scholarly journals May C-peptide index be a new marker to predict proteinuria in anemic patients with type 2 diabetes mellitus?

2020 ◽  
Vol 54 (1) ◽  
pp. 1-5
Author(s):  
Bilal Katipoglu ◽  
Mustafa Comoglu ◽  
Ihsan Ates ◽  
Nisbet Yilmaz ◽  
Dilek Berker
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Oral Antidiabetic Agent ◽  
C Peptide ◽  
Significant Difference ◽  
Reliable Marker

AbstractObjective. C-peptide is a reliable marker of beta cell reserve and is associated with diabetic complications. Furthermore, HbA1c level is associated with micro- and macro-vascular complications in diabetic patients. HbA1c measurement of diabetic patients with anemia may be misleading because HbA1c is calculated in percent by taking reference to hemoglobin measurements. We hypothesized that there may be a relationship between C-peptide index (CPI) and proteinuria in anemic patients with type 2 diabetes mellitus (T2DM). Therefore, the aim of the present study was to investigate the association between C-peptide levels and CPI in anemic patients with T2DM and proteinuria.Methods. The patients over 18 years of age with T2DM whose C-peptide levels were analyzed in Endocrinology and Internal medicine clinics between 2014 and 2018 with normal kidney functions (GFR>60 ml/min) and who do not use any insulin secretagogue oral antidiabetic agent (i.e. sulfonylurea) were enrolled into the study.Results. Hemoglobin levels were present in 342 patients with T2DM. Among these 342 cases, 258 (75.4%) were non-anemic whereas 84 (24.6%) were anemic. The median DM duration of the anemic group was statistically significantly higher in T2DM (p=0.003). There was no statistically significant difference found in proteinuria prevalence between non-anemic and anemic patient groups (p=0.690 and p=0.748, respectively). Anemic T2DM cases were corrected according to the age, gender, and duration of DM. C-peptide and CPI levels were not statistically significant to predict proteinuria (p=0.449 and p=0.465, respectively).Conclusion. The present study sheds light to the association between C-peptide, CPI, and anemic diabetic nephropathy in T2DM patients and indicates that further prospective studies are needed to clarify this issue.

scholarly journals Relationship between homocysteine and non-dipper pattern in patients with type 2 diabetes mellitus

2012 ◽  
Vol 56 (5) ◽  
pp. 285-290 ◽  
Author(s):  
Serdal Korkmaz ◽  
Abdulkerim Yilmaz ◽  
Gürsel Yildiz ◽  
Fatih Kiliçli ◽  
Serhat Içağasioğlu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Nocturnal Blood Pressure ◽  
Type 2 Dm ◽  
Significant Difference

OBJECTIVE: The rate of reduction of nocturnal blood pressure (NBP) is lesser than normal in patients with type 2 diabetes mellitus (type 2 DM). Hyperhomocysteinemia (HHC) disrupts vascular structure and function, no matter the underlying causes. The risk of development of vascular disease is greater in diabetic patients with hyperhomocysteinemia than in patients with normal homocystein levels. The aim of the study was to investigate whether there are differences of homocystein levels in dipper and non-dippers patients with type 2 DM. SUBJECTS AND METHODS: We compared 50 patients (33 females, 17 males) with type 2 DM and 35 healthy individuals (18 females, 17 males ) in a control group. Ambulatory blood pressure monitoring (ABPM) was performed and homocysteine levels were measured in all patients. RESULTS: We found that the percentage of non-dipper pattern was 72% in patients with type 2 DM and 57% in control group. In diabetic and control individuals, homocystein levels were higher in non-dipper (respectively 13.4 ± 8.1 µmol/L and 11.8 ± 5 µmol/L) than in dipper subjects (respectively, 11.8 ± 5.8 µmol/L and 10.1 ± 4.2 µmol/L), but there was no significant difference between the two groups (respectively, p = 0.545, p = 0.294). CONCLUSION: In both groups, homocystein levels were higher in non-dipper than in dipper participants, but there was no significant difference between the groups. High homocystein levels and the non-dipper pattern increases cardiovascular risk. Therefore, the relationship between nocturnal blood pressure changes and homocystein levels should be investigated in a larger study.

scholarly journals Gender based variation of lipid abnormalities in type-2 diabetes mellitus patients

2021 ◽  
Vol 9 (10) ◽  
pp. 3068
Author(s):  
Arpita Jaidev ◽  
Hitesh Shah ◽  
Liggy Andrews ◽  
Bhavisha N. Vagheda
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Male And Female ◽  
Significant Difference

