scholarly journals The effect of peptide tyrosine tyrosine (PYY3–36), a selective Y2 receptor agonist on streptozotocin-induced diabetes in albino rats

2019 ◽  
Vol 53 (1) ◽  
pp. 26-33
Author(s):  
Heba A. Abdel-Hamid ◽  
Mona M. I. Abdalla ◽  
Nagwa M. Zenhom ◽  
Rasha F. Ahmed
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
Visceral Fat ◽  
Glycogen Content ◽  
Liver Glycogen ◽  
Serum Levels ◽  
Albino Rats ◽  
Liver Glycogen Content ◽  
Intake Water

AbstractObjective. The aim of the present study was to assess the effect of the PYY3–36, as a potential therapy for the type 2 diabetes mellitus (T2DM), induced by high fat diet (HFD) and an intraperitoneal (i.p.) administration of streptozotocin (STZ) in albino rats.Methods. Forty adult male albino Wistar rats were divided into: 1) control group (C, in which the rats were fed with a standard diet and received vehicle; 2) diabetic group (D, in which T2DM was induced by feeding the rats with HFD for four weeks followed by a single i.p. injection of 35 mg/kg STZ, this group was also allowed to have HFD till the end of the study; and 3) D+PYY3–36 group (in which the diabetic rats were treated with 50 µg/kg i.p. PYY3–36 twice a day for one week). Food intake, water intake, body weight (b.w.), visceral fat weight (VFW), liver glycogen content, serum levels of glucose, insulin, and interleukin-6 (IL-6), were measured. Homeostatic-model assessment of insulin resistance (HOMA-IR) was estimated. The gene expression of the hypothalamic neuropeptide Y (NPY) and visceral nuclear factor kappa B (NF-κB) were assessed by a reverse transcription polymerase chain reaction (RT-PCR).Results. The PYY3–36 administration to the diabetic group of rats significantly increased the serum insulin levels and liver glycogen content, decreased the body weight, VFW, food intake, water intake, serum levels of the glucose, IL-6, and HOMA-IR. It also decreased the expression of both the hypothalamic NPY and the visceral fat NF-κB.Conclusion. With respect to the fact of improved insulin release and enhanced insulin sensitivity (an effect that may be mediated via suppressing accumulation of visceral fat and inflammatory markers), in the rats treated with PYY3–36, the PYY3–36 might be considered for the future as a promising therapeutic tool in T2DM.

Effect of hypoxic hypoxia and carbon monoxide on food intake, water intake, and body weight in two strains of rats

Life Sciences ◽  
1974 ◽  
Vol 14 (8) ◽  
pp. 1511-1520 ◽  
Author(s):  
George F. Koob ◽  
Zoltan Annau ◽  
Robert J. Rubin ◽  
Mark R. Montgomery
Keyword(s):  
Carbon Monoxide ◽  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
Hypoxic Hypoxia ◽  
Intake Water

scholarly journals Comparative effects of continuous infusion of m CPP, Ro 60-0175 and d -fenfluramine on food intake, water intake, body weight and locomotor activity in rats

2000 ◽  
Vol 130 (6) ◽  
pp. 1305-1314 ◽  
Author(s):  
S P Vickers ◽  
K R Benwell ◽  
R H Porter ◽  
M J Bickerdike ◽  
G A Kennett ◽  
...  
Keyword(s):  
Body Weight ◽  
Locomotor Activity ◽  
Food Intake ◽  
Continuous Infusion ◽  
Water Intake ◽  
Intake Water

scholarly journals TOXIC EFFECTS OF LARGE DOSE OF QUASSIN IN NORMAL AND DEPRIVED MICROFLORA RAT GROUPS

2021 ◽  
Vol 22 (1) ◽  
pp. 67-83
Author(s):  
Duraid A.Abbas ◽  
O.M.S. Al—Shaha,
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
Daily Food ◽  
Daily Water Intake ◽  
Control Food ◽  
Liver And Kidney ◽  
Daily Water ◽  
Control Food Intake ◽  
Intake Water

