Prevalences of lumbosacral articulation anatomic variants identified on nuclear scintigraphy and transrectal ultrasonography of Selle Français Warmbloods, French Standardbred Trotters, and Thoroughbreds and agreement between results from the imaging modalities

2022 ◽  
pp. 1-9
Author(s):  
Guillaume Vautravers ◽  
Fabrice Audigié ◽  
Jean-Marie Denoix
Keyword(s):  
Athletic Performance ◽  
Vertebral Column ◽  
Interobserver Agreement ◽  
Imaging Modality ◽  
Clinical Manifestations ◽  
Transrectal Ultrasonography ◽  
Nuclear Scintigraphy ◽  
Anatomic Variants ◽  
Clinical Records

Abstract OBJECTIVE To describe scintigraphic and transrectal ultrasonographic anatomic variants of the lumbosacral (LS) articulation in horses and to determine the agreement between results obtained with each imaging modality. ANIMALS 243 horses (81 Selle Français Warmbloods, 81 French Standardbred Trotters, and 81 Thoroughbreds). PROCEDURES A retrospective search of clinical records was conducted to identify horses that had undergone nuclear scintigraphy and transrectal ultrasonography of the LS region of the vertebral column between January 2016 and December 2019. Scintigraphic images were evaluated by 2 observers blinded to the other’s results for classification of LS articulation anatomic variants (scintigraphic type); intra- and interobserver agreement were determined. Ultrasonographic images were evaluated for classification of LS intervertebral symphysis anatomic variant (ultrasonographic grade) by 1 observer blinded to horses’ identities and scintigraphic findings; agreement analysis was performed between scintigraphic type and ultrasonographic grade. Descriptive and statistical analyses were performed to describe distribution of anatomic variants. RESULTS The scintigraphic classification system (scintigraphic type) had excellent intra- and interobserver agreement. Agreement between results for scintigraphic type and ultrasonographic grade was moderate (κ = 0.61; 95% CI, 0.52 to 0.70). Anatomic variants of the LS articulation were observed in all groups. The distribution of variants differed significantly among breeds but not sexes. CLINICAL RELEVANCE Anatomic variations of the LS articulation in horses must be known to avoid misinterpreting them as clinically meaningful findings. Further research is needed to determine potential relationships between these anatomic variants and LS lesions, their clinical manifestations, and their influence on athletic performance.

scholarly journals Osteopathic Aspects of Vertebroneurology

2017 ◽  
pp. 105-117 ◽  
Author(s):  
N. . Kozlova ◽  
V. . Belash
Keyword(s):  
Vertebral Column ◽  
Clinical Manifestations ◽  
Osteopathic Treatment ◽  
History Of ◽  
Methods Of Treatment

The article considers the main notions of vertebroneurology, the history of its development, classification of vertebrogenic diseases, their etiology and pathogenesis. The main clinical manifestations and the possibilities of diagnostics of vertebrogenic diseases are described. Both surgical and conservative methods of treatment of vertebrogenic pathologies are considered. Special attention is paid to the possibilities of osteopathic treatment of the diseases of the vertebral column as it is the most harmless and effective method. A number of frequently used osteopathic techniques which proved to be the most effective are described.

scholarly journals The Classification of Posterior Petrous Meningiomas and Its Clinical Significance

2009 ◽  
Vol 37 (3) ◽  
pp. 949-957 ◽  
Author(s):  
FJ Qu ◽  
XD Zhou ◽  
XL Wang ◽  
F Li ◽  
XD Lu ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Cranial Nerves ◽  
Clinical Manifestations ◽  
Type I ◽  
Type Ii ◽  
Resection Rate ◽  
Total Resection ◽  
Radiological Images ◽  
Clinical Records

This retrospective analysis of the clinical records of 42 patients was used to study the clinical significance of a classification system for posterior petrous meningiomas. According to clinical manifestations and radiological images, posterior petrous meningiomas were classified into three types: type I (cerebella type; 12 patients), tumours involved and compressed the cerebellum; type II (cranial nerve type; 16 patients), tumours involved the cranial nerves; and type III (combined type; 14 patients), tumours involved more than one structure such as the cerebellum, cranial nerves and the brain stem. All patients underwent microneurosurgery and the total resection rate was 90%. It was more difficult totally to resect type II and III tumours than type I tumours and the post-operative functional outcomes were worse. Microneurosurgical techniques and skills are critical to increase the total resection rate of posterior petrous meningiomas in order to decrease the mortality and disability rates.

