scholarly journals Membandingkan Kejadian Gangguan Gastrointestinal Penggunaan Aminofilin dan Salbutamol pada Pasien Eksaserbasi Asma di Surabaya

2019 ◽  
Vol 1 (1) ◽  
pp. 1-10
Author(s):  
Amelia Lorensia ◽  
Zullies Ikawati ◽  
Tri Murti Andayani ◽  
Daniel Maranatha ◽  
Rizki Amalia
Keyword(s):  
Asthma Exacerbation ◽  
Acute Asthma ◽  
Shortness Of Breath ◽  
Drug Reactions ◽  
Asthma Exacerbations ◽  
Gastrointestinal Problems ◽  
Asthma Patients ◽  
Quasi Experimental ◽  
Expiratory Air ◽  
Over Time

Abstract—Asthma is a heterogeneous disease, which is characterized by inflammation of the respiratory tract with respiratory classification such as wheezing, shortness of breath, distress in the chest and coughing over time and intensity with variations in expiratory air flow. In Indonesia the prevalence of asthma is uncertain, it is not estimated that 2-5% of Indonesia's population has asthma. The main objective of this study is to study gastrointestinal-related cases of the use of aminophylline and salbutamol in asthma exacerbation patients in hospitals in Surabaya and also to discuss gastrointestinal problems related to ADRs (Bad Drug Reactions) using the use of aminophylline and salbutamol on Naranjo scale. In this study using the Quasi Experimental method. This research was conducted in October 2014 to February 2015. The results of the study of 7 samples obtained 14.29% using ADR from the use of aminophylline and from 13 patients in the use of salbutamol was not found ADR can be used in accordance with the existing salbutamol in patients with asthma exacerbations at hospitals in Surabaya. The general benefits of this study are useful in monitoring the treatment of acute asthma patients who need salbutamol and theophylline therapy so as to reduce the incidence of ADR. Abstrak—Asma merupakan penyakit heterogen, yang ditandai dengan peradangan saluran napas kronis dengan disertai riwayat gejala pernapasan seperti mengi, sesak napas, rasa tertekan di dada dan batuk dari waktu ke waktu dan intensitas dengan variasi keterbatasan aliran udara ekspirasi. Di Indonesia prevalensi asma belum diketahui secara pasti, namun diperkirakan 2-5 % penduduk Indonesia menderita asma. Tujuan utama penelitian ini adalah untuk mengetahui perbedaan kejadian gangguan gastrointestinal pada penggunaan aminofilin dan salbutamol pada pasien eksaserbasi asma di Rumah Sakit di Surabaya serta mengetahui kejadian gangguan gastrointestinal terkait ADRs (Adverse Drug Reaction) akibat penggunaan aminofilin dan salbutamol berdasarkan penilaian Naranjo scale. Pada penelitian ini menggunakan metode Quasi Eksperimental. Penelitian ini dilakukan pada bulan Oktober 2014 sampai Februari 2015. Hasil penelitian dari 7 sampel diperoleh 14,29% mengalami ADR dari penggunaan aminofilin dan dari 13 pasien pada pengguanaan salbutamol tidak ditemukan ADR sehingga dapat disimpulkan bahwa tidak ada perbedaan kejadian gangguan gastrointestinal pada penggunaan aminofilin dan salbutamol pada pasien eksaserbasi asma di Rumah Sakit di Surabaya. Manfaat umum dari penelitian ini adalah berguna dalam monitoring pengobatan pasien asma akut terutama yang mendapat terapi salbutamol dan teofilin sehingga dapat mengurangi angka kejadian ADR.

scholarly journals Retrospective Cohort Study of Leukotriene Receptor Antagonist Therapy for Preventing Upper Respiratory Infection-Induced Acute Asthma Exacerbations

2013 ◽  
Vol 4 (3) ◽  
pp. ar.2013.4.0062 ◽  
Author(s):  
Hiroto Matsuse ◽  
Tomoko Tsuchida ◽  
Susumu Fukahori ◽  
Tetsuya Kawano ◽  
Shinya Tomari ◽  
...  
Keyword(s):  
Asthma Exacerbation ◽  
Acute Asthma ◽  
Leukotriene Receptor Antagonist ◽  
Asthmatic Patients ◽  
Asthma Exacerbations ◽  
Adult Asthmatic ◽  
Acute Asthma Exacerbation ◽  
Leukotriene Receptor ◽  
Upper Respiratory ◽  
Acute Asthma Exacerbations

Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbations. It has yet to be determined whether leukotriene receptor antagonist (LTRA) treatment prevents URI-induced acute asthma exacerbations in adults. The objective of the present study was to evaluate the preventive effects of LTRA treatment on URI-induced acute asthma exacerbations. The incidences of URI alone, acute asthma exacerbation without URI, and URI-induced acute asthma exacerbation were determined retrospectively by analyzing diary and medical records of 321 adult asthmatic patients (mean age, 56.3 ± 17.2 years; male/female ratio, 117:204) over 1 year. Results were compared between patients who had been taking an LTRA (n = 137) and those who had never taken any LTRA (n = 184) during the study periods. Significantly fewer URIs alone and acute asthma exacerbations without URI occurred in patients with than in those without prophylactic daily use of LTRA. LTRA treatment significantly reduced the durations of URIs alone and of total acute asthma exacerbations, as well as the incidence of mild exacerbations of asthma. In contrast, in patients with URI-induced acute asthma exacerbations, LTRA treatment failed to significantly reduce the interval between URI onset and acute asthma exacerbation, as well as the duration and severity of both URIs and acute asthma exacerbations. Use of an LTRA for adult asthmatic patients appears to reduce the incidences of URIs alone and acute asthma exacerbations without URI, but it failed to prevent URI-induced acute asthma exacerbations once a URI occurred.

Intravenous versus Oral Corticosteroids for Treatment of Acute Asthma Exacerbations

2002 ◽  
Vol 36 (4) ◽  
pp. 565-570 ◽  
Author(s):  
Patricia Pecora Fulco ◽  
Amista A Lone ◽  
Carol B Pugh
Keyword(s):  
Medical History ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Asthma Exacerbation ◽  
Acute Asthma ◽  
Past Medical History ◽  
Asthma Exacerbations ◽  
Acute Asthma Exacerbation ◽  
Oral Corticosteroids ◽  
Acute Asthma Exacerbations

OBJECTIVE: To compare the duration of hospitalization of patients treated with either oral or intravenous corticosteroids for an acute asthma exacerbation. METHODS: A retrospective chart review was performed on a random sample of inpatients. Patients were included with the following: a discharge diagnosis of an acute asthma exacerbation, a past medical history significant for asthma, age between 16 and 60 years, and treatment with either oral or intravenous corticosteroids at the time of admission. Exclusion criteria included: patients receiving chronic prednisone therapy, a past medical history significant for chronic obstructive pulmonary disease, an admission to the intensive care unit, or a consistent smoking habit of at least 1 pack daily. Length of hospitalization was the primary outcome measured. Secondary outcomes included 24-hour peak expiratory flow rate, 24-hour pulse oximetry (pO2), and amount of β-agonist and ipratropium used. RESULTS: Fifty-three patients were included in the final data analysis. Patients were grouped by route of corticosteroid administration (intravenous or oral). No significant differences were noted between the 2 groups for race, gender, age, height, weight, admission peak expiratory flow rate, admission pO2, or types of asthma medications used prior to admission. No significant differences were demonstrated in any of the outcome measures. CONCLUSIONS: Both the intravenous and oral corticosteroid groups demonstrated similar clinical outcomes and lengths of hospitalization in the treatment of acute asthma exacerbations. These results support the initial use of oral corticosteroids for the treatment of acute asthma exacerbations in adult patients admitted to a general medical service.

scholarly journals Analysis of eosinophil and lymphocyte concentrations on the incidence of mild and severe acute asthma exacerbations

2021 ◽  
Vol 129 (s2) ◽  
Author(s):  
Raihan Syarif Humaidy ◽  
Mohammad Subkhan ◽  
Nurma Yuliyanasari ◽  
Nabil Salim Ambar
Keyword(s):  
Lung Function ◽  
Acute Asthma ◽  
Shortness Of Breath ◽  
Progressive Decrease ◽  
Chest Tightness ◽  
Asthma Exacerbations ◽  
Acute Exacerbations ◽  
Severe Acute Asthma ◽  
Acute Asthma Exacerbations

Introduction: Exacerbation of asthma is an episode characterized by an increase in symptoms of progressive shortness of breath, coughing, wheezing, chest tightness, and a progressive decrease in lung function. Among the cells involved and activated in acute exacerbations in asthma are eosinophils and lymphocytes.

