scholarly journals Suplementação com probióticos e depressão: estratégia terapêutica?

2019 ◽  
Vol 28 (1) ◽  
pp. 31
Author(s):  
Ana Letícia Ferreira de Moraes ◽  
Rosana Gomes Arruda Leite Bueno ◽  
Marta Fuentes-Rojas ◽  
Adriane Elisabete Costa Antunes
Keyword(s):  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Bifidobacterium Longum ◽  
Bifidobacterium Bifidum ◽  
Lactobacillus Helveticus ◽  
Bifidobacterium Lactis

Evidências crescentes de que a microbiota intestinal pode influenciar no funcionamento do sistema nervoso central levaram à hipótese de que a suplementação com microrganismos chave pode ter um efeito positivo no tratamento da depressão. O objetivo desta revisão foi compilar dados da literatura científica sobre o impacto do uso de probióticos como estratégia terapêutica nos desfechos depressão e sintomas depressivos em humanos. As evidências compiladas nesta revisão indicam que a suplementação com probióticos apresenta potencial promissor como terapia adjuvante no tratamento dos sintomas associados ao transtorno de Depressão Maior e, principalmente, como ação preventiva de quadros depressivos em indivíduos saudáveis ou com depressão leve. O estado da arte aponta para o potencial efeito psicobiótico de determinadas culturas, tais como as espécies Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus helveticus, Bifidobacterium lactis, Bifidobacterium longum e Bifidobacterium bifidum recomendando-se para os próximos estudos a ênfase nas cepas específicas, dosagem e tempo de consumo para obtenção dos efeitos sobre o eixo intestino-cérebro.

scholarly journals Bifidobacterium bifidum R0071 results in a greater proportion of healthy days and a lower percentage of academically stressed students reporting a day of cold/flu: a randomised, double-blind, placebo-controlled study

2015 ◽  
Vol 113 (3) ◽  
pp. 426-434 ◽  
Author(s):  
Bobbi Langkamp-Henken ◽  
Cassie C. Rowe ◽  
Amanda L. Ford ◽  
Mary C. Christman ◽  
Carmelo Nieves ◽  
...  
Keyword(s):  
Acute Stress ◽  
Bifidobacterium Longum ◽  
Daily Intake ◽  
Bifidobacterium Bifidum ◽  
Lactobacillus Helveticus ◽  
Lower Percentage ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Symptom Intensity

Acute psychological stress is positively associated with a cold/flu. The present randomised, double-blind, placebo-controlled study examined the effect of three potentially probiotic bacteria on the proportion of healthy days over a 6-week period in academically stressed undergraduate students (n 581) who received Lactobacillus helveticus R0052, Bifidobacterium longum ssp. infantis R0033, Bifidobacterium bifidum R0071 or placebo. On each day, participants recorded the intensity (scale: 0 = not experiencing to 3 = very intense) for nine cold/flu symptoms, and a sum of symptom intensity >6 was designated as a day of cold/flu. B. bifidum resulted in a greater proportion of healthy days than placebo (P≤ 0·05). The percentage of participants reporting ≥ 1 d of cold/flu during the 6-week intervention period was significantly lower with B. bifidum than with placebo (P< 0·05). There were no effects of B. infantis or L. helveticus compared with placebo on either outcome. A predictive model accounted for influential characteristics and their interactions on daily reporting of cold/flu episodes. The proportion of participants reporting a cold on any given day was lower at weeks 2 and 3 with B. bifidum and B. infantis than with placebo for the average level of stress and the most commonly reported number of hours of sleep. Daily intake of bifidobacteria provides benefit related to cold/flu outcomes during acute stress.

Beneficial Interrelationships Between Certain Microorganisms and Humans: Candidate Microorganisms for Use as Dietary Adjuncts1,2

1979 ◽  
Vol 42 (2) ◽  
pp. 164-167 ◽  
Author(s):  
S. E. GILLILAND
Keyword(s):  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Intestinal Tract ◽  
Bifidobacterium Bifidum ◽  
Enteric Pathogens ◽  
Survival And Growth ◽  
The Stability

The lactobacilli most often mentioned as beneficial dietary adjuncts are Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus bifidus (Bifidobacterium bifidum). These organisms all possess characteristics which would permit their survival and growth in the intestinal tract. They also produce antagonistic actions toward enteric pathogens. Various products are available which contain these organisms; however, there does appear to be a need for improving the stability of these bacteria in such products.

