CLINICAL FEATURES OF THE COURSE OF COVID-19 IN HOSPITALIZED CHILDREN OF VARIOUS AGES

2021 ◽  
Vol 100 (6) ◽  
pp. 31-38
Author(s):  
S.V. Bychkova ◽  
◽  
G.B. Malgina ◽  
N.N. Plyusnina ◽  
E.V. Volhin ◽  
...  
Keyword(s):  
Child Care ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Controlled Study ◽  
Source Of Infection ◽  
Different Ages ◽  
Leukocyte Counts ◽  
And Gender ◽  
The Relationship ◽  
Research Institute

Despite the global prevalence of Coronavirus disease 2019 (COVID-19) and the study of the disease around the world, there are many questions about the clinical course, diagnosis and prevention of new infection. There is even less research on the course of COVID-19 infection in children than in adults. The variability of symptoms in children, their frequency, severity, and prognostic value are not well understood. In order to analyze the nature of the course of COVID-19 in children of different ages, a single-center prospective open continuous controlled study was carried out, which included patients under the age of 18 years, hospitalized for one month (May 2020) with COVID-19 infection at the Urals Scientific and Research Institute for Maternal and Child Care of the Ministry of Healthcare of Russian Federation (Yekaterinburg, Sverdlovsk Oblast, Russia). The study was approved by the local ethics committee. Materials and methods of research: on the basis of the Ural Scientific Research Institute for Maternal and Child Care, 107 children 0–17 years old with mild and moderate forms of COVID-19 infection were examined. More than 70% of admitted patients are infants and preschool children. Results and discussions: the intrafamilial focus became the main source of infection. The most frequent clinical manifestations on admission were cough, pyrexia, catarrhal symptoms; on the 5–6th day, the appearance of gastrointestinal syndrome in the form of diarrhea, nausea, vomiting was noted more often in children under 3 years of age. The asymptomatic course of COVID-19 infection was observed more often in schoolchildren (up to 67% of adolescents 13–17 years old). In patients under 1 year of age, asymptomatic course was noted much less frequently (37.5%). In children under 3 years of age, pneumonia was more often confirmed (up to 33%) and gastrointestinal syndrome in the form of diarrhea, nausea, vomiting (up to 50% of patients under 1 year of age). According to laboratory data, in children under 3 years old, a decrease in erythrocytes, hemoglobin, hematocrit was more often observed, and in schoolchildren and adolescents (7–17 years old) – a decrease in leukocyte counts, lymphopenia. Conclusion: In the analysis of the course of COVID-19 infection in children of different ages, a hypothesis about two variants of clinical manifestations has been put forward. In the first variant, pneumonia with COVID-19 was characterized by persistent, poorly controlled fever, severe symptoms of intoxication, impaired microcirculation, changes in the electrocardiogram, more pronounced changes in indicators of general and biochemical blood tests. In the second variant, pneumonia was tolerated by children more easily, was characterized by less pronounced symptoms of intoxication, inhibited by hyperthermia, but patients had positive PCR tests for SARS-CoV-2 longer. Our study did not establish the relationship between the pneumonia variant and the age and gender of the patients, but there may be a need for further research.

scholarly journals Clinical Characteristics of Asymptomatic Patients with SARS-CoV-2 in Zhejiang: An Imperceptible Source of Infection

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Wei Dai ◽  
Xinmiao Chen ◽  
Xiaoting Xu ◽  
Zhefeng Leng ◽  
Wenwen Yu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Transmission Risk ◽  
Asymptomatic Group ◽  
Symptomatic Group ◽  
Source Of Infection ◽  
Asymptomatic Patients ◽  
Novel Coronavirus

