Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI

White matter hyperintensity (WMH) is common in healthy adults in their 60s and can be seen as early as in their 30s and 40s. Alterations in the brain structural and functional profiles in adults with WMH have been repeatedly studied but with a focus on late-stage WMH. To date, structural and functional MRI profiles during the very early stage of WMH remain largely unexplored. To address this, we investigated multimodal MRI (structural, diffusion, and resting-state functional MRI) profiles of community-dwelling asymptomatic adults with very early-stage WMH relative to age-, sex-, and education-matched non-WMH controls. The comparative results showed significant age-related and age-independent changes in structural MRI-based morphometric measures and resting-state fMRI-based measures in a set of specific gray matter (GM) regions but no global white matter changes. The observed structural and functional anomalies in specific GM regions in community-dwelling asymptomatic adults with very early-stage WMH provide novel data regarding very early-stage WMH and enhance understanding of the pathogenesis of WMH.

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Mindfulness Meditation Is Related to Long-Lasting Changes in Hippocampal Functional Topology during Resting State: A Magnetoencephalography Study

Neural Plasticity ◽

10.1155/2018/5340717 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Anna Lardone ◽

Marianna Liparoti ◽

Pierpaolo Sorrentino ◽

Rosaria Rucco ◽

Francesca Jacini ◽

...

Keyword(s):

Resting State ◽

Mindfulness Meditation ◽

Brain Connectivity ◽

Brain Networks ◽

Brain Network ◽

Long Term Effects ◽

Age Related ◽

Functional Topology ◽

The Right ◽

The Brain

It has been suggested that the practice of meditation is associated to neuroplasticity phenomena, reducing age-related brain degeneration and improving cognitive functions. Neuroimaging studies have shown that the brain connectivity changes in meditators. In the present work, we aim to describe the possible long-term effects of meditation on the brain networks. To this aim, we used magnetoencephalography to study functional resting-state brain networks in Vipassana meditators. We observed topological modifications in the brain network in meditators compared to controls. More specifically, in the theta band, the meditators showed statistically significant (p corrected = 0.009) higher degree (a centrality index that represents the number of connections incident upon a given node) in the right hippocampus as compared to controls. Taking into account the role of the hippocampus in memory processes, and in the pathophysiology of Alzheimer’s disease, meditation might have a potential role in a panel of preventive strategies.

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Heritability of head motion during resting state functional MRI in 462 healthy twins

NeuroImage ◽

10.1016/j.neuroimage.2014.08.010 ◽

2014 ◽

Vol 102 ◽

pp. 424-434 ◽

Cited By ~ 39

Author(s):

Baptiste Couvy-Duchesne ◽

Gabriëlla A.M. Blokland ◽

Ian B. Hickie ◽

Paul M. Thompson ◽

Nicholas G. Martin ◽

...

Keyword(s):

Functional Mri ◽

Resting State ◽

Head Motion

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Impact of anaesthesia on static and dynamic functional connectivity in mice

10.1101/2021.03.18.436098 ◽

2021 ◽

Author(s):

Tomokazu Tsurugizawa ◽

Daisuke Yoshimaru

Keyword(s):

Functional Connectivity ◽

Functional Mri ◽

Resting State ◽

Low Frequency ◽

Resting State Fmri ◽

Brain Network ◽

List Type ◽

Thalamic Nuclei ◽

Dynamic Functional Connectivity ◽

Subcortical Regions

AbstractA few studies have compared the static functional connectivity between awake and anaesthetized states in rodents by resting-state fMRI. However, impact of anaesthesia on static and dynamic fluctuations in functional connectivity has not been fully understood. Here, we developed a resting-state fMRI protocol to perform awake and anaesthetized functional MRI in the same mice. Static functional connectivity showed a widespread decrease under anaesthesia, such as when under isoflurane or a mixture of isoflurane and medetomidine. Several interhemispheric connections were key connections for anaesthetized condition from awake. Dynamic functional connectivity demonstrates the shift from frequent broad connections across the cortex, the hypothalamus, and the auditory-visual cortex to frequent local connections within the cortex only. Fractional amplitude of low frequency fluctuation in the thalamic nuclei decreased under both anaesthesia. These results indicate that typical anaesthetics for functional MRI alters the spatiotemporal profile of the dynamic brain network in subcortical regions, including the thalamic nuclei and limbic system.HighlightsResting-state fMRI was compared between awake and anaesthetized in the same mice.Anaesthesia induced a widespread decrease of static functional connectivity.Anaesthesia strengthened local connections within the cortex.fALFF in the thalamus was decreased by anaesthesia.