Effect of Lithium Chloride and Sodium Propionate on Growth of Selected Probiotics

2011 ◽  
Vol 480-481 ◽  
pp. 66-69
Author(s):  
He Chen ◽  
Li Yuan Ji ◽  
Guo Wei Shu ◽  
Zhao Wei Wang
Keyword(s):  
Optical Density ◽  
Lithium Chloride ◽  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Lactobacillus Rhamnosus ◽  
Bifidobacterium Bifidum ◽  
Significant Inhibition ◽  
Lactobacillus Bulgaricus ◽  
Sodium Propionate

Effect of Lithium Chloride (LiCl) and Sodium Propionate (CH3CH2COONa) on growth of Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus bulgaricus, Lactobacillus casei and Lactobacillus rhamnosus was studied by measuring optical density at 600nm (OD600) and pH using MRS media as the control. The addition of each substance (%, w/v) was 0.025%, 0.05%, 0.1%, 0.2% and 0.3%. Results were as follows: addition of LiCl has the significant inhibition on growth of Lactobacillus acidophilus, Bifidobacterium bifidum and Lactobacillus bulgaricus at incubation 12h. The optimum selective concentration of LiCl in MRS media was 0.1% both for Lactobacillus acidophilus and Lactobacillus bulgaricus. Lactobacillus rhamnosus can tolerate the substances mentioned above. Sodium Propionate has no effect for any of five strains.

Development and Use of tuf Gene–Based Primers for the Multiplex PCR Detection of Lactobacillus acidophilus, Lactobacillus casei Group, Lactobacillus delbrueckii, and Bifidobacterium longum in Commercial Dairy Products

2009 ◽  
Vol 72 (1) ◽  
pp. 93-100 ◽  
Author(s):  
SEN-JE SHEU ◽  
WEN-ZHE HWANG ◽  
HSIN-CHIH CHEN ◽  
YU-CHENG CHIANG ◽  
HAU-YANG TSEN
Keyword(s):  
Multiplex Pcr ◽  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Bacterial Species ◽  
Bifidobacterium Longum ◽  
Fermented Milk ◽  
Lactobacillus Delbrueckii ◽  
Milk Products ◽  
Pcr Method ◽  
Primer Sets

PCR primers specific for the detection of Lactobacillus acidophilus, Lactobacillus casei group, Lactobacillus delbrueckii, and Bifidobacterium longum were designed based on the elongation factor Tu gene (tuf). The specificity of these four primer sets were confirmed by PCR with 88 bacterial strains of Lactobacillus, Enterococcus, Bifidobacterium, and other bacterial species. Results indicated that these primer sets generated predicted PCR products of 397, 230, 202, and 161 bp for L. acidophilus, L. delbrueckii, L. casei group, and B. longum, respectively. Bacterial species other than the target organisms tested did not generate false-positive results. When these four primer sets were combined for the simultaneous detection of the lactic acid bacteria (LAB) in fermented milk products including yogurt, the LAB species listed on the labels of these products could be identified without the preenrichment step. The identification limit for each LAB strain with this multiplex PCR method was N × 103 CFU/ml in milk samples. The results of our multiplex PCR method were confirmed by PCR assay using primers based on the 16S rDNA or the 16S–23S intergenic spacer region and by biochemical tests using the API 50 CHL kit. When this multiplex PCR method was used with the determination of counts of total viable LAB and bifidobacteria, the quality of commercial fermented milk products could be assured.

scholarly journals Exploring the bone sparing effects of postbiotics in the postmenopausal rat model

2021 ◽  
Author(s):  
Nima Montazeri-Najafabady ◽  
Younes Ghasemi ◽  
Mohammad Hossein Dabbaghmanesh ◽  
Yousef Aashoori ◽  
Pedram Talezadeh ◽  
...  
Keyword(s):  
Bone Loss ◽  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Lactobacillus Reuteri ◽  
Bifidobacterium Longum ◽  
Bacillus Coagulans ◽  
Attractive Alternative ◽  
Sprague Dawley ◽  
Ovx Rats ◽  
Probiotic Strains

