scholarly journals TOXIC EFFECTS OF LARGE DOSE OF QUASSIN IN NORMAL AND DEPRIVED MICROFLORA RAT GROUPS

2021 ◽  
Vol 22 (1) ◽  
pp. 67-83
Author(s):  
Duraid A.Abbas ◽  
O.M.S. Al—Shaha,
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
Daily Food ◽  
Daily Water Intake ◽  
Control Food ◽  
Liver And Kidney ◽  
Daily Water ◽  
Control Food Intake ◽  
Intake Water

Eighteen rats were divided into three equal groups. The first group was closed orally with quassin, the second group was dosed with quassin after the gut flora were suppressed by difierent antibiotics, and the third group was served as a control. Food intake, water intake, and change in body weight were measured daily before dosing, during two weeks of dosing, and during one week after stopping dosing. Two eats from each group were killed at the end of each week, and stomach, liver, and kidney were collected for histopathologic examination. The results show a significant decline in daily food intake and daily change in body weight, and a significant increase in daily water intake in both dosed groups during the dosing period. Microscopic lesions were seen in the kidneys of both dosed rats group killed at the end of first and second week

Regulatory and secondary water intake in rats with lesions of the zona incerta

1976 ◽  
Vol 230 (4) ◽  
pp. 1049-1057 ◽  
Author(s):  
MD Evered ◽  
GJ Mogenson
Keyword(s):  
Water Intake ◽  
Fluid Balance ◽  
Zona Incerta ◽  
Water Losses ◽  
Daily Food Intake ◽  
Excretory Function ◽  
Daily Food ◽  
Daily Water Intake ◽  
Electrolytic Lesions ◽  
Daily Water

Bilateral electrolytic lesions of the zona incerta (ZI) permanently reduced daily water intake of rats by 20-30%. Lesioned rats did not differ from controls in daily food intake, body weight, hematocrit, or serum osmolality, Na+ or K+ levels. The hypodipsia was not caused by changes in water requirements or excretory function or by a nonspecific depression of behavior. Compensatory reductions in water losses maintained fluid balance. Lesioned rats drank as much water as controls in response to intracellular and extracellular dehydration, but unlike controls, appeared to restrict their daily water intake to these regulatory responses. Lesions of the ZI attenuated the ingestion of extra water observed when rats were maintained on a liquid diet adequate to meet fluid requirements, and daily water intake of lesioned but not control rats closely followed changes in water needs. It was concluded that lesions of the ZI reduce daily water intake towards minimal requirements for fluid balance by attenuating secondary drinking (drinking independent of water needs for fluid homeostasis.

Effect of hypoxic hypoxia and carbon monoxide on food intake, water intake, and body weight in two strains of rats

Life Sciences ◽  
1974 ◽  
Vol 14 (8) ◽  
pp. 1511-1520 ◽  
Author(s):  
George F. Koob ◽  
Zoltan Annau ◽  
Robert J. Rubin ◽  
Mark R. Montgomery
Keyword(s):  
Carbon Monoxide ◽  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
Hypoxic Hypoxia ◽  
Intake Water

scholarly journals Comparative effects of continuous infusion of m CPP, Ro 60-0175 and d -fenfluramine on food intake, water intake, body weight and locomotor activity in rats

2000 ◽  
Vol 130 (6) ◽  
pp. 1305-1314 ◽  
Author(s):  
S P Vickers ◽  
K R Benwell ◽  
R H Porter ◽  
M J Bickerdike ◽  
G A Kennett ◽  
...  
Keyword(s):  
Body Weight ◽  
Locomotor Activity ◽  
Food Intake ◽  
Continuous Infusion ◽  
Water Intake ◽  
Intake Water

scholarly journals Central and peripheral control of food intake

2017 ◽  
Vol 51 (1) ◽  
pp. 52-70 ◽  
Author(s):  
M. M. I. Abdalla
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Energy Expenditure ◽  
Current Knowledge ◽  
The Body ◽  
Therapeutic Implications ◽  
New Therapeutic Approaches ◽  
Control Food ◽  
Adiposity Signals ◽  
Control Food Intake

Abstract The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. The obesity has an evil effect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake. Centrally, the food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals. Comprehension of the signals that control food intake and energy balance may open a new therapeutic approaches directed against the obesity and its associated complications, as is the insulin resistance and others. In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity.