Eighteen rats were divided into three equal groups. The first group was closed orally with quassin, the second group was dosed with quassin after the gut flora were suppressed by difierent antibiotics, and the third group was served as a control. Food intake, water intake, and change in body weight were measured daily before dosing, during two weeks of dosing, and during one week after stopping dosing. Two eats from each group were killed at the end of each week, and stomach, liver, and kidney were collected for histopathologic examination. The results show a significant decline in daily food intake and daily change in body weight, and a significant increase in daily water intake in both dosed groups during the dosing period. Microscopic lesions were seen in the kidneys of both dosed rats group killed at the end of first and second week

scholarly journals Nandrolone decanoate inhibits gluconeogenesis and decreases fasting glucose in Wistar male rats

2014 ◽  
Vol 220 (2) ◽  
pp. 143-153 ◽  
Author(s):  
Stephan Pinheiro Frankenfeld ◽  
Leonardo Pires de Oliveira ◽  
Daniele Leão Ignacio ◽  
Raquel Guimarães Coelho ◽  
Mariana Nigro Mattos ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Glucose Uptake ◽  
Glycogen Content ◽  
Liver Glycogen ◽  
Serum Levels ◽  
Male Rats ◽  
Nandrolone Decanoate ◽  
Liver Glycogen Content ◽  
The Impact

The use of anabolic–androgenic steroids to improve physical performance or appearance has increased notably. The doses used are 10- to 100- fold higher than the therapeutic dose (TD), and this abuse can cause several side effects. Glucose metabolism is significantly affected by anabolic–androgenic steroid abuse, but studies about glycemic regulation during fasting are scarce. There are some evidences showing that testosterone can antagonize glucocorticoids action, which are crucial to glucose production during fasting. Thus, the aim of this study was to determine the impact of supraphysiological doses (SDs) of nandrolone decanoate (DECA) on rat glucose metabolism during fasting. Male Wistar rats were treated with i.m. injections of vehicle, a low TD (0.016 mg/100 g b.w.-TD group) or a high SD (1 mg/100 g b.w.-SD group) of DECA, once a week for 8 weeks. After 12 h fasting, we evaluated glucose and pyruvate tolerance tests, liver glycogen content, serum levels of gluconeogenic substrates, insulin and corticosterone, glucose uptake and hexokinase (HK) activity in skeletal muscle, and the adrenal catecholamine content. SD group had increased serum insulin levels and a blunted response to insulin regarding glucose uptake in skeletal muscle. Fasting serum glucose decreased significantly in SD group, as well as the pyruvate tolerance test and liver glycogen content. Moreover, serum levels of glycerol were increased in SD group. Our data indicate that SDs of DECA exert effects on different regulatory points of glucose metabolism, resulting in defective gluconeogenesis and decreased skeletal muscle glucose uptake in response to insulin.

Muscle and liver glycogen content: diurnal variation and endurance

1979 ◽  
Vol 47 (2) ◽  
pp. 425-428 ◽  
Author(s):  
J. H. Clark ◽  
R. K. Conlee
Keyword(s):  
Glycogen Content ◽  
Vastus Lateralis ◽  
Liver Glycogen ◽  
Diurnal Variations ◽  
Albino Rats ◽  
Hepatic Glycogen ◽  
Glycogen Depletion ◽  
Liver Glycogen Content ◽  
Exercise Endurance ◽  
Glycogen Stores

The purpose of this study was to determine the influence of diurnal variations of muscle and liver glycogen stores on exercise endurance in male albino rats. Animals were swum to exhaustion at either 0700 or 1900 h, after which samples of soleus, white vastus lateralis, and red vastus lateralis muscles as well as liver were excised and subsequently analyzed for glycogen content. Glycogen content of all tissues from nonexercising control animals was higher in the morning than in the evening. Consequently, animals at 0700 h swam 60% longer than those at 1900 h (209 +/- 20 min vs. 130 +/- 23 min, respectively). However, because the skeletal tissues of the exhausted animals were not totally depleted of glycogen, it was concluded that fatigue under the swim protocol was the result of hypoglycemia secondary to hepatic glycogen depletion. The results of this study demonstrate the physiological consequences of diurnal glycogen fluctuation and establish experimental support for the importance of controlling this variable in rodent exercise investigations.

Sign in / Sign up

Export Citation Format

Share Document