Total vs. partial aponeurectomy for Dupuytren’s contracture — A literature review

AbstractThe etiology of Dupuytren’s disease is controversial and thus the disease can only be treated when it presents with symptoms to warrant intervention. Surgical treatment is the method of choice to preserve hand dexterity and function. It is advisable to perform surgery at an early stage of disease progression, but various surgical techniques have been advocated. A partial fasciectomy is recommend by many authors, whereas a total aponeurectomy, where all palmar tissue is removed, might reduce the risk of recurrent disease due to the widespread removal of aponeurosis. The total aponeurectomy is performed less frequently due to the potential complications of this technique. In order to achieve an objective comparison of both surgical options we performed a literature meta-analysis, involving a comparison of surgical indications, results and complications following partial and total aponeurectomy, which are described in detail within this review article.

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Open and Minimal Approaches to Pancreatic Adenocarcinoma

Gastroenterology Research and Practice ◽

10.1155/2020/4162657 ◽

2020 ◽

Vol 2020 ◽

pp. 1-12

Author(s):

Ricky H. Bhogal ◽

Stephanos Pericleous ◽

Aamir Z. Khan

Keyword(s):

Pancreatic Cancer ◽

Neoadjuvant Treatment ◽

Surgical Techniques ◽

Treatment Strategies ◽

Outcome Data ◽

Review Article ◽

Surgical Approaches ◽

Minimal Access ◽

Surgical Methods ◽

Surgical Options

Surgical options and approaches to pancreatic cancer are changing in the current era. Neoadjuvant treatment strategies for pancreatic cancer combined with the increased use of minimal access surgical techniques mean that the modern pancreatic surgeon requires mastering a number of surgical approaches with to optimally manage patients. Whilst traditional open surgery remains the most frequent approach for surgery, the specific steps during surgery may need to be modified in light of the aforementioned neoadjuvant treatments. Robotic and laparoscopic approaches to pancreatic resection are feasible, but these surgical methods remain in their infancy. In this review article, we summarise the current surgical approaches to pancreatic cancer and how these are adapted to the minimal access setting with discussion of the patient outcome data.

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Investigation of Severe Craniomaxillofacial Battle Injuries Sustained by U.S. Service Members: A Case Series

Craniomaxillofacial Trauma & Reconstruction ◽

10.1055/s-0032-1329542 ◽

2012 ◽

Vol 5 (4) ◽

pp. 243-252 ◽

Cited By ~ 8

Author(s):

Pamela R. Brown Baer ◽

Joseph C. Wenke ◽

Steven J. Thomas ◽

Colonel Robert G. Hale

Keyword(s):

Surgical Techniques ◽

Case Series ◽

Wound Dehiscence ◽

Service Members ◽

Natural Form ◽

Form And Function ◽

The Face ◽

Surgical Options ◽

And Function ◽

Battle Injuries

This case series describes craniomaxillofacial battle injuries, currently available surgical techniques, and the compromised outcomes of four service members who sustained severe craniomaxillofacial battle injuries in Iraq or Afghanistan. Demographic information, diagnostic evaluation, surgical procedures, and outcomes were collected and detailed with a follow-up of over 2 years. Reconstructive efforts with advanced, multidisciplinary, and multiple revision procedures were indicated; the full scope of conventional surgical options and resources were utilized. Patients experienced surgical complications, including postoperative wound dehiscence, infection, flap failure, inadequate mandibular healing, and failure of fixation. These complications required multiple revisions and salvage interventions. In addition, facial burns complicated reconstructive efforts by delaying treatment, decreasing surgical options, and increasing procedural numbers. All patients, despite multiple surgeries, continue to have functional and aesthetic deficits as a result of their injuries. Currently, no conventional treatments are available to satisfactorily reconstruct the face severely ravaged by explosive devices to an acceptable level, much less to natural form and function.

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The ENIGMA Brain Injury Working Group: Approach, Challenges, and Potential Benefits

10.31234/osf.io/t96xb ◽

2019 ◽

Cited By ~ 7

Author(s):

Elisabeth A. Wilde ◽

Emily L. Dennis ◽

David F Tate

Keyword(s):

Brain Injury ◽

Working Group ◽

Meta Analysis ◽

Special Issue ◽

Group Approach ◽

Challenges And Opportunities ◽

Brain Structure And Function ◽

Potential Benefits ◽

And Function ◽

Neuroimaging Genetics

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Brain Injury working group includes 8 subgroups, based largely on injury mechanism and patient population. This introduction to the special issue summarizes the history, organization, and objectives of ENIGMA Brain Injury, and includes a discussion of strategies, challenges, opportunities and goals common across 6 of the subgroups under the umbrella of ENIGMA Brain Injury. The following articles in this special issue, including 6 articles from different subgroups, will detail the challenges and opportunities specific to each subgroup.

