scholarly journals Influence of electromagnetic waves at frequencies of 150,176...150,664 GHz on brain microcirculation under conditions of prolonged experimental ischemia

2016 ◽  
Vol 15 (3) ◽  
pp. 64-69
Author(s):  
A. N. Ivanov ◽  
M. A. Sakhan ◽  
I. O. Bugaeva
Keyword(s):  
Electromagnetic Radiation ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Male Rats ◽  
Cerebrovascular Insufficiency ◽  
Actual Problem ◽  
Flow Modulation ◽  
Low Intensity ◽  
The Impact ◽  
Brain Microcirculation

Introduction and purpose. Chronic cerebrovascular insufficiency - an actual problem of modern medicine. The key pathogenetic link of this group of diseases is a long-term violation of perfusion in the microvasculature. Currently, it is shown that low-intensity electromagnetic radiation at frequencies of millimeter and submillimeter ranges had an influence on processes in the microcirculation. The aim of this study was to examine the impact on perfusion indices in the vessels of the brain microcirculation in conditions of chronic ischemia. Materials and methods. Experiments were conducted on 52 male rats, which were divided into 3 groups. The first group consisted of 27 rats, which model of chronic cerebral hypoperfusion were reproduced. The second group consisted of 15 rats with chronic cerebral hypoperfusion and daily 30-minute exposure to low-intensity electromagnetic radiation at frequencies 150.176...150.664 GHz. 10 sham-operated rats for the analysis microcirculation mechanisms used the method of laser Doppler flowmetry were included in the third (control) group. The average perfusion, as well as active and passive mechanisms flow modulation were investigated. The main results and discussion. It was found that low-intensity electromagnetic radiation at frequencies 150.176...150.664 GHz contributes to the normalization of perfusion parameters in conditions of prolonged ischemia due to stimulation of active and passive flow modulation mechanisms. This effect is probably related to the prevention of endothelial dysfunction, as well as the influence of electromagnetic radiation on the functional activity of platelets and blood rheology. Conclusion. Thus, the results of the study suggest that low-intensity electromagnetic radiation at frequencies 150.176...150.664 GHz, is a promising method for non-drug correction of perfusion disturbances at long cerebrovascular insufficiency.

scholarly journals Effect of electromagnetic radiation from a mobile phone (1745 MHz) on the condition of the reproductive system of male rats during their postnatal development

2019 ◽  
Vol 16 (2) ◽  
pp. 216-225
Author(s):  
N. V. Chueshova ◽  
F. I. Vismont ◽  
I. A. Cheshyk
Keyword(s):  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Reproductive System ◽  
Age Groups ◽  
Serum Testosterone ◽  
The Body ◽  
Male Rats ◽  
Early Puberty ◽  
Low Intensity ◽  
The Impact

A comprehensive assessment of the morphofunctional changes in the reproductive system of male rats of several age groups was carried out, starting from the prepubertal period (50–52 days) and until they reach puberty (4,5 months) under the conditions of exposure to low-intensity electromagnetic radiation from a mobile phone (EMR MP, 1745 MHz, power density of 0.2–20 µW/cm2). It was established that the nature of the revealed morphofunctional changes in the reproductive system of male rats exposed to low-intensity EMR from MT largely depends on the exposure duration and the age of animals. The impact of EMR from MT (for 7 days) on the body of male rats during puberty leads to significant changes in the developing reproductive system. Namely, against the background of an increase in the mass of epididymis and seminal vesicles, the development of degenerative changes in the testes was revealed, manifested by the inhibition of the proliferative activity and the activation of differentiation of spermatogenic epithelial cells – spermatids, which is accompanied by a significant increase in the number of epididymal spermatozoa (early puberty), while their viability decreases and serum testosterone concentrations increase. On the contrary, the prolonged (for 60 and 90 days) exposure of EMR from MT to the organism of male rats from the early puberty period and until they reach puberty is characterized by a weakly expressed spermatogenic epithelium reaction, but also the most characteristic decrease in the number and viability of spermatozoa, as well as by the increase in concentration of testosterone in blood serum. The complex of identified disorders in the morphofunctional state of the reproductive system of male rats indicates the inhibition of its function under the influence of low-intensity EMR from MT, which may be a factor affecting the decline in male fertility.