Use of photodynamic therapy for photodamage skin (review of literature)

2019 ◽  
Vol 1 (7) ◽  
pp. 19-23
Author(s):  
S. I. Surkichin ◽  
N. V. Gryazeva ◽  
L. S. Kholupova ◽  
N. V. Bochkova
Keyword(s):  
Photodynamic Therapy ◽  
Comparative Evaluation ◽  
Clinical Manifestations ◽  
Light Sources ◽  
Review Of Literature ◽  
Photosensitizing Agents ◽  
Selection Of

The article provides an overview of the use of photodynamic therapy for photodamage of the skin. The causes, pathogenesis and clinical manifestations of skin photodamage are considered. The definition, principle of action of photodynamic therapy, including the sources of light used, the classification of photosensitizers and their main characteristics are given. Analyzed studies that show the effectiveness and comparative evaluation in the selection of various light sources and photosensitizing agents for photodynamic therapy in patients with clinical manifestations of photodamage.

scholarly journals Interobserver agreement of the Paris and simplified classifications of superficial colonic lesions: a Western study

2021 ◽  
Vol 09 (03) ◽  
pp. E388-E394
Author(s):  
Francesco Cocomazzi ◽  
Marco Gentile ◽  
Francesco Perri ◽  
Antonio Merla ◽  
Fabrizio Bossa ◽  
...  
Keyword(s):  
Interobserver Agreement ◽  
Classification Systems ◽  
Sensitivity Analyses ◽  
Size Estimation ◽  
Rater Agreement ◽  
Staff Members ◽  
Video Clips ◽  
Paris Classification ◽  
Level Of Agreement

Abstract Background and study aims The Paris classification of superficial colonic lesions has been widely adopted, but a simplified description that subgroups the shape into pedunculated, sessile/flat and depressed lesions has been proposed recently. The aim of this study was to evaluate the accuracy and inter-rater agreement among 13 Western endoscopists for the two classification systems. Methods Seventy video clips of superficial colonic lesions were classified according to the two classifications, and their size estimated. The interobserver agreement for each classification was assessed using both Cohen k and AC1 statistics. Accuracy was taken as the concordance between the standard morphology definition and that made by participants. Sensitivity analyses investigated agreement between trainees (T) and staff members (SM), simple or mixed lesions, distinct lesion phenotypes, and for laterally spreading tumors (LSTs). Results Overall, the interobserver agreement for the Paris classification was substantial (κ = 0.61; AC1 = 0.66), with 79.3 % accuracy. Between SM and T, the values were superimposable. For size estimation, the agreement was 0.48 by the κ-value, and 0.50 by AC1. For single or mixed lesions, κ-values were 0.60 and 0.43, respectively; corresponding AC1 values were 0.68 and 0.57. Evaluating the several different polyp subtypes separately, agreement differed significantly when analyzed by the k-statistics (0.08–0.12) or the AC1 statistics (0.59–0.71). Analyses of LSTs provided a κ-value of 0.50 and an AC1 score of 0.62, with 77.6 % accuracy. The simplified classification outperformed the Paris classification: κ = 0.68, AC1 = 0.82, accuracy = 91.6 %. Conclusions Agreement is often measured with Cohen’s κ, but we documented higher levels of agreement when analyzed with the AC1 statistic. The level of agreement was substantial for the Paris classification, and almost perfect for the simplified system.

