scholarly journals Multi-colour extrusion fused deposition modelling: a low-cost 3D printing method for anatomical prostate cancer models

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael Y. Chen ◽  
Jacob Skewes ◽  
Maria A Woodruff ◽  
Prokar Dasgupta ◽  
Nicholas J Rukin
Keyword(s):  
Prostate Cancer ◽  
3D Printing ◽  
Low Cost ◽  
Fused Deposition Modelling ◽  
Fused Deposition ◽  
Cancer Models ◽  
Printing Method

A Low-Cost Method to Prepare Biocompatible Filaments with Enhanced Physico-mechanical Properties for FDM 3D Printing

2020 ◽  
Vol 18 ◽  
Author(s):  
Deck Khong Tan ◽  
Niko Münzenrieder ◽  
Mohammed Maniruzzaman ◽  
Ali Nokhodchi
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Fused Deposition Modelling ◽  
Processing Temperature ◽  
Melt Extrusion ◽  
Screw Extruder ◽  
Fused Deposition ◽  
Single Screw ◽  
Pharmaceutical Applications ◽  
Twin Screw

Background: Fused Deposition Modelling (FDM) 3D printing has received much interest as a fabrication method in the medical and pharmaceutical industry due to its accessibility and cost-effectiveness. A low-cost method to produce biocompatible and biodegradable filaments can improve the usability of FDM 3D printing for biomedical applications. Objectives: The feasibility of producing low-cost filaments suitable for FDM 3D printing via single screw and twin-screw hot melt extrusion was explored. Methods: A single-screw extruder and a twin-screw extruder were used to produce biocompatible filaments composed of varying concentrations of polyethylene glycol (PEG) at 10%, 20%, 30% w/w and polylactic acid (PLA) 90%, 80% and 70% w/w, respectively. DSC, TGA and FTIR were employed to investigate the effect of PEG on the PLA filaments. Results: The presence of PEG lowered the processing temperature of the formulation compositions via melt-extrusion, making it suitable for pharmaceutical applications. The use of PEG can lower the melting point of the PLA polymer to 170 °C, hence lowering the printing temperature. PEG can also improve the plasticity of the filaments, as the rupture strain of twinscrew extruded filaments increased up to 10-fold as compared to the commercial filaments. Advanced application of FTIR analysis confirmed the compatibility and miscibility of PEG with PLA. Conclusion: Twin-screw extrusion is more effective in producing a polymeric mixture of filaments as the mixing is more homogenous. The PEG/PLA filament is suitable to be used in 3D printing of medical or pharmaceutical applications such as medical implants, drug delivery systems, or personalised tablets.

scholarly journals A 3D Printed, Constriction-Resistive Sensor for the Detection of Ultrasonic Waves

2021 ◽  
Keyword(s):  
Structural Health Monitoring ◽  
3D Printing ◽  
Health Monitoring ◽  
Low Cost ◽  
Ultrasonic Waves ◽  
Fused Deposition Modelling ◽  
Fused Filament Fabrication ◽  
Engineering Structures ◽  
Structural Health ◽  
Fused Deposition

Abstract. Ultrasonic waves, either bulk waves or guided waves, are commonly used for non-destructive evaluation, for example in structural health monitoring. Traditional sensors for detecting ultrasonic waves include metallic strain gauges and piezoelectric ceramics. Recently piezoresistive nanocomposites have emerged as a promising sensor with high sensing range. In this paper, a constriction-resistive based sensor made from a graphene reinforced PLA filament is developed using a fused deposition modelling 3D printing approach as a novel type of ultrasonic sensor for structural health monitoring purposes. The sensor is made of very low-cost and recyclable thermoplastic material, which is lightweight and can be either directly printed onto the surface of various engineering structures, or embedded into the interior of a structure via fused filament fabrication 3D printing. These characteristics make this sensor a promising candidate compared to the traditional sensors in detecting ultrasonic waves for structural health monitoring. The printed sensors can detect ultrasonic signals with frequencies around 200 kHz, with good signal-to-noise ratio and sensitivity. When deployed between two adjacent printed tracks , and exploiting a novel kissing-bond mechanism, the sensor is capable of detecting ultrasonic waves. Several confirmatory experiments were carried out on this printed sensor to validate the capability of the printed sensor for structural health monitoring.