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Faculty of 1000 evaluation for Efficacy of tai chi on pain, stiffness and function in patients with osteoarthritis: a meta-analysis.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718006754.793477048 ◽

2013 ◽

Author(s):

Joanne Jordan ◽

Amanda Nelson

Keyword(s):

Tai Chi ◽

Meta Analysis ◽

And Function

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Faculty Opinions recommendation of Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736758913.793567263 ◽

2019 ◽

Author(s):

Anil D'Cruz ◽

Richa Vaish ◽

Harsh Dhar

Keyword(s):

Oral Cancer ◽

Neck Dissection ◽

Real World ◽

Early Stage ◽

Meta Analysis ◽

Randomised Trial ◽

Elective Neck Dissection

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Fractal analysis in biology and medicine

Dalʹnevostočnyj medicinskij žurnal ◽

10.35177/1994-5191-2020-4-85-92 ◽

2020 ◽

pp. 85-92

Keyword(s):

Fractal Analysis ◽

A Priori ◽

Research Work ◽

Structure And Function ◽

Review Article ◽

Living Systems ◽

Modern Biology ◽

Additional Information ◽

Important Additional Information ◽

And Function

The review article discusses the possibilities of using fractal mathematical analysis to solve scientific and applied problems of modern biology and medicine. The authors show that only such an approach, related to the section of nonlinear mechanics, allows quantifying the chaotic component of the structure and function of living systems, that is a priori important additional information and expands, in particular, the possibilities of diagnostics, differential diagnosis and prediction of the course of physiological and pathological processes. A number of examples demonstrate the specific advantages of using fractal analysis for these purposes. The conclusion can be made that the expanded use of fractal analysis methods in the research work of medical and biological specialists is promising.

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miR-224 is an early-stage biomarker of hepatocellular carcinoma with miR-224 and miR-125b as prognostic biomarkers

Biomarkers in Medicine ◽

10.2217/bmm-2020-0099 ◽

2020 ◽

Vol 14 (15) ◽

pp. 1485-1500

Author(s):

Lichao Yang ◽

Chunmeng Wei ◽

Yasi Li ◽

Xiao He ◽

Min He

Keyword(s):

Hepatocellular Carcinoma ◽

Systematic Review ◽

Survival Analysis ◽

Sensitivity And Specificity ◽

Poor Prognosis ◽

Early Stage ◽

Meta Analysis ◽

Benign Lesion ◽

Diagnostic Efficiency ◽

Low Expression

Aim: The aim was to systematically investigate the miRNA biomarkers for early diagnosis of hepatocellular carcinoma (HCC). Materials & methods: A systematic review and meta-analysis of miRNA expression in HCC were performed. Results: A total of 4903 cases from 30 original studies were comprehensively analyzed. The sensitivity and specificity of miR-224 in discriminating early-stage HCC patients from benign lesion patients were 0.868 and 0.792, which were superior to α-fetoprotein. Combined miR-224 with α-fetoprotein, the sensitivity and specificity were increased to 0.882 and 0.808. Prognostic survival analysis showed low expression of miR-125b and high expression of miR-224 were associated with poor prognosis. Conclusion: miR-224 had a prominent diagnostic efficiency in early-stage HCC, with miR-224 and miR-125b being valuable in the prognostic diagnosis.

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Adjuvant trastuzumab regimen for HER2-positive early-stage breast cancer: a systematic review and meta-analysis

Expert Review of Clinical Pharmacology ◽

10.1080/17512433.2019.1637252 ◽

2019 ◽

Vol 12 (8) ◽

pp. 815-824 ◽

Cited By ~ 4

Author(s):

Anne Julienne Genuino ◽

Usa Chaikledkaew ◽

Due Ong The ◽

Thanyanan Reungwetwattana ◽

Ammarin Thakkinstian

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Early Stage ◽

Meta Analysis ◽

Early Stage Breast Cancer ◽

Her2 Positive ◽

Adjuvant Trastuzumab

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Impact of Chemotherapy in the Adjuvant Setting of Early Stage Uterine Leiomyosarcoma: A Systematic Review and Updated Meta-Analysis

Cancers ◽

10.3390/cancers12071899 ◽

2020 ◽

Vol 12 (7) ◽

pp. 1899

Author(s):

Alessandro Rizzo ◽

Margherita Nannini ◽

Annalisa Astolfi ◽

Valentina Indio ◽

Pierandrea De Iaco ◽

...

Keyword(s):

Systematic Review ◽

Recurrence Rate ◽

Locoregional Recurrence ◽

Early Stage ◽

Meta Analysis ◽

Distant Recurrence ◽

Uterine Leiomyosarcoma ◽

Primary Surgery ◽

Locoregional Recurrence Rate ◽

Meta Analyses

Background: Although the use of adjuvant chemotherapy (AC) appears to be increasing over the past few years, several clinical trials and previous meta-analyses failed to determine whether AC could improve clinical outcomes in uterine leiomyosarcoma (uLMS). The aim of this systematic review and meta-analysis was to compare AC (with or without radiotherapy) versus observation (obs) after primary surgery in early stage uLMS. Materials and Methods: Randomized controlled (RCTs) and non-randomized studies (NRSs) were retrieved. Outcomes of interest were as follows: distant recurrence rate, locoregional recurrence rate and overall recurrence rate. Results about distant recurrence rate, locoregional recurrence rate and overall recurrence rate were compared by calculating odds ratios (ORs) with 95% confidence intervals (CIs); ORs were combined with Mantel–Haenszel method. Results: Nine studies were included in the analysis, involving 545 patients (AC: 252, obs: 293). Compared with obs, AC did not reduce locoregional and distant recurrence rate, with a pooled OR of 1.36 and 0.63, respectively. Similarly, administration of AC did not decrease overall recurrence rate in comparison to obs. Conclusion: According to our results, AC (with or without radiotherapy) did not decrease recurrence rate in early stage uLMS; thus, the role of AC in this setting remains unclear.

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