scholarly journals Interobserver agreement of Prostate Imaging–Reporting and Data System (PI-RADS–v2)

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Hala Maher Ahmed ◽  
Ahmed Ebrahim Ebeed ◽  
Ahmed Hamdy ◽  
Mohamed Abou El-Ghar ◽  
Ahmed Abdel Khalek Abdel Razek
Keyword(s):  
Interobserver Agreement ◽  
Imaging Modality ◽  
Peripheral Zone ◽  
Transitional Zone ◽  
Data System ◽  
3 Tesla ◽  
Prostate Imaging ◽  
Percent Agreement ◽  
3 Tesla Mri

Abstract Background A retrospective study was conducted on 71 consecutive patients with suspected prostate cancer (PCa) with a mean age of 56 years and underwent mp-MRI of the prostate at 3 Tesla MRI. Two readers recognized all prostatic lesions, and each lesion had a score according to Prostate Imaging–Reporting and Data System version 2 (PI-RADS-v2). Purpose of the study To evaluate the interobserver agreement of PI-RADS-v2 in characterization of prostatic lesions using multiparametric MRI (mp-MRI) at 3 Tesla MRI. Results The overall interobserver agreement of PI-RADS-v2 for both zones was excellent (k = 0.81, percent agreement = 94.9%). In the peripheral zone (PZ) lesions are the interobserver agreement for PI-RADS II (k = 0.78, percent agreement = 83.9%), PI-RADS III (k = 0.66, percent agreement = 91.3 %), PI-RADS IV (k = 0.69, percent agreement = 93.5%), and PI-RADS V (k = 0.91, percent agreement = 95.7 %). In the transitional zone (TZ) lesions are the interobserver agreement for PI-RADS I (k = 0.98, percent of agreement = 96%), PI-RADS II (k = 0.65, percent agreement = 96%), PI-RADS III (k = 0.65, percent agreement = 88%), PI-RADS IV (k = 0.83, percent agreement = 96%), and PI-RADS V (k = 0.82, percent agreement = 92%). Conclusion We concluded that PI-RADS-v2 is a reliable and a reproducible imaging modality for the characterization of prostatic lesions and detection of PCa.

scholarly journals AB1048 RHUPUS SYNDROME IN A TERTIARY HOSPITAL

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1815.1-1815
Author(s):  
I. Martínez Cordellat ◽  
R. Gonzalez Mazario ◽  
M. De la Rubia Navarro ◽  
C. Pávez Perales ◽  
S. Leal Rodriguez ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Tertiary Hospital ◽  
Jak Inhibitors ◽  
Systematic Revision ◽  
Erosive Arthritis ◽  
Rheumatoid Nodules ◽  
Clinical Records ◽  
Low Prevalence ◽  
First Diagnosis

Background:Rhupus syndrome (RhS) is a rare combination of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Different studies describe RhS cases that begin with erosive arthritis and the presence of rheumatoid factor (RF) and/or anti CCP and then the SLE symptoms.Objectives:Despite the fact that RhS shows a low prevalence, it would be useful to know clinical characteristics of RhS patients since their therapy and outcome differ from those having RA or SLE alone.Methods:Retrospective study with systematic revision of electronic clinical records of RhS patients was performed. Demographic, clinical and immunological data were collected.Results:Eight RhS patients were included (all fulfilled SLICC 2012 criteria for SLE and ACR 2010 for RA). Mean age was 67.3 (45-84) years (7 were female).In 3 cases RA was the first diagnosis with a mean evolution of 4.5 years until SLE diagnosis. In contrast, in 5 cases SLE was the first diagnosis with a mean evolution of 7.2 years until RA diagnosis. Photosensitivity and arthritis were the predominant clinical manifestations. One patient presents pericarditis and other case showed rheumatoid nodules in elbows. Renal, pulmonary or neurological affection was no reported.4 patients were under biological/JAK inhibitors therapies (2 abatacept, 1 rituximab and 1 baricitinib) with favorable response of treatment.Conclusion:In contrast to other series, only the 37.5% of our RhS cases begins with polyarticular seropositive arthritis. The 62.5% started with SLE symptoms as haematological alterations, cutaneous and serological manifestation, and showed longer progression to have polyarticular affection. Thus, RhS diagnosis is earlier in patients that begin with RA symptoms. 4 RhS patients were refractory to DMARd treatments, where biological/JAK inhibitors therapies are needed.Disclosure of Interests:None declared

scholarly journals Classification of lymphoid neoplasms: the microscope as a tool for disease discovery