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Brain Resting State Functional Networks in Infants with Prenatal Opioid Exposure

Proceedings of IMPRS ◽

10.18060/25736 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Nicole Steinhardt ◽

Ramana Vishnubhotla ◽

Yi Zhao ◽

David M. Haas ◽

Gregory M. Sokol ◽

...

Keyword(s):

Functional Connectivity ◽

Functional Mri ◽

Gestational Age ◽

Resting State ◽

Brain Regions ◽

Brain Network ◽

Anterior Cingulate ◽

Global Network ◽

Neurodevelopmental Outcomes ◽

Distinct Component

Purpose: Infants of mothers with opioid and substance use can present with postnatal withdrawal symptoms and are at risk of poor neurodevelopmental outcomes in later childhood. Identifying methods to evaluate the consequences of substance exposure on the developing brain can help initiate proactive therapies to improve outcomes for opioid-exposed neonates. Additionally, early brain imaging in infancy has the potential to identify early brain developmental alterations that could prognosticate neurodevelopmental outcomes in these children. In this study, we aim to identify differences in global brain network connectivity in infants with prenatal opioid exposure compared to healthy control infants, using resting-state functional MRI performed at less than 2 months completed gestational age. Materials and Methods: In this prospective, IRB-approved study, we recruited 20 infants with prenatal opioid exposure and 20 healthy, opioid naïve infants. Anatomic imaging and resting-state functional MRI were performed at less than 48 weeks corrected gestational age, and rs-fMRI images were co-registered to the UNC neonate brain template and 90 anatomic atlas-labelled regions. Covariate Assisted Principal (CAP) regression was performed to identify brain network functional connectivity that was significantly different among infants with prenatal opioid exposure compared to healthy neonates. Results: Of the 5 significantly different CAP components identified, the most distinct component (CAP5, p= 3.86 x 10-6) spanned several brain regions, including the right inferior temporal gyrus, bilateral Hesch’s gyrus, left thalamus, left supramarginal gyrus, left inferior parietal lobule, left superior parietal gyrus, right anterior cingulate gyrus, right gyrus rectus, left supplementary motor area, and left pars triangularis. Functional connectivity in this network was lower in the infants with prenatal opioid exposure compared to non-opioid exposed infants. Conclusion: This study demonstrates global network alterations in infants with prenatal opioid exposure compared to non-opioid exposed infants. Future studies should be aimed at identifying clinical significance of this altered connectivity.

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Age-related changes in spatial and temporal features of resting state fMRI

10.1101/109181 ◽

2017 ◽

Author(s):

Shruti G. Vij ◽

Jason S. Nomi ◽

Dina R. Dajani ◽

Lucina Q. Uddin

Keyword(s):

Resting State ◽

Large Scale ◽

Spectral Composition ◽

Brain Network ◽

Functional Networks ◽

Functional Changes ◽

Age Related ◽

Temporal Features ◽

Functional Brain Network ◽

Age Related Changes

AbstractDevelopment and aging are associated with functional changes in the brain across the lifespan. These changes can be detected in spatial and temporal features of resting state functional MRI (rs-fMRI) data. Independent vector analysis (IVA) is a whole-brain multivariate approach that can be used to comprehensively assess these changes in spatial and temporal features. We present a multi-dimensional approach to assessing age-related changes in spatial and temporal features of statistically independent components identified by IVA in a cross-sectional lifespan sample (ages 6-85 years). We show that while large-scale brain network configurations remain consistent throughout the lifespan, changes continue to occur in both local organization and in the spectral composition of these functional networks. We show that the spatial extent of functional networks decreases with age, but with no significant change in the peak functional loci of these networks. Additionally, we show differential age-related patterns across the frequency spectrum; lower frequency correlations decrease across the lifespan whereas higher-frequency correlations increase. These changes indicate an increasing stability of networks with age. In addition to replicating results from previous studies, the current results uncover new aspects of functional brain network changes across the lifespan that are frequency band-dependent.

