Nocturnal Polysomnographic Correlates of Daytime Sleepiness

2012 ◽  
Vol 110 (1) ◽  
pp. 63-72 ◽  
Author(s):  
William D. S. Killgore ◽  
Vincent F. Capaldi ◽  
Melanie L. Guerrero
Keyword(s):  
Linear Regression ◽  
Slow Wave ◽  
Daytime Sleepiness ◽  
Chart Review ◽  
Slow Wave Sleep ◽  
Total Sleep Time ◽  
Retrospective Chart Review ◽  
Sleep Time ◽  
Stepwise Linear Regression ◽  
Two Indices

The relations of nighttime Polysomnographic sleep variables with daytime sleepiness scores on the Epworth Sleepiness Scale were assessed in a retrospective chart review of 38 patients referred to a sleep clinic. Of the variables assessed, only slow wave sleep was statistically significantly correlated with daytime sleepiness, regardless of whether the analysis was based on absolute minutes of slow wave sleep or percentage of total sleep time spent in slow wave sleep. Stepwise linear regression suggested that other Polysomnographic variables did not provide additional predictive value beyond the two indices of slow wave sleep. Apparently, reduced quantity of slow wave sleep was weakly but significantly related to increased daytime sleepiness among these sleep-clinic patients.

scholarly journals Slow Wave Sleep of Elite and Nonelite Gymnasts Is Influenced by Weekly Training Hours, Not by Fitness Level

2021 ◽  
pp. 1-7
Author(s):  
Jasmien Dumortier ◽  
An Mariman ◽  
Jan Boone ◽  
Liesbeth Delesie ◽  
Els Tobback ◽  
...  
Keyword(s):  
Physical Fitness ◽  
Eye Movement ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Sleep Efficiency ◽  
Fitness Level ◽  
Time In Bed ◽  
Weekly Training

Purpose: This study aimed to determine the influencing factors of potential differences in sleep architecture between elite (EG) and nonelite (NEG) female artistic gymnasts. Methods: Twelve EG (15.1 [1.5] y old) and 10 NEG (15.3 [1.8] y old) underwent a nocturnal polysomnography after a regular training day (5.8 [0.8] h vs 2.6 [0.7] h), and, on a separate test day, they performed an incremental treadmill test after a rest day in order to determine physical fitness status. A multiple linear regression assessed the predictive value of training and fitness parameters toward the different sleep phases. Total sleep time and sleep efficiency (proportion of time effectively asleep to time in bed), as well as percentage of nonrapid eye movement sleep phase 1 (NREM1) and 2 (NREM2), slow wave sleep (SWS), and rapid eye movement sleep (REM), during a single night were compared between EG and NEG using an independent-samples t test. Results: Peak oxygen uptake influenced NREM1 (β = 1.035, P = .033), while amount of weekly training hours predicted SWS (β = 1.897, P = .032). No differences were documented between EG and NEG in total sleep time and sleep efficiency. SWS was higher in EG (36.9% [11.4%]) compared with NEG (25.9% [8.3%], P = .020), compensated by a lower proportion of NREM2 (38.7% [10.2%] vs 48.4% [6.5%], P = .017), without differences in NREM1 and REM. Conclusions: The proportion of SWS was only predicted by weekly training hours and not by training hours the day of the polysomnography or physical fitness, while NREM1 was linked with fitness level. Sleep efficiency did not differ between EG and NEG, but in EG, more SWS and less NREM2 were identified.

scholarly journals A Validation Study of a Commercial Wearable Device to Automatically Detect and Estimate Sleep

Biosensors ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 185
Author(s):  
Dean J. Miller ◽  
Gregory D. Roach ◽  
Michele Lastella ◽  
Aaron T. Scanlan ◽  
Clint R. Bellenger ◽  
...  
Keyword(s):  
Eye Movement ◽  
Sensitivity And Specificity ◽  
Validation Study ◽  
Slow Wave Sleep ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Rapid Eye Movement Sleep ◽  
Two Stage ◽  
Manual Adjustment ◽  
Light Sleep

