scholarly journals The true identity of Pascal’s mite and the diachronic use of ciron

Acarologia ◽  
2019 ◽  
Vol 59 (2) ◽  
pp. 261-278
Author(s):  
Henri M. André
Keyword(s):  
Sarcoptes Scabiei ◽  
Everyday Language ◽  
Acarus Siro ◽  
Scabies Mite

The identity of Blaise Pascal’s mite is examined. Linguistics, morphology, habitat and size reveal that Pascal’s mite is not Acarus siro L., as usually thought, but Sarcoptes scabiei (L.). The diachronic use of the popular term ciron is explored from a number of different perspectives. In everyday language and in Pascal’s time, the term used to designate A. siro L. was mite (used singly, in English and French) and not ciron, a word restricted to the scabies mite; its use is also investigated. The classification of mites in the 17th and 18th centuries is reviewed.

scholarly journals Handling of Scabies in Domestic Cat at Q-one Petklinik Surabaya

2021 ◽  
Vol 2 (2) ◽  
pp. 50
Author(s):  
Bagus Uda Palgunadi ◽  
Katarina Kole Grace Wangge ◽  
Lailia Dwi Kusuma Wardhani
Keyword(s):  
Physical Condition ◽  
Microscopic Examination ◽  
Direct Contact ◽  
Supportive Therapy ◽  
Sarcoptes Scabiei ◽  
The Body ◽  
Domestic Cat ◽  
Domestic Cats ◽  
Scabies Mite ◽  
Facial Area

Background: Scabies is a skin disease caused by Sarcoptes scabiei. Scabies is transmitted through direct contact with animals affected by scabies or contact with the source of scabies mite in area of cat lives. Purpose: This study aims to determine the management of scabies at Q-One PetKlinik Surabaya. Method: Handling domestic cats affected by S.scabiei began with an interview with the  owner and examinated with the physical condition of cats, and observed the body that was infected with S.scabiei. Scrabbing on scabs was conducted in the cat’s body which was located in the facial area, and followed by microscopic examination to observe the S.scabiei mite. Results: During April 2021, there were 13 domestic cats affected by scabies. Treatment for scabies was by administrated drugs containing 5% Permethrin. Cats were also given supportive therapy by grooming with antiectoparasite shampoo after two weeks from being given drugs. Conclusion: Handling cases of scabies in domestic cats at Q-One PetKlinik Surabaya is performed by cleaning the scab, applying an ointment containing 5% permethrin, and giving anti-histamine and anti-parasitic as well as providing supportive therapy in the form of grooming using shampoo containing anti-ectoparasites.

Molecular drug targets for scabies: a medicinal chemistry perspective

2020 ◽  
Vol 12 (24) ◽  
pp. 2225-2238
Author(s):  
Wali Inam ◽  
Shelley Walton ◽  
Sheraz Khan ◽  
Wajahat Mahmood
Keyword(s):  
Protein Interactions ◽  
Drug Targets ◽  
Proteolytic Enzymes ◽  
Hydrolytic Enzymes ◽  
Sarcoptes Scabiei ◽  
Causative Organism ◽  
Protein Protein Interactions ◽  
Scabies Mite ◽  
Nonpeptide Ligands ◽  
Global Population

Sarcoptes scabiei is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.

scholarly journals Mechanisms for a Novel Immune Evasion Strategy in the Scabies Mite Sarcoptes Scabiei: A Multigene Family of Inactivated Serine Proteases

2003 ◽  
Vol 121 (6) ◽  
pp. 1419-1424 ◽  
Author(s):  
Peter Wilson ◽  
Robert Slade ◽  
Bart J. Currie ◽  
Shelley F. Walton ◽  
Deborah C. Holt ◽  
...  
Keyword(s):  
Immune Evasion ◽  
Multigene Family ◽  
Serine Proteases ◽  
Sarcoptes Scabiei ◽  
Evasion Strategy ◽  
Scabies Mite

scholarly journals Increased Allergic Immune Response to Sarcoptes scabiei Antigens in Crusted versus Ordinary Scabies

2010 ◽  
Vol 17 (9) ◽  
pp. 1428-1438 ◽  
Author(s):  
Shelley F. Walton ◽  
Susan Pizzutto ◽  
Amy Slender ◽  
Linda Viberg ◽  
Deborah Holt ◽  
...  
Keyword(s):  
Immune Response ◽  
House Dust ◽  
House Dust Mite ◽  
Mononuclear Cells ◽  
Sarcoptes Scabiei ◽  
Clinical Severity ◽  
Serum Ige ◽  
Dust Mite ◽  
Scabies Mite ◽  
Crusted Scabies