Objective. Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, was first identified in December 2019 in Wuhan, China, and has since spread globally, resulting in an ongoing pandemic. However, the study of asymptomatic patients is still rare, and the understanding of its potential transmission risk is still insufficient. In this study, epidemiological investigations were conducted in the Zhejiang province to understand the epidemiology and clinical characteristics of asymptomatic patients with COVID-19. Methods. This retrospective study was carried out on 22 asymptomatic patients and 234 symptomatic patients with COVID-19 who were hospitalized in Zhejiang Duodi Hospital from January 21 to March 16, 2020. The characteristics of epidemiology, demography, clinical manifestations, and laboratory data of mild patients were compared and analyzed. Results. The median age was 28 years in asymptomatic patients and 48 years in symptomatic patients. The proportion who were female was 77.3% in asymptomatic patients and 36.3% in symptomatic patients (p<0.001). The proportion of patients with coexisting diseases was 4.5% in asymptomatic patients and 38.0% in symptomatic patients (p=0.002). The proportion of patients with increased CRP was 13.6% in the asymptomatic group and 61.1% in the symptomatic group (p<0.001). The proportion of patients received antiviral therapy was 45.5% in the asymptomatic group and 97.9% in the symptomatic group (p<0.001). The proportion of patients received oxygen therapy was 22.7% in the asymptomatic group and 99.1% in symptomatic patients (p<0.001). By March 16, 2020, all patients were discharged from the hospital, and no symptoms had appeared in the asymptomatic patients during hospitalization. The median course of infection to discharge was 21.5 days in asymptomatic patients and 22 days in symptomatic patients. Conclusions. Asymptomatic patients are also infectious; relying only on clinical symptoms, blood cell tests, and radiology examination will lead to misdiagnosis of most patients, leading to the spread of the virus. Investigation of medical history is the best strategy for screening asymptomatic patients, especially young people, women, and people without coexisting disease, who are more likely to be asymptomatic when infected. Although the prognosis is good, isolation is critical for asymptomatic patients, and it is important not to end isolation early before a nucleic acid test turns negative.

Hyperlipidemia in noise-induced hearing loss

2007 ◽  
Vol 137 (4) ◽  
pp. 603-606 ◽  
Author(s):  
Ning-Chia Chang ◽  
Ming-Lung Yu ◽  
Kuen-Yao Ho ◽  
Chi-Kung Ho
Keyword(s):  
Hearing Loss ◽  
Medical Center ◽  
Academic Medical Center ◽  
Laboratory Data ◽  
Noise Induced Hearing Loss ◽  
Academic Medical ◽  
Southern Taiwan ◽  
And Gender ◽  
One Year ◽  
The Relationship

Objectives To assess the influence of hyperlipidemia on the development of noise-induced hearing loss (NIHL). Study Design This case-control study analyzed data from the Department of Preventive Medicine at one academic medical center in southern Taiwan. Subjects and Methods We collected the laboratory data from routine health examinations administered to workers who were exposed to noise greater than 85 dBA over a one-year period. We analyzed the relationships of cholesterol and triglyceride levels with NIHL. Results A total of 4071 cases were analyzed. After adjusting for age and gender, hypertriglyceridemia was found to be related to NIHL (aOR = 1.281; 95% CI, 1.088–1.507), but hypercholesterolemia was not (aOR = 0.951; 95% CI, 0.795–1.138). Conclusions This study, one of the largest to date to study the relationship between hyperlipidemia and NIHL, found that individuals with hypertriglyceridemia are at greater risk of NIHL. On the basis of this finding, workers exposed to high noise levels should be educated on control of triglyceride levels to help reduce their risk of NIHL.

The Relationship of Digit Ratio (2D:4D) and Gender-Role Orientation in Four National Samples

2007 ◽  
Vol 28 (2) ◽  
pp. 78-87 ◽  
Author(s):  
Stefan J. Troche ◽  
Nina Weber ◽  
Karina Hennigs ◽  
Carl-René Andresen ◽  
Thomas H. Rammsayer
Keyword(s):  
Gender Role ◽  
Sex Role ◽  
Role Orientation ◽  
Sexually Dimorphic ◽  
Gender Role Orientation ◽  
Left Hand ◽  
Fourth Finger ◽  
And Gender ◽  
Relationship Of ◽  
The Relationship

Abstract. The ratio of second to fourth finger length (2D:4D ratio) is sexually dimorphic with women having higher 2D:4D ratio than men. Recent studies on the relationship between 2D:4D ratio and gender-role orientation yielded rather inconsistent results. The present study examines the moderating influence of nationality on the relationship between 2D:4D ratio and gender-role orientation, as assessed with the Bem Sex-Role Inventory, as a possible explanation for these inconsistencies. Participants were 176 female and 171 male university students from Germany, Italy, Spain, and Sweden ranging in age from 19 to 32 years. Left-hand 2D:4D ratio was significantly lower in men than in women across all nationalities. Right-hand 2D:4D ratio differed only between Swedish males and females indicating that nationality might effectively moderate the sexual dimorphism of 2D:4D ratio. In none of the examined nationalities was a reliable relationship between 2D:4D ratio and gender-role orientation obtained. Thus, the assumption of nationality-related between-population differences does not seem to account for the inconsistent results on the relationship between 2D:4D ratio and gender-role orientation.