scholarly journals A comparative efficacy of Russian bronchodilating drugs in therapy of asthma with regards to pathological agents

2005 ◽  
pp. 42-45
Author(s):  
A. V. Skorlyakov ◽  
T. G. Shapovalova ◽  
M. M. Kirillov ◽  
V. V. Arzhnikov
Keyword(s):  
Asthma Exacerbation ◽  
Acute Asthma ◽  
Comparative Efficacy ◽  
Laboratory Parameters ◽  
Decisive Influence ◽  
Asthma Patients ◽  
Acute Asthma Exacerbation

We examined 364 asthma patients while treated in the Saratov pulmonary centre from 1989 to 2002. The aim of the work was to improve medication course programs including Russian oral bronchodilating drugs. The coefficient of harmony of changes which indicates a rate and synchrony of dynamics of clinical and laboratory parameters under a therapy was calculated using the method of regressive and graphic ratio. Severity of acute asthma exacerbation and, at less extent, severity of asthma course were proven to exert decisive influence upon results of the therapy

scholarly journals Differences of Respiratory Rate Between Salbutamol and Aminofilin in Exacerbation Asthma

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Amelia Lorensia ◽  
Zullies Ikawati ◽  
Tri Murti Andayani ◽  
Daniel Maranatha
Keyword(s):  
Data Collection ◽  
Respiratory Rate ◽  
Experimental Method ◽  
Asthma Exacerbation ◽  
T Test ◽  
Purposive Sampling ◽  
Breath Rate ◽  
Asthma Exacerbations ◽  
Quasi Experimental ◽  
The Difference

Exacerbation of asthma is a progressive step in progressive breathing, coughing, wheezing, breathing. In Indonesia salbutamol nebulation is used for the therapy of the first exacerbation attack. In addition, intravenous aminophylline is also recommended as a therapy, even if the use of aminophylline abroad is reduced due to its smaller effectiveness and often leads to greater unwanted reaction events. The effectiveness of asthma exacerbation therapy needs to be monitored and one of the monitoring parameters that is easily seen is the rate of breath.The aim of this study was to investigate the difference in respiratory rate values using salbutamol nebulisation and intravenous aminophylline in patients with asthma exacerbations in hospitals in Surabaya. The research was conducted by using quasi experimental method and data collection by purposive sampling. Analysis of the data to be used is a independent t-test. The results showed that the salbutamol group decreased respiratory rate by 50.00%, there were also patients who experienced an increase of breath rate of 13.64%. In the aminophylline group experienced a decrease in respiratory rate of 43.75% with an increase of breath rate of 18.75%. From the results of the study, it is necessary to monitor the effectiveness and the need to monitor the unwanted reactions of both treatments so that the therapies produced in the treatment of asthma exacerbations are more effective.Key words: Aminophylline, exacerbation asthma, respiratory rate, salbutamol 

scholarly journals Take my breath away: a case of lactic acidosis in an asthma exacerbation

CJEM ◽  
2011 ◽  
Vol 13 (04) ◽  
pp. 284-288 ◽  
Author(s):  
Reid McGonigle ◽  
Robert A. Woods
Keyword(s):  
Lactic Acidosis ◽  
Asthma Exacerbation ◽  
Elevated Serum ◽  
Respiratory Alkalosis ◽  
Serum Lactate ◽  
Shortness Of Breath ◽  
Emergency Physicians ◽  
Asthma Exacerbations ◽  
History Of ◽  
Bronchodilator Treatment

ABSTRACT:A 36-year-old male with a history of chronic asthma presented to an emergency department with shortness of breath consistent with an asthma exacerbation. He had persistent tachypnea following inhaled bronchodilator treatment; thus, the workup and differential diagnosis were expanded. He was found to have a mixed respiratory alkalosis and metabolic acidosis with elevated serum lactate without an obvious cause and was admitted to hospital. His case was reviewed, and the lactic acidosis was thought to be caused by inhaled β2-agonist use. Emergency physicians should be aware of the potential side effects of inhaled β2-agonists as lactic acidosis may complicate clinical assessment and management of asthma exacerbations and lead to unnecessary and potentially dangerous escalations in therapy.

scholarly journals Partnership among hospitals to reduce healthcare associated infections: a quasi-experimental study in Brazilian ICUs