Abstract Background Postmenopausal osteoporosis is a concern of health organizations, and current treatments do not seem enough. Postbiotics as bioactive compounds produced by probiotics may be an attractive alternative for bone health. In this study, we prepared, formulated, and compared the effects of cell lysate and supernatant of five native probiotic strains (Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei, Bifidobacterium longum, and Bacillus coagulans) in ovariectomized (OVX) rats. Methods The probiotic strains were isolated, and their cell-free supernatants and biomasses as postbiotics were extracted and formulated using standard microbial processes. The Sprague-Dawley rats were fed by 1 × 109 CFU/ml/day postbiotic preparations and ovariectomized. Dual-energy X-ray absorptiometry (DEXA) scans were accomplished to evaluate femur, spine, and tibia BMD. The serum biochemical markers [calcium, phosphorus, and alkaline phosphatase] were assessed. Results Postbiotics could considerably improve the global and femur area in OVX rats. In the case of global BMC, Lactobacillus casei lysate and supernatant, Bacillus coagulans lysate and supernatant, lysate of Bifidobacterium longum and Lactobacillus acidophilus, and Lactobacillus reuteri supernatant significantly increased BMC. We found Bacillus coagulans supernatant meaningfully enriched tibia BMC. Conclusion Postbiotic could ameliorate bone loss resulting from estrogen deficiency. Also, the effects of postbiotics on different bone sites are strain-dependent. More clinical studies need to explore the optimal administrative dose and duration of the specific postbiotics in protecting bone loss.

Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial

2016 ◽  
Vol 7 (3) ◽  
pp. 327-336 ◽  
Author(s):  
T. Culpepper ◽  
M.C. Christman ◽  
C. Nieves ◽  
G.J. Specht ◽  
C.C. Rowe ◽  
...  
Keyword(s):  
Undergraduate Students ◽  
Rating Scale ◽  
Bifidobacterium Longum ◽  
Randomised Trial ◽  
Secondary Analysis ◽  
Antibiotic Use ◽  
Bifidobacterium Bifidum ◽  
Lactobacillus Helveticus ◽  
Controlled Study ◽  
Double Blind

Psychological stress is associated with gastrointestinal (GI) distress. This secondary analysis from a randomised, double-blind, placebo-controlled study examined whether three different probiotics could normalise self-reported stress-associated GI discomfort and reduce overall self-reported stress. Undergraduate students (n=581) received Lactobacillus helveticus R0052, Bifidobacterium longum ssp. infantis R0033, Bifidobacterium bifidum R0071, or placebo. Participants self-reported 2 outcomes for a 6-week period, which included final academic exams: daily level of stress (0=no stress to 10=extremely stressed) and weekly three diarrhoea-related symptoms (DS, 1=no discomfort to 7=severe discomfort) using the GI Symptom Rating Scale. Self-reported stress was positively related to DS (P=0.0068). Mean DS scores were lower with B. bifidum versus placebo at week 2 at the average level of stress and the average body mass index (BMI). DS scores were lower with B. bifidum at week 5 versus week 0 and 1 and with B. infantis R0033 at week 6 versus week 0. DS scores were higher when antibiotics were used in the prior week with placebo (P=0.0092). DS were not different with or without antibiotic use with the probiotics. Only B. bifidum had an effect on self-reported stress scores (P=0.0086). The self-reported stress score was also dependent on hours of sleep per day where it decreased by 0.13 for each additional hour of sleep. During a stressful period, B. bifidum R0071 decreases DS and self-reported stress scores. This trial was registered at clinicaltrials.gov as NCT01709825.

Effect of Bile and Nalidixic Acid on Growth of Selected Probiotics

2011 ◽  
Vol 322 ◽  
pp. 248-251
Author(s):  
Guo Wei Shu ◽  
Zhen Xing Ma ◽  
Zhao Wei Wang ◽  
He Chen
Keyword(s):  
Nalidixic Acid ◽  
Optical Density ◽  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Lactobacillus Rhamnosus ◽  
Bifidobacterium Bifidum ◽  
Significant Inhibition ◽  
Lactobacillus Bulgaricus ◽  
De Man ◽  
Mrs Broth

Effect of bile and nalidixic acid on growth of Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus bulgaricus, Lactobacillus casei and Lactobacillus rhamnosus was studied by measuring the optical density at 600nm (OD600) and pH using De Man, Rogosa and Sharpe (MRS ) broth as the control. The addition of bile (%, w/v) was 0.03%, 0.06%, 0.09%, 0.12% and 0.15% and the addition of nalidixic acid (%, w/v) was 0.003%, 0.009%, 0.015%, 0.045% and 0.075%. Results were as follows: addition of bile at the concentration above 0.06% has a significant inhibition on the growth of L. bulgaricus and B. bifidum at incubation 24h. The optimum selective concentration of bile in MRS media was 0.06% for L. bulgaricus and B. bifidum. Addition of nalidixic acid has no effect on the growth of the five selected probiotics at incubation 24h. Addition of nalidixic acid in MRS can not use to realize selective enumeration in yogurt product containing probiotics.

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