scholarly journals Comparison of early forecasts of the incidence of thyroid cancer in residents of the Russian Federation after the Chernobyl accident with observational data

2021 ◽  
Vol 14 (4) ◽  
pp. 45-59
Author(s):  
I. A. Zvonova ◽  
M. I. Balonov

A review of methods for assessing doses in the thyroid gland, predictions of the long-term consequences of its irradiation and the actual incidence of thyroid cancer in residents of four regions of the Russian Federation with the most significant radioactive fallout after the Chernobyl accident are presented. The method for assessing doses in the thyroid gland is based on the results of monitoring in May-June 1986 of radioiodine in the environment, food and in the body of residents. Thyroid doses in the population were used to justify medical and social protection measures, as well as epidemiological studies. In addition, the authorities needed forecasts of the possible morbidity of the population in order to organize adequate medical care. Most of the thyroid cancer cases were predicted among the adult population, which was not confirmed by observations 35 years after the accident. The prognosis of the incidence of thyroid cancer in preschool children differed in different studies due to the use of different coefficients of reducing the biological effectiveness of 131I radiation in the thyroid gland and long-term external and internal irradiation of the whole body with a low dose rate compared to the effect of acute exposure. The increase in the incidence of thyroid cancer among children began five years after the accident at the Chernobyl nuclear power plant. Examples of the dynamics of the incidence for children in the Bryansk region of the Russian Federation are given. The 2018 UNSCEAR Report showed that for 1986-2015, among children and adolescents under 18 years of age on the day of the accident in Belarus, Ukraine and four regions of Russia, more than 19 thousand thyroid cancer cases were detected, of which the share of radiation-induced diseases was estimated at 25%. For four regions of Russia, this amounts to 460 cases with a range of possible estimates from 130 to 900 cases. The highest morbidity was manifested among younger children exposed at the age of 0-4 years. In older children and adolescents, the proportion of radiation-induced diseases has significantly decreased 30 years after the accident. In general, early forecasts of radiation-induced thyroid cancer incidence in children in four regions of the Russian Federation with high levels of radioactive fallout are consistent with the data of subsequent 30-year epidemiological observations within an order of magnitude. With regard to thyroid cancer in adults, such a comparison is difficult, since no radiogenic increase in the incidence has been detected.

Author(s):  
V.K. Ivanov ◽  
◽  
V.V. Kashcheev ◽  
S.Yu. Chekin ◽  
M.A. Maksioutov ◽  
...  

Some areas of the Russian Federation were contaminated with radionuclides released as a re-sult of the Chernobyl accident. The current paper clarifies some items of the previously published study based on NRER (National Radiation-Epidemiological Registry, the Registry) data. The pre-vious issue presented estimates of radiation risks of cancer incidence among the population of four the most contaminated regions of the Russian Federation: Bryansk, Kaluga, Oryol and Tula oblasts. Risks of thyroid cancer are estimated with account of screening effect. The cohort con-sisted of more than 327 thousand people resided in the contaminated areas. The average dose to the thyroid of children and adolescents was 0.174 Gy, the average dose to the thyroid of adults was 0.035 Gy. Thyroid cancer was diagnosed in 1549 members of the cohort during the follow-up period from 1991 over 2019, among them 423 cases were children and adolescents at the accident and 1126 cases were adults. Significant increase in thyroid cancer incidence was ob-served in adults exposed internally through the intake of iodine-131 at a young age. The statisti-cally significant radiation risk of thyroid cancer persists over 30 years after exposure. The risk de-creases with increasing the attained age. In people exposed to radiation before the age of 1 year and reaching the age of 20 years, the coefficient of excess relative risk of thyroid cancer (ERR/Gy) was 4.61. Radiation associated thyroid cancer is attributed to 20.6% of the cohort mem-bers exposed internally through the intake of radioiodine isotopes in their childhood and adoles-cence, and thyroid cancer from intake of radioiodine is attributed to 58% of cases exposed to ra-diation under 4 years of age. Marked screening effect (ES) was found during the disease diag-nosing, screening coefficient was 5.6 for children and 2.1 for adults. There were not attributed to radiation statistically significant risks of solid cancers, including radiation induced breast cancer in females, in the cohort of people resided in the areas contaminated with radionuclides. Radia-tion risk of leukemia was also not identified, although the average value of excess relative risk in men exceeded zero. Further observations of the cohort of persons resided in areas contaminated with radionuclides will increase the statistical power of radiation-epidemiological studies and clarify the assessment of radiation risks of human for chronic exposure at low doses.