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ladjane Santos Wolmer de Melo ◽  
Maria Verônica Monteiro de Abreu ◽  
Bernuarda Roberta de Oliveira Santos ◽  
Maria das Graças Washington Casimiro Carr ◽  
Maria Fernanda Aparecida Moura de Souza ◽  
...  
Keyword(s):  
Experimental Study ◽  
Length Of Stay ◽  
Public Hospitals ◽  
Incidence Density ◽  
Healthcare Associated Infections ◽  
Collaborative Project ◽  
Quasi Experimental ◽  
Tract Infections ◽  
Healthcare Associated ◽  
Over Time

Abstract Background Healthcare-associated infections (HAIs) are relevant in developing countries where frequencies can be at least 3 times higher than in developed countries. The purpose of this research was to describe the intervention implemented in intensive care units (ICUs) to reduce HAIs through collaborative project and analyze the variation over 18 months in the incidence density (ID) of the three main HAIs: ventilator associated pneumonia (VAP), central line-associated bloodstream infections (CLABSIs) and catheter-related urinary tract infections (CAUTIs) and also the length of stay and mortality in these ICUs. Methods A quasi-experimental study in five public adult clinical-surgical ICUs, to reduce HAIs, through interventions using the BTS-IHI “Improvement Model”, during 18 months. In the project, promoted by the Ministry of Health, Brazilian philanthropic hospitals certified for excellence (HE), those mostly private, certified as excellence and exempt from security contributions, regularly trained and monitored public hospitals in diagnostics, data collection and in developing cycles to improve quality and to prevent HAIs (bundles). In the analysis regarding the length of stay, mortality, the IDs of VAP, CLABSIs and CAUTIs over time, a Generalized Estimating Equation (GEE) model was applied for continuous variables, using the constant correlation (exchangeable) between assessments over time. The model estimated the average difference (β coefficient of the model) of the measures analyzed during two periods: a period in the year 2017 (prior to implementing the project) and in the years 2018 and 2019 (during the project). Result A mean monthly reduction of 0.427 in VAP ID (p = 0.002) with 33.8% decrease at the end of the period and 0.351 in CAUTI ID (p = 0.009) with 45% final decrease. The mean monthly reduction of 0.252 for CLABSIs was not significant (p = 0.068). Length of stay and mortality rates had no significant variation. Conclusions Given the success in reducing VAP and CAUTIs in a few months of interventions, the achievement of the collaborative project is evident. This partnership among public hospitals/HE may be applied to other ICUs including countries with fewer resources.

scholarly journals Depression Levels Influence the Rate of Asthma Exacerbations in Females

2021 ◽  
Vol 11 (6) ◽  
pp. 586
Author(s):  
Papaporfyriou Anastasia ◽  
Tseliou Eleni ◽  
Mizi Eleftheria ◽  
Ntontsi Xenia ◽  
Papathanasiou Eygenia ◽  
...  
Keyword(s):  
Control Level ◽  
Depression Scale ◽  
Low Frequency ◽  
Anxiety And Depression ◽  
Asthmatic Patients ◽  
Asthma Exacerbations ◽  
Depression Subscale ◽  
Global Initiative For Asthma ◽  
Asthma Patients ◽  
Global Initiative

Background: Anxiety and depression are common psychological disturbances among asthmatic patients. The aim of the present study is the assessment of anxiety and depression in asthmatic patients and their correlation with symptoms control level and number of exacerbations per year. Methods: One hundred patients with asthma diagnosis, according to the Global Initiative for Asthma (GINA), aged > 18 years old, having a stable disease, were included. Emotional status was evaluated using the Hospital Anxiety Depression Scale (HADS). Patients were followed up for a year to assess the number and severity of exacerbations. Results: Most of our patients were female (58%), middle-aged (mean = 54 ± 13), and married (81%), with low frequency of smoking habits (smokers, ex-smokers and non-smokers were 26%, 30% and 37%, respectively) and low levels of both anxiety and depression [median (interquartile range (IQR)) = 4(2) and median (IQR) = 4(2), respectively]. At the low and moderate level of the depression subscale, female patients experienced asthma exacerbations more frequently compared to male patients (adjusted Incidence Rate Ratio (aIRR) = 4.30; 95% Confidence Interval (CI): 1.94–9.53 and aIRR = 1.82; 95% CI: 1.07–3.13, respectively). Conclusions. Clinicians should evaluate asthma patients for depression, as gender differentially influences outcomes among those with low and moderate levels of depression, with female asthmatics presenting more frequent exacerbations.

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