scholarly journals Reactions of eosinophilic granulocytes in the sputum and peripheral blood of children suffering from bronchial asthma with signs of eosinophilic and non-eosinophilic inflammation of the bronchi

2017 ◽  
Vol 8 (1) ◽  
pp. 15-18
Author(s):  
O. K. Koloskova ◽  
T. M. Bilous ◽  
M. V. Dikal ◽  
U. V. Lomakina ◽  
T. G. Kopchuk ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Peripheral Blood ◽  
Comparison Group ◽  
Absolute Risk ◽  
Eosinophil Cationic Protein ◽  
Clinical Group ◽  
Group I ◽  
Bronchial Inflammation ◽  
Number Of Patients ◽  
Eosinophil Granulocytes

The aim of research was to improve the management of bronchial asthma in children by examining the peculiarities and diagnostic value of reaction markers of eosinophil granulocytes in the sputum and peripheral blood of patients with signs of eosinophil and non-eosinophil phenotypes of this disease. A cohort of 118 school-age children suffering from BA was examined during a period free from attacks. Group I (the main group ) included 61 schoolchildren with signs of eosinophil phenotype (EP) of asthma detected by the character of bronchial inflammation with eosinophil granulocytes present in the sputum at a level of >3%, group II (the comparison group) included 57 patients with a lower number of eosinophils in the sputum (non-eosinophil phenotype (NP) of BA). The average index of the relative content of eosinophils in the peripheral blood among the representatives of group I was 5.82 ± 0.63%, and in children with the signs of NPBA – 6.02 ± 0.74% (P > 0.05), and average indices in the groups of absolute eosinophil number in the blood were 0.37 ± 0.04 and 0.41 ± 0.05 respectively (P > 0.05). The negative reserve of NBT eosinophils in the sputum as a test to verify EPBA showed the following diagnostic values: specificity – 83.3%, predicted value of a positive result – 95.6%. IL-5 content in the blood serum of children with EPBA was 5.99 ± 1.74 ng/ml, in patients of group ІІ – only 1.99 ± 0.49 ng/ml (P < 0.05). Eosinophil cationic protein (ЕСР) in the sputum of patients of group I reached 2.72 ± 0.35 ng/ml, and in the comparison group – only 1.74 ± 0.34 ng/ml (P < 0.05), when the content of ECP in sputum was >1.0 ng/ml the risk of EPBA showed a statistically significant increase: OR = 4.13, RR = 2.02, and AR – 0.34. The efficacy of the standardized basic anti-inflammatory therapy in patients of clinical group I was higher as compared to the children with the signs of NPBA, which was illustrated by the reduced risk of inadequate control of the disease: the index of absolute risk decrease was 31.7%, relative risk – 57.1% with necessary minimal number of patients – 1.75. 

scholarly journals CLINICAL COURSE AND CONTROL OF BRONCHIAL ASTHMA INDICATORS IN OVERWEIGHT SCHOOLCHILDREN

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
L.A. Ivanova ◽  
M.N. Haras ◽  
I.B. Horbatiuk ◽  
A.O. Shkilnyuk
Keyword(s):  
Body Weight ◽  
Bronchial Asthma ◽  
The Body ◽  
Excess Body Weight ◽  
Clinical Group ◽  
Overweight Children ◽  
Group I ◽  
Negative Effect ◽  
And Control ◽  
Bodymass Index

The aim of the study - to study the clinical features and indicators for asthma control inoverweight children to optimize treatment strategies.Material and methods. 200 schoolchildren with asthma who were treated in the pulmoallergy department of the Chernivtsi Regional Children's Clinical Hospital have beenexamined. 52 patients with excess body weight (body mass index was greater than 25,0)belonged to group I, and children with body weight corresponding to the age norm (bodymass index from 18,0 to 24,9) were included into clinical group II under observation.Results. It has been found that the average number of points according to the ASTquestionnaire in patients of group I reached 14,0 ± 1,33 points, and in the comparisongroup – 16,3 ± 0,54 points (p˃0,05). At the same time, the share of patients withuncontrolled course of the disease among the overweight children reached 61,5% incomparison to 48,3% in the comparison group (p˃0,05).Indices of the risk of uncontrolled asthma (the sum of AST test scores <16) in childrenwith overweight have shown the following results: odds ratio = 1,6 (95% CI: 0,29-8,59),relative risk = 1,4 95% CI: 1,00-2,08) and attributive risk = 6,8%. Before treatment theindex of AKDNFG - 2,4 dinitrophenylhydrazones (AKDNFG) of the main character in thegroup of excess body weight children was 60,8 mmol /g of protein, and in group of normalbody weight children – 59,6 ± 9 mmol /g of protein. After the course of basic therapy,these indices gave next results – 47,2 ± 4,18 mmol/g of protein in group I and 4,3 ± 0,29mmol /g of protein (p> 0,05) in group II.Conclusions. Bronchial asthma in overweight children is more likely to debut at an earlyage and characterized by a persistent course. Predisposition to the body overweight inpatients with bronchial asthma has a negative effect on the indices of the disease controlachievement, although it is accompanied by an evidence decrease of the inflammatoryprocess of the respiratory tract in the course of treatment.

