RECOMBINANT TUBERCULOSIS ALLERGEN: 10 YEARS OF EXPERIENCE WITH THE TEST IN CHILDREN AND ADOLESCENTS IN THE RUSSIAN FEDERATION (META-ANALYSIS DATA)

2020 ◽  
Vol 99 (3) ◽  
pp. 121-129
Author(s):  
D.A. Kudlay ◽  
◽  
A.A. Starshinova ◽  
I.F. Dovgalyuk ◽  
◽  
...  
2021 ◽  
Vol 14 (4) ◽  
pp. 45-59
Author(s):  
I. A. Zvonova ◽  
M. I. Balonov

A review of methods for assessing doses in the thyroid gland, predictions of the long-term consequences of its irradiation and the actual incidence of thyroid cancer in residents of four regions of the Russian Federation with the most significant radioactive fallout after the Chernobyl accident are presented. The method for assessing doses in the thyroid gland is based on the results of monitoring in May-June 1986 of radioiodine in the environment, food and in the body of residents. Thyroid doses in the population were used to justify medical and social protection measures, as well as epidemiological studies. In addition, the authorities needed forecasts of the possible morbidity of the population in order to organize adequate medical care. Most of the thyroid cancer cases were predicted among the adult population, which was not confirmed by observations 35 years after the accident. The prognosis of the incidence of thyroid cancer in preschool children differed in different studies due to the use of different coefficients of reducing the biological effectiveness of 131I radiation in the thyroid gland and long-term external and internal irradiation of the whole body with a low dose rate compared to the effect of acute exposure. The increase in the incidence of thyroid cancer among children began five years after the accident at the Chernobyl nuclear power plant. Examples of the dynamics of the incidence for children in the Bryansk region of the Russian Federation are given. The 2018 UNSCEAR Report showed that for 1986-2015, among children and adolescents under 18 years of age on the day of the accident in Belarus, Ukraine and four regions of Russia, more than 19 thousand thyroid cancer cases were detected, of which the share of radiation-induced diseases was estimated at 25%. For four regions of Russia, this amounts to 460 cases with a range of possible estimates from 130 to 900 cases. The highest morbidity was manifested among younger children exposed at the age of 0-4 years. In older children and adolescents, the proportion of radiation-induced diseases has significantly decreased 30 years after the accident. In general, early forecasts of radiation-induced thyroid cancer incidence in children in four regions of the Russian Federation with high levels of radioactive fallout are consistent with the data of subsequent 30-year epidemiological observations within an order of magnitude. With regard to thyroid cancer in adults, such a comparison is difficult, since no radiogenic increase in the incidence has been detected.


2020 ◽  
pp. 113-129
Author(s):  
Nikolay GAGIEV ◽  
◽  
Lyudmila GONCHARENKO ◽  
Sergey SYBACHIN ◽  
Anna SHESTAKOVA ◽  
...  

In 2021, the Russian Federation will assume the chairmanship of the Arctic Council. This fact confirms the special attention of the country’s leadership to the unique geostrategic region. In December 2020, President of the Russian Federation Vladimir Putin, at an online meeting with volunteers and finalists of the contest “Volunteer of Russia”, noted that Russia would grow with the Arctic and the territories of the North. Many Russian citizens’ lives and the state’s success in the international arena depend on this territory’s development. One of the most important mechanisms for achieving the stated goals is national projects (NP), which should make a significant contribution to the development of the country’s territory. The purpose of the study is to assess NP in the subjects that are entirely related to the Arctic zone: Murmansk region, Nenets Autonomous okrug (NAO), Yamalo-Nenets Autonomous okrug (YANAO), and Chukotka Autonomous okrug (CHAO). In the course of the work, general scientific research methods were applied: comparative analysis, data comparison, induction, deduction, etc. The study results showed that, despite all the differences in economic and geographical position, financial condition, population, and regional development priorities, all Arctic regions have similar problems that hinder the effective development of territories. Without solving the problems indicated in the work, it is impossible to expect a qualitative «breakthrough» and implement the NP’s goals.