Chronic cerebral hypoperfusion in male rats results in sustained HPA activation, and hyperinsulinemia

2021 ◽  
Author(s):  
Theresa A. Lansdell ◽  
Anne M Dorrance
Keyword(s):  
Insulin Resistance ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Male Rats ◽  
Lower Blood Glucose ◽  
Insulin Resistant ◽  
Lower Blood ◽  
Bilateral Carotid ◽  
Glucose Tolerance Tests ◽  
Bilateral Carotid Artery

Vascular contributions to cognitive impairment and dementia (VCID) is a spectrum of cognitive deficits caused by cerebrovascular disease, for which insulin resistance is a major risk factor. A major cause of VCID is chronic cerebral hypoperfusion (CCH). Under stress, sustained hypothalamic-pituitary-adrenal axis (HPA) activation can result in insulin resistance. Little is known about the effects of CCH on the HPA axis. We hypothesized that CCH causes sustained HPA activation and insulin resistance. Male rats were subjected to bilateral carotid artery stenosis (BCAS) for 12 weeks to induce CCH and VCID. BCAS reduced cerebral blood flow and caused memory impairment. Plasma adrenocorticotropic hormone was increased in the BCAS rats (117.2 ± 9.6 vs. 88.29 ± 9.1 pg/mL, BCAS vs. sham, p = 0.0236), as was corticosterone (220 ± 21 vs. 146 ± 18 ng/g feces, BCAS vs. sham, p = 0.0083). BCAS rats were hypoglycemic (68.1 ± 6.1 vs. 76.5± 5.9 mg/dL, BCAS vs. sham, p = 0.0072), with increased fasting insulin (481.6 ± 242.6 vs. 97.94± 40.02 pmol/L, BCAS vs. sham, p = 0.0003) indicating BCAS rats were insulin resistant (HOMA-IR:11.71 ± 6.47 vs. 2.62 ± 0.93; BCAS vs. control, p = 0.0008). Glucose tolerance tests revealed that BCAS rats had lower blood glucose AUCs than controls (250 ± 12 vs. 326 ± 20 mg/dL/h, BCAS vs. sham, p = 0.0075). These studies indicate that CCH causes sustained activation of the HPA and results in insulin resistance, a condition that is expected to worsen VCID.

Postradiation Effects of Low Intensity Electromagnetic Radiation with a Frequency of 900 MHz in Rat Liver

2020 ◽  
Vol 65 (3) ◽  
pp. 53-58
Author(s):  
M. Petrosyan ◽  
L. Nersesova ◽  
E. Karalova ◽  
A. Avetisyan ◽  
L. Abroyan ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Blood Serum ◽  
Electromagnetic Radiation ◽  
Rat Liver ◽  
Dna Content ◽  
Transcriptional Activity ◽  
Serum Creatine Kinase ◽  
Male Rats ◽  
Low Intensity ◽  
Post Radiation