scholarly journals BIOMARKERS OF INFLAMMATION AT BRONCHIAL ASTHMA IN CHILDREN WITH ALTERNATIVE DEBUT OF THE DISEASE

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
O.K. Koloskova ◽  
Т.М. Bilous ◽  
О.P. Korotun ◽  
F.V. Herman ◽  
V.V. Bilous ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Process ◽  
Community Acquired Pneumonia ◽  
Clinical Group ◽  
Group Iii ◽  
The Third ◽  
Group I ◽  
Comparison Groups ◽  
Discrete Nature ◽  
Personalized Approach

Objectives - to analyze the activity of the inflammatory process in the airways of childrenwith bronchial asthma depending on different onset of the disease.Material and methods. Keeping to the principles of bioethics a comprehensiveretrospective examination of 319 children suffering from BA was performed. In 257children (clinical group I) bronchial asthma developed against a background of chronicobstructive bronchitis. The second clinical group included 43 children, in whom asthmadebuted after community-acquired pneumonia. The third (III) clinical group consistedof 19 children in whom asthma was first verified after inpatient treatment for asthmaticstatus.Results. According to the severity of bronchial asthma, it was found that the representativesof the III clinical group, compared with other patients, significantly more often had a severecourse of the disease. For patients of the I clinical group in the debut it is characterizedby increased eosinophils and decreased neutrophil counts in sputum, for patients ofgroup II - increased eosinophils and epitheliocytes, but a decrease in lymphocytes, andfor children of clinical group III - low eosinophils sputum with a simultaneous increasein neutrophils. In particular, a statistically significant increase in the content of VEGF,a decrease in the content of cationic proteins, MMP-9, and interleukins-6, and -13 inthe sputum indicates the predominance of neoangiogenesis in children of clinical groupIII. Instead, in the representatives of the II clinical group the remodeling processes weremainly caused by the inflammatory process with the release of intracellular eosinophiliccationic proteins.Conclusion. These data indicate the discrete nature of the type and severity of theinflammatory process of the respiratory tract in the dynamics of observation in childrenof clinical comparison groups, which suggests the presence of certain phenotypicdifferences due to the alternative onset of the disease, which in its turn was determinedby different triggers. Such deviations of the inflammatory process indicate that patientswith asthma require a personalized approach to differentiated diagnostic monitoring andtargeted anti-inflammatory treatment, taking into account the peculiarities of the onsetof the disease.

scholarly journals Efficiency of bronchial asthma control in children of school age depending on the features of the disease debut

2021 ◽  
Vol 25 (1(97)) ◽  
pp. 54-62
Author(s):  
O. Koloskova ◽  
T. Bilous ◽  
N. Shevchenko ◽  
G. Bilyk
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Status Asthmaticus ◽  
Chronic Obstructive ◽  
Clinical Group ◽  
Chronic Obstructive Bronchitis ◽  
Group I ◽  
Asthma In Children ◽  
Anti Inflammatory ◽  
Basic Treatment

