scholarly journals PENYEBARAN GUMPALAN DALAM PEMBULUH DARAH (DISSEMINATED INTRAVASCULAR COAGULATION) AKIBAT RACUN GIGITAN ULAR

2018 ◽  
Vol 14 (1) ◽  
pp. 37
Author(s):  
Prihatini . ◽  
Trisnaningsih . ◽  
Muchdor . ◽  
U N Rachman
Keyword(s):  
Renal Failure ◽  
Snake Venom ◽  
Disseminated Intravascular Coagulation ◽  
World Wide ◽  
Clinical Symptoms ◽  
Toxic Substance ◽  
Necrotic Tissue ◽  
Snake Bites ◽  
Diabetic Syndrome

Cases of snake bites were seldom happened in town. From the 2500–3000 world-wide distributed species of snakes, 500 are venomous. The snake produce some toxic substance which is dangerous in men , and could cause morbidity or mortality. It’s caused byophitoxaemia, which influence the permeability of capilers with consequence bleeding. There patients must be examined physically, localas well systemic. The laboratoric examinations were based on clinical symptoms, by determination of the snake venom causal and thesequalae in the human body, including coagulopathy, anemia as well as renal failure, etc. The snake venom may cause necrotic tissue offoot and anemia by trombocytopenia.The condition of this victim patient was severre due to his diabetic syndrome. This article presenteda study of snake bite incident on an old man with DIC laboratoric results, following anemia and renal failure which caused his death.

scholarly journals A Study of Complications of Poisonous Snake Bites

2021 ◽  
Vol 10 (32) ◽  
pp. 2602-2608
Author(s):  
Sandip Ashok Mohale ◽  
Anuj Ramesh Varma ◽  
Gopikishan Ramkishan Bharadiya ◽  
Sourya Acharya ◽  
Shilpa Abhay Bawankule
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Longitudinal Study ◽  
Disseminated Intravascular Coagulation ◽  
Rural Areas ◽  
Adverse Reactions ◽  
Clinical Manifestations ◽  
Age Group ◽  
Snake Bites ◽  
Agricultural Labourers

BACKGROUND The present study was taken up to study the clinical manifestations, complications, and outcome in patients with poisonous snake bites admitted to Vivekanand Hospital, Latur (Maharashtra). METHODS This was a longitudinal study. Adult snakebite patients admitted from December 2012 to November 2014 were studied. RESULTS Mostly males (71.4 %) in the age group 18 - 29 years (58.6 %) were affected. Farmers (71.4 %) in rural areas (87.1 %) are the major sufferers. The neurotoxic venom poisoning ptosis (100 %) was commonest manifestation and was found in all cases. Palatal and pharyngeal palsy, ophthalmoplegia, respiratory palsy were also seen. In hemotoxic poisoning, bleeding from the bite site (73 %) was the commonest manifestation followed by hematuria (48.6 %) and gum bleeding (24.3 %). Among complications of poisonous snakebites, cellulitis (86.5 %) was the most common followed by acute renal failure (47.6 %), disseminated intravascular coagulation (DIC) (23.8 %), respiratory paralysis (12.7 %) and shock (4.28 %). Adverse reactions to anti-snake venom (ASV) were noted in 16 (22.9 %) patients. Total 10 patients died (14.3 %) mostly were due to acute renal failure (26.6 %). CONCLUSIONS Snakebite is common among agricultural labourers. Mostly males in the age group 18 - 29 years were bitten during 12 noon to 6 pm. Peak incidence peaked in between May to October. Viper bites were more common than Elapidae in this study. In neurotoxic envenomation, ptosis was the commonest and earliest symptom while in hemotoxic envenomation, most common symptoms were bleeding from bite site and hematuria. The commonest complications were cellulitis, acute renal failure and DIC. Early hospitalization and timely ASV were the corner stone in the treatment of snakebite. KEY WORDS Snakebite, Neurotoxic, Elapidae, Viperidae

Evaluation of Snake Venom’s PhospholipaseA2 Enzyme Inhibition Activity of Cyphostemma adenocoule