Background: Dyslipidemia has a varying pattern among the male and female patients of type 2 diabetes mellitus (DM).Methods: This study was conducted in the out-patient department (OPD) of department of medicine at GMERS, Patan, Gujarat from July 2020 to December 2020 for a period of six months. Fasting blood sugar, hemoglobin A1c (FBS, HbA1c) lipid profile triacylglycerol-triglyceride, total cholesterol, low density lipoprotein cholesterol and high-density lipoprotein cholesterol (TG, TC, LDL-C, and HDLC) were measured. Statistical analyses were performed with the SPSS software program.Results: A total number of 200 type 2 DM patients (100 males and 100 females) attending to GMERS OPD were recruited in this study. Blood sugar was higher than normal in both male and female (FBS=142.44±36.21, 146.40±41.49 respectively). TG level was also higher in two groups of study subjects with female level slightly more than male (164.99±67.1and 138.21±70 respectively) with no significant difference between the groups (p>0.05).Total cholesterol and LDL-C level was within normal physiological level in both groups, where-as these levels were higher in female in comparison to male (TC=198.07±40.82 and 169.5±36.13 respectively, LDLC=118±34 and 99±27, respectively), showing significant difference between the groups (p=0.014). HDL-C was not below normal in both male (41±5.4) and female (43.99±4.31); however, HDL-C was slightly higher in female than male and the difference was significant (p=0.0129).Conclusions: Dyslipidemia was noticed in a greater proportion of female diabetic patients than male diabetic patients.

scholarly journals TCF7L2 Gene Polymorphism as a Risk for Type 2 Diabetes Mellitus and Diabetic Microvascular Complications

2021 ◽  
Author(s):  
Noran Talaat Aboelkhair ◽  
Heba Elsayed Kasem ◽  
Amera Anwar Abdelmoaty ◽  
Rawhia Hassan Eledel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Diabetic Patients ◽  
Tcf7l2 Gene ◽  
Significant Difference ◽  
Patient Groups ◽  
Diabetic Microvascular Complications

Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition with various genetics and environmental influences that affects the capacity of the body to produce or use insulin resulting in hyperglycemia, which may lead to variable complications. It is one of the world’s rising health problems. There is emerging evidence that some genetic polymorphisms can impact the risk of evolving T2DM. We try to determine the relationship of (rs7903146) variant of the Transcription factor 7-like 2 (TCF7L2) gene with T2DM and its microvascular complications.Methods and Results: This case-control study included 180 subjects: 60 diabetic patients without complications, 60 diabetic patients with microvascular complications and 60 matched healthy controls. Genotypes of rs7903146 (C/T) SNP in the TCF7L2 gene were evaluated by real-time polymerase chain reaction via TaqMan allelic discrimination. Logistic regression was used to detect the most independent factor for development of diabetes and diabetic microvascular complications. Variant homozygous TT and heterozygous TC genotypes were significantly increased in diabetic without complications and diabetic with complications groups than controls (p=0.003, 0.001) respectively. The T allele was more represented in both patient groups than controls with no significant difference between patient groups. TT genotype as well as T allele was significantly associated with increased T2DM risk.Conclusion: The T allele of rs7903146 polymorphism of TCF7L2 confers susceptibility to development of T2DM. However, no significant association was found for diabetic complications.

scholarly journals Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Alfi Dewi Sholat ◽  
Dairion Gatot ◽  
Savina Handayani ◽  
Andri Iskandar Mardia ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Pai 1

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

scholarly journals Relationship Research of PPAR-r Gene Polymorphisms with Adiponectin and Leptin in Type 2 Diabetes Mellitus

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Jia Feng ◽  
Shujin Wang ◽  
Hong Zuo ◽  
Xufeng Liu ◽  
Guohong Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Obese Group ◽  
Diabetic Patients ◽  
Peroxisome Proliferator ◽  
Type 2 Diabetic Patients ◽  
Significant Difference