Objective. To assess the effectiveness of achieving and maintaining control of bronchial asthma in children during dynamic observation, depending on the characteristics of the onset of the disease. Material and methods. In order to study the peculiarities of the course and controllability of bronchial asthma in children, depending on the alternative onset of the disease, 319 children were comprehensively examined by the "experience-control" method in parallel groups using a simple random sample on the basis of the Regional Children's Clinical Hospital in Chernivtsi. In 257 patients (I clinical group), bronchial asthma developed on the background of chronic obstructive bronchitis, the II clinical group included 43 children in whom BA debuted after suffering community-acquired pneumonia, and the third (III) clinical group was formed by 19 children in whom BA was verified after inpatient treatment for status asthmaticus. Research results. It was shown that the representatives of the III clinical group, compared with other patients, probably more often had the phenotype of early asthma and severe disease, and the ratio of the chances of severe asthma in the future for these children compared with the cohort of group I was 6.8. According to the results of self-assessment of asthma control on standardized questionnaires GINA and AST, as well as using a clinical-instrumental assessment scale, it was found that the level of disease control in all groups was insufficient, and the distribution of children in clinical groups in group III relative to other patients with partially controlled and uncontrolled asthma predominated. The conducted standard anti-inflammatory basic treatment allowed to achieve certain positive changes in patients of clinical observation groups, and the representatives of the III clinical group required more active basic anti-inflammatory therapy, in particular, the volume of the 1st step in GINA compared to patients of the I group was prescribed twice less often, and the 4th - 6.9 times more often. Conclusion. Patients with the onset of bronchial asthma in the form of status asthmaticus further retain a worse level of control over the disease as compared to patients with chronic obstructive bronchitis or pneumonia in history. This cohort of patients requires a larger volume of basic treatment, as well as a personalized approach to prescribing therapy with the obligatory consideration of the characteristics of asthma onset.

scholarly journals DIAGNOSTIC SIGNIFICANCE OF CLINICAL AND LABORATORY INDICES IN VERIFICATION OF ACUTE NON-STREPTOCOCCAL TONSYLOPHARYNGITIS IN CHILDREN

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
L.A. Ivanova ◽  
I.B. Horbatiuk ◽  
Ir.B. Horbatiuk ◽  
I.V. Balaniuk ◽  
A.O. Shkilnyuk
Keyword(s):  
Odds Ratio ◽  
Absolute Risk ◽  
Posterior Pharyngeal Wall ◽  
Diagnostic Value ◽  
Clinical Group ◽  
Blood Leukocytes ◽  
Diagnostic Significance ◽  
Pharyngeal Wall ◽  
Clinical Scales ◽  
Group I

The aim of the study - to study the diagnostic significance of clinical and laboratoryparameters in the verification of acute non-streptococcal tonsillopharyngitis in childrenin order to determine rational treatment tactics.Material and methods. To achieve this aim, two clinical groups were formed. The first (I,main) group consisted of 66 patients with acute tonsillopharyngitis of non-streptococcaletiology, as evidenced by the negative result of bacterial examination of the lavage ofthe pharynx and posterior pharyngeal wall. The second (II) clinical group included 32children diagnosed with "streptococcal acute tonsillopharyngitis".Results. The total score on the McIsaac scale, which did not exceed 2 points, wasregistered in 15.2 ± 4.4% of group I patients and 6.2 ± 4.2% of patients in the comparisongroup. The sensitivity of the method was 15.2%, specificity – 93.7%, positive and negativepredicted value – 83.3% and 34.8%, respectively, with odds ratio – 2.6 [95% CI: 0.5-13,0]. The average content of leukocytes in the blood less than 8.9 × 109/l was registeredin 57.6% of patients of group I and 48.8% of representatives of the second (P˃0.05). Thesensitivity of this laboratory test in the detection of non-streptococcal tonsillopharyngitiswas 57.6%, specificity – 55.6%, predicted value of a positive result – 54.1%, predictedvalue of a negative result – 59.1%. The relative risk of non-streptococcal etiology of ATPwhen registering a patient with less than 8.9 × 109/l of peripheral blood leukocytes was1.7 (95% CI 0.9-2.9), the absolute risk – 0.1 with odds ratio of 1.7 (95% CI 0.9-2.9).Conclusions. The proposed clinical scales and some paraclinical parameters haveinsufficient diagnostic value, so they cannot be used independently for early verificationof non-streptococcal etiology of tonsillopharyngitis in children.

The interaction of human peripheral blood eosinophils with bacterial lipopolysaccharide is CD14 dependent

Blood ◽  
2001 ◽  
Vol 97 (1) ◽  
pp. 235-241 ◽  
Author(s):  
Sabine G. Plötz ◽  
Arnd Lentschat ◽  
Heidrun Behrendt ◽  
Werner Plötz ◽  
Lutz Hamann ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Lipid A ◽  
Human Peripheral Blood ◽  
Eosinophil Cationic Protein ◽  
Bacterial Lipopolysaccharide ◽  
Dependent Manner ◽  
Tnf Α ◽  
Eosinophil Granulocytes ◽  
Blood Eosinophils ◽  
Dose Dependent