Purpose: To study the changes in the activity of the liver and blood serum creatine kinase (KK) and the nucleus-nucleolus apparatus of hepatocytes of rats, subjected to the low-intensity electromagnetic radiation of 900 MHz and 25 µW/cm2 energy flux density, typical for a range of mobile phones. Material and methods: The experiments were carried out on white outbred male rats of 6 months of age, weighing 180–200g. The generator Panoramic X1-42 was used as a source of radiation having a frequency of 900 MHz. The activity of CK in the blood serum and liver extracts respectively was determined spectrophotometrically, based on the accumulation of free creatine. Using the extent of the DNA content in rat hepatocytes relative to the accepted standard, the distribution of hepatocytes in ploidy (measured in percentage poins) was detected; so was determined the ratio of eu- and aneuploid cells. Results: It appears that the two-hour single total exposure of rats causes more substantial changes in the activity levels of rats both liver and serum creatine kinase than the total time-wise comparable fractional exposure; while the enzyme exhibits signs of significant adaptation. A decrease in the average DNA content of the nucleus and nucleolus, as well as the average number of nucleolus per nucleus, along with an increase in the number of nucleolus-free nuclei after a single radiofrequency irradiation act indicates certain inhibition of the transcriptional activity of hepatocytes. At the same time, a post-radiation increase of hypodiploid cells, half of which are nucleolus-free hepatocytes, as well as an increase in the number of triploid cells, accompanied by a decrease in the number of tetraploid hepatocytes and the disappearance of hypertetraploid hepatocytes, indicate the incidence of death of a significant number of hepatocytes. Conclusion: The rat liver CK is sensitive to the action of both single low-intensity electromagnetic radiation with a frequency of 900 MHz and that dispersed through fractional exposure: the biological effect of a single exposure is more pronounced. The dynamics of the post-radiation changes occurring in the hepatocyte population upon their single radiofrequency irradiation indicates certain inhibition of the transcriptional activity of the hepatocytes, as well as the incidence of death of a significant number of hepatocytes.

scholarly journals REACTION OF MOLLUSCSHELIX ALBESCENSFOR LOW INTENSITY ELECTROMAGNETIC RADIATION EFFECTS OF EXTREMELY HIGH FREQUENCY

2020 ◽  
Vol 9 (5(74)) ◽  
pp. 38-44
Keyword(s):  
Electromagnetic Radiation ◽  
High Frequency ◽  
Radiation Effects ◽  
Antinociceptive Effect ◽  
Opioid System ◽  
Low Intensity ◽  
Nociceptive Sensitivity ◽  
Extremely High Frequency ◽  
Regulation Mechanisms ◽  
The Impact

The effect of low-intensity EMR EHFon the parameters of nociceptive sensitivity of molluscs Helix albescens. It is shown that EMR EHF has a pronounced antinociceptive effect in the regulation mechanisms of which the importance played by opioid system, whose role at different stages of the impact of EMR EHF varies

Biological effects of low-intensity radiofrequency fields and risk assessment for biota

2020 ◽  
Vol 60 (9) ◽  
pp. 592-596
Author(s):  
Elena I. Sarapultseva ◽  
Darya V. Uskalova ◽  
Ksenya V. Ustenko
Keyword(s):  
Radio Frequency ◽  
Electromagnetic Radiation ◽  
Electromagnetic Fields ◽  
Negative Impact ◽  
Biological Effects ◽  
High Sensitivity ◽  
Communication Technologies ◽  
Natural Ecosystems ◽  
Low Intensity ◽  
Different Levels

Despite the fact that there are still conflicting opinions about the damage caused by modern wireless communication technologies, most scientists report on the negative biological effects of low-intensity radio frequency electromagnetic radiation at different levels of the organization of live nature. There is no doubt that there is a need not only for a sanitary and hygienic assessment of man-made electromagnetic effects on humans, but also for an environmental assessment for biota. The purpose of the study was to assess the potential environmental risk of electromagnetic impact in the centimeter range on natural ecosystems. The initial data were the authors' own results in the field of radiobiology of non-ionizing radiation, as well as published of other researchers. The article analyzes the biological effects of radio frequency electromagnetic fields detected in organisms of different systematic groups and levels of organization. The data on the non-thermal biological effects of electromagnetic fields indicate a high sensitivity of different species to this factor. The analyzed research results emphasize the need to take into account the features of non-thermal effects of electromagnetic radiation on biota, since these radiations can have a negative impact on different hierarchical levels in natural ecosystems.

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