽

pp. 376-377 ◽

Cited By ~ 2

Author(s):

René W L M Niessen ◽

Roy J Lamping ◽

Augueste Sturk ◽

Marjolein Peters

Keyword(s):

Length Polymorphism ◽

Promoter Region ◽

Antithrombin Iii ◽

Activity Levels ◽

Antithrombin Iii Activity

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On the Natural Blood Coagulation Inhibitor System Investigations of Inhibitor Factors Based on Antithrombin Deficient Blood

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654884 ◽

1965 ◽

Vol 14 (03/04) ◽

pp. 473-489 ◽

Cited By ~ 13

Author(s):

O Egeberg

Keyword(s):

Normal Level ◽

Antithrombin Iii ◽

Strong Support ◽

Blood Protein ◽

Coagulation Inhibitor ◽

Inhibitor System ◽

Normal Human ◽

Partial Deficiency ◽

Antithrombin Iii Activity ◽

Prothrombinase Activity

SummaryNatural coagulation inhibitor factors were studied in sera, or in fractions of sera, from patients with congenital partial deficiency of antithrombin and from normal persons. In the patients’ sera the progressive antithrombin (antithrombin III) and heparin cofactor (antithrombin II) had both been measured around 50 per cent of normal level.No decreased activity could be demonstrated in the patients’ sera as to antiprothrombinase, the inhibitor against blood intrinsic prothrombinase activity.For anticonvertin, the inhibitor against the tissue convertin complex, the activity was found decreased to about the same level as that demonstrated for antithrombin III and II. The results lend strong support to the hypothesis that the activities measured as anticonvertin, antithrombin III and antithrombin II represent functions of the same blood protein, which on the other side appears to be distinct from antiprothrombinase. In accordance with this explanation, an antithrombin III concentrate had also antithrombin II and anticonvertin activity, and further, adsorption of a normal human serum with convertin appeared to specifically reduce its antithrombin III activity.The inhibitor against activated antihemophilic C factor (AHC’ = activated f. XI) was studied in sera adsorbed with BaS04 and celite. The inhibitor activity was found at normal level in the patients’ sera, consistent with the view that anti-AHC’ is distinct from antithrombin III, II and from anticonvertin. No acceleration of the anti-AHC’ activity could be demonstrated after addition to the inhibition mixture of weak solutions of heparin.The results are discussed.

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The Prevalence of Hereditary Antithrombin-III Deficiency in Patients with a History of Venous Thromboembolism

Thrombosis and Haemostasis ◽

10.1055/s-0038-1660123 ◽

1985 ◽

Vol 54 (04) ◽

pp. 744-745 ◽

Cited By ~ 29

Author(s):

R Vikydal ◽

C Korninger ◽

P A Kyrle ◽

H Niessner ◽

I Pabinger ◽

...

Keyword(s):

Venous Thrombosis ◽

Antithrombin Iii ◽

Positive Family History ◽

Normal Range ◽

The Family ◽

History Of ◽

Antithrombin Iii Deficiency ◽

Recurrent Venous Thrombosis ◽

Antithrombin Iii Activity ◽

Slight Deficiency

SummaryAntithrombin-III activity was determined in 752 patients with a history of venous thrombosis and/or pulmonary embolism. 54 patients (7.18%) had an antithrombin-III activity below the normal range. Among these were 13 patients (1.73%) with proven hereditary deficiency. 14 patients were judged to have probable hereditary antithrombin-III deficiency, because they had a positive family history, but antithrombin-III deficiency could not be verified in other members of the family. In the 27 remaining patients (most of them with only slight deficiency) hereditary antithrombin-III deficiency was unlikely. The prevalence of hereditary antithrombin-III deficiency was higher in patients with recurrent venous thrombosis.

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Induced hyperglycemia alters antithrombin III activity but not its plasma concentration in healthy normal subjects

Diabetes ◽

10.2337/diabetes.36.3.320 ◽

1987 ◽

Vol 36 (3) ◽

pp. 320-323 ◽

Cited By ~ 5

Author(s):

A. Ceriello ◽

D. Giugliano ◽

A. Quatraro ◽

G. Consoli ◽

A. Stante ◽

...

Keyword(s):

Plasma Concentration ◽

Antithrombin Iii ◽

Normal Subjects ◽

Antithrombin Iii Activity

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High-Dose Conjugated Estrogens do not Reduce Antithrombin III Activity in Tall Girls

Hormone and Metabolic Research ◽

10.1055/s-2007-1018741 ◽

1983 ◽

Vol 15 (08) ◽

pp. 412-412 ◽

Cited By ~ 2

Author(s):

W. v. Petrykowski ◽

Barbara Schmidt

Keyword(s):

Antithrombin Iii ◽

High Dose ◽

Conjugated Estrogens ◽

Tall Girls ◽

Antithrombin Iii Activity

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First day dynamic changes in antithrombin III activity after supplementation have a predictive value in critically ill patients

American Journal of Hematology ◽

10.1002/ajh.20696 ◽

2006 ◽

Vol 81 (12) ◽

pp. 907-914 ◽

Cited By ~ 16

Author(s):

Satoshi Gando ◽

Atsushi Sawamura ◽

Mineji Hayakawa ◽

Hirokatsu Hoshino ◽

Nobuhiko Kubota ◽

...

Keyword(s):

Critically Ill ◽

Critically Ill Patients ◽

Predictive Value ◽

Antithrombin Iii ◽

Dynamic Changes ◽

Antithrombin Iii Activity

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Transcervical resection of endometrium as a conservative management of dysfunctional uterine bleeding in premenopausal patients

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20194600 ◽

2019 ◽

Vol 8 (11) ◽

pp. 4208

Author(s):

Girish A. Pote ◽

Namita Nandkumar Raut

Keyword(s):

Uterine Bleeding ◽

Reproductive Age ◽

Response To Treatment ◽

P Value ◽

Uterine Perforation ◽

Efficacy Rate ◽

Age Group ◽

Dysfunctional Uterine Bleeding ◽

Bleeding Score ◽

Transcervical Resection

Background: Dysfunctional uterine bleeding (DUB) affects 10% to 15% women of reproductive age group. A prospective observational study was performed to study the efficacy, rate of satisfaction and adverse effects of Transcervical resection of endometrium (TCRE) in the treatment of DUB in premenopausal women.Methods: 30 patients with DUB attending the hospital underwent TCRE and patients were followed up after 6 week, 3 months, 6 months up to 1 year and there bleeding score was calculated. Their response to treatment, complications and satisfaction rate were studied.Results: 43.3% of the women in this study were in the age group of 40-44 years. Post TCRE, 43.33% (n=13) had hypomenorrhea. 33.33% (n=10) had regular cycle, 13.33% (n=4) women had amenorrhea and 10% (n=3) had no response and underwent hysterectomy. 86.66% (n=26) women were satisfied with the treatment whereas 13.33% (n=4) were not satisfied. One patient had uterine perforation and serosal bowel injury due to extended cautery injury. Bleeding reduced considerably and a statistically significant (paired t-test, p-value <0.05) difference was observed in pre and post procedure (6 weeks, 3 months, 6 months and 1 year) bleeding scores.Conclusions: Considering advantages like shorter operative time, uterine conservation and early mobility TCRE is a procedure of choice in patients in whom hysterectomy is either technically difficult or medically contraindicated or in those who are not suitable for long term medical management.

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