The Relationship between Body Image and Exercise Adherence in Fitness Centre Exercising Sample

2018 ◽  
Vol 1 (80) ◽  
Author(s):  
Rasa Jankauskienė ◽  
Brigita Miežienė
Keyword(s):  
Body Image ◽  
Exercise Adherence ◽  
Physical Activity Promotion ◽  
Well Being ◽  
Social Physique Anxiety ◽  
Men And Women ◽  
Activity Promotion ◽  
And Gender ◽  
Body Self ◽  
The Relationship

Research background and hypothesis. The analysis of factors which might infl uence exercise adherence is important issue for physical activity promotion. Studies show that exercisers’ body image is important factor associated with well being, exercise motivation and specifi c exercise–related behaviour.Research aim was is to examine the relationship between exercise adherence, body image and social physique anxiety in a sample of fi tness centre participants. Research methods. Members of fi tness centres (n = 217, 66 of them were women) provided their answers on exercise experience, in three subscales (appearance evaluation, appearance orientation and overweight preoccupation) of The Multidimensional Body-Self Relations Questionnaire (MBSRQ-AS; Brown et al., 1990) and Social Physique Anxiety Scale (SPAS; Hart et al., 1989). Mean age of the sample was 29.02 (9.85) years (range = 18–68 years).Research results. Women demonstrated higher appearance orientation, overweight preoccupation and social physique anxiety compared to men. However, we observed no signifi cant differences in appearance evaluation, appearance orientation and overweight preoccupation in the groups of different exercise experience of men and women. When overweight respondents (≥ 25 kg / m²) were excluded from the analysis, there were no statistically signifi cant differences observed in body image and social physique anxiety in exercise experience groups of men and women. Exercising longer than 6 years signifi cantly predicted overweight preoccupation [95% CI: 1.25–16.94] controlled by age and gender. Discussion and conclusions. Exercising men demonstrated more positive body image and lower social physique anxiety compared to women, except for appearance evaluation. There were observed no body image and social physique relationships with exercise adherence observed in the sample of fi tness centre participants, however, exercise experience longer than 6 years predicted overweight preoccupation.Keywords: body image concerns, exercise experience, self-presentation.

Cerebral Amyloid Angiopathy in Combination with Paroxysmal Atrial Fibrillation

2020 ◽  
Vol 25 (4) ◽  
pp. 31-37
Author(s):  
A. A. Kornilova ◽  
O. V. Lagoda ◽  
M. M. Tanashyan
Keyword(s):  
Atrial Fibrillation ◽  
Cerebral Amyloid Angiopathy ◽  
Paroxysmal Atrial Fibrillation ◽  
Past History ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Cerebral Haemorrhage ◽  
Exclusion Criterion ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid

The present article addresses the definition of cerebral amyloid angiopathy (CAA) and its symptoms based on the analysis of the medical case; the issues of diagnosis and treatment of this pathology are discussed. The Boston criteria, which became the basis for diagnosis, study of clinical manifestations and progression of CAA and approaches to its therapy, are presented. Methods and modes of neuroimaging, including magnetic resonance imaging (MRI), which verify micro cerebral haemorrhage, are described. At the same time, the role and significance of cardiac arrhythmias in the genesis of ischemic stroke are discussed, and scales for assessing the risk of its occurrence are presented. The observation of the neurological, somatic, neuroimaging, neuropsychological status of a 62-year-old patient confirms quite rare combination of probable CAA, paroxysmal atrial fibrillation and repeated hemorrhagic functional apoplexy (FA). The relevance of the case described, is a complex clinical dilemma based on mutually exclusive recommendations for the pharmacological correction of such conditions. It is emphasized that in many multicenter clinical studies on the effectiveness of antithrombotic medication (antiaggregants, anticoagulants) in the treatment and prevention of ischaemic functional apoplexy , an important exclusion criterion is a hemorrhagic stroke in past history (including the multiple changes in haemostasis indicators). Taking into account the obtained clinical and laboratory data in the dynamics, the tactics of treating the described patient were determined. The results of studies related to the treatment of comorbid pathology that should become the subject of the development of a personalized algorithm for managing patients in each specific case, are discussed.

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