scholarly journals Cellulose Nanocrystals Preparation as Pharmaceuticals Excipient : a Review

2020 ◽  
Vol 2 (2) ◽  
pp. 42
Author(s):  
Margaretha Efa Putri ◽  
Anis Yohana Chaerunisaa ◽  
Marline Abdassah
Keyword(s):  
Cellulose Nanocrystals ◽  
Dosage Form ◽  
Isolation Procedure ◽  
Chemical Agent ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Excipient ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
Different Characteristics

Cellulose nanocrystals is a cellulose derivates which has been widely researched and observed as an chemical agent. Different with cellulose that has been widely used as pharmaceutical excipient especially in solid dosage form, cellulose in nanocrystals form is not available in pharmaceutical grade. Cellulose nanocrystals have different characteristics and quality which is depend on its preparation including sourcing, isolation procedure, and hydrolysis reaction involved. This difference is very important to deeply observed its impact in pharmaceutical dosage form with different active ingredients. In addition, cellulose nanocrystals should meet FDA requirement as pharmaceutical excipient. This review  describe cellulose nanocrystals preparation and its characteristics, its application to active pharmaceutical ingredients, and its properties in order to meet FDA requirement.Keywords: Cellulose, nanocrystals, pharmaceutical excipient

scholarly journals Recovery of Active Pharmaceutical Ingredients from Unused Solid Dosage-Form Drugs

ACS Omega ◽  
2020 ◽  
Vol 5 (45) ◽  
pp. 29147-29157
Author(s):  
Dhanang Edy Pratama ◽  
Wen-Chen Hsieh ◽  
Ahmed Elmaamoun ◽  
Hung Lin Lee ◽  
Tu Lee
Keyword(s):  
Dosage Form ◽  
Active Pharmaceutical Ingredients ◽  
Solid Dosage Form ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage

scholarly journals Fabrication of an osmotic 3D printed solid dosage form for controlled release of active pharmaceutical ingredients

2020 ◽  
Vol 143 ◽  
pp. 105176 ◽  
Author(s):  
Christos I. Gioumouxouzis ◽  
Emmanouil Tzimtzimis ◽  
Orestis L. Katsamenis ◽  
Anthi Dourou ◽  
Catherine Markopoulou ◽  
...  
Keyword(s):  
Controlled Release ◽  
Dosage Form ◽  
Active Pharmaceutical Ingredients ◽  
Solid Dosage Form ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
3D Printed

scholarly journals Mini Review : Sedem System as a Tool to Characterize Excipients in Solid Dosage Form

2021 ◽  
Vol 3 (1) ◽  
pp. 20
Author(s):  
Iyan Sopyan ◽  
Rizka Guntina Khairunisa
Keyword(s):  
Drug Design ◽  
Dosage Form ◽  
Maximum Amount ◽  
Active Pharmaceutical Ingredients ◽  
Critical Quality Attributes ◽  
Solid Dosage Form ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
Preformulation Studies ◽  
New System

SeDem System is a new system that can be applied in solid dosage form preformulation studies of medicines. It have parameters to evaluates critical quality attributes of materials that have an impact on final drug product’s quality. SeDeM studies could be used as a method for identifying the best excipient and calculating the maximum amount of excipient required for formulation. SeDeM method can , providing formulation with the lowest amount of excipients as it combines the Active Pharmaceutical Ingredients (API) with only one excipient and the standard formula of lubricants, thus avoiding the used of unnecessary excipients, such as diluents, binders and agglutinants. The information given by the SeDeM system contributes to a quality by drug design development.Keywords: SeDeM System, Excipients

scholarly journals UV SPECTROPHOTOMETRIC ANALYSIS AND VALIDATION OF ACYCLOVIR IN SOLID DOSAGE FORM

2020 ◽  
pp. 100-103
Author(s):  
AKSHATA LASURE ◽  
AFAQUE ANSARI ◽  
MALLINATH KALSHETTI
Keyword(s):  
Dosage Form ◽  
Quantitative Estimation ◽  
Spectroscopic Method ◽  
Pharmaceutical Formulations ◽  
Spectrophotometric Analysis ◽  
Pharmaceutical Dosage Form ◽  
Solid Dosage ◽  
Ich Guidelines ◽  
Double Beam ◽  
Routine Assay

