Features of atopic reactivity in children with bronchial asthma

Bronchial asthma is a chronic disease characterized by reversible airway obstruction with clinical manifestations of recurrent wheezing episodes, airway inflammation, and their hyperreactivity. Timely diagnosis of bronchial asthma in early childhood will allow adequate prescribing therapy and controlled management of patients, which in the future will reduce the risk of serious complications and improve the quality of life of patients.The aim of the study – to identify the influencing factors on the manifestations of atopic reactivity in children with bronchial asthma, depending on the content of IgE specific to house dust antigens in the blood serum, in order to optimize the management of the disease.Material and methods. A comprehensive clinical and paraclinical examination of 79 school-age children with atopic bronchial asthma was carried out in the Regional Children's Clinical Hospital and the City Children's Polyclinic in Chernivtsi. According to the concentration of specific IgE to the house dust allergen, the patients were divided into two clinical groups. The first (I) clinical group included 55 children in whom the concentration of these antibodies in the blood exceeded 3.5 kU / l, the second group (II) consisted of 24 patients in which the level of specific IgE was below this value. According to the main clinical signs, the comparison groups were compared.Results. It was found that the proportion of patients in the first group who had contact with tobacco smoking of their parents was higher than in the comparison group. Constant contact with tobacco smoke, when both parents have this bad habit in the family, increases the likelihood of developing hypersensitivity to house dust in children with asthma by almost 9 times. At the same time, bronchial asthma was more often combined with atopic dermatitis in these patients, while low concentration of specific IgE to house dust was associated with comorbidity of asthma with allergic rhinitis. The risk of moderate to severe bronchial asthma in patients with low IgE levels increases significantly. The probability of developing the phenotypes of late-onset asthma and exercise-induced asthma in children with low concentrations of specific IgE to house dust increases by 3 and 2 times, respectively. The number of schoolchildren with an extremely high concentration of IgE (more than 100 kU/l) to D. Pteronyssinus antigens was twice as high as in the comparison group, and every second patient also had very high levels of antibodies to D. Farinae tick.Conclusion. Children with atopic hypersensitivity to house dust allergens have an increased chance of comorbid bronchial asthma and atopic dermatitis, late-onset asthma and physical exertion, asthma is much more severe, which must be taken into account when personalizing specific therapy.

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Clinic al and immunologic al characteristic ofinfants with atopic dermatitis

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja790 ◽

2011 ◽

Vol 8 (5) ◽

pp. 31-36

Author(s):

Natal'ya Aleksandrovna Ivanova ◽

G A Kuz'mina ◽

L T Kochish ◽

N N Begaeva ◽

N M Afanas'eva ◽

...

Keyword(s):

Atopic Dermatitis ◽

House Dust ◽

Clinical Manifestations ◽

Milk Proteins ◽

Goat Milk ◽

Specific Ige ◽

Cow Milk ◽

Enzyme Analysis ◽

Group I ◽

Chicken Eggs

Background. The research is focused on the particularities of formation and course of atopic dermatitis in infancy depending on the range of sensitization and class of revealed antibodies. Methods. The article presents the results of clinical and immunological observation of 116 children aged from 1 month to 3 years with the clinical-anamnestic signs of atopic dermatitis. The immunological observation consisted of the following stages: determination of concentration of the general IgE, quantitative testing of concentrations of the serum IgE and IgG4 antibodies to allergens of cow and goat milk, chicken eggs and wheat, house dust and through the immune-enzyme analysis. Results and discussion. According to the results of the immunological observation the patients were divided into 3 groups: I - IgE+IgG4 - positive, II - IgG4 - positive, III - absence of above-mentioned classes of antibodies. The patients of group I are characterized by the early sensitization to cow milk proteins, the manifestation of the disease up to 3 months appears on pure breast feeding. The detection of the specific IgE antibodies to allergens of chicken eggs is a sign of danger of the development of sensitization towards inhalation house dust allergens and of the formation of respiratory allergy. For the children of group II the later age of manifestation of skin process (in more than half of children after introduction of milk food) and easier course of disease are significant. Anamnesis of the disease and the clinical manifestations of one third of patients of group III in the absence of the evidence of IgE-sensitization coincides with that of the patients of group I (age of manifestation, severity of disease). In accordance with received results, we can suggest that in this group there are patients with the unidentified immunopathological mechanism of formation of the disease. Conclusion. The immunological observation of infants by the detection of the specific IgE and IgG4 antibodies to widespread food allergens allows to reveal the peculiarities of immune response which in their turn define the clinical-anamnestic signs of atopic dermatitis.

