scholarly journals Charcot Foot, a Rare and Severe Complication of Diabetes Mellitus

2020 ◽  
Vol 25 (1) ◽  
pp. 32-35
Author(s):  
Alin Mihețiu ◽  
Ioana Matei ◽  
Alexandra Sandu ◽  
Elena Rizea ◽  
Sînziana Nicolae
Keyword(s):  
Diabetes Mellitus ◽  
Rare Disease ◽  
External Fixation ◽  
Acute Phase ◽  
Early Recognition ◽  
Severe Complication ◽  
Charcot Foot ◽  
Bone Damage ◽  
Patients With Diabetes ◽  
Charcot Neuropathy

AbstractCharcot foot or Charcot neuropathy is a rare disease found in patients with diabetes mellitus and is characterized by bone damage to the foot leading to deformities, instability, functional impotence and even amputation. The mechanism is still under discussion, without a consensus regarding the pathophysiology of this condition. The treatment is a complex one, non-surgical and surgical, the non-surgical one addressing especially the acute phase of the disease, the surgical one being complex and ranging from osteotomy, debridement, arthrodesis, internal or external fixation or even amputation. A good management of diabetes, of its peripheral complications, an early recognition of the Charcot type foot, prevents the evolution towards this serious condition.

scholarly journals Diagnosis And Treatment Of Emphysematous Pyelonephritis In Patients With Diabetes

2021 ◽  
Vol 03 (01) ◽  
pp. 87-90
Author(s):  
Nurillo Makhmudov ◽  
◽  
Zukhra Kosimova ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Rare Disease ◽  
Diagnosis And Treatment ◽  
Medical Institute ◽  
Emphysematous Pyelonephritis ◽  
Glucose Levels ◽  
Blood Tests ◽  
Post Surgery ◽  
Patients With Diabetes

In this study we report on our experience in treating two patients diagnosed with a rare disease of emphysematous pyelonephritis, who were admitted to the Urology department of Fergana Medical Institute during 2018. We provide details on each test conducted on patients, pre- and post-surgery. Our analysis shows that to prevent complications in patients with diabetes mellitus, dispensary observation with control of glucose levels, urine and blood tests is necessary.

Role of Dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus

2011 ◽  
Vol 40 (8) ◽  
pp. 991-999 ◽  
Author(s):  
Virna Zampa ◽  
Irene Bargellini ◽  
Loredana Rizzo ◽  
Francesca Turini ◽  
Simona Ortori ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Dynamic Mri ◽  
Charcot Foot ◽  
Patients With Diabetes

scholarly journals Influence of Patient Setting and Dedicated Limb Salvage Efforts on Outcomes in Charcot-Related Foot Ulcer

2019 ◽  
Vol 18 (4) ◽  
pp. 362-366 ◽  
Author(s):  
Brian M. Schmidt ◽  
Crystal M. Holmes
Keyword(s):  
Diabetes Mellitus ◽  
Limb Salvage ◽  
Patient Outcomes ◽  
Foot Ulcer ◽  
Outpatient Setting ◽  
Inpatient Setting ◽  
Charcot Foot ◽  
Specialist Care ◽  
Charcot Neuroarthropathy ◽  
Patients With Diabetes

Charcot neuroarthropathy is a devastating consequence of diabetes mellitus and peripheral neuropathy. Because of its rarity, the condition is often misdiagnosed or poorly managed. When misadventure occurs, patients with Charcot neuroarthropathy can suffer ulceration, infection, amputation, and death. When patients have Charcot-related foot ulcers, the risks are amplified. Utilizing advanced electronic medical record analysis, a 30-month investigation was undertaken to determine if patients with diabetes mellitus and a concomitant diagnosis of Charcot-related foot ulcer were at greater risk of complications because of location setting of initial treatment for their condition. Charcot foot–related ulcers that are diagnosed in the outpatient setting had established foot specialist care. The outpatient management of the condition lead to a significant reduction in the amount of admissions to a higher acuity setting. However, patient outcomes did not vary once established and dedicated limb salvage efforts were employed. In this large contemporary population managed in a tertiary health system, patients with Charcot-related foot ulcer had negative outcomes when they were initially treated in an inpatient setting and had a significantly greater likelihood of readmission as compared with individuals who had established focused limb salvage care.

Surgical treatment of midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes: a systematic review

2020 ◽  
Vol 29 (Sup6) ◽  
pp. S19-S28
Author(s):  
Crystal L. Ramanujam ◽  
Alan C. Stuto ◽  
Thomas Zgonis
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Surgical Treatment ◽  
External Fixation ◽  
Revisional Surgery ◽  
Cochrane Library ◽  
Soft Tissue Reconstruction ◽  
Charcot Neuroarthropathy ◽  
Wide Range ◽  
Patients With Diabetes

Objective: A wide range of clinical presentations of Charcot neuroarthropathy of the foot with concomitant osteomyelitis in patients with diabetes has been described. Existing literature provides an equally diverse list of treatment options. The purpose of this systematic review was to assess the outcomes specifically for the surgical management of midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes. Method: A systematic review was conducted by three independent reviewers using the following databases and search engines: Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane Library, EMBASE (Excerpta Medica dataBASE), Google Scholar, Ovid, PubMed and Scopus. Search terms used were: Charcot neuroarthropathy, osteoarthropathy, neuro-osteoarthropathy, neurogenic arthropathy, osteomyelitis, midfoot, foot, ankle, diabetes mellitus, ulceration, wound, infection, surgical offloading, diabetic reconstruction, internal fixation, external fixation. Studies meeting the following criteria were included: English language studies, studies published from 1997–2017, patients with diabetes mellitus surgically treated for Charcot neuroarthropathy of the midfoot (specified location) with concomitant osteomyelitis, with or without internal and/or external fixation, follow-up period of six months or more postoperatively, documentation of healing rates, complications, and need for revisional surgery. Studies which were entirely literature reviews, descriptions of surgical-only technique and/or cadaveric studies, patients without diabetes, studies that did not specify location of osteomyelitis and Charcot neuroarthropathy, and treatment proximal to and including Chopart's/midtarsal joint specifically talonavicular, calcaneocuboid, subtalar, ankle were excluded. Results: A total of 13 selected studies, with a total of 114 patients with diabetes of which 56 had surgical treatment for midfoot Charcot neuroarthropathy with osteomyelitis, met the above inclusion criteria and were used for data extraction. Conclusion: Surgical intervention for midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes demonstrated a relatively high success rate for a range of procedures including debridement with simple exostectomy, arthrodesis with or without internal or external fixation, and advanced soft tissue reconstruction. However, this systematic review emphasises the need for larger, better designed studies to investigate the efficacy and failure rates of surgical treatment in this group of patients.

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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