2020 ◽  
Vol 14 (3) ◽  
pp. 196-202
Author(s):  
Atul Kaushik ◽  
Teamrat S. Tesfai ◽  
Daniel K. Barkh ◽  
Furtuna K. Ghebremeskel ◽  
Habtom G. Zerihun ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Snake Venom ◽  
Ethanol Extract ◽  
Egg Yolk ◽  
Chloroform Extract ◽  
Inhibition Activity ◽  
Traditional Use ◽  
Snake Bites ◽  
Ethanol Extracts

Background: A snake bite is fundamentally an injury often resulting in puncture wounds meted out by the animal's fangs and occasionally resulting in envenomation. Rate of snake bites around 5,400,000 bites per year leads to over 2,500,000 envenomings and around 125,000 fatal cases annually. Snake venom enzymes are rich in metalloproteinases, phospholipaseA2, proteinases, acetylcholinesterases and hyaluronidases. Objective: Cyphostemma adenocoule is traditionally being used for the treatment of snake bites in Eritrea. The present research was aimed at evaluating the snake venom enzyme inhibition activity of C. adenocoule against puff adder venom and developing a base for the traditional use of the plant against snakebites in Eritrea. Methods: The anti-venom activity of C. adenocoule was assessed in-vitro through phospholipaseA2 enzyme inhibition assay using egg yolk as a cell. The ethanol and chloroform extracts of C. adenocoule showed in vitro anti phospholipase A2 activity, whereas the water extracts of the plant showed no activity. Results: Among the extracts of C. adenocoule, the highest percentage of inhibition was obtained from chloroform extract (95.55% at 100mg/ml). The extract showed prominent activity at different concentrations (34.7% at10mg/ml, 48.8% at 20mg/ml, 54.8% at 40mg/ml, 60.9% at 60mg/ml, 80.5% at 80mg /ml). The ethanol extract also showed certain activity at various concentrations (25.22% at10mg/ml, 14.78% at 20mg/ml, 2.6% at40mg/ml). The activity of the chloroform extracts increases as concentration increases, whereas the activity of the ethanol extracts decreases as concentration increases. The aqueous extract of C. adenocoule did not show any activity at all concentrations. Conclusion: In this study, the chloroform and ethanol extracts of the plant inhibited the enzyme of interest and thus proved the efficacy of anti-snake venom activity of the plant.

LRF and TRF test during long-term danazol treatment: increase of the LH and FSH responses but decrease of the prolactin and TSH responses

1983 ◽  
Vol 104 (1) ◽  
pp. 1-5 ◽  
Author(s):  
J. Leppäluoto ◽  
L. Rönnberg ◽  
P. Ylöstalo
Keyword(s):  
Clinical Symptoms ◽  
Follicular Phase ◽  
Blood Samples ◽  
Hormone Levels ◽  
Coefficients Of Variation ◽  
The Mean ◽  
Thyroid Hormone Levels ◽  
Low Serum

Abstract. Seven patients suffering from severe endometriosis were treated with danazol 200 mg × 3 daily for 6 months. Clinical symptoms were alleviated and menses disappeared in response to the treatment. After cessation of the treatment the menstrual bleedings returned in 1–3 months. Blood samples for determination of gonadotrophins, prolactin (Prl), oestradiol (E2), progesterone, thyroid hormones and thyrotrophin in radioimmunoassays were taken and a combined TRF and LRF test carried out in the follicular phase before treatment, at the 6th month of treatment and after reappearance of the first menses. There were no statistically significant changes in the basal levels of serum FSH, LH or TSH during the danazol treatment. Neither was there any change in episodic secretions of FSH, LH or Prl, as determined by the mean coefficients of variation of the hormone levels in seven consecutive samples taken at 20 min intervals. On the other hand, serum E2, Prl and thyroid hormone levels were significantly decreased in the 6th month of treatment. In the TRF-LRF test the responses of serum FSH and LH were significantly higher and those of serum Prl and TSH significantly lower during danazol treatment than before. Prl responses remained lowered after the treatment. It appears that low serum oestrogen levels, induced by the danazol treatment, sensitize the pituitary gonadotrophs to exogenous LRF, but make the sensitivity of thyrotrophs and lactotrophs lower to exogenous TRF. These results thus indicate that danazol does not make the pituitary gonadotrophs insensitive to LRF, but danazol may rather inhibit the secretion of hypothalamic LRF.

scholarly journals Multi-residue analytical methods for the determination of pesticides and PPCPs in water by LC-MS/MS: a review