2021 ◽  
Vol 66 (6) ◽  
pp. 5-9
Author(s):  
L. Il'in ◽  
V. Ivanov ◽  
I. Linge ◽  
V. Kashcheev ◽  
O. Kochetkov ◽  
...  

Purpose: In an article prepared on the basis of the conclusion of the Russian Scientific Commission on Radiological Protection (RSCRP) at the Department of Medical Sciences of the Russian Academy of Sciences "Assessment of the radiological consequences of the Chernobyl accident after 35 years according to the National Radiation and Epidemiological Register" (NRER), the main conclusions of the large-scale radiation-epidemiological studies carried out. Material and methods: The work uses information NRER – liquidators of the consequences of the Chernobyl accident and the Branch Register of FMBA of Russia – liquidators. When assessing the excess relative risk of malignant neoplasms, the EPICURE. Results: The current status of the National Radiation and Epidemiological Register, which is currently functioning within the framework of the Law of the Russian Federation of 30.12.2012 No. 329-FZ “On Amendments to Certain Legislative Acts of the Russian Federation in terms of ensuring that changes in the health status of certain categories of citizens are taken into account exposed to radiation". For the first time in an integral form, the article presents the medical radiological consequences of the accident at the Chernobyl nuclear power plant for the population of Russia. It was found that an increase in the incidence of thyroid cancer due to incorporated exposure to 131I was found in a cohort of children and adolescents (28 856 people) who received radiation doses of more than 200 mGy in 1986. There was no increase in the incidence of thyroid cancer among the adult population. Analysis of the incidence of solid cancers in the territories of the Bryansk, Kaluga, Tula and Oryol regions contaminated with radionuclides did not reveal an increase in the frequency of this pathology for children and adults. It is shown that in the cohort of liquidators of the Chernobyl accident, who received radiation doses of more than 150 mGy (35 303 people), an increase in the incidence of leukemia during the first 11 years after the accident at the Chernobyl nuclear power plant and solid cancers was revealed in comparison with the spontaneous level. Conclusions: The article points out serious limitations associated with a high degree of uncertainty in the received personal dosimetric data on liquidators in 1986–1987. and the need to use the total dose from all types of radiation (professional, emergency, medical, natural) to calculate the radiation risk. RSCRP emphasizes the high urgency of continuing work on reducing the uncertainty of dosimetry data and assessing the radiological consequences of the Chernobyl accident based on a comprehensive analysis of the NRER data.


Author(s):  
Sergey Pavlovich Romanenko ◽  
Irina Igorevna Novikova

Child health indicators in Russia indicate a negative trend for more than three decades. The formation of children’s health is determined by environmental factors, the level of development of the education system, a complex of socio-economic factors, and lifestyle. The study conducted a retrospective assessment of the incidence of children and adolescents with diseases etiologically related to the food factor in the Russian Federation as a whole and the subjects where cadet corps are located. Analysis of official data of the Ministry of health of the Russian Federation from 2011 to 2019 on the total incidence of food-related factors indicates an increase in the incidence of endocrine diseases, diabetes, and obesity in children aged 0–14 years. Children aged 15–17 years showed an increase in the average long-term indicator for diseases of the endocrine system, thyroid diseases, diabetes, obesity, and anemia. Ranking of subjects of the Volga Federal district based on the average long-term data of morbidity indicators, etiologically related to the food factor, made it possible to identify risk areas. According to the results of ranking 1 rank place was taken by the Republic of Tatarstan, the second — Bashkortostan, third place — the Chuvash Republic, fourth place — Perm Krai, fifth place — Udmurt Republic, sixth place — Nizhny Novgorod oblast. According to these diseases, the negative dynamics remains. In General, on the territory of the Volga Federal district, the incidence of children and adolescents corresponds to all-Russian trends, however, the situation is much worse for a number of diseases that are etiologically related to the food factor, namely, diseases of the endocrine system and obesity.


