NeuroPort: Retractor tubular personalizado para cirugías mínimamente invasivas fabricado mediante impresión 3D por estereolitografía

Mapping Intimacies ◽

10.24254/cnib.21.52 ◽

2021 ◽

Author(s):

◽

C. J. González Leal

Keyword(s):

High Resolution ◽

3D Printing ◽

Brain Tumors ◽

Vascular Malformations ◽

Low Cost ◽

Lighting System ◽

Minimal Invasion ◽

The Brain ◽

Intended Use ◽

Printing Method

NeuroPort is a low cost customized biodevice for minimal invasion surgeries designed within Servicio Neurocirugía UANL and Departamento de Ingeniería Biomédica; and manufactured by stereolithography, a high- resolution 3D printing method. This biodevice provides a channel of approach for subcortical and intraventricular cerebral surgical procedures with an intended use in the treatment of diseases such as brain tumors, anomalies or vascular malformations, parenchymal hematomas, among others. It has a design that minimizes tissue damage by displacing the tissues of the brain during the advance toward the desired abnormality; in addition to its integration with neuronavigational equipment and its own lighting system. All these features designed to make the surgical procedure faster and safer for the patient, facilitating the work of the neurosurgeon.

Download Full-text

Multi-material integrated 3D printing of cylindrical Li-ion battery

Journal of Manufacturing Science and Engineering ◽

10.1115/1.4052707 ◽

2021 ◽

pp. 1-28

Author(s):

Weiping Zhou ◽

Xiying Li ◽

Huiling Duan ◽

Pengyu Lv

Keyword(s):

3D Printing ◽

Low Cost ◽

Li Ion Battery ◽

Print Head ◽

Integrated Devices ◽

One Step ◽

Li Ion ◽

Printed Battery ◽

Discharge Capacities ◽

Printing Method

Abstract A simple, low cost and highly efficient method of fabrication has always been the goal of manufacturing technology. In order to improve the speed of fabrication and simplify the preparation steps, this work proposes a multi-material integrated 3D printing method, aiming to obtain the desired structure from the print head in one step. As a typical example, a cylindrical Li-ion battery (LIB) with core-shell structure was integrally fabricated using this method. A multi-material print head is designed based on the structure to be printed. Special inks with the characteristics of non-Newtonian fluid for the LIB were developed. Anode, cathode, separator layer, and packaging layer were easily printed simultaneously, and the printing parameters were studied. Electrochemical performance of the printed battery was tested with the charge and discharge capacities of the printed battery up to 147 and 99 mAh g−1 at 0.1 C rate, respectively. The proposed multi-material integrated printing method greatly reduces the printing process and improves the fabrication efficiency. This system can be directly extended to fabricate other integrated devices such as supercapacitors. Based on this idea, it should also be possible to design different print heads to print other periodic structure in one step.

Download Full-text

Study of Microscale Three-Dimensional Printing Using Near-Field Melt Electrospinning

Volume 2: Additive Manufacturing; Materials ◽

10.1115/msec2017-2960 ◽

2017 ◽

Author(s):

Xiangyu You ◽

Chengcong Ye ◽

Ping Guo

Keyword(s):

High Resolution ◽

3D Printing ◽

Low Cost ◽

Near Field ◽

Three Dimensional ◽

Thin Wall ◽

Direct Writing ◽

Melt Electrospinning ◽

Wall Structures ◽

Jet Trajectory

Three-dimensional (3D) printing of microscale structures with high resolution (sub-micron) and low cost is still a challenging work for the existing 3D printing techniques. Here we report a direct writing process via near-field melt electrospinning to achieve microscale printing of single filament wall structures. The process allows continuous direct writing due to the linear and stable jet trajectory in the electric near-field. The layer-by-later stacking of fibers, or self-assembly effect, is attributed to the attraction force from the molten deposited fibers and accumulated negative charges. We demonstrated successful printing of various 3D thin wall structures (freestanding single walls, double walls, annular walls, star-shaped structures, and curved wall structures) with a minimal wall thickness less than 5 μm. By optimizing the process parameters of near-field melt electrospinning (electric field strength, collector moving speed, and needle-to-collector distance), ultrafine poly (ε-caprolactone) (PCL) fibers have been stably generated and precisely stacked and fused into 3D thin-wall structures with an aspect ratio of more than 60. It is envisioned that the near-field melt electrospinning can be transformed into a viable high-resolution and low-cost microscale 3D printing technology.