2012 ◽  
Vol 10 (3) ◽  
pp. 876-899 ◽  
Author(s):  
Ednei Primel ◽  
Sergiane Caldas ◽  
Ana Escarrone
Keyword(s):  
Mass Spectrometry ◽  
Analytical Methods ◽  
Environmental Samples ◽  
World Wide ◽  
Matrix Effects ◽  
Tandem Mass ◽  
Selective Determination ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

AbstractResidues of pesticides, pharmaceutical and personal care products (PPCPs) are contaminants of world-wide concern. Consequently, there is a growing need to develop reliable analytical methods, which enable rapid, sensitive and selective determination of these pollutants in environmental samples, at trace levels. In this paper, a review of the liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for the determination of pesticides and PPCPs in the environment is presented. Advanced aspects of current LC-MS/MS methodology, including sample preparation and matrix effects, are discussed.

Automated Determination of the Position of Ships by Satellites

1967 ◽  
Vol 20 (03) ◽  
pp. 281-285
Author(s):  
H. C. Freiesleben
Keyword(s):  
Celestial Body ◽  
World Wide ◽  
Artificial Satellites ◽  
Radio Waves ◽  
The Moon ◽  
Position Determination ◽  
The Earth ◽  
Navigational Aids ◽  
Automated Determination

It has recently been suggested that 24-hour satellites might be used as navigational aids. To what category of position determination aids should these be assigned ? Is a satellite of this kind as it were a landmark, because, at least in theory, it remains fixed over the same point on the Earth's surface, in which case it should be classified under land-based navigation aids ? Is it a celestial body, although only one tenth as far from the Earth as the Moon ? If so, it is an astronomical navigation aid. Or is it a radio aid ? After all, its use for position determination depends on radio waves. In this paper I shall favour this last view. For automation is most feasible when an object of observation can be manipulated. This is easiest with radio aids, but it is, of course, impossible with natural stars.At present artificial satellites have the advantage over all other radio aids of world-wide coverage.

scholarly journals Cervical Cat Scratch Disease Lymphadenitis in a Patient with Immunoglobulin M Antibodies to Toxoplasma gondii

2002 ◽  
Vol 9 (2) ◽  
pp. 496-498
Author(s):  
Mardjan Arvand ◽  
Ilkay Kazak ◽  
Sergije Jovanovic ◽  
Hans-Dieter Foss ◽  
Oliver Liesenfeld
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Symptoms ◽  
Bartonella Henselae ◽  
Cervical Lymphadenopathy ◽  
Immunoglobulin M ◽  
Cat Scratch Disease ◽  
Specific Immunoglobulin ◽  
Acute Toxoplasmosis

ABSTRACT We report on a young patient with chronic cervical lymphadenopathy and serological and histological evidence for infection with Bartonella henselae and Toxoplasma gondii. Serological follow-up studies, including testing for avidity of Toxoplasma-specific immunoglobulin G antibodies, assisted in the determination of the cause of the acute lymphadenitis. Our results suggest that the clinical symptoms were most likely due to cat scratch disease rather than to acute toxoplasmosis.

scholarly journals Determination of Radical Species in the Kidney of Rats with Chronic Renal Failure by the Spin Trapping Method

Nephron ◽  
1995 ◽  
Vol 70 (3) ◽  
pp. 382-384 ◽  
Author(s):  
Takako Yokozawa ◽  
Naoki Fujitsuka ◽  
Hikokichi Oura ◽  
Akitane Mori ◽  
Hiroshi Kashiwagi
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Spin Trapping ◽  
Radical Species ◽  
Trapping Method

scholarly journals Renal Failure from Snake Bites

1980 ◽  
Vol 3 (6) ◽  
pp. 319-321 ◽  
Author(s):  
K.S. Chugh ◽  
V. Sakhuja
Keyword(s):  
Renal Failure ◽  
Snake Bites

One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1

2014 ◽  
Vol 50 (44) ◽  
pp. 5837-5839 ◽  
Author(s):  
Man Pan ◽  
Yao He ◽  
Ming Wen ◽  
Fangming Wu ◽  
Demeng Sun ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Snake Venom ◽  
Structure Determination ◽  
Native Chemical Ligation ◽  
One Pot ◽  
Chemical Ligation ◽  
Venom Toxin ◽  
Snake Venom Toxin ◽  
Switch Strategy

An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation.

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