2021 ◽  
Vol 244 ◽  
pp. 12027
Author(s):  
Elena Sergeevna Sergushina ◽  
Oleg Vladimirovich Kabanov ◽  
Valentina Alekseevna Bogatyrskaya

The article briefly describes the current state of orphans who are in social shelters. The article considers the legal and technological bases of the activities of such institutions in the Russian Federation in the field of restoring child-parent relations. An example is given of the activities of the GKUSO RM “Republican Social Shelter for children and adolescents “Nadezhda”” (Republic of Mordovia). The structure and activities of the shelter, goals, objectives, technologies and project activities are analyzed in detail.


2021 ◽  
Vol 66 (2) ◽  
pp. 421-437
Author(s):  
Vardan E. Bagdasaryan ◽  
◽  
Pavel P. Baldin ◽  
Sergey I. Resnyansky ◽  
◽  
...  

The purpose of this study is to reconstruct the historical representation of the highest state power in modern Russia (the level of the president) by examining the texts of the presidential messages to the Federal Assembly from 1994 to 2020. As a key research method, content analysis, both semantic and quantitative, was applied. Fragments of messages containing an appeal to events, phenomena, personalities of the past and the historical process as a whole have been examined. The quantitative analysis has revealed the number of usages of the word “history” and the total textual quantity of historical references in the messages. The thinkers of the past quoted by the Presidents associated with various ideological connotations have been considered as a special indicative position. The generalized content analysis data is accumulated in the table in the article, which has the potential for further independent use in studying the dynamics of power discourse in Russia. The results of the study enable to confirm the fact of the paradigm shift in the perception of history at the highest state level in Russia lying in the transition from the liberal version of the theory of modernization to a nationally conservative approach similar to the theory of civilizations. Three Presidents of the Russian Federation — B. N. Yeltsin, D. A. Medvedev and V. V. Putin — despite the coincidence of positions on several issues of interpreting the past, presented different visions of the historical process in the texts of the messages. The integration of the current policy into the general outline of history is characteristic of all the messages, which points to the preservation of the tradition of historiosophical perception of the state activity in the Russian Federation, in spite of different versions of historiosophy. The transformation of historical politics in Russia is an indicator of the ideological inversion of the Russian state as a whole, the transition from a liberal to a nationally conservative model. The attitude of the authorities to the history reveals the potential of using axiological vectors of the current policy as a means of reconstruction.


2020 ◽  
Vol 16 (30) ◽  
pp. 16-22
Author(s):  
I.V. Mayev ◽  
◽  
D.N. Andreyev ◽  
D.S. Bordin ◽  
Yu.A. Kucheryavy ◽  
...  

Purpose – the systematization of data on the resistance of Helicobacter pylori to clarithromycin in the Russian Federation. Material and methods. Necessary investigations were searched in the electronic databases MEDLINE/PubMed, EMBASE, Cochrane, and the Russian Science Citation Index (RSCI), published between January and September, 2020. The final analysis included original publications from periodically reviewed foreign and Russian publications, as well as dissertations that used validated H. pylori resistance assessment tests with detailed descriptive statistics that allow the resulting data to be included in the meta-analysis. Results. The final analysis included 16 studies (1227 isolates). The generalized indicator of H. pylori resistance to clarithromycin in the Russian Federation was 11.85% (95% confidence interval (CI) 7.315–17.302; I2 = 86.19%). When analyzing papers published over the past ten years, H. pylori resistance to clarithromycin was 10.39% (95% CI 7.103–14.219; I2 = 61.29%). In Moscow and the Moscow Region, the generalized indicator of H. pylori resistance to clarithromycin was 10.87% (95% CI 7,280–15,439; I2 = 50.57%), in St. Petersburg – 22.26% (95% CI 9,525–38,470; I2 = 84.75%), Smolensk – 5.74% (95% CI 3,511–8,789; I2 = 0.00%), Kazan – 10.0% (95% CI 5,023–17,355; I2 = 45.22%). Conclusion. The results show that the resistance of H. pylori to clarithromycin in Russia does not exceed the 15% threshold regulated by the Maastricht-V Consensus, which allows us to consider a triple regimen of anti-Helicobacter therapy with clarithromycin as a first-line therapy. At the same time, to achieve the maximum effect when using classical triple therapy and to level the risk of further progression of clarithromycin resistance of H. pylori in Russia, it is advisable to use methods of its optimization.


Sign in / Sign up

Export Citation Format

Share Document