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Evaluating the Sensitivity of Resting-State BOLD Variability to Age and Cognition after Controlling for Motion and Cardiovascular Influences: A Network-Based Approach

Cerebral Cortex ◽

10.1093/cercor/bhaa138 ◽

2020 ◽

Vol 30 (11) ◽

pp. 5686-5701 ◽

Cited By ~ 4

Author(s):

Peter R Millar ◽

Steven E Petersen ◽

Beau M Ances ◽

Brian A Gordon ◽

Tammie L S Benzinger ◽

...

Keyword(s):

Resting State ◽

White Matter Hyperintensities ◽

Cardiovascular Health ◽

Resting State Fmri ◽

Head Motion ◽

Cognitively Normal ◽

Age Related ◽

Large N ◽

Normal Individuals ◽

Age Dependent

Abstract Recent functional magnetic resonance imaging (fMRI) studies report that moment-to-moment variability in the BOLD signal is related to differences in age and cognition and, thus, may be sensitive to age-dependent decline. However, head motion and/or cardiovascular health (CVH) may contaminate these relationships. We evaluated relationships between resting-state BOLD variability, age, and cognition, after characterizing and controlling for motion-related and cardiovascular influences, including pulse, blood pressure, BMI, and white matter hyperintensities (WMH), in a large (N = 422) resting-state fMRI sample of cognitively normal individuals (age 43–89). We found that resting-state BOLD variability was negatively related to age and positively related to cognition after maximally controlling for head motion. Age relationships also survived correction for CVH, but were greatly reduced when correcting for WMH alone. Our results suggest that network-based machine learning analyses of resting-state BOLD variability might yield reliable, sensitive measures to characterize age-related decline across a broad range of networks. Age-related differences in resting-state BOLD variability may be largely sensitive to processes related to WMH burden.

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Head Motion and Correction Methods in Resting-state Functional MRI

Magnetic Resonance in Medical Sciences ◽

10.2463/mrms.rev.2015-0060 ◽

2016 ◽

Vol 15 (2) ◽

pp. 178-186 ◽

Cited By ~ 25

Author(s):

Masami GOTO ◽

Osamu ABE ◽

Tosiaki MIYATI ◽

Hidenori YAMASUE ◽

Tsutomu GOMI ◽

...

Keyword(s):

Functional Mri ◽

Resting State ◽

Head Motion

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Age- and sex-related topological organisation of human brain functional networks and their relationship to cognition

10.1101/2021.07.25.453293 ◽

2021 ◽

Author(s):

Heidi Foo ◽

Anbupalam Thalamuthu ◽

Jiyang Jiang ◽

Forrest C Koch ◽

Karen Mather ◽

...

Keyword(s):

Cognitive Performance ◽

Resting State ◽

Brain Regions ◽

Brain Network ◽

Functional Networks ◽

State Graph ◽

Uk Biobank ◽

Age Related ◽

Functional Brain Network ◽

Age And Sex

Age and sex have been associated with changes in functional brain network topology, which may in turn affect cognition in older adults. We explored this question further by examining differences in 11 resting-state graph theory measures with respect to age, sex, and their relationships with cognitive performance in 17,127 UK Biobank participants. Age was associated with an overall decrease in the effectiveness of network communication (i.e. integration) and loss of functional specialisation (i.e. segregation) of specific brain regions. Sex differences were also observed, with women showing more efficient networks which were less segregated than in men. Age-related changes were also more apparent in men than women, which suggests that men may be more vulnerable to cognitive decline with age. Interestingly, while network segregation and strength of limbic network were only nominally associated with cognitive performance, the network measures collectively were significantly associated with cognition. This may imply that individual measures may be inadequate to capture much of the variance in neural activity or its output and need further refinement.

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