The aims of this study were to: (1) compare actigraphy (ACTICAL) and a commercially available sleep wearable (i.e., WHOOP) under two functionalities (i.e., sleep auto-detection (WHOOP-AUTO) and manual adjustment of sleep (WHOOP-MANUAL)) for two-stage categorisation of sleep (sleep or wake) against polysomnography, and; (2) compare WHOOP-AUTO and WHOOP-MANUAL for four-stage categorisation of sleep (wake, light sleep, slow wave sleep (SWS), or rapid eye movement sleep (REM)) against polysomnography. Six healthy adults (male: n = 3; female: n = 3; age: 23.0 ± 2.2 yr) participated in the nine-night protocol. Fifty-four sleeps assessed by ACTICAL, WHOOP-AUTO and WHOOP-MANUAL were compared to polysomnography using difference testing, Bland–Altman comparisons, and 30-s epoch-by-epoch comparisons. Compared to polysomnography, ACTICAL overestimated total sleep time (37.6 min) and underestimated wake (−37.6 min); WHOOP-AUTO underestimated SWS (−15.5 min); and WHOOP-MANUAL underestimated wake (−16.7 min). For ACTICAL, sensitivity for sleep, specificity for wake and overall agreement were 98%, 60% and 89%, respectively. For WHOOP-AUTO, sensitivity for sleep, wake, and agreement for two-stage and four-stage categorisation of sleep were 90%, 60%, 86% and 63%, respectively. For WHOOP-MANUAL, sensitivity for sleep, wake, and agreement for two-stage and four-stage categorisation of sleep were 97%, 45%, 90% and 62%, respectively. WHOOP-AUTO and WHOOP-MANUAL have a similar sensitivity and specificity to actigraphy for two-stage categorisation of sleep and can be used as a practical alternative to polysomnography for two-stage categorisation of sleep and four-stage categorisation of sleep.

Influence of hypothalamic and ambient temperatures on sleep in kangaroo rats

1979 ◽  
Vol 237 (1) ◽  
pp. R80-R88 ◽  
Author(s):  
S. Sakaguchi ◽  
S. F. Glotzbach ◽  
H. C. Heller
Keyword(s):  
Slow Wave Sleep ◽  
Total Sleep Time ◽  
Paradoxical Sleep ◽  
Sleep Time ◽  
Peripheral Stimulus ◽  
Kangaroo Rats ◽  
Hypothalamic Temperature ◽  
Ambient Temperatures ◽  
Thermoregulatory System

Unanesthetized, unrestrained kangaroo rats (Dipodomys) were studied to examine the changes in the frequency and duration of sleep states caused by long-term manipulations of hypothalamic temperature (Thy) at a thermoneutral (30 degrees C) and a low (20 degrees C) ambient temperature (Ta). A cold stimulus present in either the hypothalamus or the skin decreased both the total sleep time (TST) and the ratio of paradoxical sleep (PS) to TST. At a low Ta, TST, but not the PS-to-TST ratio, was increased by raising Thy, indicating that a cold peripheral stimulus could differentially inhibit PS. At a thermoneutral Ta, cooling Thy decreased both TST and the PS/TST. Changes in the amount of PS were due largely to changes in the frequency, but not the duration, of individual episodes of PS, suggesting that the transition to PS is partially dependent on the thermoregulatory conditions existing during slow-wave sleep (SWS). These results are consistent with the recent findings that the thermoregulatory system is functional during SWS but is inhibited or inactivated during PS.

scholarly journals Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients—a retrospective chart review

2021 ◽  
Author(s):  
Azzeddine Kermad ◽  
Jacques Speltz ◽  
Guy Danziger ◽  
Thilo Mertke ◽  
Robert Bals ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Retrospective Study ◽  
Linear Regression ◽  
Chart Review ◽  
Distress Syndrome ◽  
Minute Ventilation ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
High Doses ◽  
End Tidal

Abstract Purpose In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute Respiratory Distress Syndrome). Methods Charts of all 20 patients with COVID-19 ARDS admitted to the ICU of a German University Hospital during the first wave of the pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, isoflurane was used in 97 days, while in 187 days, propofol was used for 12 h or more. The effect and dose of these two sedatives were compared. Mixed sedation days were excluded. Results Patients’ age (median [interquartile range]) was 64 (60–68) years. They were invasively ventilated for 36 [21–50] days. End-tidal isoflurane concentrations were high (0.96 ± 0.41 Vol %); multiple linear regression yielded the ratio (isoflurane infusion rate)/(minute ventilation) as the single best predictor. Infusion rates were decreased under ECMO (3.5 ± 1.4 versus 7.1 ± 3.2 ml∙h−1; p < 0.001). In five patients, the maximum recommended dose of propofol of 4 mg∙hour−1∙kg−1ABW was exceeded on several days. On isoflurane compared to propofol days, neuro-muscular blocking agents (NMBAs) were used less frequently (11% versus 21%; p < 0.05), as were co-sedatives (7% versus 31%, p < 0.001); daily opioid doses were lower (720 [720–960] versus 1080 [720–1620] mg morphine equivalents, p < 0.001); and RASS scores indicated deeper levels of sedation (− 4.0 [− 4.0 to − 3.0] versus − 3.0 [− 3.6 to − 2.5]; p < 0.01). Conclusion Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses of both drugs were needed in severely ill COVID-19 patients.