Abstract Bacterial lipopolysaccharide (LPS, endotoxin) is a ubiquitous component of dust and air pollution and is suspected to contribute after inhalation to an activation of eosinophils in bronchial tissues of asthmatic patients, provoking inflammatory and allergic processes. We were therefore interested in the interaction of eosinophil granulocytes with LPS and have examined the activation of and uptake to human peripheral blood eosinophils by LPS. Eosinophils were stimulated by LPS and the endotoxic component lipid A and the release of tumor necrosis factor alpha (TNF-α) and of the eosinophil-specific granule protein eosinophil cationic protein (ECP) was estimated. The results show induction of TNF-α and ECP-release by LPS and lipid A in a dose-dependent manner. Anti-CD14 monoclonal antibody (moAb) (clone MEM-18) and the synthetic lipid A partial structure 406 blocked the release of TNF-α and ECP by LPS-stimulated eosinophils. Studies with radioactively labeled LPS showed dose-dependent uptake of3H-LPS to eosinophils. The 3H-LPS uptake was found to be specific because preincubation with unlabeled LPS, compound 406 and also anti-CD14 antibodies inhibited uptake of3H-LPS to eosinophil granulocytes. By flow cytometry using anti-CD14 moAb and by reverse transcriptase-polymerase chain reaction (RT-PCR) technique, CD14 expression was detectable. Furthermore, messenger RNA (mRNA) expression of Toll-like receptors (TLR) 2 and TLR 4 was detected, indicating the presence of these CD14 coreceptors. The results indicate that eosinophils can take up LPS and can be stimulated by LPS in a CD14-dependent manner. Hence, in addition to allergens, eosinophils interact with endotoxin, a process that possibly exacerbates ongoing inflammatory and allergic processes.

scholarly journals Kariological indicators of buccal epitelia in newborns under sepsis, which parents have constantly lived in the conditions of various ecological conditions

2020 ◽  
Vol 19 (1) ◽  
pp. 13-19
Author(s):  
O. V. Vlasova
Keyword(s):  
High Risk ◽  
Neonatal Sepsis ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Low Risk ◽  
Clinical Group ◽  
Average Risk ◽  
Buccal Epithelium ◽  
Group I

The generally accepted and accessible method of cytogenetic assessment of the mutagenic effect of factors of various nature is the micronucleus test. Now this test is one of the non-invasive methods of population survey, which are influenced by environmental pollution. Objective: to establish the characteristics of karyological indicators of buccal epithelium in children of patients with neonatal sepsis, whose parents constantly lived in different environmental conditions. Material and methods. To study this goal, a comprehensive examination of 260 newborns who underwent neonatal sepsis in 2015-2018 was carried out. A suggested feature of a comprehensive assessment of the long-term load on the body of parents of newborns of anthropogenic pollution of air, water and soil in the regions of the region was the proposed environmental risk coefficient (CER) taking into account the environmental situation in the regional centers. So, the first clinical group (the main one) included patients with neonatal sepsis, whose parents constantly lived for months with a CER of 2,0 or more and with an unfavorable ecological characterization of the regional center. The second group (comparisons) was formed by newborns with sepsis, whose parents lived permanently in areas with a low risk of adverse effects of these environmental factors on their bodies (CER<2,0). A micronuclear test of exfoliative buccal epithelium in patients with neonatal sepsis was performed and evaluated in the immunological laboratory of the Department of Pediatrics and Pediatric Infectious Diseases of the Bukovynian State Medical University according to the method of V.N. Kalaev. Results and its discussion. In the main group, children with a high risk of cytogenetic disorders significantly prevailed with a slight decrease in the quota of patients with low risk. So, in group I with a low risk of cytogenetic disorders there were 42,1 % of cases, with an average risk of 5,3 %, and with a high risk of 52,7 % of cases. In the comparison group, respectively, with a low risk of cytogenetic disorders there were 54,5 %, (P>0,05) cases, with an average risk of – 12,1 %, (P>0,05), and with a high risk of – 33,3 %, (P=0,05) cases. Conclusions. As a result of the karyological test of exfoliate buccal epithelium, it can be noted that in newborns of the main group, compared with children of the comparison group, cytogenetic disturbances and, in some cases, violation of cell kinetics in the form of proliferation and apoptosis were significantly more often detected. The accumulation index of cytogenetic disorders was also significantly higher in group I patients due to the predominance of patients with a high risk of cytogenetic disorders in them

scholarly journals Gambaran Jumlah Eosinofil Darah Tepi Penderita Asma Bronkial di Bangsal Paru RSUP Dr. M. Djamil Padang