ABSTRACT Scabies, a parasitic skin infestation by the burrowing “itch” mite Sarcoptes scabiei, causes significant health problems for children and adults worldwide. Crusted scabies is a particularly severe form of scabies in which mites multiply into the millions, causing extensive skin crusting. The symptoms and signs of scabies suggest host immunity to the scabies mite, but the specific resistant response in humans remains largely uncharacterized. We used 4 scabies mite recombinant proteins with sequence homology to extensively studied house dust mite allergens to investigate a differential immune response between ordinary scabies and the debilitating crusted form of the disease. Subjects with either disease form showed serum IgE against recombinant S. scabiei cysteine and serine proteases and apolipoprotein, whereas naive subjects showed minimal IgE reactivity. Significantly (P < 0.05) greater serum IgE and IgG4 binding to mite apolipoprotein occurred in subjects with crusted scabies than in those with ordinary scabies. Both subject groups showed strong proliferative responses (peripheral blood mononuclear cells) to the scabies antigens, but the crusted scabies group showed increased secretion of the Th2 cytokines interleukin 5 (IL-5) and IL-13 and decreased Th1 cytokine gamma interferon (IFN-γ) in response to the active cysteine protease. These data confirm that a nonprotective allergic response occurs in the crusted disease form and demonstrate that clinical severity is associated with differences in the type and magnitude of the antibody and cellular responses to scabies proteins. A quantitative IgE inhibition assay identified IgE immunoreactivity of scabies mite antigens distinct from that of house dust mite antigens, which is potentially important for specific scabies diagnosis and therapy.

scholarly journals An Aspartic Protease of the Scabies Mite Sarcoptes scabiei Is Involved in the Digestion of Host Skin and Blood Macromolecules

2013 ◽  
Vol 7 (11) ◽  
pp. e2525 ◽  
Author(s):  
Wajahat Mahmood ◽  
Linda T. Viberg ◽  
Katja Fischer ◽  
Shelley F. Walton ◽  
Deborah C. Holt
Keyword(s):  
Sarcoptes Scabiei ◽  
Aspartic Protease ◽  
Scabies Mite

Complement evasion of the scabies mite Sarcoptes scabiei

2009 ◽  
Vol 46 (14) ◽  
pp. 2849 ◽  
Author(s):  
K. Fischer ◽  
F. Bergström ◽  
S. Reynolds ◽  
C. Willis ◽  
M. Johnstone ◽  
...  
Keyword(s):  
Sarcoptes Scabiei ◽  
Scabies Mite

scholarly journals Ácaros Astigmata y Prostigmata de Importancia Médica en el Perú

2014 ◽  
Vol 58 (2) ◽  
pp. 112
Author(s):  
Zoila Guillén ◽  
Giuliana Romero ◽  
Elizabeth Pareja ◽  
Miguel Valencia ◽  
Martha López ◽  
...  
Keyword(s):  
Sarcoptes Scabiei ◽  
Tyrophagus Putrescentiae ◽  
Acarus Siro ◽  
Demodex Brevis ◽  
De Medicina

En el presente trabajo reportamos especies de ácaros Astigmata y Prostigmata que producen patología humana en el Perú. El estudio se hizo en pacientes que acudieron al Instituto de Medicina Tropical «Daniel A. Carrión» Huinco y en polvo doméstico de Lima, Lambayeque, Trujillo y Ucayali; se consideraron además referencias bibliográficas publicadas al respecto. Hallamos los siguientes Astigmata: Tyrophagus putrescentiae, Acarus siro, Suidasia sp., Dermatophagoides pteromyssinus, Glycyphagus domesticus, y Sarcoptes scabiei; y los Prostigmata: Demodex brevis, Demodex follicalorum, Tarsonemus sp. y Trombicula irritans.

Scabies

2019 ◽  
pp. 331-338
Keyword(s):  
Life Cycle ◽  
Sarcoptes Scabiei ◽  
Second Line ◽  
First Line ◽  
Practical Advice ◽  
Modes Of Transmission ◽  
Clinical Presentations ◽  
Scabies Mite ◽  
Crusted Scabies ◽  
In Pregnancy

Infestation of the human by the parasitic scabies mite, Sarcoptes scabiei var hominis, is discussed in this chapter on scabies. The life cycle of the mite is outlined, and the epidemiology and modes of transmission are discussed. The clinical presentations of classical scabies, crusted scabies, scabies in someone with HIV, and scabies incognito are all explained in turn. Diagnosis is discussed and first-line management with permethrin, with malathion as a second-line alternative, are explained. The accompanying practical advice on how to use the treatments that should be given to patients is detailed. The treatment of crusted scabies, considerations in pregnancy/breastfeeding, and emerging resistance are mentioned.

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