036 The Effect of Exercise on Sleep Architecture and Memory Consolidation during a Daytime Nap

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A16-A16
Author(s):  
Megan Collins ◽  
Erin Wamsley ◽  
Hailey Napier ◽  
Madeline Ray
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Declarative Memory ◽  
Sleep Stage ◽  
Sleep Time ◽  
Learning Task ◽  
Memory Retention ◽  
Verbal Information ◽  
Significant Difference

Abstract Introduction Slow wave sleep (SWS) is thought to especially benefit declarative memory (i.e., memory for facts and events). As such, recent studies have used various methods to experimentally increase the amount of slow wave sleep that participants obtain, with the goal of assessing how SWS affects declarative memory consolidation. Studies dating back decades have reported that exercising before sleep may increase time spent in SWS. Thus, the aim of the current project was to determine whether exercising after learning verbal information enhances slow wave sleep during a subsequent nap and/or enhances memory for verbal information. Methods Participants who exercised regularly were recruited to attend two 2.5hr laboratory sessions. During each session, they trained on a paired associates learning task and then completed either a 20min cardiovascular exercise routine or a 20min stretching routine. Following a 1hr nap opportunity, participants were tested on their memory. PSG was recorded during the nap, and scored following AASM criteria. Participants were excluded from analysis if they failed to sleep for at least 10 min. Following exclusions, n=30 participants were included in analysis. Results Contrary to our hypotheses, there was no significant difference between the exercise and stretching conditions for minutes spent in slow wave sleep (p=.16), % time spent in slow wave sleep (p=.22), or raw improvement in paired associated performance (p=.23). The amount of SWS obtained during the nap did not correlate with performance in either condition (SWS min vs. memory in exercise condition: r28=.10, p=.60; sleep condition: r28=-.06, p=.74). Exercise did not affect time spent in any other sleep stage, nor did it affect total sleep time. Conclusion Contrary to our hypotheses and the results of prior research, we were unable to detect a significant effect of exercise on slow wave sleep. Also contrary to our hypotheses, exercise did not affect memory retention across the nap interval. These null results could indicate that there is no effect of exercise on nap sleep and/or associated memory retention. However, it could also be that we lacked sufficient power to detect effects that were smaller than expected. Support (if any):

scholarly journals 1092 Attention-deficit/hyperactivity Disorder Symptoms And Sleep Characteristics Within A Seasonal Affective Disorder Spectrum

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A415-A416
Author(s):  
K N Kim ◽  
D L Wescott ◽  
P L Franzen ◽  
B P Hasler ◽  
K A Roecklein
Keyword(s):  
Sleep Quality ◽  
Sleep Duration ◽  
Adhd Symptom ◽  
Symptom Severity ◽  
Daytime Sleepiness ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Sleep Onset Latency ◽  
Adhd Symptoms ◽  
Depression Severity

Abstract Introduction Seasonal affective disorder (SAD) increases risk for attention-deficit/hyperactivity disorder (ADHD), although the mechanism linking SAD and ADHD is unknown. Prior research has identified insomnia and delayed sleep phase in both ADHD and SAD. We hypothesized that sleep duration and timing in SAD would be associated with the severity of ADHD symptoms. Methods Adults with SAD (n = 45) and subsyndromal SAD (S-SAD; n = 18) aged 19-66 years from Pittsburgh, PA., were assessed for ADHD symptoms, self-report sleep quality, depression severity, and daytime sleepiness in the Winter. Participants wore an Actiwatch for 4-14 days, from which we calculated sleep-onset latency, total sleep time, sleep midpoint, and sleep efficiency. We conducted a hierarchical multivariate linear regression to determine if sleep characteristics predict ADHD symptom severity in our sample while controlling for depressive symptoms. Age and gender were added in Step 1, seasonal depression severity in Step 2, actigraphy-based total sleep time, sleep onset latency, midpoint, and efficiency in Step 3, and self-reported sleep quality and daytime sleepiness in Step 4. Results Participants mostly scored in the “likely” or “highly likely” ADHD range (87.30%, n=55), higher than the national prevalence rate (4.4%). When controlling for age, gender, and depression severity, only shorter actigraphy-based total sleep time was associated with higher ADHD symptom severity (β=-0.30, p&lt;0.05). However, when self-reported sleep quality and daytime sleepiness were added as predictors, total sleep time was no longer a statistically-significant predictor of ADHD symptom severity and only daytime sleepiness predicted ADHD symptom severity (β=0.31, p&lt;0.05). Conclusion Our results suggest that individuals with SAD who experience daytime sleepiness and/or possibly shorter actigraphy-based sleep duration experience higher ADHD symptom severity. Treatments like Trans-C or CBT-I to improve daytime sleepiness and sleep duration may be indicated for SAD patients who present with comorbid ADHD symptoms. Support NIMH K.A.R. MH103303