Blood ◽  
2008 ◽  
Vol 112 (12) ◽  
pp. 4384-4399 ◽  
Author(s):  
Elaine S. Jaffe ◽  
Nancy Lee Harris ◽  
Harald Stein ◽  
Peter G. Isaacson
Keyword(s):  
Molecular Mechanisms ◽  
Nk Cell ◽  
Clinical Manifestations ◽  
Lymphoid Cells ◽  
World Health ◽  
International Studies ◽  
Lymphocyte Function ◽  
Lymphoid Neoplasms

AbstractIn the past 50 years, we have witnessed explosive growth in the understanding of normal and neoplastic lymphoid cells. B-cell, T-cell, and natural killer (NK)–cell neoplasms in many respects recapitulate normal stages of lymphoid cell differentiation and function, so that they can be to some extent classified according to the corresponding normal stage. Likewise, the molecular mechanisms involved the pathogenesis of lymphomas and lymphoid leukemias are often based on the physiology of the lymphoid cells, capitalizing on deregulated normal physiology by harnessing the promoters of genes essential for lymphocyte function. The clinical manifestations of lymphomas likewise reflect the normal function of lymphoid cells in vivo. The multiparameter approach to classification adopted by the World Health Organization (WHO) classification has been validated in international studies as being highly reproducible, and enhancing the interpretation of clinical and translational studies. In addition, accurate and precise classification of disease entities facilitates the discovery of the molecular basis of lymphoid neoplasms in the basic science laboratory.

POLYNEURITIS IN CHILDREN

PEDIATRICS ◽  
1958 ◽  
Vol 22 (5) ◽  
pp. 972-990
Author(s):  
Niels L. Low ◽  
Julia Schneider ◽  
Sidney Carter
Keyword(s):  
Clinical Picture ◽  
Cranial Nerve ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Severity Of The Disease ◽  
Clinical Records

Polyneuritis in children is becoming more common. The clinical picture is variable; it may be manifested by motor and sensory findings, or by a combination of peripheral and cranial nerve signs and symptoms. The etiology is usually obscure. The pathologic picture varies with the severity of the disease and differs according to the stage at which the patient dies, but all fatal cases show the same main characteristic changes. Clinical records of 30 cases, 17 boys and 13 girls from 17 months to 16 years of age, are reviewed. The clinical manifestations, course and treatment are described.

Muscular syndrome in patients with inflammatory and degenerative diseases of joints and vertebral column

1999 ◽  
Vol 80 (2) ◽  
pp. 113-116
Author(s):  
R. A. Khabirov
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatic Diseases ◽  
Clinical Picture ◽  
Skeletal Muscles ◽  
Vertebral Column ◽  
Degenerative Diseases ◽  
Muscular System ◽  
Pathogenetic Mechanisms ◽  
Diagnosis Criteria

The manifestations of muscular syndrome affecting the gravity and prediction of the disease take place in the most widespread and invalidizing rheumatic diseases: osteoarthrosis, rheumatoid arthritis and ankylosing spondylarthritis. Paraclinical studies showed heterogeneity of pathogenetic mechanisms in lesion of skeletal muscles in rheumatic diseases. The differentiated methods of the treatment of patients with osteoarthrosis, rheumatoid arthritis and ankylosing spondylarthritis taking into account the clinical picture and pathogenesis of muscular syndrome, as well as the diagnosis criteria and classification of muscular system lesion are suggested.

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