2013 ◽  
Vol 2 (3) ◽  
pp. 122
Author(s):  
Demas Nico M Manurung ◽  
Ellyza Nasrul ◽  
Irvan Medison
Keyword(s):  
Bronchial Asthma ◽  
Peripheral Blood ◽  
Basic Protein ◽  
Eosinophil Cationic Protein ◽  
Asthma Patient ◽  
Blood Eosinophil ◽  
Major Basic Protein ◽  
Cationic Protein ◽  
Peripheral Blood Eosinophil ◽  
Bronchial Asthma Patient

AbstrakAsma merupakan penyakit gangguan inflamasi kronis saluran pernapasan dengan banyak sel serta elemen seluler yang berperan. Asma dihubungkan dengan hiperresponsif bronkus, keterbatasan aliran udara dan gejala pernapasan yang bersifat reversibel. Salah satu sel yang diketahui berperan besar dalam patogenesis asma adalah eosinofil. Eosinofil melepaskan berbagai mediator seperti Major Basic Protein, Eosinophil Cationic Protein, peroksidase eosinofil, leukotrien C4, serta Platelet-Activating Faktor yang akan merusak epitel saluran napas serta menyebabkan peradangan. Penelitian ini dilaksanakan pada bulan Januari sampai Desember 2012 di Bagian Rekam Medik RSUP Dr. M. Djamil Padang dengan tujuan untuk melihat gambaran jumlah eosinofil darah tepi pada penderita asma bronkial yang dirawat inap. Penelitian yang dilakukan bersifat deskriptif dengan tinjauan retrospektif. Penelitian dilakukan dengan melihat data rekam medis penderita asma bronkial yang dirawat inap di Bangsal Paru RSUP Dr. M. Djamil Padang periode Januari 2010-Desember 2012. Dalam periode dua tahun tersebut, diperoleh 18 sampel yang digunakan pada penelitian ini. Hasil yang diperoleh ialah 4 penderita memiliki jumlah eosinofil darah tepi normal (40-400/mm3) (22,22%) dan 14 penderita memiliki jumlah eosinofil darah tepi dibawah normal (<40/mm3) (77,78%). Tidak ditemukan penderita asma dengan eosinofilia (>400/mm3). Jumlah eosinofil darah tepi pada penderita asma bronkial lebih banyak dibawah normal.Kata kunci: Asma Bronkial, EosinofilAbstractAsthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Asthma is associated with hyperresponsif bronchi, airflow limitation, and respiratory symptomps that are reversible. One of cells which is known to play a major role in asthma pathogenesis is eosinophil. Eosinophil release a variety of mediators such as Major Basic Protein, Eosinophil Cationic Protein, Eosinophil Peroxidase, Leukotriene C4, and Platelet Activating Factor that will damage airway epithelium and cause inflammation. The research was conducted in January 2012 through December 2012 at Medical Records Department of RSUP Dr. M. Djamil Padang aiming to see the overview of peripheral blood eosinophil number in patient with bronchial asthma who are hospitalized. The research conducted is using descriptive retrospective review. The study is done by looking medical record data of bronchial asthma patient hospitalized in pulmonary ward of RSUP Dr. M. Djamil Padang in the period of January 2010-December 2012. In the two year period, there are 18 patients which are used in the study. The results are 4 patients had normal peripheral blood eosinophil number (40-400/mm3)(22,22%), 14 patients had low peripheral blood eosinophil number (<40/mm3)(77,78%). There is no patient with eosinophilia (>400/mm3). Peripheral blood eosinophil number in bronchial asthma patient is mostly low.Keywords: Bronchial Asthma, Eosinophil

scholarly journals Features of atopic reactivity in children with bronchial asthma

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 71-76
Author(s):  
H. Myslytska ◽  
O. Koloskova ◽  
U. Marusyk ◽  
O. Stavnichuk
Keyword(s):  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
House Dust ◽  
Comparison Group ◽  
Late Onset ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Specific Ige ◽  
School Age Children ◽  
Clinical Group