Objective: To investigate the peroxisome proliferator-activated receptor-? (peroxisome) in patients with type 2 diabetes mellitus. Proliferators-activated receptors-?, PPARs-? (?) gene polymorphisms about serum lipofuscin and leptin. Methods: One hundred and twenty patients with type 2 diabetes admitted to our hospital from June 2015 to June 2018 were selected. The patients were divided into an obese group and a non-obese group of 60 patients each according to their waist circumference. A polymerase chain reaction-length polymorphism protocol was implemented in all patients to explore the PPAR-? gene polymorphism, and blood glucose, lipid, adiponectin and leptin levels were measured in both groups. Results: PPAR-? gene polymorphisms in type 2 diabetic patients were dominated by wild-type homozygous; The levels of total cholesterol, triglyceride and LDL cholesterol in the obese group were significantly higher than those in the non-obese group, while the levels of HDL cholesterol were lower than those in the non-obese group. There is significant difference in comparison between groups (P<0.05) Those carrying the A allele had a significant lipid disorder profile and decreased adiponectin levels. Conclusions: PPAR-? gene polymorphisms in type 2 diabetes are not significantly associated with adiponectin and leptin, and only in the obese group, the patients with the Allele A showed significant dyslipidemia and a declining trend of adiponectin levels.

scholarly journals A STUDY OF LIPID PROFILE IN DIABETES MELLITUS TYPE-2 PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Vipin Kumar ◽  
Maya Pensiya ◽  
V B Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Sugar Levels ◽  
And Control

Background: To study the lipid profile in diabetes mellitus in type 2 Diabetes mellitus patients. Methods: This is a cross sectional case control study. 100 patients of type 2 diabetes mellitus and 100 age and sex matched healthy controls were taken. Lipid profile were done in cases and controls using appropriate tests. Results: The fasting blood sugar levels in all the diabetics were significantly higher as compare to control. There was significant difference in mean HDL, Triglycerides level in diabetic and control patients. There was no significant difference in LDL, Cholesterol level in Diabetic and control patients. Conclusion: We concluded that there is a high prevalence of elevated lipid levels among the diabetic patients. Keywords: Diabetes Mellitus -2, Cholesterol, Lipid Profile

scholarly journals Evaluation of Liver in Type 2 Diabetes Mellitus Using Unenhanced Computed Tomography

2020 ◽  
Vol 10 (4) ◽  
pp. 402-406
Author(s):  
Huda Osama ◽  
Afraa Siddig ◽  
Awadia Gareeballah ◽  
Moawia Gameraddin ◽  
Hanady Elyas Osman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Disease ◽  
Effective Control ◽  
Diabetic Patients ◽  
Ct Attenuation ◽  
Significant Difference ◽  
The Impact

Background: Chronic liver disease occurs due to different etiologies. Most diabetic patients are unaware that the effective control of hyperglycemia might reduce complications and mortality rates. Fatty liver disease is considered a risk factor of hepatic cirrhosis and cancers. Methods and Results: We conducted a case-control study to assess the impact of type 2 diabetes mellitus (T2DM) on the liver using a CT scan. A total of 100 patients with T2DM and 96 non-diabetic patients as a control group were selected using a convenient sampling method. There was a significant difference in liver attenuation in diabetic and control groups. The CT attenuation values of the liver, pancreas, and spleen were significantly lower in patients with T2DM than in non-diabetics (P<0.001). There was a significant negative correlation between the duration of T2DM and CT attenuation of the liver, pancreas, and spleen (P<0.01). Conclusion: The CT attenuation of the liver was significantly lower in T2DM than in the non-diabetic patients, and liver attenuation decreased as the duration of T2DM increased.

scholarly journals EFFECTIVENESS OF A MEDICATION BOOKLET AND COUNSELING ON TREATMENT ADHERENCE IN TYPE 2 DIABETES MELLITUS PATIENTS

2017 ◽  
Vol 9 ◽  
pp. 28 ◽  
Author(s):  
Iin Presetiawati ◽  
Retnosari Andrajati ◽  
Rani Sauriasari
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Before And After ◽  
Adherence Scale ◽  
Hba1c Levels

Objective: This study aimed to evaluate the effectiveness of counseling and the use of a medication booklet on the level of treatment compliancethrough reduced levels of glycated hemoglobin (HbA1C) and Morisky Medication Adherence Scale (MMAS-8) scores in patients with type 2 diabetesmellitus.Methods: This pre-experimental prospectively study was conducted at Dr. Adjidarmo General Hospital, KabupatenLebak, Banten Province, Indonesia.The study sample consisted of 30 type 2 diabetic patients who met the inclusion and exclusion criteria and who underwent a counseling interventionsession and received a medication booklet. Compliance was measured against the MMAS-8 scores and HbA1C levels before the intervention and after10 weeks of administration of counseling and receipt of the booklet).Results: The MMAS-8 scores before and after the intervention were 2.63±1.50 and 0.7±1.18, respectively. The HbA1C levels before and after theintervention were 11.31±2.95 and 8.12±2.79, respectively. The measurement results for MMAS-8 and HbA1C were analyzed using the Wilcoxon test.Conclusions: The analysis showed a significant difference (p<0.001) between the HbA1Cvalues and MMAS-8 scores before and after the intervention.Therefore, this study’s finding indicate that the provision of counseling and an informational booklet can improve type 2 diabetes mellitus patientcompliance with treatment.

