Evaluation of the Fetal Heart Rate during Amniocentesis in Fetuses with Normal and Abnormal Karyotype

Abstract Introduction. We monitored the fetal heart rate (FHR) during amniocentesis in fetuses at 16-22 weeks of gestation and investigated whether an abnormal FHR was associated with chromosomal abnormalities. Methods. This prospective study involved 600 women at 16-22 weeks of gestation who underwent genetic amniocentesis. The FHR, expressed as beats for minute, was recorded before (FHR1), immediately after (FHR2) and 60 min after (FHR3) the invasive procedure. Structural malformations detected by ultrasound and multiple pregnancy were excluded from the study. Results. Chromosomal abnormalities have been diagnosed in 27 fetuses. Mean FHR decrease after amniocentesis has been observed in normal and in abnormal fetuses. The mean variation during amniocentesis was significant in both groups (P<0.01). The comparison between the mean FHR of the two groups showed no differences in FHR1 and FHR2 (P>0.05) but a significant difference in FHR3 (P<0.05). Conclusion. The FHR decreased after amniocentesis; the decrease was larger in chromosomally abnormal fetuses than in normal fetuses. This difference in heart rate reaction to amniocentesis might be due to cardiac defects or developmental delay associated with the abnormal karyotype.

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RELATIONSHIP AMONG MATERNAL, PRENATAL AND PREGNANCY OUTCOME IN RANGELI MUNICIPALITY OF NEPAL

International Journal of Research -GRANTHAALAYAH ◽

10.29121/granthaalayah.v8.i11.2020.2279 ◽

2020 ◽

Vol 8 (11) ◽

pp. 204-210

Author(s):

Asmita Mahato ◽

Barsha Shrestha

Keyword(s):

Heart Rate ◽

Birth Weight ◽

Pregnant Women ◽

Gestational Age ◽

Fetal Heart Rate ◽

Maternal Age ◽

Fetal Heart ◽

Significant Difference ◽

Newborn Weight ◽

The Mean

Background: The incidence of pregnancy complications may be due to risk factors during pregnancy. Whether maternal parameters like age, gravida/ parity, gestational age, and fetal heart rate have any influence to the delivery outcome and newborn weight is a big quest. A young age at birth is more common in Nepal and carries a less social stigma, and hence enforces this study to understand the impact. Objective and methodology: The objectives of this retrospective study were to evaluate the maternal and prenatal outcomes of pregnancies and the effects of the age of the pregnancy, gravida, gestational age, and newborn weight. Pregnant women giving birth in Rangeli Hospital, Morang (Nepal) in 2019 were retrospectively screened. Pregnant women of all age group were included in this study. Results: Mean maternal age for delivery of child was 22.45 ±0.225 years. 41.9% of study subjects were primigravida (G1), while 58.1% were multi-gravida (G2-4). The mean age of primigravida is 20.57 ±0.025 years. Mean gestational week, fetal heart rate (FHR), and newborn weight were 38.18 ±0.11, 140.91 ±0.43, and 2870.65 ±26.13 g respectively. Almost one-third (32.1%) of the newborn were preterm babies. 20.9% of the newborn child was low birth weight. Spontaneous vaginal delivery was seen in 90.7% of the pregnancy while 7.9% had caesarean section. Conclusion: A significant positive correlation was seen of age with gravida, parity, and newborn weight. Newborn weight was significantly related to gestational age. There is no significant difference between the mean maternal age of mother delivering preterm baby or term-baby. No significant difference in the mean age of the mother or the mean gestational duration between male and female children could be established. Significant mean differences were seen in the maternal age of LBW child and normal birth weight child.

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Evaluating the Effect of Dexmedetomidine Intravenous Infusion on Labor Pain Management in Primipar Term Pregnant Women

10.21203/rs.3.rs-103141/v1 ◽

2020 ◽

Author(s):

Abasali Delavari ◽

Arezoo Esmailzadeh ◽

Mahdi Dehgan ◽

Marzieh Lak

Keyword(s):

Heart Rate ◽

Pregnant Women ◽

Drug Administration ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Intervention Group ◽