Download Full-text

Desarrollo de un Sistema de Cultivo Tisular Híbrido y Multicomponente Usando Polímeros de Soporte Impresos 3D

10.24254/cnib.21.40 ◽

2021 ◽

Author(s):

◽

C. A. Romero Zepeda

Keyword(s):

Tissue Engineering ◽

Pharmaceutical Industry ◽

3D Printing ◽

Low Cost ◽

Three Dimensional ◽

Alternative Methods ◽

Structural Elements ◽

Different Types ◽

Organ On A Chip ◽

Printing Method

The development of different types of Organ on a Chip has attract the attention of pharmaceutical industry to develop alternative methods for ensuring the efficiency of drugs before approval. A dual bioprinting-culturing system was developed to construct the needed elements needed for creating three dimensional tissues including the corresponding instrumented device that may keep the environment conditions that may reinforce the cells´ growth. The proposed 3D printing platform considering the principles of an Organ on a Chip for the creation of a hybrid system of scaffolds for tissue engineering using polylactic acid. The usage of the 3D printing method allows the modification and creation of a flexible platform with different structures to a low cost, including the possibility of introducing the structural elements to create multi component tissues. The developed system was tested using a traditional fibroblasts culture.

Download Full-text

Study of Microscale Three-Dimensional Printing Using Near-Field Melt Electrospinning

Journal of Micro and Nano-Manufacturing ◽

10.1115/1.4037788 ◽

2017 ◽

Vol 5 (4) ◽

Cited By ~ 2

Author(s):

Xiangyu You ◽

Chengcong Ye ◽

Ping Guo

Keyword(s):

High Resolution ◽

3D Printing ◽

Low Cost ◽

Near Field ◽

Three Dimensional ◽

Thin Wall ◽

Direct Writing ◽

Melt Electrospinning ◽

Wall Structures ◽

Jet Trajectory

Three-dimensional (3D) printing of microscale structures with high-resolution (submicron) and low-cost is still a challenging work for the existing 3D printing techniques. Here, we report a direct writing process via near-field melt electrospinning (NFME) to achieve microscale printing of single filament wall structures. The process allows continuous direct writing due to the linear and stable jet trajectory in the electric near field. The layer-by-layer stacking of fibers, or self-assembly effect, is attributed to the attraction force from the molten deposited fibers and accumulated negative charges. We demonstrated successful printing of various 3D thin-wall structures with a minimal wall thickness less than 5 μm. By optimizing the process parameters of NFME, ultrafine poly (ε-caprolactone) (PCL) fibers have been stably generated and precisely stacked and fused into 3D thin-wall structures with an aspect ratio of more than 60. It is envisioned that the NFME can be transformed into a viable high-resolution and low-cost microscale 3D printing technology.

Download Full-text

Mathematical modeling of therapeutic neural stem cell migration in mouse brain with and without brain tumors

Mathematical Biosciences and Engineering ◽

10.3934/mbe.2022119 ◽

2022 ◽

Vol 19 (3) ◽

pp. 2592-2615

Author(s):

Justin Gomez ◽

◽

Nathanael Holmes ◽

Austin Hansen ◽

Vikram Adhikarla ◽

...

