PRIMARY HYPOTHYROIDISM IN A HIGH-RISK NEUROBLASTOMA PATIENT AFTER 131I-MIBG THERAPY: A CLINICAL CASE REPORT AND LITERATURE REVIEW

2021 ◽  
Vol 100 (3) ◽  
pp. 258-266
Author(s):  
D.T. Utalieva ◽  
◽  
S.B. Babakhanova ◽  
E.Yu. Ilyina ◽  
N.A. Andreeva ◽  
...  
Keyword(s):  
Case Report ◽  
High Risk ◽  
Literature Review ◽  
Clinical Case ◽  
Molecular Genetic ◽  
High Risk Patient ◽  
Primary Hypothyroidism ◽  
High Dose ◽  
131I Mibg ◽  
Mibg Therapy

In recent decades, there has been marked progress in understanding the biology of the most common extracranial solid tumor of childhood – neuroblastoma (NB), which led to a significant improvement in treatment outcomes due to stratification of patients into risk groups, intensification of treatment of patients with metastatic disease and the presence of unfavorable molecular genetic markers. Survivors who have received multimodal therapies, including chemotherapy, high-dose therapy and autologous peripheral stem-cell transplantation, 131I-metaiodobenzylguanidine (131I-MIBG) therapy, radiation therapy, and immunotherapy have a high risk of developing long-term side effects of treatment (LT SE). The study of the nature and frequency of LT SE after completion of therapy in patients with NB is important to ensure the quality of life and minimize severe health disorders. This article presents a literature review and description of a clinical case report of primary hypothyroidism in a high-risk patient with NB who received multicomponent treatment, including 131I-metaiodobenzylguanidine therapy due to the persistence of MIBG-positive foci after the induction chemotherapy.

scholarly journals Therapeutic experience of an 89-year-old high-risk patient with incarcerated cholecystolithiasis: A case report and literature review

2020 ◽  
Vol 8 (20) ◽  
pp. 4908-4916
Author(s):  
Zong-Ming Zhang ◽  
Chong Zhang ◽  
Zhuo Liu ◽  
Li-Min Liu ◽  
Ming-Wen Zhu ◽  
...  
Keyword(s):  
Case Report ◽  
High Risk ◽  
Literature Review ◽  
High Risk Patient ◽  
Risk Patient ◽  
Therapeutic Experience

Myotonic dystrophy Rossolimo-Churchman-Steinert-Batten (clinical case)

2020 ◽  
pp. 71-72
Author(s):  
И.А. Синельникова ◽  
И.В. Сопрунова ◽  
О.П. Николаева
Keyword(s):  
Case Report ◽  
Myotonic Dystrophy ◽  
Clinical Case ◽  
Molecular Genetic ◽  
Ctg Repeats ◽  
Molecular Genetic Method ◽  
Genetic Method ◽  
Family Case ◽  
Dmpk Gene

В статье представлено описание семейного случая миотонической дистрофии Россолимо-Штейнерта-Куршмана-Баттена. Диагноз подтвержден в результате ДНК-диагностики: выявлено увеличенное число копий CTG-повтора гена DMPK, ответственного за развитие миотонической дистрофии. A family case report of Rossolimo-Steinert-Curschmann myotonic dystrophy is presented. An increased number of copies of CTG-repeats of the DMPK gene responsible for the development of MD, i.e., the diagnosis was confirmed by molecular genetic method.

scholarly journals Surgical treatment of Eagle’s Syndrome through intraoral access: a case report and literature review

2021 ◽  
Vol 1 (1) ◽  
pp. 15-21
Author(s):  
Rodrigo Cristhian Avelino Bezerra ◽  
Jonas Nogueira Ferreira Maciel Gusmão ◽  
Bruno Frota Amora Silva ◽  
Rodrigo Lemos Alves ◽  
Eliardo Silveira Santos ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Literature Review ◽  
Facial Pain ◽  
Clinical Case ◽  
Styloid Process ◽  
Eagle’S Syndrome ◽  
Intraoral Approach ◽  
Eagle Syndrome ◽  
Review Study

The styloid process is a bone projection that originates in the tympanic portion of the temporal bone. The enlongation of the styloid process, or the ossification of the styloid process, can originate a series of symptoms such as dysphagia, odynophagia, facial pain, otalgia, headache, tinnitus and trismus, establishing the clinical picture of Eagle Syndrome. In this report, we present an important clinical case of adult patient diagnosed with Eagle’s Syndrome who underwent surgery for reduction of the enlongated styloid process, by intraoral approach, added to a literature review study.

scholarly journals High-dose olanzapine in treatment resistant schizophrenia. A case report and literature review

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S115-S115
Author(s):  
Ciara Clarke ◽  
Clodagh Rushe ◽  
Fintan Byrne
Keyword(s):  
Case Report ◽  
Literature Review ◽  
The Body ◽  
Psychotic Symptoms ◽  
High Dose ◽  
Extensive Literature ◽  
Treatment Resistant ◽  
Persecutory Delusions ◽  
Full Resolution ◽  
One Year

ObjectiveWe report a case of a 58-year-old gentleman who was hospitalised intermittently for one year due to treatment resistant schizophrenia. Prior to hospitalisation he had been prescribed standard antipsychotics for decades without full resolution of positive psychotic symptoms. During his final admission lasting six months he was guarded, suspicious, irritable, constantly paced the corridor and displayed thought block and paranoid persecutory delusions. He would not enter the assessment room or allow any blood or ECG monitoring, however, he was compliant with oral medication. He was successfully treated with high dose olanzapine (40mg/day) and was discharged to the community. The aim of this study is to bring awareness and add to the body of evidence for the use of high-dose olanzapine in patients with treatment resistant schizophrenia in whom a trial of clozapine is not possible.Case reportThe patient gave written consent for this case report to be written and presented. An extensive literature review was performed and key papers were identified. Discussion focuses on the key areas in the literature.DiscussionThis case demonstrates that high-dose olanzapine can be used effectively as an alternative to clozapine in treatment resistant schizophrenia.ConclusionThis case highlights the need for further evaluation of high-dose olanzapine as an alternative to clozapine in patients with treatment-resistant schizophrenia.

High-dose adenosine for refractory supraventricular tachycardia: a case report and literature review

2016 ◽  
Vol 27 (5) ◽  
pp. 981-984 ◽  
Author(s):  
Gal Dadi ◽  
Daniel Fink ◽  
Giora Weiser
Keyword(s):  
Heart Failure ◽  
Case Report ◽  
Literature Review ◽  
Cardiogenic Shock ◽  
Sinus Rhythm ◽  
Supraventricular Tachycardia ◽  
Electrical Cardioversion ◽  
High Dose ◽  
Prompt Treatment ◽  
Unstable Patient

AbstractSupraventricular tachycardia is the most common significant arrhythmia in children. If prolonged, it may cause heart failure and progress to cardiogenic shock warranting prompt treatment. The recommended interventions following vagal manoeuvres are intravenous adenosine and in the unstable patient electrical cardioversion. We present an infant with an unstable supraventricular tachycardia that was resistant to electrical cardioversion and recommended doses of adenosine. He reverted to sinus rhythm with a higher dose of adenosine, suggesting that such doses may be required in refractory supraventricular tachycardia.

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