Labor Pain ◽

Control Group ◽

Significant Difference ◽

The Mean

Abstract Background: The pain of labor is very severe. Most women prefer painless labor to routine labor if they are aware of the methods of analgesia. The aim of this study was to evaluate the effect of Dexmedetomidine intravenous infusion on labor pain management in primipar term pregnant women. Methods: In this Non-randomized clinical trial with control group, all primipar term pregnant women were enrolled in the study. In the intervention group, after the active phase of labor, Dexmedetomidine was given according to the protocol and continued until phase two of labor. The control group received no intervention to reduce pain. Patients in both groups were evaluated for, fetal heart rate, Apgar scores, vital signs, pain intensity and sedation score. Results: There were no significant difference in primary fetal heart rate, primary maternal hemodynamics, and mean Apgar scores of 1 and 5 minutes, between the two groups (p>0.05). There was no significant difference in the mean of fetal heart rate in different stages between two groups. Intra-group analysis in the intervention group showed that mean systolic and diastolic blood pressure were significantly decreased after drug administration but were in normal range. The active phase of labor in the intervention group was significantly shorter than the control group (p = 0.002). The mean VAS score after Dexmedetomidine administration decreased significantly from 9.25 at baseline to 4.61 after drug administration, 3.88 during labor and 1.88 after placental expulsion. The mean RSS score after Dexmedetomidine administration increased significantly from 1 at baseline to 2.05 after drug administration, 2.22 during labor and 2.05 after placental expulsion. Conclusion: Based on results, it seems that administration of Dexmedetomidine to manage labor pain with careful monitoring of mother and fetus is recommended. Due to limited studies, further larger and multicenter studies are needed to be performed.Trial registration: This study was registered on Iranian registry of clinical trials, identification number IRCT20161022030421N5, registered on February 2, 2019, https://irct.ir/trial/40134.

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Effect of Oligohydramnios on Fetal Heart Rate Patterns during Term Labor Induction

American Journal of Perinatology ◽

10.1055/s-0038-1675152 ◽

2018 ◽

Vol 36 (07) ◽

pp. 715-722

Author(s):

Janine S. Rhoades ◽

Molly J. Stout ◽

George A. Macones ◽

Alison G. Cahill

Keyword(s):

Heart Rate ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Secondary Analysis ◽

Neonatal Morbidity ◽

Fetal Monitoring ◽

Secondary Outcome ◽

Significant Difference ◽

Electronic Fetal Monitoring ◽

Consecutive Term

Objective To estimate the effect of oligohydramnios on fetal heart rate (FHR) patterns in patients undergoing induction of labor (IOL) at term. Study Design Secondary analysis of a prospective cohort study of consecutive term, singleton deliveries from 2010 to 2015. We included all patients who underwent IOL. Our primary outcomes were electronic fetal monitoring (EFM) characteristics in the 2 hours preceding delivery. Outcomes were compared between those induced with oligohydramnios and those induced without a diagnosis of oligohydramnios. Our secondary outcome was composite neonatal morbidity. Logistic regression was used to control for confounders. Results Of 3,787 patients who underwent IOL, 147 had a diagnosis of oligohydramnios and 3,640 were included in the no oligohydramnios group. There was no significant difference in EFM characteristics between the two groups. There was no difference in composite neonatal morbidity. In patients with oligohydramnios, EFM patterns with baseline tachycardia for 30 minutes or greater were significantly associated with composite neonatal morbidity (31.3 vs. 5.3% adjusted odds ratio 8.63, 95% confidence interval 2.18, 34.1]). Conclusion Term patients undergoing IOL with oligohydramnios had EFM patterns that did not differ from their induced peers.

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Fetal Heart Rate Regresses toward the Mean in the Third Trimester

Journal of Korean Medical Science ◽

10.3346/jkms.2012.27.7.794 ◽

2012 ◽

Vol 27 (7) ◽

pp. 794 ◽

Cited By ~ 1

Author(s):

Young-Sun Park ◽

Jeong-Kyu Hoh ◽

Moon-Il Park

Keyword(s):

Heart Rate ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Third Trimester ◽

The Third ◽

The Mean

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Fetal Heart Rate and Nuchal Translucency in Detecting Chromosomal Abnormalities Other Than Down Syndrome

Obstetrics and Gynecology ◽

10.1016/s0029-7844(98)00102-1 ◽

1998 ◽

Vol 92 (1) ◽

pp. 68-71 ◽

Cited By ~ 10

Author(s):

J Martinez

Keyword(s):

Heart Rate ◽

Down Syndrome ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Chromosomal Abnormalities ◽

Nuchal Translucency

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Validation of a new algorithm for the short-term variation of the fetal heart rate: an antepartum prospective study

Journal of Perinatal Medicine ◽

10.1515/jpm-2017-0035 ◽

2018 ◽

Vol 46 (6) ◽

pp. 599-604 ◽

Cited By ~ 5

Author(s):

Christina Kouskouti ◽

Hella Jonas ◽

Kerstin Regner ◽

Pia Ruisinger ◽

Julia Knabl ◽

...