Objective: A new, economical, sensitive, simple, rapid UV spectrophotometric method has been developed for the estimation of Acyclovir in pure form and pharmaceutical formulation. Methods: This UV method was developed using distilled water as a solvent. In the present method, the wavelength selected for analysis was 254 nm. UV-Visible double beam spectrophotometer (Systronic 2201) was used to carry out the spectral analysis. The ICH guidelines were used to validate the method. Results: The method was validated for linearity, range, accuracy, precision, robustness, LOD and LOQ. Linearity was found in the range of 5-30µg/ml. Accuracy was performed by using a recovery study. The amount of drug recovered was found to be in the range of 100.1-100.5 %. The % RSD value was found to be less than 2. Conclusion: The proposed UV spectroscopic method was found to be accurate, precise, stable, linear, specific, and simple for quantitative estimation of acyclovir in bulk and pharmaceutical dosage form. Hence the present UV spectroscopic method is suitable for the routine assay of acyclovir in bulk and pharmaceutical formulations.

scholarly journals Pharmaceutical Excipients and Drug Metabolism: A Mini-Review

2020 ◽  
Vol 21 (21) ◽  
pp. 8224
Author(s):  
Rahul Patel ◽  
James Barker ◽  
Amr ElShaer
Keyword(s):  
Fatty Acids ◽  
Drug Metabolism ◽  
Dosage Form ◽  
Active Pharmaceutical Ingredients ◽  
Drug Bioavailability ◽  
Incubation Condition ◽  
Pharmaceutical Excipients ◽  
Pharmaceutical Ingredients ◽  
Form Design ◽  
The Right

Conclusions from previously reported articles have revealed that many commonly used pharmaceutical excipients, known to be pharmacologically inert, show effects on drug transporters and/or metabolic enzymes. Thus, the pharmacokinetics (absorption, distribution, metabolism and elimination) of active pharmaceutical ingredients are possibly altered because of their transport and metabolism modulation from the incorporated excipients. The aim of this review is to present studies on the interaction of various commonly-used excipients on pre-systemic metabolism by CYP450 enzymes. Excipients such as surfactants, polymers, fatty acids and solvents are discussed. Based on all the reported outcomes, the most potent inhibitors were found to be surfactants and the least effective were organic solvents. However, there are many factors that can influence the inhibition of CYP450, for instance type of excipient, concentration of excipient, type of CYP450 isoenzyme, incubation condition, etc. Such evidence will be very useful in dosage form design, so that the right formulation can be designed to maximize drug bioavailability, especially for poorly bioavailable drugs.

scholarly journals Recent Advanced of Multiple Unite Pellet System (MUPS) Technology in Formulation of Pharmaceutical Products: A Review

2020 ◽  
Vol 9 (10) ◽  
pp. 20202-20214
Author(s):  
V. K . Chatap ◽  
Deshbandhu Joshi
Keyword(s):  
Oral Route ◽  
Pharmaceutical Products ◽  
Active Pharmaceutical Ingredients ◽  
Blood Profile ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
Drug Substances ◽  
Form Design ◽  
Multiple Unit ◽  
User Friendly

The oral route of drug administration is the most important and most user-friendly route of administration. In recent years, Multiple Unit Pellet Systems (MUPS) tablets are widely used in solid dosage form design. MUPS is considered to provide pharmacokinetic advantages compared to monolithic dosage forms. Combination of drug substances and release profiles can be provided by formulating the MUPS tablets with different pellet qualities or combining pellets with drugs in powder or granulated form. MUPS tablet contains several hundred of coated pellets of active pharmaceutical ingredients which delivered the drug at predetermined rate and absorption to provide constant blood profile. MUPS are easily administered as disintegratable tablet which disperse into their subunits across the stomach and the small intestine, leading to predictable oral transition and constant bioavailability.

scholarly journals Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations

2018 ◽  
Author(s):  
Deepak Gupta ◽  
Deepak Bhatia ◽  
Vivek Dave ◽  
Vijaykumar Sutariya ◽  
Sheeba Varghese Gupta
Keyword(s):  
Dosage Form ◽  
Selection Process ◽  
Therapeutic Agents ◽  
Active Pharmaceutical Ingredients ◽  
Salt Form ◽  
Pharmaceutical Ingredients ◽  
Salt Selection ◽  
Pharmaceutical Properties ◽  
Positive Effect ◽  
Salt Forms