scholarly journals An Association of Fasting C-Peptide Levels and Vascular Complications in Chronic Type 2 Diabetes Mellitus Patients

2021 ◽  
Author(s):  
T Thippeswamy ◽  
Nirmal Nithin ◽  
Prathima Chikkegowda
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Protective Role ◽  
Macrovascular Complications ◽  
C Peptide ◽  
Peptide Level

Introduction: Numerous biochemical markers are being used in clinical practice for the prediction and prognostication of vascular complications among non diabetic individuals. Of late, fasting C-peptide levels is being investigated for its possible role in the prediction and protection of vascular complications of diabetes. It is also being explored for its protective role in prevention of vascular complications among patients with diabetes mellitus. Aim: The present study was undertaken with an objective to assess the strength of association of fasting C-peptide levels in the development of microvascular and macrovascular complications. Materials and Methods: An observational cross-sectional study involving 100 subjects with Type 2 Diabetes mellitus (T2DM) having an objective evidence of vascular complications were included into the study. The study period was 18 months from October 2017 to September 2019. After an overnight fasting of atleast 12 hours, C-peptide level estimation was done by Electro-Chemiluminescence Assay (ECLA) method. Results: The overall mean fasting C-peptide level among subjects with microvascular complications (0.73±0.55 ng/mL) was significantly decreased compared with subjects having macrovascular complications (2.44±0.72 ng/mL, with p-value being <0.001). Among microvascular complications, the mean fasting C-peptide level was least in subjects with diabetic retinopathy (0.64±0.35 ng/mL). Among patients with macrovascular complications, preserved C-peptide levels were observed in subjects with ischemic heart disease (2.35±0.75 ng/mL). Conclusion: Fasting serum C-peptide levels are significantly reduced among subjects with chronic T2DM having microvascular complications when compared to macrovascular complications. Also, with preserved serum levels, fasting C-peptide might have a protective role in the prevention of macrovascular complications among subjects with diabetes mellitus.

scholarly journals Assessing microRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and T2DM Patients Having First-Degree Relatives With T2DM 

2020 ◽  
Author(s):  
Wu Xu ◽  
Li Yashan ◽  
Man Baohua ◽  
Li Dexuan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
C Peptide ◽  
First Degree Relatives ◽  
Significant Difference ◽  
Normal Glucose

Abstract Background:The pancreatic islet specific microRNA-375 (miR-375) is reported to be upregulated in diabetes patients suppressing the glucose-induced insulin secretion. In this clinical study we aimed to assess the significance of miR-375 among type 2 diabetes mellitus (T2DM) patients and their first-degree relatives with normal glucose tolerance (FD-NGT) and those with T2DM (FD-T2DM).Methods:We included 56 Han Chinese individuals who received medical health check-ups from January 2018 to September 2018 in the Outpatient Department of Endocrinology, The Third Hospital of Yunnan Province, China. They were categorized as normal glucose tolerance (NGT), T2DM, FD-NGT and FD-T2DM. OGTT, C-Peptide and Insulin tests were performed to confirm the diagnosis. The miR-375 levels were determined by Quantitative real-time RT-PCR (qRT-PCR).Results:The OGTT test showed a significant difference in T2DM and FD-T2DM groups compared with NGT and FD-NGT (p＜0.05). Similar results were observed during C-Peptide and insulin tests. Interestingly, the 2-hour insulin test showed FD-NGT group having a significantly higher mean ± standard error of (64.240±12.775) compared to NGT (28.836±10.875). Assessment of miR-375 expression levels in 4 groups showed a significant up-regulation in T2DM and FD-T2DM compared with NGT and FD-NGT group. A slight increase in miRNA expression was observed in FD-NGT compared with NGT group but was not statistically significant.Conclusion: A significantly higher miR-375 expression was observed in T2DM and FD-T2DM groups compared with NGT and FD-NGT and thus, miR-375 may serve as a stable biomarker for the early prediction of T2DM among high-risk individuals.

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