scholarly journals Optimization of Abs 3D-Printing Method and Parameters

1970 ◽  
Vol 3 (1) ◽  
pp. 44-51
Author(s):  
Paweł Żur ◽  
Alicja Kołodziej ◽  
Andrzej Baier ◽  
Grzegorz Kokot
Keyword(s):  
3D Printing ◽  
Tensile Test ◽  
Acrylonitrile Butadiene Styrene ◽  
Fused Deposition Modelling ◽  
Fused Deposition ◽  
Electric Car ◽  
University Of Technology ◽  
Static Tensile ◽  
3D Printed ◽  
Printing Method

The paper presents research on the method of 3D-printing ABS (Acrylonitrile butadiene styrene). Series of specimens were 3D-printed in FDM (Fused Deposition Modelling) technology with variable parameters. The influence of the following parameters has been checked: temperature of printing and infill density. Moreover, the material properties of raw, unprocessed ABS have been inspected. The tensile strength of specimens and Young’s modulus have been determined in a static tensile test. Tests were carried out in compliance with the ASTM D638-14 standard. Obtained results were then compared with the material datasheet. Optimum printing method has been defined. The carried out research resulted in optimizing the printing method for ABS vehicle parts applied in Silesian Greenpower electric car. The car has been developed by students of The Silesian University of Technology in Gliwice, Poland as an interfaculty students’ project. Results of the tensile test research have been analysed and discussed and conclusions have been presented in the following article.

scholarly journals A Low-Cost Multi-Sensor Data Acquisition System for Fault Detection in Fused Deposition Modelling

Sensors ◽  
2022 ◽  
Vol 22 (2) ◽  
pp. 517
Author(s):  
Satish Kumar ◽  
Tushar Kolekar ◽  
Shruti Patil ◽  
Arunkumar Bongale ◽  
Ketan Kotecha ◽  
...  
Keyword(s):  
3D Printing ◽  
Data Acquisition ◽  
Low Cost ◽  
Data Acquisition System ◽  
Acquisition System ◽  
Sensor Data ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Sensor Data Acquisition

Fused deposition modelling (FDM)-based 3D printing is a trending technology in the era of Industry 4.0 that manufactures products in layer-by-layer form. It shows remarkable benefits such as rapid prototyping, cost-effectiveness, flexibility, and a sustainable manufacturing approach. Along with such advantages, a few defects occur in FDM products during the printing stage. Diagnosing defects occurring during 3D printing is a challenging task. Proper data acquisition and monitoring systems need to be developed for effective fault diagnosis. In this paper, the authors proposed a low-cost multi-sensor data acquisition system (DAQ) for detecting various faults in 3D printed products. The data acquisition system was developed using an Arduino micro-controller that collects real-time multi-sensor signals using vibration, current, and sound sensors. The different types of fault conditions are referred to introduce various defects in 3D products to analyze the effect of the fault conditions on the captured sensor data. Time and frequency domain analyses were performed on captured data to create feature vectors by selecting the chi-square method, and the most significant features were selected to train the CNN model. The K-means cluster algorithm was used for data clustering purposes, and the bell curve or normal distribution curve was used to define individual sensor threshold values under normal conditions. The CNN model was used to classify the normal and fault condition data, which gave an accuracy of around 94%, by evaluating the model performance based on recall, precision, and F1 score.

Application of Fused Deposition Modelling (FDM) Method of 3D Printing in Drug Delivery

2017 ◽  
Vol 23 (3) ◽  
pp. 433-439 ◽  
Author(s):  
Jingjunjiao Long ◽  
Hamideh Gholizadeh ◽  
Jun Lu ◽  
Craig Bunt ◽  
Ali Seyfoddin
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Accurate Dose ◽  
Drug Delivery Devices ◽  
3D Printing Technique

Three-dimensional (3D) printing is an emerging manufacturing technology for biomedical and pharmaceutical applications. Fused deposition modelling (FDM) is a low cost extrusion-based 3D printing technique that can deposit materials layer-by-layer to create solid geometries. This review article aims to provide an overview of FDM based 3D printing application in developing new drug delivery systems. The principle methodology, suitable polymers and important parameters in FDM technology and its applications in fabrication of personalised tablets and drug delivery devices are discussed in this review. FDM based 3D printing is a novel and versatile manufacturing technique for creating customised drug delivery devices that contain accurate dose of medicine( s) and provide controlled drug released profiles.

