scholarly journals HCV Infection and Chronic Renal Disease

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sofija Sekulic ◽  
Zeljko Mijailovic ◽  
Dejan Petrovic ◽  
Ruzica Lukic ◽  
Marina Jovanovic ◽  
...  
Keyword(s):  
Public Health ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Chronic Renal Disease ◽  
Public Health Problem ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Chronic Hepatitis C Virus ◽  
Stage Renal Disease ◽  
End Stage

Abstract Chronic Hepatitis C virus (HCV) infection is defined as persistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver disease and cirrhosis. It’s serious public health problem, affects about 71 million people worldwide. HCV doesn’t destroy hepatocytes directly. It activates the host's innate and acquired immune system and causes liver injury indirectly. Behind hepatic, HCV can cause extra-hepatic manifestations. One of them is renal disease which can lead to end-stage renal disease, ESRD. The prevalence of HCV infection in patients on hemodialysis is high, ranging from 5% to 60%. HCV infection is a significant cause of morbidity and mortality in patients with ESRD on hemodialysis. In this review, we discuss HCV infection and chronic renal disease as comorbidities, their severity and outcome.

scholarly journals Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ruzica Lukic ◽  
Nevena Gajovic ◽  
Ivan Jovanovic ◽  
Milena Jurisevic ◽  
Zeljko Mijailovic ◽  
...  
Keyword(s):  
Renal Disease ◽  
Disease Severity ◽  
End Stage Renal Disease ◽  
Chronic Renal Disease ◽  
Hcv Infection ◽  
Galectin 3 ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Hepatitis C virus infection (HCV), one of the greatest causes of liver disease, is a frequent complication in patients with end-stage renal disease (ESRD) on dialysis. ESRD is defined as decreased glomerular filtration and also accompanied by impaired function of the immune system. Galectin-3 is aβ-galactoside-binding lectin, involved in various biological processes including pathogenesis of chronic renal disease. The aim of our study was to estimate disease severity in ESRD HCV+patients and analyze the serum concentrations of IL-1β, IL-4, IL-23, and IL-6; anti-HCV antibodies; and galectin-3. Also, we attempted to determine potential correlation between galectin-3 level and parameters of disease severity ALT and AST. Our results showed decreased levels of ALT and AST (p=0.00), demonstrating less liver destruction in ESRD HCV+patients in comparison to HCV+patients. Increased levels of IL-6 (p=0.03) implicate a hepatoprotective role of IL-6 in these patients. Also, level of galectin-3 (p=0.00) in the serum of ESRD HCV+patients was higher than that of HCV+patients. This alteration was accompanied with negative correlation between galectin-3 and AST and ALT, respectively (p=0.029;p=0.033). The presence of increased systemic levels of IL-6 and Gal-3 in ESRD HCV+patients may be an attempt to counteract or limit ongoing proinflammatory processes and to downregulate chronic inflammation, suggesting the new aspects of HCV infection in ESRD patients.

The role of VEGF rs699947 polymorphism in End-Stage Renal Disease: A preliminary study

2021 ◽  
pp. 19-23
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Protective Factor ◽  
Public Health Problem ◽  
Turkish Population ◽  
Control Group ◽  
Case Group ◽  
Important Public Health Problem ◽  
Stage Renal Disease ◽  
End Stage

Aim: End-Stage Renal Disease (ESRD) is an important public health problem worldwide with an increasing incidence and prevalence. There are many environmental and genetic factors which contribute to the development of ESRD. Vascular endothelial growth factor (VEGF) has been suggested to play an important role in renal pathophysiology. The aim of this study was to determine the probable relation between ESRD and VEGF gene rs699947 polymorphism in Turkish population. Material and Method: Genotyping of rs699947 was carried out in 50 ESRD patients on dialysis treatment and 30 healthy controls, using a Kompetitive Allelic-Specific PCR (KASP) method following DNA isolation. Demographic and clinical characteristics of the patients were recorded. Results: The prevalance of rs699947 AA genotype was found to be higher in the control group, but it was not statistically significant (p>0.05) . Conclusion: Although statistically insignificant, the frequency of AA genotype was higher in the control group compared to the case group, therefore we concluded that AA genotype may be a protective factor for ESRD in Turkish population. However, this conclusion needs to be further verified by future studies performed in larger study groups.

The Frequency of Pulmonary Hypertension among End Stage Renal Disease Patients on Hemodialysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Irfan Mirza ◽  
Ahmad Zeb Khan ◽  
Mufti Baleegh ◽  
Amirullah . ◽  
Tahir Rashid ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Public Health Problem ◽  
Sampling Technique ◽  
Global Public Health ◽  
Endstage Renal Disease ◽  
Mortality And Morbidity ◽  
Stage Renal Disease ◽  
End Stage

Background: Chronic kidney disease is one of the global public health problem. It is a major cause of mortality and morbidity. Endstage renal disease patients will have either option of renal transplant or dialysis. Although dialysis is an effective form of renalreplacement therapy but it also have long term side effects. Pulmonary hypertension is one of them.Objective: To find frequency of pulmonary hypertension among end stage renal disease patients on hemodialysis in our populationMaterial and Methods: In this study a total of 163 patients were included, using 18.8% prevalence of pulmonary hypertension inend stage renal disease patients on hemodialysis, with 95% confidence interval and 6% margin of error, using WHO software. Moreover non-probability consecutive sampling technique was used for sample collection.Results: Our study shows that mean age was 52 years with SD ± 8.21. Fifty five percent patients were male and 73(45%) patientswere female. Forty eight percent patients had pulmonary hypertension.Conclusion: Our study concludes that the incidence of pulmonary hypertension was found to be one of the major contributingfactor among end stage renal disease patients on hemodialysis in our population.

scholarly journals SP315ARCHITECT HEPATITIS C VIRUS (HCV) CORE ANTIGEN TEST: A HCV RNA SCREENING ALTERNATIVE IN END-STAGE RENAL DISEASE (ESRD) AND HEMODIALYSIS PATIENTS?