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ETIOPATHOGENETIC FEATURES OF ATOPIC DERMATITIS IN PRESCHOOL CHILDREN

Russian Journal of Skin and Venereal Diseases ◽

10.18821/1560-9588-2017-20-6-347-351 ◽

2017 ◽

Vol 20 (6) ◽

pp. 347-351

Author(s):

Khusan Kh. Akhrorov ◽

D. D Nabieva

Keyword(s):

Atopic Dermatitis ◽

Preschool Children ◽

Severe Disease ◽

Clinical Signs ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Specific Ige ◽

Preschool Age ◽

Food Factor ◽

Co Morbidity

Objective. To determine the most important etiopathogenetic factors of formation, with their subsequent influence on the severity of atopic dermatitis (AD) in preschool children. Material and methods. 58 children aged 2 to 5 years with AD were examined. Clinical examination of patients, a general analysis of blood and urine, koproovocystoscopy, the determination of specific IgE (to food, household, epidermal, pollen allergens) by ELISA, examination of feces for dysbiosis were performed. Assessment of clinical manifestations of AD was carried out on the bases of the SCORAD system (1997). Results. The obtained data indicated that in the severe course of the disease the first clinical signs of AD were observed already in early childhood (up to a year). Hereditary burden for allergic diseases was determined on average 74.1%, but with moderate and severe pollen sensitization was recorded - in 46.6%, epidermal - in 13.8% of patients. Factors contributing to AD aggravation in pre-school children are the food factor (72.4%), contact with plant dust (43.1%) and stressful situations (17.2%). In patients with severe disease the rates of these factors were higher from 9 to 35%. The highest incidence of co-morbidity noted among children with severe AD was 2 times higher in patients with moderate severity. Conclusion. The AD severity in children of preschool age depends directly on the simultaneous presence of several major etiopathogenetic factors. In particular, the presence of food (72.47%) and pollen (54.5%) sensitization of the organism against the background of hereditary burden on allergic diseases (90.9%) leads to disease complication, which is 9% to 35% higher than in patients with moderate to mild severity.

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EARLY SENSITIZATION TO HOUSE DUST MITE IS A MAJOR RISK FACTOR FOR SUBSEQUENT DEVELOPMENT OF BRONCHIAL ASTHMA IN JAPANESE INFANTS WITH ATOPIC DERMATITIS: RESULTS OF A 4-YEAR FOLLOW-UP STUDY

PEDIATRICS ◽

10.1542/peds.112.s2.479b ◽

2003 ◽

Vol 112 (Supplement_2) ◽

pp. 479-480

Author(s):

Helen Skolnick

Keyword(s):

Atopic Dermatitis ◽

Risk Factor ◽

Bronchial Asthma ◽

House Dust ◽

House Dust Mite ◽

Subsequent Development ◽

Follow Up Study ◽

Dust Mite ◽

Japanese Infants

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House dust mite sensitisation and association with atopic dermatitis in Brunei

Clinical and Translational Allergy ◽

10.1186/s13601-019-0304-5 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Haziq Emran ◽

Christina Siew Eng Chieng ◽

Surita Taib ◽

Anne Catherine Cunningham

Keyword(s):

Atopic Dermatitis ◽

House Dust ◽

House Dust Mite ◽

Retrospective Cohort ◽

Specific Ige ◽

Dermatophagoides Pteronyssinus ◽

Food Allergens ◽

Dust Mite ◽

Storage Mite ◽

Tropical Areas

AbstractIgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (Dermatophagoides pteronyssinus, D.farinae, Blomia tropicalis) were highest in this population and correlated with atopic dermatitis (p < 0.001). Shrimp and peanut were the most common food allergens. A dominance of house/storage mite sensitization is seen in Brunei which is consistent with other tropical countries.