Choice of the salts of therapeutic agents or active pharmaceutical ingredients (API) is based on the physicochemical properties of API and the dosage form considerations. The appropriate salt can have positive effect on overall therapeutic and pharmaceutical effects of API. However, the incorrect salt form can negatively affect the overall pharmaceutical outcomes of the API. This review addresses various criteria for choosing appropriate salt form along with the effect of salt forms on API’s pharmaceutical properties. In addition to comprehensive review of the criteria, this review also gives a brief historic perspective of the salt selection process.

scholarly journals DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ETHINYL ESTRADIOL AND GESTODENE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

2021 ◽  
pp. 49-58
Author(s):  
D. SUCHITRA ◽  
BATTU SATYANARAYANA
Keyword(s):  
Ethinyl Estradiol ◽  
Degradation Products ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Active Pharmaceutical Ingredients ◽  
Economic Stability ◽  
Pharmaceutical Dosage Form ◽  
Stability Indicating ◽  
Pharmaceutical Ingredients ◽  
Rp Hplc

Objective: The principal objective of this study is to develop and validate a simple, new, fast, selective, precise, and economic stability-indicating the RP-HPLC method for the simultaneous estimation of Ethinyl estradiol and Gestodene in a bulk and pharmaceutical dosage form. Methods: The present method was developed and validated on a Waters HPLC system using Phenomenex Gemini C18(250 mm × 4.6 mm i.d., 5 µm particle size) column and mobile phase composition of phosphate buffer: Acetonitrile (75:25 v/v) and the pH was adjusted to 3.6 using dilute orthophosphoric acid. The system was regulated at 1.0 ml/min flow rate at 237 nm UV detection. Results: The two drugs Ethinyl Estradiol and Gestodene, were eluted at 1.788 min and 3.475 min retention time, respectively. The analytical parameters such as accuracy, precision, linearity, LOD, LOQ, ruggedness, and robustness were used for validating the developed method according to International Conference on Harmonisation [ICH] guidelines. Linearity was exhibited over the concentration range of 10-50µg/ml and 25-125µg/ml for Ethinyl Estradiol and Gestodene, respectively. The method revealed the Limit of Detection and Quantitation values for Ethinyl Estradiol and Gestodene were 1.399µg/ml, 3.909µg/ml and 4.24µg/ml, 11.85µg/ml, respectively. The stress testing was carried out to give rise to degradation products by exposing the drugs to acid, alkali, thermal, oxidative, photolytic, and hydrolytic degradation. The obtained data showed that the content of Active pharmaceutical ingredients and the degradation products were successfully separated without any interference, which confirmed the stability-indicating nature of the developed method. Conclusion: The new, simple, rapid, selective, precise, and economic stability-indicating RP-HPLC method has been successfully developed and validated. It can be satisfactorily applied for the periodic laboratory quantitative estimation of Ethinyl Estradiol and Gestodene in formulations and active pharmaceutical ingredients.

scholarly journals FORMULATION AND BIO-AVAILABILITY PARAMETERS OF PHARMACEUTICAL SUSPENSION

2017 ◽  
Vol 9 (3) ◽  
pp. 8
Author(s):  
Pakpi Doye ◽  
Tanya Mena ◽  
Nilimanka Das
Keyword(s):  
Dosage Form ◽  
Systemic Circulation ◽  
Therapeutic Success ◽  
Pharmaceutical Dosage Form ◽  
Routes Of Administration ◽  
Solid Dosage ◽  
Formulation Parameters ◽  
Enteric Coated ◽  
Semi Solid ◽  
Form Development

The suspension is a biphasic liquid or semi-solid dosage form where the finely divided insoluble solid drug particles are homogeneously dispersed in a liquid or semi-solid medium. The solid drug particles act here as the dispersed phase and the liquid or the semi-solid as the dispersion medium. Suspensions contribute to pharmaceutical dosage form development by supplying drugs that are insoluble in all acceptable medium and often distasteful. Suspension translates such drugs into more bio-available form when compared to capsules, tablets, coated tablets, enteric coated tablets and sustained release products. The dosage form is palatable to the patient and many are doing well when applied to the skin or mucous membrane. This particular dosage form is also applied for injecting drugs into the systemic circulation. Therefore, pharmaceutical suspension finds its application through three different routes of administration namely oral, externally applied suspension and injectable one. The success of any dosage form largely depends on formulation parameters and the factors that influence the bioavailability which ultimately dictate the therapeutic success of the formulated dosage form. Hence, it is obvious to discuss the formulation parameters and the factors influencing bioavailability of suspension for the therapeutic success of it.

Sign in / Sign up

Export Citation Format

Share Document