Keyword(s):

Heart Rate ◽

Reference Values ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Normal Values ◽

Short Term ◽

Mean Values ◽

Relevant Reference ◽

Term Variation ◽

The Mean

Abstract Aims: Currently one of the most widespread systems for the computerized analysis of the fetal heart rate (FHR) is the Dawes-Redman system, where the short-term variation (STV) of the FHR is measured by dividing each minute into 16 segments (STV16). Technical progress has allowed for the development of a new algorithm, which measures the STV by dividing each minute into 240 segments (STV240), thus approximating the beat-to-beat variation. The STV240 still lacks reference values. Our aim was to develop clinically relevant reference values for the STV240 and compare them to the ones for the STV16. Methods: In a single centre, observational study, a total of 228 cardiotocograms were registered and subsequently analyzed with both algorithms (STV240 and STV16). Results: The 95% confidence interval (CI) was calculated for both algorithms. The values of the STV240 were significantly lower in comparison to the ones of the STV16. Not only the mean values but also the 95th percentile of the STV240 lay beneath the existent cut-off value for the STV16. Conclusions: Every clinician using the new algorithm must be aware that the normal values for the STV240 lie beneath the, up until now, established cut-off values for the STV16.

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Reference values for fetal heart rate in cattle in the first trimester of pregnancy

Acta Veterinaria Hungarica ◽

10.1556/004.2019.028 ◽

2019 ◽

Vol 67 (2) ◽

pp. 274-281

Author(s):

Lea Lénárt ◽

Marcel Taverne ◽

Peter Wolleswinkel ◽

Zoltán Gubik ◽

László Molnár ◽

...

Keyword(s):

Heart Rate ◽

Fetal Heart Rate ◽

Fetal Heart ◽

First Trimester ◽

Reference Curve ◽

Singleton Pregnancy ◽

Array Transducer ◽

Significant Difference ◽

Bovine Fetuses ◽

First Trimester Of Pregnancy

The aim of this study was to create a fetal heart rate (FHR) reference curve for singleton bovine fetuses in the first trimester of gestation and to determine its possible relationship with the outcome of pregnancy. Forty-eight Holstein-Friesian cows with one fetus and five cows with twins were used. Fetal heart beatings were recorded on videotape during transrectal scanning with a 5 and/or 7.5 MHz linear array transducer on a weekly basis between Days 40 and 95 of gestation. FHR was calculated by averaging the results of five counts of the same record by the same observer. For singleton pregnancies, a reference curve was created using the mean, the standard deviation (SD) and the 5th and 95th percentiles. The FHR increased from Days 40–46 (173 beats/min) to Days 61–67 (183 beats/min). After a peak, the FHR decreased slowly until Days 89–95 (175 beats/min), while the SD increased. There was no significant difference between singleton and twin fetuses. in the aborted and lost fetuses in twin gestation due to fetal reduction, both bradycardia and tachycardia were detected compared to the singleton pregnancy reference curve.

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Heart rate and body temperature during free diving of Weddell seals

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1987.253.2.r344 ◽

1987 ◽

Vol 253 (2) ◽

pp. R344-R351 ◽

Cited By ~ 15

Author(s):

R. D. Hill ◽

R. C. Schneider ◽

G. C. Liggins ◽

A. H. Schuette ◽

R. L. Elliott ◽

...

Keyword(s):

Heart Rate ◽

Body Temperature ◽

Adult Male ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Weddell Seal ◽

The Body ◽

Weddell Seals ◽

The Mean ◽

Slow Onset

We have developed and successfully used the first microprocessor-controlled monitors for collection of data on depth, heart rate, and body temperature of one fetal and five adult male freely swimming Weddell seals. Adult seals almost invariably experienced a prompt bradycardia at the start of each dive, and the mean heart rate during diving was significantly lower for dives greater than 20 min (P greater than 0.999). The heart rate was also significantly greater during the ascent portion of dives when compared with the descent portion (P greater than 0.95). The fetal seal experienced a slow onset of bradycardia when its mother dived; during diving the fetal heart rate decreased by an average of 1.1 beats/min for each minute of the dive. The fetal heart rate generally took approximately 10 min to recover to predive levels after its mother resurfaced to breathe. The body temperature of one adult male Weddell seal showed a decrease of greater than 1.5 degrees C from resting levels before dives of greater than 15 min were initiated and a drop of over 2 degrees C before dives of greater than 30 min duration.

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