Keyword(s):

Brain Tumors ◽

Mouse Brain ◽

Low Cost ◽

Three Dimensional ◽

Intracerebral Injection ◽

Tumor Site ◽

Stem Cell Migration ◽

Proposed Model ◽

The Central Nervous System ◽

The Brain

<abstract><p>Neural stem cells (NSCs) offer a potential solution to treating brain tumors. This is because NSCs can circumvent the blood-brain barrier and migrate to areas of damage in the central nervous system, including tumors, stroke, and wound injuries. However, for successful clinical application of NSC treatment, a sufficient number of viable cells must reach the diseased or damaged area(s) in the brain, and evidence suggests that it may be affected by the paths the NSCs take through the brain, as well as the locations of tumors. To study the NSC migration in brain, we develop a mathematical model of therapeutic NSC migration towards brain tumor, that provides a low cost platform to investigate NSC treatment efficacy. Our model is an extension of the model developed in Rockne et al. (PLoS ONE 13, e0199967, 2018) that considers NSC migration in non-tumor bearing naive mouse brain. Here we modify the model in Rockne et al. in three ways: (i) we consider three-dimensional mouse brain geometry, (ii) we add chemotaxis to model the tumor-tropic nature of NSCs into tumor sites, and (iii) we model stochasticity of migration speed and chemosensitivity. The proposed model is used to study migration patterns of NSCs to sites of tumors for different injection strategies, in particular, intranasal and intracerebral delivery. We observe that intracerebral injection results in more NSCs arriving at the tumor site(s), but the relative fraction of NSCs depends on the location of injection relative to the target site(s). On the other hand, intranasal injection results in fewer NSCs at the tumor site, but yields a more even distribution of NSCs within and around the target tumor site(s).</p></abstract>

Download Full-text

Low-cost circular LED dome lighting system for Insecta (Hexapoda) image capture in self-assembly stereomicroscope

EntomoBrasilis ◽

10.12741/ebrasilis.v14.e957 ◽

2021 ◽

Vol 14 ◽

pp. e957

Author(s):

André da Silva Ferreira ◽

Freddy Bravo ◽

Ivan Castro

Keyword(s):

High Resolution ◽

Self Assembly ◽

Low Cost ◽

The Other ◽

Lighting System ◽

Image Capture ◽

Other Hand ◽

3D Printers ◽

High Resolution Images ◽

Lighting Systems

The use of high-resolution images in studies of morphology, taxonomy and systematics has been increasingly frequent, especially in Insecta. However, suitable lighting systems are still very expensive and/or difficult to use. On the other hand, currently the use of 3D printers has helped to make lighting equipment more accessible for researchers to equip their laboratories. Here we present a low-cost circular LED dome lighting system for capturing scientific micro and macro photography on a self-assembly stereomicroscope. We also present the necessary components for making the dome, as well as the elements used to capture the photographs.

Download Full-text

Influence of procedural noise on the glossiness of 2.5D printed patches

Color and Imaging Conference ◽

10.2352/issn.2169-2629.2021.29.105 ◽

2021 ◽

Vol 2021 (29) ◽

pp. 105-110

Author(s):

Abigail Trujillo Vazquez ◽

Donatela Šarić ◽

Susanne Klein ◽

Carinna Parraman

Keyword(s):

High Resolution ◽

Low Cost ◽

Surface Structures ◽

Uv Curable ◽

Procedural Approach ◽

Perlin Noise ◽

Elevation Data ◽

Specular Gloss ◽

Printing Method ◽

Effect Of Surface

Perlin noise, a type of procedural noise, was used for the design of elevation files for 2.5D printing. This printing method uses elevation data from a height map to create physical relief by superimposing layers of ink. In this experiment, the grayscale values of noise functions were used as elevation values to build different surface structures in UV curable ink by 2.5D printing. Printed samples with varying levels of Perlin noise were created and their reflectance properties were studied by measuring the values of specular gloss. The roughness and specular gloss of the printed surfaces were effectively influenced when varying the persistence and octaves of the noise functions. The aim of implementing the procedural approach to a high-resolution printing method has been to explore the reflectance properties of custom noise functions when transferred to the physical realm. This might contribute to better understand the effect of surface structure on the appearance of materials. Potentially, this approach will enable the use of relief printing to produce structures with a more natural appearance and a desired gloss value by using a low-cost computing process.

Download Full-text