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i450-i450
Author(s):  
Rita Valério Alves ◽  
Rita Abrantes ◽  
Hernâni Gonçalves ◽  
Maria Leonor Gonçalves ◽  
Karina Lopes ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Hemodialysis Patients ◽  
Core Antigen ◽  
Hcv Rna ◽  
Antigen Test ◽  
Stage Renal Disease ◽  
End Stage

Electrolyte Disorders

2016 ◽  
pp. 571-578
Author(s):  
Qi Qian
Keyword(s):  
Public Health ◽  
United States ◽  
Health Care ◽  
Chronic Kidney Disease ◽  
End Stage Renal Disease ◽  
Public Health Problem ◽  
The United States ◽  
Electrolyte Disorders ◽  
Stage Renal Disease ◽  
End Stage

Chronic kidney disease (CKD) is a worldwide public health problem. In the United States, the prevalence of end-stage renal disease is increasing, especially among patients older than 65 years. More than 20 million people in the United States are thought to have CKD, and this population consumes a disproportionate amount of health care resources. CKD is also associated with increased mortality, particularly from cardiovascular causes.

scholarly journals The Relationship between IL-1β, IL-17, IL-33 and Bcl-2 and the Development of Diabetic Nephropathy

2021 ◽  
Author(s):  
Ahmed Nabil ◽  
Basant Mahmoud ◽  
Adel Abdel-Moneim ◽  
Zinab Negeem
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cell Lymphoma ◽  
Chronic Renal Disease ◽  
Sodium Concentration ◽  
Positive Correlations ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Relationship

Abstract Background: Diabetic nephropathy (DN) is among the main complications of diabetes mellitus, and it has been the major factor of renal failure. The current investigation aims to address the association between beta-cell lymphoma-2 (Bcl-2), interleukin (IL)-1β, IL-17, and IL-33 with the development of DN. Methods: In this study, twenty healthy volunteers plus hundred patients have been signed up. According to their biochemical markers, patients were categorized into 5 groups; diabetic, chronic renal disease, diabetic chronic renal disease, end-stage renal disease, and diabetic end-stage renal disease. Results: Our results showed a noticeable elevation in IL-1β and IL-17 levels and a reduce in IL-33 and Bcl-2 levels in all investigated groups relative to the healthy group. Positive correlations were reported between IL-1β with FBS and creatinine levels, IL-17, with HbA1c% and sodium levels. However, negative correlations were exerted between IL-33 with urea and sodium concentration, Bcl2 with HbA1c%, and creatinine levels.Conclusion: The present data revealed a marked relationship between Bcl-2, IL-1β, IL-17, and IL-33 levels and the progression of DN. Therefore, understanding the molecular pathways of inflammatory and apoptotic activities-related DN could be translated into the development of therapeutic strategies.

scholarly journals Spontaneous changes in the rate of decline in reciprocal serum creatinine: errors in predicting the progression of renal disease from extrapolation of the slope.

1992 ◽  
Vol 2 (7) ◽  
pp. 1186-1191
Author(s):  
B V Shah ◽  
A S Levey
Keyword(s):  
Renal Disease ◽  
Serum Creatinine ◽  
End Stage Renal Disease ◽  
Chronic Renal Disease ◽  
Linear Regression Analysis ◽  
Effect Of Therapy ◽  
The Mean ◽  
Rate Of Decline ◽  
Stage Renal Disease ◽  
End Stage

The slope of reciprocal serum creatinine (1/Pcr) versus time has been used to measure the rate of progression of chronic renal disease, predict the interval until onset of end-stage renal disease, and assess the effect of therapy. In order to determine the errors that might result from extrapolating the slope of 1/Pcr versus time beyond the interval of observation, we applied a method of linear regression analysis to search for spontaneous changes in slope in 21 patients from New England Medical Center and 56 patients in three published studies in whom the decline in 1/Pcr appeared constant (r greater than or equal to 0.84 for the correlation of 1/Pcr versus time). Significant changes in the slope (breakpoints) were identified in one third to one half of the 77 patients and appeared to be spontaneous. The second slope was less steep in 49 patients (6.1%); the mean value for serum creatinine at the time of the breakpoint was 5.3 mg/dL; the mean change in slope (absolute value) was 0.005 dL/mg/month (adults) and 0.017 dL/mg/month (children); and the mean error in prediction of the interval until the final value for serum creatinine was 27% of the actual interval. We conclude that spontaneous breakpoints in the slope of 1/Pcr versus time are very frequent, even among patients with an apparent constant rate of decline. Breakpoints may cause errors in extrapolating the slope to predict the interval until the onset of end-stage renal disease and to assess the effect of therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Sign in / Sign up

Export Citation Format

Share Document