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Prevalence and severity of allergic rhinitis in house dust mite-allergic patients with bronchial asthma or atopic dermatitis

Clinical & Experimental Allergy ◽

10.1046/j.1365-2745.2002.01461.x ◽

2002 ◽

Vol 32 (8) ◽

pp. 1160-1165 ◽

Cited By ~ 38

Author(s):

I. Terreehorst ◽

A. J. Oosting ◽

Z. Tempels-Pavlica ◽

J. G. R. De Monchy ◽

C. A. F. M. Bruijnzeel-Koomen ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

House Dust ◽

House Dust Mite ◽

Dust Mite

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The clinical efficacy of prophylactic therapy of the bronchial asthma in children with an early and late onset of the disease

Bukovinian Medical Herald ◽

10.24061/2413-0737.xvii.1.65.2013.26 ◽

2013 ◽

Vol 17 (1 (65)) ◽

pp. 106-109

Author(s):

S. I. Sazhyn

Keyword(s):

Bronchial Asthma ◽

Clinical Efficacy ◽

Early Onset ◽

Odds Ratio ◽

Late Onset ◽

School Age Children ◽

Prophylactic Therapy ◽

School Age ◽

Asthma In Children ◽

Basic Treatment

The results of the clinical efficacy of basic treatment of school-age children with bronchial asthma have been presented. It has been found that patients with an early-onset phenotype of asthma had a higher risk of not gaining control over the symptoms of the disease (odds ratio – 6,0) and exacerbations (odds ratio – 2,7) compared with children whose disease set in after six years.

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Reactions of eosinophilic granulocytes in the sputum and peripheral blood of children suffering from bronchial asthma with signs of eosinophilic and non-eosinophilic inflammation of the bronchi

Regulatory Mechanisms in Biosystems ◽

10.15421/021703 ◽

2017 ◽

Vol 8 (1) ◽

pp. 15-18

Author(s):

O. K. Koloskova ◽

T. M. Bilous ◽

M. V. Dikal ◽

U. V. Lomakina ◽

T. G. Kopchuk ◽

...

Keyword(s):

Bronchial Asthma ◽

Peripheral Blood ◽

Comparison Group ◽

Absolute Risk ◽

Eosinophil Cationic Protein ◽

Clinical Group ◽

Group I ◽

Bronchial Inflammation ◽

Number Of Patients ◽

Eosinophil Granulocytes

The aim of research was to improve the management of bronchial asthma in children by examining the peculiarities and diagnostic value of reaction markers of eosinophil granulocytes in the sputum and peripheral blood of patients with signs of eosinophil and non-eosinophil phenotypes of this disease. A cohort of 118 school-age children suffering from BA was examined during a period free from attacks. Group I (the main group ) included 61 schoolchildren with signs of eosinophil phenotype (EP) of asthma detected by the character of bronchial inflammation with eosinophil granulocytes present in the sputum at a level of >3%, group II (the comparison group) included 57 patients with a lower number of eosinophils in the sputum (non-eosinophil phenotype (NP) of BA). The average index of the relative content of eosinophils in the peripheral blood among the representatives of group I was 5.82 ± 0.63%, and in children with the signs of NPBA – 6.02 ± 0.74% (P > 0.05), and average indices in the groups of absolute eosinophil number in the blood were 0.37 ± 0.04 and 0.41 ± 0.05 respectively (P > 0.05). The negative reserve of NBT eosinophils in the sputum as a test to verify EPBA showed the following diagnostic values: specificity – 83.3%, predicted value of a positive result – 95.6%. IL-5 content in the blood serum of children with EPBA was 5.99 ± 1.74 ng/ml, in patients of group ІІ – only 1.99 ± 0.49 ng/ml (P < 0.05). Eosinophil cationic protein (ЕСР) in the sputum of patients of group I reached 2.72 ± 0.35 ng/ml, and in the comparison group – only 1.74 ± 0.34 ng/ml (P < 0.05), when the content of ECP in sputum was >1.0 ng/ml the risk of EPBA showed a statistically significant increase: OR = 4.13, RR = 2.02, and AR – 0.34. The efficacy of the standardized basic anti-inflammatory therapy in patients of clinical group I was higher as compared to the children with the signs of NPBA, which was illustrated by the reduced risk of inadequate control of the disease: the index of absolute risk decrease was 31.7%, relative risk – 57.1% with necessary minimal number of patients – 1.75.

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Clinical manifestations of atopy in children up to two years of age

Vojnosanitetski pregled ◽

10.2298/vsp1108690i ◽

2011 ◽

Vol 68 (8) ◽

pp. 690-695 ◽

Cited By ~ 1

Author(s):

Nevenka Ilic ◽

Vesna Velickovic ◽

Dragoljub Djokic ◽

Nebojsa Rankovic ◽

Gordana Kostic ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Developed Countries ◽

Specific Ige ◽

Food Allergies ◽

Atopic Diseases ◽

Ige Antibodies ◽

Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

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