scholarly journals 1241 A Case of Chronic Hypoventilation of Unknown Etiology with Improvement from a Wake Promoting Agent

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A473-A473
Author(s):  
Melissa Cole ◽  
Thomas Isaacs ◽  
Amee Patel
Keyword(s):  
Serum Ferritin ◽  
Daytime Sleepiness ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Chronic Insomnia ◽  
Sweat Test ◽  
Unknown Etiology ◽  
Serum Bicarbonate ◽  
Sleep Study ◽  
Work Up

Abstract Introduction We present a patient with chronic insomnia, excessive daytime sleepiness, and sleep-related hypoventilation that improved with a wake promoting agent in conjunction with BPAP. Report of Case A 15-year-old male with Cystic Fibrosis (single F508del mutation, positive sweat test, FEV1% of 98%) and Autism who presented with frequent headaches, chronic insomnia, and daytime sleepiness (PDSS of 22). Current medications included albuterol as needed. Sleep history was significant for restless leg symptoms. Labs revealed low serum ferritin. Sleep study two years prior showed an AHI of 3.4 and PMLD of 18.4. After completion of iron therapy and initiation of gabapentin, his chronic insomnia and serum ferritin improved. However, patient continued to have aggressive behavior, headaches, and snoring. Sleep study was repeated and revealed mild OSA with hypoventilation (AHI of 6.41, &gt;28% of total sleep time with TCO2 above 50 mm Hg). Initial serum bicarbonate was 29 mmol/L and progressively increased to 34 mmol/L. Due to evidence of persistent chronic hypoventilation, patient was trialed on BPAP. Subsequent sleep study with BPAP showed an AHI of 0, but with worsening sleep related hypoventilation (TCO2 of 56mmHg, &gt; 70% total sleep time with TCO2 above 50 mm Hg). Genetic, endocrine, and neurological work up for hypoventilation was negative. Due to persistent daytime sleepiness (PDSS of 24), MSLT was performed and showed evidence of hypersomnia. Modafinil was then initiated. With the combination of nocturnal BPAP use and Modafinil, daytime sleepiness improved (PDSS of 15) and he had normalization of CO2 and bicarbonate levels. Conclusion We present a patient with CF, with minimal lung disease, who demonstrated a negative work up for sleep related hypoventilation, in which dysregulation of control of breathing improved with the use of a wake promoting agent in conjunction with BPAP.

Sleep and Psychological Abuse Among Cohabiting Couples: A Pilot Study

Partner Abuse ◽  
2017 ◽  
Vol 8 (4) ◽  
pp. 347-360
Author(s):  
Sharon Rose ◽  
Linda Berg-Cross ◽  
Nancy A. Crowell
Keyword(s):  
Sleep Quality ◽  
Relationship Satisfaction ◽  
Sleep Deprivation ◽  
Daytime Sleepiness ◽  
Psychological Abuse ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Cohabiting Couples ◽  
Survey Results ◽  
The Relationship

This study explored the relationship between psychological abuse and sleep deprivation among nonclinical cohabiting couples. Thirty-one couples participated in completing a variety of sleep measures, a psychological abuse scale, and a relationship satisfaction survey. Results indicated a persistent relationship between everyday sleep deficits (sleep quality, daytime sleepiness, and self-reported total sleep time) and the perceived perpetration and felt victimization of psychological abuse. Overall, results were as hypothesized, but there were gender differences. Male psychological abuse victimization and perpetration were significantly related to sleep quality and daytime sleepiness, but for women, only sleep duration was predictive of felt victimization. The sleep variables were significantly related to women’s—but not men’s—reported relationship satisfaction. Overall, minimal sleep deprivation appears to be related to increased psychological abuse perpetration and victimization even among a normative population scoring outside the clinical range on these measures. Implications for prevention and treatment are discussed.

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