2020 ◽  
Vol 26 (6) ◽  
pp. 577-583
Author(s):  
L. A. Tuaeva ◽  
I. Z. Toguzova ◽  
S. K. Tokaeva

The presented study develops theoretical and methodological foundations for assessing the fiscal sustainability of the constituent entities of the Russian Federation in perspective.Aim. The study aims to develop a systems approach to assessing the fiscal sustainability of the constituent entities of the Russian Federation in the medium and long term.Tasks. The authors analyze the major approaches to assessing the fiscal sustainability of federal subjects and determine the significance of quantitative and qualitative assessment methods in the development of a methodology for assessing the fiscal sustainability of federal subjects in the medium and long term.Methods. This study uses scientific methods of cognition, analysis and synthesis, comparison and analogy, systems and institutional approaches to assess the fiscal sustainability of federal subjects.Results. The authors examine the major approaches to assessing the fiscal sustainability of federal subjects developed by Russian scientific schools and disciplines; approaches used by state and local authorities; approaches to assessing the fiscal sustainability of federal subjects used by international and national rating agencies; foreign experience. In general, this implies the development of a universal system of indicators for assessing the fiscal sustainability of federal subjects.Conclusions. It is substantiated that under the current conditions of new challenges, particularly in the context of the coronavirus pandemic, it is necessary to assess the long-term balance and sustainability of the budgets of federal subjects using a systems approach based on quantitative and qualitative methods, making allowance for the medium- and long-term prospects to make efficient management decisions at different levels of the economic system.


2021 ◽  
Author(s):  
Natalia Nikolaeva ◽  
Nikita Grinev ◽  
Pavel Barabanov ◽  
Elena Kulyuasova ◽  
Nikolay Kulyuasov

"The transition of Russia to sustainable economic growth is impossible without stimulating the use of the achievements of science and education, high technologies, promoting innovative activity as an essential premise for the development of social production and subjects of economic relations. For the state, the promotion of innovation is a priority in the economic policy sector, since it is the level of scientific and technological development that largely determines the long-term strategic advantages of the country, and the prospects for the development of the state largely dependent on the level of innovation development. For a long time, the Ministry of Economic Development of the Russian Federation has been implementing the Strategy for Innovative Development of the Russian Federation. It includes 20 key steps and is developed based on the provisions of the concept of long-term development of the Russian Federation. The main results should have been, firstly, an increase in spending on science and innovation, and secondly, an increase in the share of industrial enterprises that introduce innovations in production. It was assumed that their share will increase by 4-5 times by 2020, compared with 2010 year. Not everything has been achieved, and there is a lot to strive for. This study is devoted to the driver of scientific and technological progress - the chemical complex of Russia. The chemical complex plays a significant role in the implementation of the most important socio-economic programs of the country. The study is devoted to the consideration of the most important prospects and key alternatives for the development of the chemical industry related to different areas of innovation. Conclusions will be made on key technologies and products that can change the position of the chemical industry in the global market."


Lex Russica ◽  
2021 ◽  
Vol 74 (2) ◽  
pp. 64-79
Author(s):  
R. V. Tkachenko

The paper is devoted to the examination of issues related to the increasing importance of budgetary regulation for the proper functioning of a modern innovative society. The key role of the budgetary regulation in the financial process of the State is particularly acute in the context of systemic crises that include socio-economic consequences caused by the spread of a new coronavirus infection (COVID-19) in Russia. In the course of the study, the features of changes in the state financial policy caused by the above-mentioned crisis phenomena are highlighted. The paper describes various approaches to the interpretation of the budgetary regulation as a category of financial law, explores various types and legal forms of methods of the budgetary regulation, analyses mechanisms and the impact of the State on the budget system through the existing legal structure of the budgetary regulation. It is determined that the rules of financial law governing the whole complex of public relations concerning the distribution and redistribution of the national product between the levels of the budget system of the Russian Federation constitute the institution of financial law, namely: the budgetary regulation. The author concludes that the approach based on the concentration of basic powers in the financial field at the federal level significantly slows down the dynamics of development of economic activity in the majority of regions of Russia, while the need for breakthrough innovative development of Russian society determinates the expansion of long-term tax sources of income for regional budgets. In this regard, it is proposed to consolidate additional regulation for revenues gained by regional and local budgets in the form of targeted deductions from federal taxes on a long-term basis.


2015 ◽  
Author(s):  
Tatyana Mikhailovna Maleva ◽  
Elena M. Avraamova ◽  
E. Gurvich ◽  
Natalya Vasil'evna Zubarevich ◽  
Aleksandra Grigor'evna Polyakova

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