Bronchial asthma is a chronic disease characterized by reversible airway obstruction with clinical manifestations of recurrent wheezing episodes, airway inflammation, and their hyperreactivity. Timely diagnosis of bronchial asthma in early childhood will allow adequate prescribing therapy and controlled management of patients, which in the future will reduce the risk of serious complications and improve the quality of life of patients.The aim of the study – to identify the influencing factors on the manifestations of atopic reactivity in children with bronchial asthma, depending on the content of IgE specific to house dust antigens in the blood serum, in order to optimize the management of the disease.Material and methods. A comprehensive clinical and paraclinical examination of 79 school-age children with atopic bronchial asthma was carried out in the Regional Children's Clinical Hospital and the City Children's Polyclinic in Chernivtsi. According to the concentration of specific IgE to the house dust allergen, the patients were divided into two clinical groups. The first (I) clinical group included 55 children in whom the concentration of these antibodies in the blood exceeded 3.5 kU / l, the second group (II) consisted of 24 patients in which the level of specific IgE was below this value. According to the main clinical signs, the comparison groups were compared.Results. It was found that the proportion of patients in the first group who had contact with tobacco smoking of their parents was higher than in the comparison group. Constant contact with tobacco smoke, when both parents have this bad habit in the family, increases the likelihood of developing hypersensitivity to house dust in children with asthma by almost 9 times. At the same time, bronchial asthma was more often combined with atopic dermatitis in these patients, while low concentration of specific IgE to house dust was associated with comorbidity of asthma with allergic rhinitis. The risk of moderate to severe bronchial asthma in patients with low IgE levels increases significantly. The probability of developing the phenotypes of late-onset asthma and exercise-induced asthma in children with low concentrations of specific IgE to house dust increases by 3 and 2 times, respectively. The number of schoolchildren with an extremely high concentration of IgE (more than 100 kU/l) to D. Pteronyssinus antigens was twice as high as in the comparison group, and every second patient also had very high levels of antibodies to D. Farinae tick.Conclusion. Children with atopic hypersensitivity to house dust allergens have an increased chance of comorbid bronchial asthma and atopic dermatitis, late-onset asthma and physical exertion, asthma is much more severe, which must be taken into account when personalizing specific therapy.

scholarly journals A double blind, randomized, placebo controlled, phase IV, proof-of-concept, comparative study to evaluate the efficacy and safety of Swasawin asthaloc tablets when given as add-on therapy in patients suffering from mild to moderate persistent bronchial asthma

2017 ◽  
Vol 5 (11) ◽  
pp. 4929
Author(s):  
Shilpa P. Karande ◽  
Renuka P. Munshi ◽  
Dipti A. Kumbhar
Keyword(s):  
Symptom Score ◽  
Bronchial Asthma ◽  
Asthma Symptom ◽  
Holding Time ◽  
Breath Holding ◽  
Inflammatory Disorder ◽  
Group I ◽  
Bronchial Inflammation ◽  
Asthma Symptom Score ◽  
Persistent Bronchial Asthma

Background: Asthma, known as “Tamaka Shwasa” in Ayurveda, as a chronic inflammatory disorder of the airways associated with increased airway hyper-responsiveness, recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night/early morning. The key component to improving control and preventing attacks is the avoidance of triggers. Swasawin Asthaloc tablet, a polyherbal proprietary medication, is claimed to be effective in asthma. The Objective of the study was to evaluate the safety and efficacy of Swasawin Asthaloc tablets when given as add-on therapy to patients suffering from mild to moderate persistent bronchial asthma.Methods: The study was initiated after receiving Institutional Ethics Committee approval. Patients suffering from mild-to-moderate persistent bronchial asthma were randomized to 2 study groups after written informed consent process for 6 months. Group I received the study medication Swasawin Asthaloc tablet (1 tablet twice daily) in addition to regular anti-asthmatic medications (inhaler ± oral medications). Group II received Placebo tablets in a similar dose as add-on therapy. The study efficacy parameters included spirometry, breath holding time (BHT), Asthma symptom score and Ayurvedic Asthma symptom score.Results: 60 patients were enrolled in the study, of which 50 patients completed the study. In case of spirometry, both FEV1 and PEFR values showed statistically significant improvement at the end of 6 months therapy. Significant improvement in the Breath Holding Time (BHT), Ayurvedic Asthma symptom score and Asthma symptom score was observed in the active group as compared to the baseline (p <0.001).Conclusions: Add-on therapy with Swasawin Asthaloc tablets helped in reducing bronchial inflammation and improving asthmatic symptoms by virtue of its anti-inflammatory, bronchodilatory and antihistaminic properties. Hence it can be used as add-on therapy in patients with mild-to-moderate persistent bronchial asthma and may decrease the need for rescue medications especially steroids.

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