Single and Multi-objective Optimization of Processing Parameters for Fused Deposition Modeling in 3D Printing Technology

2020 ◽  
Vol 17 (1) ◽  
pp. 7542-7551 ◽  
Author(s):  
V. H. Nguyen ◽  
T. N. Huynh ◽  
T. P. Nguyen ◽  
T. T. Tran
Keyword(s):  
Genetic Algorithm ◽  
3D Printing ◽  
Case Studies ◽  
Fused Deposition Modeling ◽  
Low Cost ◽  
Processing Parameters ◽  
Fused Deposition Modelling ◽  
Multi Objective Optimization ◽  
Multi Objective ◽  
Fused Deposition

This paper presents practice and application of Design of Experiment techniques and Genetic Algorithm in single and multi-objective optimization with low cost, robustness, and high effectiveness through 3D printing case studies. 3D printing brings many benefits for engineering design, product development, and production process. However, it faces many challenges related to parameters control. The wrong parameter setup can result in excessive time, high production cost, waste material, and low-quality printing. This study is conducted to optimize the parameter sets for 3D Fused Deposition Modelling (FDM) products. The parameter sets, i.e., layer height, infill percentage, printing temperature, printing speed with different levels are experimented and analyzed to build mathematic models. The objectives are to describe the relationship between the inputs (parameter values) and the outputs (printing quality in term of weight, printing time and tensile strength of products). Single-objective and multi-objective models according to user’s desire are constructed and studied to identify the optimal set, optimal trade-off set of parameters. Besides, an integrated method of response surface methodology and Genetic algorithm to deal with multi-objective optimization is discussed in the paper. 3D printer, testing machines, and quality tools are used for doing experiments, measurement and collecting data. Minitab and Matlab software aid for analysis and decision-making. Proposed solutions for handling multi-objective optimization through 3D Fused Deposition Modelling product printing case study are practical and can extend for other case studies.

scholarly journals An Overview of Natural Polymers as Reinforcing Agents for 3D Printing

2021 ◽  
Vol 5 (4) ◽  
pp. 78
Author(s):  
Beatrice Sabbatini ◽  
Alessandra Cambriani ◽  
Marco Cespi ◽  
Giovanni Filippo Palmieri ◽  
Diego Romano Perinelli ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Industrial Wastes ◽  
Fused Deposition Modelling ◽  
Natural Polymers ◽  
Fused Deposition ◽  
Glass Carbon

Three-dimensional (3D) printing, or additive manufacturing, is a group of innovative technologies that are increasingly employed for the production of 3D objects in different fields, including pharmaceutics, engineering, agri-food and medicines. The most processed materials by 3D printing techniques (e.g., fused deposition modelling, FDM; selective laser sintering, SLS; stereolithography, SLA) are polymeric materials since they offer chemical resistance, are low cost and have easy processability. However, one main drawback of using these materials alone (e.g., polylactic acid, PLA) in the manufacturing process is related to the poor mechanical and tensile properties of the final product. To overcome these limitations, fillers can be added to the polymeric matrix during the manufacturing to act as reinforcing agents. These include inorganic or organic materials such as glass, carbon fibers, silicon, ceramic or metals. One emerging approach is the employment of natural polymers (polysaccharides and proteins) as reinforcing agents, which are extracted from plants or obtained from biomasses or agricultural/industrial wastes. The advantages of using these natural materials as fillers for 3D printing are related to their availability together with the possibility of producing printed specimens with a smaller environmental impact and higher biodegradability. Therefore, they represent a “green option” for 3D printing processing, and many studies have been published in the last year to evaluate their ability to improve the mechanical properties of 3D printed objects. The present review provides an overview of the recent literature regarding natural polymers as reinforcing agents for 3D printing.