Safety Assessment ofLactobacillus fermentumCECT5716, a probiotic strain isolated from human milk

2009 ◽  
Vol 76 (2) ◽  
pp. 216-221 ◽  
Author(s):  
Federico Lara-Villoslada ◽  
Saleta Sierra ◽  
María Paz Díaz-Ropero ◽  
Juan Miguel Rodríguez ◽  
Jordi Xaus ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Oral Administration ◽  
Human Milk ◽  
Bacterial Translocation ◽  
Probiotic Strain ◽  
Oxidative Markers ◽  
Control Food ◽  
Stress Oxidative ◽  
Control Food Intake

Lactobacillus fermentumCECT5716, a probiotic strain isolated from human milk, was characterized in a previous study. The objective of this study was to evaluate its sensitivity to antibiotics and its potential toxicity and translocation ability after oral administration to mice. For this puropose, 40 Balb/C mice were divided in two groups (n=20 per group). One group was treated orally with 1010colony forming units (cfu)/mouse/day ofLb. fermentumCECT5716 during 28 d. The other group only received the excipient and was used as control. Food intake, body weight, bacterial translocation and different biochemical and haematological parameters were analysed. Oral administration ofLb. fermentumCECT5716 to mice had no adverse effects on mice. There were no significant differences in body weight or food intake between control and probiotic-treated mice. No bacteraemia was observed and there was no treatment-associated bacterial translocation to liver or spleen. Stress oxidative markers were not different in control and probiotic-treated mice. These results suggest that the strainLb. fermentumCECT5716 is non-pathogenic for mice even in doses 10,000 times higher (expressed per kg of body weight) than those normally consumed by humans.

Effect of restricted water intake during summer on the digestibility of cell-wall constituents, nitrogen retention and water excretion in Marwari sheep

1977 ◽  
Vol 89 (3) ◽  
pp. 605-608 ◽  
Author(s):  
H. C. Bohra ◽  
P. K. Ghosh
Keyword(s):  
Cell Wall ◽  
Body Weight ◽  
Water Intake ◽  
Dry Matter ◽  
Nitrogen Retention ◽  
Moisture Loss ◽  
Water Excretion ◽  
Daily Water Intake ◽  
Restricted Group ◽  
Daily Water

SummaryStudies were made on the effect of 50% reduction in daily water intake during summer on food intake, digestibility coefficients of the cell-wall constituents (CWC), nitrogen retention and water excretion in urine and faeces in the Marwari breed of sheep of the Rajasthan desert, India. The water-restricted animals consumed 54 and 42% less dry matter and digestible energy respectively than normally-watered animals. The digestibility coefficients of different CWC were apparently, though not significantly, higher in water-restricted animals. Throughout the study period, animals of both the groups, particularly the water-restricted group, remained in negative nitrogen balance. Moisture loss through the faeces was about 22% less in the water-restricted group than in the control animals. The water-restricted animals lost 21·1% of body weight in 23 days and these animals, when allowed water ad libitum, were able to recover 71·5 % of the lost body weight within 3 days.

In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake

2018 ◽  
Vol 69 (5) ◽  
pp. 1229-1232
Author(s):  
Eugeniu Mihalas ◽  
Adriana Balan ◽  
Ana Petcu (Sirghe) ◽  
Laura Gavrila ◽  
Carmen Savin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Water Intake ◽  
Fasting Blood Glucose ◽  
Chronic Administration ◽  
Short Term Treatment ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Daily Water Intake ◽  
Daily Water

Amoxicillin it is the most commonly prescribed antibiotic agent and the first intention in the short-term treatment of infections in children. The aim of this study was to assess the effects of amoxicillin/clavulanic acid (AMC) chronic administration on the laboratory mice�s body weight (BW), water intake and values of non-fasting blood glucose levels (n-FBG). Thus, twenty-eight C57BL/6 male mice, of similar age, randomly divided into a control and 3 treatment groups (n = 7) received subcutaneous injection, once per day, for 60 days. During the experiment the n-FBG, daily water intake, and BW changes were recorded every 10 days. The results of our study revealed that the chronic administration of AMC, at a concentration of 100 and 150 mg/kg BW/day, increased capillary n-FGB, and can be associated with a significant increase in the BW and daily water intake in mice.

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