Performance of Low-Cost 3D Printer in Medical Application

2021 ◽  
Author(s):  
Nor Aiman Sukindar ◽  
Azib Azhari Awang Dahan ◽  
Sharifah Imihezri Syed Shaharuddin ◽  
Nor Farah Huda Abd Halim
Keyword(s):  
Low Cost ◽  
Medical Application ◽  
Fused Deposition Modelling ◽  
3D Printer ◽  
Layer By Layer ◽  
Total Deformation ◽  
Element Analysis ◽  
Porosity Level ◽  
Fused Deposition ◽  
Printing Parameters

Abstract Fused Deposition Modelling (FDM) is an additive manufacturing (AM) process that produces a physical object directly from a CAD design using layer-by-layer deposition of the filament material that is extruded via a nozzle. In industry, FDM has become one of the most used AM processes for the production of low batch quantity and functional prototypes, due to its safety, efficiency, reliability, low cost, and ability to process manufacturing-grade engineering thermoplastic. Recently, the market is flooded with the availability of low-cost printers produced by numerous companies. This research aims to investigate the effect of different porosity levels on a scaffold structure produced using a low-cost 3D printer. Comparisons of these porous structures were made in terms of Von-Mises strain, total deformation, as well as compressive stress. Various porosity levels were created by varying printing parameters, including layer height, infill density, and shell thickness by slicing the initial solid CAD file using Repetier Host 3D printing software. Finite Element Analysis (FEA) simulation was then performed on the created scaffold structures by using Ansys Workbench 19.2. The simulation result indicates that the greater porosity level will result in higher total deformation of the structure. Meanwhile, the compression test shows that the minimum strength value obtained was favourable at 22 MPa and had exceeded that of the trabecular femur (15 MPa). However, its porosity level (maximum at 52%) was still below that of the minimum threshold of porosity level of 70 percent. However, the printing parameters currently used can be adjusted in the future. Therefore, it was deduced that the low-cost 3D printer offers promising potential to fabricate different porosity structures with multiple outcomes.

scholarly journals Advanced Pharmaceutical Applications of Hot-Melt Extrusion Coupled with Fused Deposition Modelling (FDM) 3D Printing for Personalised Drug Delivery

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 203 ◽  
Author(s):  
Deck Tan ◽  
Mohammed Maniruzzaman ◽  
Ali Nokhodchi
Keyword(s):  
3D Printing ◽  
Hot Melt Extrusion ◽  
Pharmaceutical Products ◽  
Fused Deposition Modelling ◽  
Melt Extrusion ◽  
3D Object ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
Pharmaceutical Applications ◽  
Hot Melt

Three-dimensional printing, also known as additive manufacturing, is a fabrication process whereby a 3D object is created layer-by-layer by depositing a feedstock material such as thermoplastic polymer. The 3D printing technology has been widely used for rapid prototyping and its interest as a fabrication method has grown significantly across many disciplines. The most common 3D printing technology is called the Fused Deposition Modelling (FDM) which utilises thermoplastic filaments as a starting material, then extrudes the material in sequential layers above its melting temperature to create a 3D object. These filaments can be fabricated using the Hot-Melt Extrusion (HME) technology. The advantage of using HME to manufacture polymer filaments for FDM printing is that a homogenous solid dispersion of two or more pharmaceutical excipients i.e., polymers can be made and a thermostable drug can even be introduced in the filament composition, which is otherwise impractical with any other techniques. By introducing HME techniques for 3D printing filament development can improve the bioavailability and solubility of drugs as well as sustain the drug release for a prolonged period of time. The latter is of particular interest when medical implants are considered via 3D printing. In recent years, there has been increasing interest in implementing a continuous manufacturing method on pharmaceutical products development and manufacture, in order to ensure high quality and efficacy with less batch-to-batch variations of the pharmaceutical products. The HME and FDM technology can be combined into one integrated continuous processing platform. This article reviews the working principle of Hot Melt Extrusion and Fused Deposition Modelling, and how these two technologies can be combined for the use of advanced pharmaceutical applications.

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